Research Animal Support Facility (RASF)

Equipment/facility: Facility

  • Location

    United States

Equipments Details

Description

The Transgenic Animal Core provides Science Park investigators with a cost-effective means of developing genetically engineered animal models. Our services include:
*Generation of transgenic mouse founders by pronuclear microinjection of DNA constructs into fertilized FVB embryos (or other strains as needed)
*Generation of chimeric mice by blastocyst injection of gene-targeted ES cell lines
Rederivation of transgenic and other specialized mouse strains by embryo transfer
*Archival storage of frozen embryos and sperm from transgenic and other specialized mouse strains
*Gene knockout and knock-in mouse models using zinc-finger nuclease technology
*Consultation, technical support and training to investigators wishing to establish their own genetically modified animals
Transgenic Services_Sperm Freezing
Transgenic Services_DNA CONSTRUCT
Transgenic Services_Frozen Embryos
Transgenic Services_Rederivation

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