• 60446 Citations
  • 96 h-Index
1972 …2019
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Research Output 1972 2019

2019

An independent poor-prognosis subtype of breast cancer defined by a distinct tumor immune microenvironment

OSBREAC, Dec 1 2019, In : Nature communications. 10, 1, 5499.

Research output: Contribution to journalArticle

Open Access
Tumor Microenvironment
prognosis
Infiltration
breast
Tumors
9 Citations (Scopus)

Breast cancer quantitative proteome and proteogenomic landscape

Consortia Oslo Breast Cancer Research Consortium (OSBREAC), Dec 1 2019, In : Nature communications. 10, 1, 1600.

Research output: Contribution to journalArticle

Open Access
proteome
Proteome
breast
Tumors
tumors

Correction to: Pan-cancer analysis of homozygous deletions in primary tumours uncovers rare tumour suppressors (Nature Communications, (2017), 8, 1, (1221), 10.1038/s41467-017-01355-0)

Cheng, J., Demeulemeester, J., Wedge, D. C., Vollan, H. K. M., Pitt, J. J., Russnes, H. G., Pandey, B. P., Nilsen, G., Nord, S., Bignell, G. R., White, K. P., Børresen-Dale, A. L., Campbell, P. J., Kristensen, V. N., Stratton, M. R., Lingjærde, O. C., Moreau, Y. & Van Loo, P., Dec 1 2019, In : Nature communications. 10, 1, 525.

Research output: Contribution to journalComment/debate

document markup languages
suppressors
deletion
HTML
Tumors
1 Citation (Scopus)

Correction to: Landscape of somatic mutations in 560 breast cancer whole-genome sequences (Nature, (2016), 534, 7605, (47-54), 10.1038/nature17676)

Nik-Zainal, S., Davies, H., Staaf, J., Ramakrishna, M., Glodzik, D., Zou, X., Martincorena, I., Alexandrov, L. B., Martin, S., Wedge, D. C., Van Loo, P., Ju, Y. S., Smid, M., Brinkman, A. B., Morganella, S., Aure, M. R., Lingjærde, O. C., Langerød, A., Ringnér, M., Ahn, S. M. & 68 others, Boyault, S., Brock, J. E., Broeks, A., Butler, A., Desmedt, C., Dirix, L., Dronov, S., Fatima, A., Foekens, J. A., Gerstung, M., Hooijer, G. K. J., Jang, S. J., Jones, D. R., Kim, H. Y., King, T. A., Krishnamurthy, S., Lee, H. J., Lee, J. Y., Li, Y., McLaren, S., Menzies, A., Mustonen, V., O’Meara, S., Pauporté, I., Pivot, X., Purdie, C. A., Raine, K., Ramakrishnan, K., Rodríguez-González, F. G., Romieu, G., Sieuwerts, A. M., Simpson, P. T., Shepherd, R., Stebbings, L., Stefansson, O. A., Teague, J., Tommasi, S., Treilleux, I., Van den Eynden, G. G., Vermeulen, P., Vincent-Salomon, A., Yates, L., Caldas, C., van’t Veer, L., Tutt, A., Knappskog, S., Tan, B. K. T., Jonkers, J., Borg, Å., Ueno, N. T., Sotiriou, C., Viari, A., Futreal, P. A., Campbell, P. J., Span, P. N., Van Laere, S., Lakhani, S. R., Eyfjord, J. E., Thompson, A. M., Birney, E., Stunnenberg, H. G., van de Vijver, M. J., Martens, J. W. M., Børresen-Dale, A. L., Richardson, A. L., Kong, G., Thomas, G. & Stratton, M. R., Feb 7 2019, In : Nature. 566, 7742, p. E1

Research output: Contribution to journalComment/debate

Open Access
Genome
Breast Neoplasms
Mutation
2 Citations (Scopus)

Genome-wide association study of germline variants and breast cancer-specific mortality

NBCS Collaborators, Mar 19 2019, In : British journal of cancer. 120, 6, p. 647-657 11 p.

Research output: Contribution to journalArticle

Open Access
Genome-Wide Association Study
Breast Neoplasms
Mortality
Meta-Analysis
Long Noncoding RNA
3 Citations (Scopus)

miR-342-5p as a Potential Regulator of HER2 Breast Cancer Cell Growth

Lindholm, E. M., Leivonen, S. K., Undlien, E., Nebdal, D., Git, A., Caldas, C., Børresen-Dale, A. L. & Kleivi, K., Jan 1 2019, In : MicroRNA (Shariqah, United Arab Emirates). 8, 2, p. 155-165 11 p.

Research output: Contribution to journalArticle

Breast Neoplasms
Growth
Cytochrome Reductases
Guanine Nucleotide Exchange Factors
Cytochromes b5
1 Citation (Scopus)

miRNA expression changes during the course of neoadjuvant bevacizumab and chemotherapy treatment in breast cancer

Lindholm, E. M., Ragle Aure, M., Haugen, M. H., Kleivi Sahlberg, K., Kristensen, V. N., Nebdal, D., Børresen-Dale, A. L., Lingjærde, O. C. & Engebraaten, O., Oct 1 2019, In : Molecular oncology. 13, 10, p. 2278-2296 19 p.

Research output: Contribution to journalArticle

Open Access
MicroRNAs
Breast Neoplasms
Drug Therapy
Therapeutics
Combination Drug Therapy

Noninvasive profiling of serum cytokines in breast cancer patients and clinicopathological characteristics

Jabeen, S., Espinoza, J. A., Torland, L. A., Zucknick, M., Kumar, S., Haakensen, V. D., Lüders, T., Engebraaten, O., Børresen-Dale, A. L., Kyte, J. A., Gromov, P., Naume, B., Kristensen, V., Gromova, I. & Tekpli, X., Feb 1 2019, In : OncoImmunology. 8, 2, e1537691.

