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Research Output 1994 2018

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Article
2018
6 Citations

A Comprehensive Pan-Cancer Molecular Study of Gynecologic and Breast Cancers

The Cancer Genome Atlas Research Network, Apr 9 2018, In : Cancer Cell. 33, 4, p. 690-705.e9

Research output: Contribution to journalArticle

Breast Neoplasms
Atlases
Long Noncoding RNA
Decision Trees
Genome

ADH1B promotes mesothelial clearance and ovarian cancer infiltration

Gharpure, K. M., Lara, O. D., Wen, Y., Pradeep, S., LaFargue, C., Ivan, C., Rupaimoole, R., Hu, W., Mangala, L. S., Wu, S., Nagaraja, A. S., Baggerly, K. A. & Sood, A. K., May 18 2018, In : Oncotarget. 9, 38, p. 25115-25126 12 p.

Research output: Contribution to journalArticle

Ovarian Neoplasms
Neoplasms
Adjuvant Chemotherapy
Cell Adhesion
Extracellular Matrix
12 Citations

An Integrated TCGA Pan-Cancer Clinical Data Resource to Drive High-Quality Survival Outcome Analytics

The Cancer Genome Atlas Research Network, Apr 5 2018, In : Cell. 173, 2, p. 400-416.e11

Research output: Contribution to journalArticle

Atlases
Genes
Genome
Survival
Neoplasms
6 Citations

A Pan-Cancer Analysis of Enhancer Expression in Nearly 9000 Patient Samples

The Cancer Genome Atlas Research Network, Apr 5 2018, In : Cell. 173, 2, p. 386-399.e12

Research output: Contribution to journalArticle

Genes
Tumors
Neoplasms
Computational methods
Chromatin

Association of biobehavioral factors with non-coding RNAs in cervical cancer

Liu, Q., Lu, C., Dai, W., Li, K., Xu, J., Huang, Y., Li, G., Kang, Y., Sood, A. K. & Xu, C., Jan 1 2018, In : BioScience Trends. 12, 1, p. 24-31 8 p.

Research output: Contribution to journalArticle

Long Noncoding RNA
Untranslated RNA
Uterine Cervical Neoplasms
cancer
Gene Ontology
3 Citations

A-to-I miR-378a-3p editing can prevent melanoma progression via regulation of PARVA expression

Velazquez-Torres, G., Shoshan, E., Ivan, C., Huang, L., Fuentes-Mattei, E., Paret, H., Kim, S. J., Rodriguez-Aguayo, C., Xie, V., Brooks, D., Jones, S. J. M., Robertson, A. G., Calin, G. A., Lopez-Berenstein, G., Sood, A. K. & Bar Eli, M., Dec 1 2018, In : Nature communications. 9, 1, 461.

Research output: Contribution to journalArticle

editing
MicroRNAs
progressions
Melanoma
3' Untranslated Regions

Bioactive lipid metabolism in platelet “first responder” and cancer biology

Kanikarla Marie, P., Kopetz, E. S., Hawk, E., Millward, S., Sood, A. K., Gresele, P., Overman, M. J., Honn, K. & Menter, D. G., Sep 1 2018, In : Cancer and Metastasis Reviews. 37, 2-3, p. 439-454 16 p.

Research output: Contribution to journalArticle

Lipid Metabolism
Blood Platelets
Eicosanoids
Thromboxanes
Epoprostenol
3 Citations

Biobehavioral modulation of the exosome transcriptome in ovarian carcinoma

Lutgendorf, S. K., Thaker, P. H., Arevalo, J. M., Goodheart, M. J., Slavich, G. M., Sood, A. K. & Cole, S. W., Feb 1 2018, In : Cancer. 124, 3, p. 580-586 7 p.

Research output: Contribution to journalArticle

Exosomes
Transcriptome
Social Support
Activating Transcription Factors
Carcinoma

Bone protection by inhibition of microRNA-182

Inoue, K., Deng, Z., Chen, Y., Giannopoulou, E., Xu, R., Gong, S., Greenblatt, M. B., Mangala, L. S., Lopez, G., Kirsch, D. G., Sood, A. K., Zhao, L. & Zhao, B., Dec 1 2018, In : Nature communications. 9, 1, 4108.

