Research Animal Support Facility (RASF)

Equipment/facility: Facility

  • Location

    United States

Description

The Transgenic Animal Core provides Science Park investigators with a cost-effective means of developing genetically engineered animal models. Our services include:
*Generation of transgenic mouse founders by pronuclear microinjection of DNA constructs into fertilized FVB embryos (or other strains as needed)
*Generation of chimeric mice by blastocyst injection of gene-targeted ES cell lines
Rederivation of transgenic and other specialized mouse strains by embryo transfer
*Archival storage of frozen embryos and sperm from transgenic and other specialized mouse strains
*Gene knockout and knock-in mouse models using zinc-finger nuclease technology
*Consultation, technical support and training to investigators wishing to establish their own genetically modified animals
Transgenic Services_Sperm Freezing
Transgenic Services_DNA CONSTRUCT
Transgenic Services_Frozen Embryos
Transgenic Services_Rederivation

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Genetically Modified Animals
Spermatozoa
Gene Knock-In Techniques
Embryonic Structures
Research Personnel
Training Support
Gene Knockout Techniques
Embryo Transfer
DNA
Zinc Fingers
Microinjections
Blastocyst
Transgenic Mice
Referral and Consultation
Animal Models
Technology
Costs and Cost Analysis
Injections
Genes