Research output: Contribution to journalArticle

Breast Neoplasms
Cytokines
Serum
Neoplasms
Tumor-Infiltrating Lymphocytes
3 Citations (Scopus)

Partially methylated domains are hypervariable in breast cancer and fuel widespread CpG island hypermethylation

Brinkman, A. B., Nik-Zainal, S., Simmer, F., Rodríguez-González, F. G., Smid, M., Alexandrov, L. B., Butler, A., Martin, S., Davies, H., Glodzik, D., Zou, X., Ramakrishna, M., Staaf, J., Ringnér, M., Sieuwerts, A., Ferrari, A., Morganella, S., Fleischer, T., Kristensen, V., Gut, M. & 9 others, van de Vijver, M. J., Børresen-Dale, A. L., Richardson, A. L., Thomas, G., Gut, I. G., Martens, J. W. M., Foekens, J. A., Stratton, M. R. & Stunnenberg, H. G., Dec 1 2019, In : Nature communications. 10, 1, 1749.

Research output: Contribution to journalArticle

Open Access
CpG Islands
DNA Methylation
methylation
breast
Methylation

PathTracer: High-sensitivity detection of differential pathway activity in tumours

Nygård, S., Lingjærde, O. C., Caldas, C., Hovig, E., Børresen-Dale, A. L., Helland, Å. & Haakensen, V. D., Dec 1 2019, In : Scientific reports. 9, 1, 16332.

Research output: Contribution to journalArticle

Open Access
Neoplasms
Gene Expression
Carcinoma, Intraductal, Noninfiltrating
Genomic Instability
Gene Expression Profiling
54 Citations (Scopus)

Polygenic Risk Scores for Prediction of Breast Cancer and Breast Cancer Subtypes

NBCS Collaborators, ABCTB Investigators & kConFab/AOCS Investigators, Jan 3 2019, In : American journal of human genetics. 104, 1, p. 21-34 14 p.

Research output: Contribution to journalArticle

Open Access
Breast Neoplasms
Estrogen Receptors
Prospective Studies
Single Nucleotide Polymorphism
Genome
1 Citation (Scopus)

Responsiveness to PD-1 Blockade in End-Stage Colon Cancer with Gene Locus 9p24.1 Copy-Number Gain

Ree, A. H., Nygaard, V., Russnes, H. G., Heinrich, D., Nygaard, V., Johansen, C., Bergheim, I. R., Hovig, E., Beiske, K., Negard, A., Børresen-Dale, A. L., Flatmark, K. & Mælandsmo, G. M., May 2019, In : Cancer Immunology Research. 7, 5, p. 701-706 6 p.

Research output: Contribution to journalArticle

Neoplasm Genes
Colonic Neoplasms
Genes
RNA Sequence Analysis
Neoplasms
9 Citations (Scopus)

The circular RNome of primary breast cancer

Smid, M., Wilting, S. M., Uhr, K., Rodríguez-González, F. G., De Weerd, V., Prager-Van Der Smissen, W. J. C., Van Der Vlugt-Daane, M., Van Galen, A., Nik-Zainal, S., Butler, A., Martin, S., Davies, H. R., Staaf, J., Van De Vijver, M. J., Richardson, A. L., MacGrogan, G., Salgado, R., Van Den Eynden, G. G. G. M., Purdie, C. A., Thompson, A. M. & 21 others, Caldas, C., Span, P. N., Sweep, F. C. G. J., Simpson, P. T., Lakhani, S. R., Van Laere, S., Desmedt, C., Paradiso, A., Eyfjord, J., Broeks, A., Vincent-Salomon, A., Futreal, A. P., Knappskog, S., King, T., Viari, A., Børresen-Dale, A. L., Stunnenberg, H. G., Stratton, M., Foekens, J. A., Sieuwerts, A. M. & Martens, J. W. M., Mar 2019, In : Genome research. 29, 3, p. 356-366 11 p.

Research output: Contribution to journalArticle

Open Access
Breast Neoplasms
RNA
circular RNA
Aromatase Inhibitors
Computer Simulation

Toward personalized computer simulation of breast cancer treatment: A multiscale pharmacokinetic and pharmacodynamic model informed by multitype patient data

Lai, X., Geier, O. M., Fleischer, T., Garred, Y., Borgen, E., Funke, S. W., Kumar, S., Rognes, M. E., Seierstad, T., Børresen-Dale, A. L., Kristensen, V. N., Engebraaten, O., Kohn-Luque, A. & Frigessi, A., Aug 15 2019, In : Cancer research. 79, 16, p. 4293-4304 12 p.

Research output: Contribution to journalArticle

Computer Simulation
Pharmacokinetics
Breast Neoplasms
Neoplasms
Angiogenesis Inhibitors
4 Citations (Scopus)

TP53 Status as a Determinant of Pro- vs Anti-Tumorigenic Effects of Estrogen Receptor-Beta in Breast Cancer

Mukhopadhyay, U. K., Oturkar, C. C., Adams, C., Wickramasekera, N., Bansal, S., Medisetty, R., Miller, A., Swetzig, W. M., Silwal-Pandit, L., Børresen-Dale, A. L., Creighton, C. J., Park, J. H., Konduri, S. D., Mukhopadhyay, A., Caradori, A., Omilian, A., Bshara, W., Kaipparettu, B. A. & Das, G. M., Nov 1 2019, In : Journal of the National Cancer Institute. 111, 11, p. 1202-1215 14 p.