Research output: Contribution to journalArticle

arthritis
Interferon-beta
interferon
MicroRNAs
Osteogenesis
6 Citations

Cancer-associated fibroblasts regulate endothelial adhesion protein LPP to promote ovarian cancer chemoresistance

Leung, S. L. C., Yeung, T-L., Yip, K. P., Wong, K. K., Ho, S. Y., Mangala, L. S., Sood, A. K., Lopez, G., Sheng, J., Wong, S. T. C., Birrer, M. J. & Mok, S., Feb 1 2018, In : Journal of Clinical Investigation. 128, 2, p. 589-606 18 p.

Research output: Contribution to journalArticle

Lipoma
Ovarian Neoplasms
Proteins
Endothelial Cells
Small Interfering RNA

CD44-targeting PLGA nanoparticles incorporating paclitaxel and FAK siRNA overcome chemoresistance in epithelial ovarian cancer

Byeon, Y., Lee, J. W., Choi, W. S., Won, J. E., Kim, G. H., Kim, M. G., Wi, T. I., Lee, J. M., Kang, T. H., Jung, I. D., Cho, Y. J., Ahn, H. J., Shin, B. C., Lee, Y. J., Sood, A. K., Han, H. D. & Park, Y. M., Nov 1 2018, In : Cancer Research. 78, 21, p. 6247-6256 10 p.

Research output: Contribution to journalArticle

Focal Adhesion Protein-Tyrosine Kinases
Paclitaxel
Nanoparticles
Small Interfering RNA
Ovarian Neoplasms
21 Citations

Cell-of-Origin Patterns Dominate the Molecular Classification of 10,000 Tumors from 33 Types of Cancer

The Cancer Genome Atlas Network, Apr 5 2018, In : Cell. 173, 2, p. 291-304.e6

Research output: Contribution to journalArticle

Tumors
Tissue
Histology
Methylation
Oncology
8 Citations

Comparative Molecular Analysis of Gastrointestinal Adenocarcinomas

The Cancer Genome Atlas Research Network, Apr 9 2018, In : Cancer Cell. 33, 4, p. 721-735.e8

Research output: Contribution to journalArticle

Adenocarcinoma
Neoplasms
Genome
Chromosomal Instability
Rectum
33 Citations

Comprehensive Characterization of Cancer Driver Genes and Mutations

The MC3 Working Group & The Cancer Genome Atlas Research Network, Apr 5 2018, In : Cell. 173, 2, p. 371-385.e18

Research output: Contribution to journalArticle

Neoplasm Genes
Tumors
Genes
Mutation
Neoplasms
Ovarian Neoplasms
Laparoscopy
Neoplasms
Stomach Diseases
Diaphragm

Defining Survivorship Trajectories Across Patients With Solid Tumors: An Evidence-Based Approach

Dood, R. L., Zhao, Y., Armbruster, S. D., Coleman, R., Tworoger, S., Sood, A. K. & Baggerly, K. A., Nov 1 2018, In : JAMA Oncology. 4, 11, p. 1519-1526 8 p.

Research output: Contribution to journalArticle

Survival Rate
Neoplasms
Mortality
Population
Primary Care Physicians
7 Citations

Driver Fusions and Their Implications in the Development and Treatment of Human Cancers

The Fusion Analysis Working Group & The Cancer Genome Atlas Research Network, Apr 3 2018, In : Cell Reports. 23, 1, p. 227-238.e3

Research output: Contribution to journalArticle

Human Development
Phosphotransferases
Genes
Gene expression
Tumors
5 Citations

Genomic, Pathway Network, and Immunologic Features Distinguishing Squamous Carcinomas

The Cancer Genome Atlas Research Network, Apr 3 2018, In : Cell Reports. 23, 1, p. 194-212.e6