Research output: Contribution to journalArticle

Open Access
Triple Negative Breast Neoplasms
Estrogen Receptor beta
Breast Neoplasms
Control Groups
p53 Genes

Two truncating variants in FANCC and breast cancer risk

ABCTB Investigators & NBCS Collaborators, Dec 1 2019, In : Scientific reports. 9, 1, 12524.

Research output: Contribution to journalArticle

Open Access
Fanconi Anemia
Breast Neoplasms
Mutation
Genes
Neoplasm Genes
2018
3 Citations (Scopus)

AKT1 low quiescent cancer cells promote solid tumor growth

Alves, C. P., Dey-Guha, I., Kabraji, S., Yeh, A. C., Talele, N. P., Solé, X., Chowdhury, J., Mino-Kenudson, M., Loda, M., Sgroi, D., Borresen-Dale, A. L., Russnes, H. G., Ross, K. N. & Ramaswamy, S., Jan 2018, In : Molecular cancer therapeutics. 17, 1, p. 254-263 10 p.

Research output: Contribution to journalArticle

Growth
Neoplasms
Oncogene Proteins
Heterografts
Integrins
5 Citations (Scopus)

Basal-like breast cancer engages tumor-supportive macrophages via secreted factors induced by extracellular S100A4

Oslo Breast Cancer Research Consortium (OSBREAC), Sep 2018, In : Molecular oncology. 12, 9, p. 1540-1558 19 p.

Research output: Contribution to journalArticle

Macrophages
Breast Neoplasms
Tumor Microenvironment
Neoplasms
Cytokines

Correction: A systematic comparison of copy number alterations in four types of female cancer [BMC Cancer., 16, (2016) (913)] DOI: 10.1186/s12885-016-2899-4

Kaveh, F., Baumbusch, L. O., Nebdal, D., Børresen-Dale, A. L., Lingjærde, O. C., Edvardsen, H., Kristensen, V. N. & Solvang, H. K., Jan 16 2018, In : BMC cancer. 18, 1, 80.

Research output: Contribution to journalComment/debate

Publications
Neoplasms

Erratum: Publisher Correction: Evidence that breast cancer risk at the 2q35 locus is mediated through IGFBP5 regulation (Nature communications (2014) 4 (4999))

Ghoussaini, M., Edwards, S. L., Michailidou, K., Nord, S., Cowper-Sal Lari, R., Desai, K., Kar, S., Hillman, K. M., Kaufmann, S., Glubb, D. M., Beesley, J., Dennis, J., Bolla, M. K., Wang, Q., Dicks, E., Guo, Q., Schmidt, M. K., Shah, M., Luben, R., Brown, J. & 191 others, Czene, K., Darabi, H., Eriksson, M., Klevebring, D., Bojesen, S. E., Nordestgaard, B. G., Nielsen, S. F., Flyger, H., Lambrechts, D., Thienpont, B., Neven, P., Wildiers, H., Broeks, A., Van't Veer, L. J., Rutgers, E. J. T., Couch, F. J., Olson, J. E., Hallberg, E., Vachon, C., Chang-Claude, J., Rudolph, A., Seibold, P., Flesch-Janys, D., Peto, J., Dos-Santos-Silva, I., Gibson, L., Nevanlinna, H., Muranen, T. A., Aittomäki, K., Blomqvist, C., Hall, P., Li, J., Liu, J., Humphreys, K., Kang, D., Choi, J. Y., Park, S. K., Noh, D. Y., Matsuo, K., Ito, H., Iwata, H., Yatabe, Y., Guénel, P., Truong, T., Menegaux, F., Sanchez, M., Burwinkel, B., Marme, F., Schneeweiss, A., Sohn, C., Wu, A. H., Tseng, C. C., Van Den Berg, D., Stram, D. O., Benitez, J., Pilar Zamora, M., Perez, J. I. A., Menéndez, P., Shu, X. O., Lu, W., Gao, Y. T., Cai, Q., Cox, A., Cross, S. S., Reed, M. W. R., Andrulis, I. L., Knight, J. A., Glendon, G., Tchatchou, S., Sawyer, E. J., Tomlinson, I., Kerin, M. J., Miller, N., Haiman, C. A., Henderson, B. E., Schumacher, F., Le Marchand, L., Lindblom, A., Margolin, S., Teo, S. H., Yip, C. H., Lee, D. S. C., Wong, T. Y., Hooning, M. J., Martens, J. W. M., Collée, J. M., van Deurzen, C. H. M., Hopper, J. L., Southey, M. C., Tsimiklis, H., Kapuscinski, M. K., Shen, C. Y., Wu, P. E., Yu, J. C., Chen, S. T., Alnæs, G. G., Borresen-Dale, A. L., Giles, G. G., Milne, R. L., McLean, C., Muir, K., Lophatananon, A., Stewart-Brown, S., Siriwanarangsan, P., Hartman, M., Miao, H., Buhari, S. A. B. S., Teo, Y. Y., Fasching, P. A., Haeberle, L., Ekici, A. B., Beckmann, M. W., Brenner, H., Dieffenbach, A. K., Arndt, V., Stegmaier, C., Swerdlow, A., Ashworth, A., Orr, N., Schoemaker, M. J., García-Closas, M., Figueroa, J., Chanock, S. J., Lissowska, J., Simard, J., Goldberg, M. S., Labrèche, F., Dumont, M., Winqvist, R., Pylkäs, K., Jukkola-Vuorinen, A., Brauch, H., Brüning, T., Koto, Y. D., Radice, P., Peterlongo, P., Bonanni, B., Volorio, S., Dörk, T., Bogdanova, N. V., Helbig, S., Mannermaa, A., Kataja, V., Kosma, V. M., Hartikainen, J. M., Devilee, P., Tollenaar, R. A. E. M., Seynaeve, C., Van Asperen, C. J., Jakubowska, A., Lubinski, J., Jaworska-Bieniek, K., Durda, K., Slager, S., Toland, A. E., Ambrosone, C. B., Yannoukakos, D., Sangrajrang, S., Gaborieau, V., Brennan, P., McKay, J., Hamann, U., Torres, D., Zheng, W., Long, J., Anton-Culver, H., Neuhausen, S. L., Luccarini, C., Baynes, C., Ahmed, S., Maranian, M., Healey, C. S., González-Neira, A., Pita, G., Rosario Alonso, M., Álvarez, N., Herrero, D., Tessier, D. C., Vincent, D., Bacot, F., de Santiago, I., Carroll, J., Caldas, C., Brown, M. A., Lupien, M., Kristensen, V. N., Pharoah, P. D. P., Chenevix-Trench, G., French, J. D., Easton, D. F. & Dunning, A. M., Apr 10 2018, In : Nature communications. 9, 1 p.