Research output: Contribution to journalArticle

Squamous Cell Carcinoma
MicroRNAs
Mutation
Epithelial Cells
Squamous Cell Neoplasms
10 Citations

Genomic and Functional Approaches to Understanding Cancer Aneuploidy

The Cancer Genome Atlas Research Network, Apr 9 2018, In : Cancer Cell. 33, 4, p. 676-689.e3

Research output: Contribution to journalArticle

Aneuploidy
Chromosomes
Neoplasms
Genome
Mutation Rate
12 Citations

Genomic and Molecular Landscape of DNA Damage Repair Deficiency across The Cancer Genome Atlas

The Cancer Genome Atlas Research Network, Apr 3 2018, In : Cell Reports. 23, 1, p. 239-254.e6

Research output: Contribution to journalArticle

DNA Repair-Deficiency Disorders
Atlases
DNA Damage
Repair
Genes
1 Citations

HN1L Promotes Triple-Negative Breast Cancer Stem Cells through LEPR-STAT3 Pathway

Liu, Y., Choi, D. S., Sheng, J., Ensor, J. E., Liang, D. H., Rodriguez-Aguayo, C., Polley, A., Benz, S., Elemento, O., Verma, A., Cong, Y., Wong, H., Qian, W., Li, Z., Granados-Principal, S., Lopez, G., Landis, M. D., Rosato, R. R., Dave, B., Wong, S. & 3 othersMarchetti, D., Sood, A. K. & Chang, J. C., Jan 1 2018, In : Stem Cell Reports. 10, 1, p. 212-227 16 p.

Research output: Contribution to journalArticle

Triple Negative Breast Neoplasms
Neoplastic Stem Cells
Stem cells
Breast Neoplasms
Transcription
1 Citations

Impact of lympho-vascular space invasion on tumor characteristics and survival outcome of women with low-grade serous ovarian carcinoma

Matsuo, K., Wong, K. K., Fotopoulou, C., Blake, E. A., Robertson, S. E., Pejovic, T., Frimer, M., Pardeshi, V., Hu, W., Choi, J. S., Sun, C. C., Richmond, A. M., Marcus, J. Z., Hilliard, M. A. M., Mostofizadeh, S., Mhawech-Fauceglia, P., Abdulfatah, E., Post, M. D., Saglam, O., Shahzad, M. M. K. & 6 othersKarabakhtsian, R. G., Ali-Fehmi, R., Gabra, H., Roman, L. D., Sood, A. K. & Gershenson, D. M., Feb 1 2018, In : Journal of surgical oncology. 117, 2, p. 236-244 9 p.

Research output: Contribution to journalArticle

Blood Vessels
Carcinoma
Survival
Neoplasms
Odds Ratio
1 Citations

Induction of anti-VEGF therapy resistance by upregulated expression of microseminoprotein (MSMP)

Mitamura, T., Pradeep, S., McGuire, M., Wu, S. Y., Ma, S., Hatakeyama, H., Lyons, Y. A., Hisamatsu, T., Noh, K., Villar-Prados, A., Chen, X., Ivan, C., Rodriguez-Aguayo, C., Hu, W., Lopez, G., Coleman, R. & Sood, A. K., Feb 8 2018, In : Oncogene. 37, 6, p. 722-731 10 p.

Research output: Contribution to journalArticle

Vascular Endothelial Growth Factor A
Neoplasms
Therapeutics
R Factors
Acetylation

Inhibiting nuclear phospho-progesterone receptor enhances antitumor activity of onapristone in uterine cancer

Huang, Y., Hu, W., Huang, J., Shen, F., Sun, Y., Ivan, C., Pradeep, S., Dood, R., Haemmerle, M., Jiang, D., Mangala, L. S., Noh, K., Hansen, J. M., Dalton, H. J., Previs, R. A., Nagaraja, A. S., McGuire, M., Jennings, N. B., Broaddus, R., Coleman, R. & 1 othersSood, A. K., Feb 1 2018, In : Molecular Cancer Therapeutics. 17, 2, p. 464-473 10 p.