Research output: Contribution to journalComment/debate

Open Access
loci
breast
cancer
communication
Breast Neoplasms

Erratum to: Pan-cancer analysis of homozygous deletions in primary tumours uncovers rare tumour suppressors (Nature Communications, (2017), 8, 1, (1221), 10.1038/s41467-017-01355-0)

Cheng, J., Demeulemeester, J., Wedge, D. C., Vollan, H. K. M., Pitt, J. J., Russnes, H. G., Pandey, B. P., Nilsen, G., Nord, S., Bignell, G. R., White, K. P., Børresen-Dale, A. L., Campbell, P. J., Kristensen, V. N., Stratton, M. R., Lingjærde, O. C., Moreau, Y. & Van Loo, P., Dec 1 2018, In : Nature communications. 9, 1, 5397.

Research output: Contribution to journalComment/debate

document markup languages
suppressors
deletion
HTML
Tumors
9 Citations (Scopus)

Intratumor heterogeneity defines treatment-resistant HER2+ breast tumors

Rye, I. H., Trinh, A., Sætersdal, A. B., Nebdal, D., Lingjærde, O. C., Almendro, V., Polyak, K., Børresen-Dale, A. L., Helland, Å., Markowetz, F. & Russnes, H. G., Nov 2018, In : Molecular oncology. 12, 11, p. 1838-1855 18 p.

Research output: Contribution to journalArticle

Breast Neoplasms
erbB-2 Genes
Therapeutics
Neoplasms
Gene Dosage
6 Citations (Scopus)

N-glycan signatures identified in tumor interstitial fluid and serum of breast cancer patients: association with tumor biology and clinical outcome

Terkelsen, T., Haakensen, V. D., Saldova, R., Gromov, P., Hansen, M. K., Stöckmann, H., Lingjærde, O. C., Børresen-Dale, A. L., Papaleo, E., Helland, Å., Rudd, P. M. & Gromova, I., Jun 2018, In : Molecular oncology. 12, 6, p. 972-990 19 p.

Research output: Contribution to journalArticle

Extracellular Fluid
Polysaccharides
Breast Neoplasms
Serum
Neoplasms
4 Citations (Scopus)

Serum cytokine levels in breast cancer patients during neoadjuvant treatment with bevacizumab

Jabeen, S., Zucknick, M., Nome, M., Dannenfelser, R., Fleischer, T., Kumar, S., Lüders, T., von der Lippe Gythfeldt, H., Troyanskaya, O., Kyte, J. A., Børresen-Dale, A. L., Naume, B., Tekpli, X., Engebraaten, O. & Kristensen, V., Nov 2 2018, In : OncoImmunology. 7, 11, e1457598.

Research output: Contribution to journalArticle

Neoadjuvant Therapy
Breast Neoplasms
Cytokines
Serum
Vascular Endothelial Growth Factor A
3 Citations (Scopus)

Time series analysis of neoadjuvant chemotherapy and bevacizumab-treated breast carcinomas reveals a systemic shift in genomic aberrations

Höglander, E. K., Nord, S., Wedge, D. C., Lingjærde, O. C., Silwal-Pandit, L., Gythfeldt, H. V. L., Vollan, H. K. M., Fleischer, T., Krohn, M., Schlitchting, E., Borgen, E., Garred, Ø., Holmen, M. M., Wist, E., Naume, B., Van Loo, P., Børresen-Dale, A. L., Engebraaten, O. & Kristensen, V., Nov 29 2018, In : Genome Medicine. 10, 1, 92.

Research output: Contribution to journalArticle

Breast Neoplasms
Drug Therapy
Vascular Endothelial Growth Factor A
Fluorouracil
Epirubicin
2017
6 Citations (Scopus)

Age, estrogen, and immune response in breast adenocarcinoma and adjacent normal tissue

Quigley, D. A., Tahiri, A., Lüders, T., Riis, M. H., Balmain, A., Børresen-Dale, A. L., Bukholm, I. & Kristensen, V., Nov 2 2017, In : OncoImmunology. 6, 11, e1356142.

Research output: Contribution to journalArticle

Estrogens
Adenocarcinoma
Breast
Tumor Microenvironment
Breast Neoplasms
34 Citations (Scopus)

A somatic-mutational process recurrently duplicates germline susceptibility loci and tissue-specific super-enhancers in breast cancers

Glodzik, D., Morganella, S., Davies, H., Simpson, P. T., Li, Y., Zou, X., Diez-Perez, J., Staaf, J., Alexandrov, L. B., Smid, M., Brinkman, A. B., Rye, I. H., Russnes, H., Raine, K., Purdie, C. A., Lakhani, S. R., Thompson, A. M., Birney, E., Stunnenberg, H. G., Van De Vijver, M. J. & 10 others, Martens, J. W. M., Børresen-Dale, A. L., Richardson, A. L., Kong, G., Viari, A., Easton, D., Evan, G., Campbell, P. J., Stratton, M. R. & Nik-Zainal, S., Mar 1 2017, In : Nature Genetics. 49, 3, p. 341-348 8 p.

Research output: Contribution to journalArticle

Odds Ratio
Breast Neoplasms
Recombinational DNA Repair
Oncogenes
Neoplasms
199 Citations (Scopus)

Association analysis identifies 65 new breast cancer risk loci

NBCS Collaborators, ABCTB Investigators & kConFab/AOCS Investigators, Nov 2 2017, In : Nature. 551, 7678, p. 92-94 3 p.

Research output: Contribution to journalArticle

Breast Neoplasms
Genes
Single Nucleotide Polymorphism
Genome-Wide Association Study
Genetic Predisposition to Disease
18 Citations (Scopus)

BRCA2 hypomorphic missense variants confer moderate risks of breast cancer

kConFab/AOCS Investigators & NBCS Collaborators, Jun 1 2017, In : Cancer research. 77, 11, p. 2789-2799 11 p.

Research output: Contribution to journalArticle

Breast Neoplasms
BRCA2 Gene
BRCA1 Gene
Risk Management
Case-Control Studies
38 Citations (Scopus)

Breast Cancer Molecular Stratification: From Intrinsic Subtypes to Integrative Clusters

Russnes, H. G., Lingjærde, O. C., Børresen-Dale, A. L. & Caldas, C., Oct 2017, In : American Journal of Pathology. 187, 10, p. 2152-2162 11 p.

Research output: Contribution to journalReview article

Breast Neoplasms
Gene Expression Profiling
Antineoplastic Agents
Neoplasms
Therapeutics
7 Citations (Scopus)

Data-driven analysis of immune infiltrate in a large cohort of breast cancer and its association with disease progression, ER activity, and genomic complexity

Dannenfelser, R., Nome, M., Tahiri, A., Ursini-Siegel, J., Vollan, H. K. M., Haakensen, V. D., Helland, Å., Naume, B., Caldas, C., Børresen-Dale, A. L., Kristensen, V. N. & Troyanskaya, O. G., Jan 1 2017, In : Oncotarget. 8, 34, p. 57121-57133 13 p.

Research output: Contribution to journalArticle

Disease Progression
Breast Neoplasms
Estrogen Receptors
Neoplasms
Lymphocytes
23 Citations (Scopus)

DNA methylation at enhancers identifies distinct breast cancer lineages

Fleischer, T., Tekpli, X., Mathelier, A., Wang, S., Nebdal, D., Dhakal, H. P., Sahlberg, K. K., Schlichting, E., Sauer, T., Geisler, J., Hofvind, S., Bathen, T. F., Engebraaten, O., Garred, Ø., Geitvik, G. A., Langerød, A., Kåresen, R., Mælandsmo, G. M., Russnes, H. G., Sørlie, T. & 12 others, Lingjærde, O. C., Skjerven, H. K., Park, D., Fritzman, B., Børresen-Dale, A. L., Borgen, E., Naume, B., Eskeland, R., Frigessi, A., Tost, J., Hurtado, A. & Kristensen, V. N., Dec 1 2017, In : Nature communications. 8, 1, 1379.

Research output: Contribution to journalArticle

methylation
DNA Methylation
breast
deoxyribonucleic acid
cancer
6 Citations (Scopus)

DNA methylation signature (SAM40) identifies subgroups of the Luminal A breast cancer samples with distinct survival

Fleischer, T., Klajic, J., Aure, M. R., Louhimo, R., Pladsen, A. V., Ottestad, L., Touleimat, N., Laakso, M., Halvorsen, A. R., Alnæs, G. I. G., Riis, M. L. H., Helland, Å., Hautaniemi, S., Lønning, P. E., Naume, B., Børresen-Dale, A. L., Tost, J. & Kristensen, V. N., Jan 1 2017, In : Oncotarget. 8, 1, p. 1074-1082 9 p.

Research output: Contribution to journalArticle

DNA Methylation
Breast Neoplasms
Survival
Adjuvant Chemotherapy
Therapeutics
10 Citations (Scopus)

Evaluation of metabolomic changes during neoadjuvant chemotherapy combined with bevacizumab in breast cancer using MR spectroscopy

Euceda, L. R., Haukaas, T. H., Giskeødegård, G. F., Vettukattil, R., Engel, J., Silwal-Pandit, L., Lundgren, S., Borgen, E., Garred, Ø., Postma, G., Buydens, L. M. C., Borresen-Dale, A-L., Engebraten, O. & Bathen, T. F., Apr 1 2017, In : Metabolomics. 13, 4, 37.

Research output: Contribution to journalArticle

Magnetic resonance spectroscopy
Metabolomics
Chemotherapy
Tumors
Magnetic Resonance Spectroscopy
17 Citations (Scopus)

Genetic modifiers of CHEK2∗1100delC-associated breast cancer risk

Breast Cancer Association Consortium & KConFab,AOCS Investigators, May 1 2017, In : Genetics in Medicine. 19, 5, p. 599-603 5 p.