Research output: Contribution to journalArticle

Uterine Neoplasms
Progesterone Receptors
Epidermal Growth Factor
Ligands
onapristone
1 Citations

Integrated Analysis of Genetic Ancestry and Genomic Alterations across Cancers

Yuan, J., Hu, Z., Mahal, B. A., Zhao, S. D., Kensler, K. H., Pi, J., Hu, X., Zhang, Y., Wang, Y., Jiang, J., Li, C., Zhong, X., Montone, K. T., Guan, G., Tanyi, J. L., Fan, Y., Xu, X., Morgan, M. A., Long, M., Zhang, Y. & 5 othersZhang, R., Sood, A. K., Rebbeck, T. R., Dang, C. V. & Zhang, L., Oct 8 2018, In : Cancer Cell. 34, 4, p. 549-560.e9

Research output: Contribution to journalArticle

Chromosomal Instability
African Americans
Neoplasms
Endometrial Neoplasms
Head and Neck Neoplasms
3 Citations

Integrated Genomic Analysis of the Ubiquitin Pathway across Cancer Types

The Cancer Genome Atlas Research Network, Apr 3 2018, In : Cell Reports. 23, 1, p. 213-226.e3

Research output: Contribution to journalArticle

Ubiquitin
Genes
Neoplasms
Tumors
Amplification
Triage
Ovarian Neoplasms
Neoplasms
Drug Therapy
Disease-Free Survival

Life stress as a risk factor for sustained anxiety and cortisol dysregulation during the first year of survivorship in ovarian cancer

Armer, J. S., Clevenger, L., Davis, L. Z., Cuneo, M., Thaker, P. H., Goodheart, M. J., Bender, D. P., Dahmoush, L., Sood, A. K., Cole, S. W., Slavich, G. M. & Lutgendorf, S. K., Aug 1 2018, In : Cancer. 124, 16, p. 3401-3408 8 p.

Research output: Contribution to journalArticle

Psychological Stress
Ovarian Neoplasms
Hydrocortisone
Survival Rate
Anxiety
13 Citations

lncRNA Epigenetic Landscape Analysis Identifies EPIC1 as an Oncogenic lncRNA that Interacts with MYC and Promotes Cell-Cycle Progression in Cancer

The Cancer Genome Atlas Research Network, Apr 9 2018, In : Cancer Cell. 33, 4, p. 706-720.e9

Research output: Contribution to journalArticle

Long Noncoding RNA
Epigenomics
Cell Cycle
Genes
Neoplasms
2 Citations

Lpa induces metabolic reprogramming in ovarian cancer via a pseudohypoxic response

Ha, J. H., Radhakrishnan, R., Jayaraman, M., Yan, M., Ward, J. D., Fung, K. M., Moxley, K., Sood, A. K., Isidoro, C., Mukherjee, P., Song, Y. S. & Dhanasekaran, D. N., Apr 15 2018, In : Cancer Research. 78, 8, p. 1923-1934 12 p.

Research output: Contribution to journalArticle

Ovarian Neoplasms
Hexokinase
Facilitative Glucose Transport Proteins
NADPH Oxidase
Protein Subunits
6 Citations

Machine Learning Detects Pan-cancer Ras Pathway Activation in The Cancer Genome Atlas

The Cancer Genome Atlas Research Network, Apr 3 2018, In : Cell Reports. 23, 1, p. 172-180.e3

Research output: Contribution to journalArticle

Atlases
Learning systems
Tumors
Genes
Chemical activation
14 Citations

Machine Learning Identifies Stemness Features Associated with Oncogenic Dedifferentiation

The Cancer Genome Atlas Research Network, Apr 5 2018, In : Cell. 173, 2, p. 338-354.e15

Research output: Contribution to journalArticle

Learning systems
Tumors
Neoplasms
Stem cells
Logistics
3 Citations

Molecular Characterization and Clinical Relevance of Metabolic Expression Subtypes in Human Cancers