Research output: Contribution to journalArticle

Breast Neoplasms
Odds Ratio
Population
Epidemiologic Studies
Genotype
150 Citations (Scopus)

HRDetect is a predictor of BRCA1 and BRCA2 deficiency based on mutational signatures

Davies, H., Glodzik, D., Morganella, S., Yates, L. R., Staaf, J., Zou, X., Ramakrishna, M., Martin, S., Boyault, S., Sieuwerts, A. M., Simpson, P. T., King, T. A., Raine, K., Eyfjord, J. E., Kong, G., Borg, Å., Birney, E., Stunnenberg, H. G., Van De Vijver, M. J., Børresen-Dale, A. L. & 13 others, Martens, J. W. M., Span, P. N., Lakhani, S. R., Vincent-Salomon, A., Sotiriou, C., Tutt, A., Thompson, A. M., Van Laere, S., Richardson, A. L., Viari, A., Campbell, P. J., Stratton, M. R. & Nik-Zainal, S., Apr 1 2017, In : Nature medicine. 23, 4, p. 517-525 9 p.

Research output: Contribution to journalArticle

Tumors
Breast Neoplasms
Mutation
Neoplasms
Logistic Models
67 Citations (Scopus)

Identification of ten variants associated with risk of estrogen-receptor-negative breast cancer