The Cancer Genome Atlas Research Network, Apr 3 2018, In : Cell Reports. 23, 1, p. 255-269.e4

Research output: Contribution to journalArticle

Tumors
Carbohydrates
Oncology
Metabolism
Vitamins
4 Citations

MYC targeted long noncoding RNA DANCR promotes cancer in part by reducing p21 levels

Lu, Y., Hu, Z., Mangala, L. S., Stine, Z. E., Hu, X., Jiang, D., Xiang, Y., Zhang, Y., Pradeep, S., Rodriguez-Aguayo, C., Lopez, G., DeMarzo, A. M., Sood, A. K., Zhang, L. & Dang, C. V., Jan 1 2018, In : Cancer Research. 78, 1, p. 64-74 11 p.

Research output: Contribution to journalArticle

Long Noncoding RNA
Neoplasms
Cell Proliferation
Ovarian Neoplasms
Modifier Genes
26 Citations

Oncogenic Signaling Pathways in The Cancer Genome Atlas

The Cancer Genome Atlas Research Network, Apr 5 2018, In : Cell. 173, 2, p. 321-337.e10

Research output: Contribution to journalArticle

Atlases
Tumors
Genes
Genome
Neoplasms
Paclitaxel
Microtubules
Ovarian Neoplasms
Phosphotransferases
Phosphorylation
4 Citations

Paclitaxel with and without pazopanib for persistent or recurrent ovarian cancer: A randomized clinical trial

Richardson, D. L., Sill, M. W., Coleman, R., Sood, A. K., Pearl, M. L., Kehoe, S. M., Carney, M. E., Hanjani, P., Van Le, L., Zhou, X. C., Secord, A. A., Gray, H. J., Landrum, L. M., Lankes, H. A., Hu, W. & Aghajanian, C., Feb 1 2018, In : JAMA Oncology. 4, 2, p. 196-202 7 p.

Research output: Contribution to journalArticle

Paclitaxel
Ovarian Neoplasms
Randomized Controlled Trials
Disease-Free Survival
Survival
9 Citations

Pan-cancer Alterations of the MYC Oncogene and Its Proximal Network across the Cancer Genome Atlas

The Cancer Genome Atlas Network, Mar 28 2018, In : Cell Systems. 6, 3, p. 282-300.e2

Research output: Contribution to journalArticle

Atlases
Oncogenes
Genome
Neoplasms
Neoplasm Genes
10 Citations

Pan-Cancer Analysis of lncRNA Regulation Supports Their Targeting of Cancer Genes in Each Tumor Context

The Cancer Genome Atlas Research Network, Apr 3 2018, In : Cell Reports. 23, 1, p. 297-312.e12

Research output: Contribution to journalArticle

Long Noncoding RNA
Neoplasm Genes
Tumors
Genes
Neoplasms
8 Citations

Pathogenic Germline Variants in 10,389 Adult Cancers

The Cancer Genome Atlas Research Network, Apr 5 2018, In : Cell. 173, 2, p. 355-370.e14

Research output: Contribution to journalArticle

Gene expression
Automatic teller machines
Tumors
Neoplasms
Genes

Perineural invasion (PNI) in vulvar carcinoma: A review of 421 cases

Salcedo, M. P., Sood, A. K., dos Reis, R., Ramalingam, P., Chen, C., Frumovitz, M., Jhingran, A., Pitcher, B., Ramirez, P. T. & Schmeler, K. M., Jan 1 2018, (Accepted/In press) In : Gynecologic oncology.

Research output: Contribution to journalArticle

Vulvar Neoplasms
Carcinoma
Disease-Free Survival
Lichen Sclerosus et Atrophicus
Survival
1 Citations

Perioperative inhibition of β-adrenergic and COX2 signaling in a clinical trial in breast cancer patients improves tumor Ki-67 expression, serum cytokine levels, and PBMCs transcriptome

Haldar, R., Shaashua, L., Lavon, H., Lyons, Y. A., Zmora, O., Sharon, E., Birnbaum, Y., Allweis, T., Sood, A. K., Barshack, I., Cole, S. & Ben-Eliyahu, S., Oct 1 2018, In : Brain, behavior, and immunity. 73, p. 294-309 16 p.

Research output: Contribution to journalArticle

Transcriptome
Adrenergic Agents
Clinical Trials
Breast Neoplasms
Cytokines
6 Citations

Peroxisomes contribute to oxidative stress in neurons during doxorubicin-based chemotherapy

Moruno-Manchon, J. F., Uzor, N. E., Kesler, S., Wefel, J. S., Townley, D. M., Nagaraja, A. S., Pradeep, S., Mangala, L. S., Sood, A. K. & Tsvetkov, A. S., Jan 1 2018, In : Molecular and Cellular Neuroscience. 86, p. 65-71 7 p.

Research output: Contribution to journalArticle

Peroxisomes
Doxorubicin
Oxidative Stress
Neurons
Drug Therapy
7 Citations

Perspective on Oncogenic Processes at the End of the Beginning of Cancer Genomics

The Cancer Genome Atlas Research Network, Apr 5 2018, In : Cell. 173, 2, p. 305-320.e10

Research output: Contribution to journalArticle

Genomics
Tumors
Genes
Neoplasms
Atlases
6 Citations

RNA interference-based therapy and its delivery systems

Chen, X., Mangala, L. S., Rodriguez-Aguayo, C., Kong, X., Lopez, G. & Sood, A. K., Mar 1 2018, In : Cancer and Metastasis Reviews. 37, 1, p. 107-124 18 p.

Research output: Contribution to journalArticle

RNA Interference
Gene Silencing
Therapeutics
Virus Diseases
MicroRNAs
13 Citations

Scalable Open Science Approach for Mutation Calling of Tumor Exomes Using Multiple Genomic Pipelines

MC3 Working Group & The Cancer Genome Atlas Research Network, Mar 28 2018, In : Cell Systems. 6, 3, p. 271-281.e7

Research output: Contribution to journalArticle

Exome
Mutation
Atlases
Neoplasms
Genomics
1 Citations

Selective delivery of PLXDC1 small interfering RNA to endothelial cells for anti-angiogenesis tumor therapy using CD44-targeted chitosan nanoparticles for epithelial ovarian cancer

Kim, G. H., Won, J. E., Byeon, Y., Kim, M. G., Wi, T. I., Lee, J. M., Park, Y. Y., Lee, J. W., Kang, T. H., Jung, I. D., Shin, B. C., Ahn, H. J., Lee, Y. J., Sood, A. K., Han, H. D. & Park, Y. M., Jan 1 2018, In : Drug Delivery. 25, 1, p. 1394-1402 9 p.

Research output: Contribution to journalArticle

Chitosan
Nanoparticles
Small Interfering RNA
Endothelial Cells
Hyaluronic Acid
10 Citations

Somatic Mutational Landscape of Splicing Factor Genes and Their Functional Consequences across 33 Cancer Types

The Cancer Genome Atlas Research Network, Apr 3 2018, In : Cell Reports. 23, 1, p. 282-296.e4

Research output: Contribution to journalArticle

Genes
Mutation
Neoplasms
Tumors
RNA
7 Citations

Spatial Organization and Molecular Correlation of Tumor-Infiltrating Lymphocytes Using Deep Learning on Pathology Images

The Cancer Genome Atlas Research Network, Apr 3 2018, In : Cell Reports. 23, 1, p. 181-193.e7

Research output: Contribution to journalArticle

Tumor-Infiltrating Lymphocytes
Lymphocytes
Pathology
Tumors
Learning

Stress, inflammation, and eicosanoids: an emerging perspective

Umamaheswaran, S., Dasari, S. K., Yang, P., Lutgendorf, S. K. & Sood, A. K., Sep 1 2018, In : Cancer and Metastasis Reviews. 37, 2-3, p. 203-211 9 p.

Research output: Contribution to journalArticle

Eicosanoids
Inflammation
Metabolic Networks and Pathways
Adrenergic Agents
Neoplasms