Milne, R. L., Kuchenbaecker, K. B., Michailidou, K., Beesley, J., Kar, S., Lindström, S., Hui, S., Lemaçon, A., Soucy, P., Dennis, J., Jiang, X., Rostamianfar, A., Finucane, H., Bolla, M. K., McGuffog, L., Wang, Q., Aalfs, C. M., Abctctb, I., Adams, M., Adlard, J. & 461 others, Agata, S., Ahmed, S., Ahsan, H., Aittom, K. Ä., Fares, A. E., Allen, J., Ambrosone, C. B., Amos, C. I., Andrulis, I. L., Anton-Culver, H., Antonenkova, N. N., Arndt, V., Arnold, N., Aronson, K. J., Auber, B., Auer, P. L., Ausems, M. G. M., Azzollini, J., François, B., Balma, J. N., Barile, M., Barjhoux, L., Barkardottir, R. B., Barrdahl, M., Barnes, D., Barrowdale, D., Baynes, C., Beckmann, M. W., Benitez, J., Bermisheva, M., Bernstein, L., Bignon, Y. J., Blazer, K. R., Blok, M. J., Blomqvist, C., Blot, W., Bobolis, K., Boeckx, B., Bogdanova, N. V., Bojesen, A., Bojesen, S. E., Bonanni, B., Anne-Lise, B. D., Bozsik, A., Bradbury, A. R., Brand, J. S., Brauch, H., Brenner, H., Brigitte, B. D. P., Brewer, C., Brinton, L., Broberg, P., Angela, B. W., Brunet, J., Brüning, T., Burwinkel, B., Buys, S. S., Byun, J., Cai, Q., Cald, T. É., Caligo, M. A., Campbell, I., Canzian, F., Caron, O., Carracedo, A., Carter, B. D., Esteban, C., Castera, L., Virginie, C. M., Chan, S. B., Jenny, C. C., Chanock, S. J., Chen, X., Cheng, T. Y. D., Chiquette, J., Christiansen, H., Claes, K. B., Clarke, C. L., Conner, T., Conroy, D. M., Cook, J., Cordina-Duverger, E., Cornelissen, S., Coupier, I., Cox, A., Cox, D. G., Cross, S. S., Cuk, K., Cunningham, J. M., Czene, K., Daly, M. B., Damiola, F., Darabi, H., Davidson, R., Leeneer, K. D. L., Devilee, P., Dicks, E., Diez, O., Ding, Y. C., Ditsch, N., Doheny, K. F., Domchek, S. M., Dorfling, C. M., Dörk, T., Dos-Santos-Silva, I., Dubois, S., Dugué, P. A., Dumont, M., Dunning, A. M., Durcan, L., Dwek, M., Dworniczak, B., Eccles, D., Eeles, R., Ehrencrona, H., Eilber, U., Ejlertsen, B., Ekici, A. B., Eliassen, A. H., Engel, C., Eriksson, M., Fachal, L., Faivre, L., Fasching, P. A., Faust, U., Figueroa, J., Flesch-Janys, D., Fletcher, O., Flyger, H., Foulkes, W. D., Friedman, E., Fritschi, L., Frost, D., Gabrielson, M., Gaddam, P., Gammon, M. D., Ganz, P. A., Gapstur, S. M., Garber, J., Garcia-Barberan, V., Garciá-Saénz, J. A., Gaudet, M. M., Gauthier-Villars, M., Gehrig, A., Georgoulias, V., Gerdes, A. M., Giles, G. G., Glendon, G., Godwin, A. K., Goldberg, M. S., Goldgar, D. E., González-Neira, A., Goodfellow, P., Greene, M. H., Grenaker, G. A. I., Grip, M., Gronwald, J., Grundy, A., Gschwantler, D. K., Guénel, P., Guo, Q., Haeberle, L., Hahnen, E., Haiman, C. A., Håkansson, N., Hallberg, E., Hamann, U., Hamel, N., Hankinson, S., Hansen, T. V., Harrington, P., Hart, S. N., Hartikainen, J. M., Healey, C. S., Hein, A., Helbig, S., Henderson, A., Heyworth, J., Hicks, B., Hillemanns, P., Hodgson, S., Hogervorst, F. B., Hollestelle, A., Hooning, M. J., Hoover, B., Hopper, J. L., Hu, C., Huang, G., Hulick, P. J., Humphreys, K., Hunter, D. J., Imyanitov, E. N., Isaacs, C., Iwasaki, M., Izatt, L., Jakubowska, A., James, P., Janavicius, R., Janni, W., Jensen, U. B., John, E. M., Johnson, N., Jones, K., Jones, M., Jukkola-Vuorinen, A., Kaaks, R., Kabisch, M., Kaczmarek, K., Kang, D., Kast, K., Keeman, R., Kerin, M. J., Kets, C. M., Keupers, M. H., Khan, S., Khusnutdinova, E., Kiiski, J. I., Kim, S. W., Knight, J. A., Konstantopoulou, I., Kosma, V. M., Kristensen, V. N., Kruse, T. A., Kwong, A., Lænkholm, A. V., Laitman, Y., Lalloo, F., Lambrechts, D., Landsman, K., Lasset, C., Lazaro, C., Marchand, L. L., Al-Ejeh, F., Margreet, G. M. A., Bacot, F., Børresen-Dale, A. L., Bressac-De, B. P., Brooks-Wilson, A., Castelao, J. E., Caux-Moncoutier, V., Chang-Claude, J., McLaes, K. B., Dieter, F. J., Gschwantler-Kaulich, D., Lecarpentier, J., Lee, A., Lee, E., Won, J. L., Lee, M. H., Lejbkowicz, F., Lesueur, F., Li, J., Lilyquist, J., Lincoln, A., Lindblom, A., Lissowska, J., Lo, W. Y., Loibl, S., Long, J., Loud, J. T., Lubinski, J., Luccarini, C., Lush, M., MacInnis, R. J., Maishman, T., Makalic, E., Kostovska, I. M., Malone, K. E., Siranoush, M., Manson, J. E., Margolin, S., Martens, J. W., Martinez, M. E., Matsuo, K., Mavroudis, D., Mazoyer, S., McLean, C., Meijers-Heijboer, H., Menéndez, P., Meyer, J., Miao, H., Miller, N., Mitchell, G., Montagna, M., Muir, K., Mulligan, A. M., Mulot, C., Nadesan, S., Nathanson, K. L., Neuhausen, S. L., Nevanlinna, H., Nevelsteen, I., Niederacher, D., Nielsen, S. F., Nordestgaard, B. G., Norman, A., Nussbaum, R. L., Olah, E., Olopade, O. I., Olson, J. E., Olswold, C., Ong, K. R., Oosterwijk, J. C., Orr, N., Osorio, A., Pankratz, V. S., Papi, L., Park-Simon, T. W., Paulsson-Karlsson, Y., Lloyd, R., Pedersen, I. S., Peissel, B., Peixoto, A., Perez, J. I., Peterlongo, P., Peto, J., Pfeiler, G., Phelan, C. M., Pinchev, M., Plaseska-Karanfilska, D., Poppe, B., Porteous, M. E., Prentice, R., Presneau, N., Prokofieva, D., Pugh, E., Pujana, M. A., Pylkäs, K., Rack, B., Radice, P., Rahman, N., Rantala, J., Rappaport-Fuerhauser, C., Rennert, G., Rennert, H. S., Rhenius, V., Rhiem, K., Richardson, A., Rodriguez, G. C., Romero, A., Romm, J., Rookus, M. A., Rudolph, A., Ruediger, T., Saloustros, E., Sanders, J., Sandler, D. P., Sangrajrang, S., Sawyer, E. J., Schmidt, D. F., Schoemaker, M. J., Schumacher, F., Schürmann, P., Schwentner, L., Scott, C., Scott, R. J., Seal, S., Senter, L., Seynaeve, C., Shah, M., Sharma, P., Shen, C. Y., Sheng, X., Shimelis, H., Shrubsole, M. J., Shu, X. O., Side, L. E., Singer, C. F., Sohn, C., Southey, M. C., Spinelli, J. J., Spurdle, A. B., Stegmaier, C., Stoppa-Lyonnet, D., Sukiennicki, G., Surowy, H., Sutter, C., Swerdlow, A., Szabo, C. I., Tamimi, R. M., Tan, Y. Y., Taylor, J. A., Tejada, M. I., Tengström, M., Teo, S. H., Terry, M. B., Tessier, D. C., Teul, A. E., Thöne, K., Thull, D. L., Tibiletti, M. G., Tihomirova, L., Tischkowitz, M., Toland, A. E., Tollenaar, R. A. M., Tomlinson, I., Tong, L., Torres, D., Tranchant, M., Truong, T., Tucker, K., Tung, N., Tyrer, J., Ulmer, H. U., Vachon, C., Christi, V. A. J., Den Berg, D. V., Ouweland, A. M. V., Van Rensburg, E. J., Varesco, L., Varon-Mateeva, R., Vega, A., Viel, A., Vijai, J., Vincent, D., Vollenweider, J., Walker, L., Wang, Z., Wang-Gohrke, S., Wappenschmidt, B., Weinberg, C. R., Weitzel, J. N., Wendt, C., Wesseling, J., Whittemore, A. S., Wijnen, J. T., Willett, W., Winqvist, R., Wolk, A., Wu, A. H., Xia, L., Yang, X. R., Yannoukakos, D., Zaffaroni, D., Zheng, W., Zhu, B., Ziogas, A., Ziv, E., Zorn, K. K., Gago-Dominguez, M., Mannermaa, A., Olsson, H., Teixeira, M. R., Stone, J., Offit, K., Ottini, L., Park, S. K., Thomassen, M., Hall, P., Meindl, A., Schmutzler, R. K., Droit, A., Bader, G. D., Pharoah, P. D., Couch, F. J., Easton, D. F., Kraft, P., Chenevix-Trench, G., Garciá-Closas, M., Antoniou, A. C. & Simard, J., Dec 1 2017, In : Nature Genetics. 49, 12, p. 1767-1778 12 p.

Research output: Contribution to journalArticle

Estrogen Receptors
Breast Neoplasms
Genome-Wide Association Study
Mutation
Disease Susceptibility
3 Citations (Scopus)

Implementing precision cancer medicine in the public health services of Norway: The diagnostic infrastructure and a cost estimate

Ree, A. H., Russnes, H. G., Heinrich, D., Dueland, S., Boye, K., Nygaard, V., Silwal-Pandit, L., Østrup, O., Hovig, E., Nygaard, V., Rødland, E. A., Nakken, S., Øien, J. T., Johansen, C., Bergheim, I. R., Skarpeteig, V., Sathermugathevan, M., Sauer, T., Lund-Iversen, M., Beiske, K. & 14 others, Nasser, S., Julsrud, L., Reisse, C. H., Ruud, E. A., Flørenes, V. A., Hagene, K. T., Aas, E., Lurås, H., Johnsen-Soriano, S., Geitvik, G. A., Lingjærde, O. C., Børresen-Dale, A. L., Mælandsmo, G. M. & Flatmark, K., Jun 2017, In : ESMO Open. 2, 2, e000158.

Research output: Contribution to journalArticle

Precision Medicine
United States Public Health Service
Norway
Costs and Cost Analysis
Biomarkers
20 Citations (Scopus)

Integrative clustering reveals a novel split in the luminal A subtype of breast cancer with impact on outcome

Aure, M. R., Vitelli, V., Jernström, S., Kumar, S., Krohn, M., Due, E. U., Haukaas, T. H., Leivonen, S. K., Vollan, H. K. M., Lüders, T., Rødland, E., Vaske, C. J., Zhao, W., Møller, E. K., Nord, S., Giskeødegård, G. F., Bathen, T. F., Caldas, C., Tramm, T., Alsner, J. & 26 others, Overgaard, J., Geisler, J., Bukholm, I. R. K., Naume, B., Schlichting, E., Sauer, T., Mills, G. B., Kåresen, R., Mælandsmo, G. M., Lingjærde, O. C., Frigessi, A., Kristensen, V. N., Børresen-Dale, A. L., Sahlberg, K. K., Borgen, E., Engebråten, O., Fodstad, Ø., Fritzman, B., Garred, Ø., Geitvik, G. A., Langerød, A., Hofvind, S., Russnes, H. G., Skjerven, H. K., Sørlie, T. & OSBREAC, Mar 29 2017, In : Breast Cancer Research. 19, 1, 44.

Research output: Contribution to journalArticle

Cluster Analysis
Breast Neoplasms
Neoplasms
MicroRNAs
Messenger RNA
4 Citations (Scopus)

Interactions between the tumor and the blood systemic response of breast cancer patients

Dumeaux, V., Fjukstad, B., Fjosne, H. E., Frantzen, J. O., Holmen, M. M., Rodegerdts, E., Schlichting, E., Børresen-Dale, A. L., Bongo, L. A., Lund, E. & Hallett, M., Sep 2017, In : PLoS computational biology. 13, 9, e1005680.

Research output: Contribution to journalArticle

Breast Cancer
tumor
breast neoplasms
Blood
Tumors
4 Citations (Scopus)

Molecular signatures reflecting microenvironmental metabolism and chemotherapy-induced immunogenic cell death in colorectal liver metastases

Østrup, O., Dagenborg, V. J., Rødland, E. A., Skarpeteig, V., Silwal-Pandit, L., Grzyb, K., Berstad, A. E., Fretland, Å. A., Mælandsmo, G. M., Børresen-Dale, A. L., Ree, A. H., Edwin, B., Nygaard, V. & Flatmark, K., Jan 1 2017, In : Oncotarget. 8, 44, p. 76290-76304 15 p.

Research output: Contribution to journalArticle

Cell Death
Neoplasm Metastasis
Drug Therapy
Liver
Colorectal Neoplasms
13 Citations (Scopus)

Pan-cancer analysis of homozygous deletions in primary tumours uncovers rare tumour suppressors

Cheng, J., Demeulemeester, J., Wedge, D. C., Vollan, H. K. M., Pitt, J. J., Russnes, H. G., Pandey, B. P., Nilsen, G., Nord, S., Bignell, G. R., White, K. P., Børresen-Dale, A. L., Campbell, P. J., Kristensen, V. N., Stratton, M. R., Lingjærde, O. C., Moreau, Y. & Van Loo, P., Dec 1 2017, In : Nature communications. 8, 1, 1221.

Research output: Contribution to journalArticle

suppressors
deletion
Tumors
tumors
cancer
19 Citations (Scopus)

Profiling of microRNAs in tumor interstitial fluid of breast tumors – A novel resource to identify biomarkers for prognostic classification and detection of cancer

Halvorsen, A. R., Helland, Å., Gromov, P., Wielenga, V. T., Talman, M. L. M., Brunner, N., Sandhu, V., Børresen-Dale, A. L., Gromova, I. & Haakensen, V. D., Jan 1 2017, In : Molecular oncology. 11, 2, p. 220-234 15 p.

Research output: Contribution to journalArticle

Extracellular Fluid
MicroRNAs
Biomarkers
Breast Neoplasms
Neoplasms
14 Citations (Scopus)

Prognostic significance of S100A4-expression and subcellular localization in early-stage breast cancer

The Oslo Breast Cancer Consortium (OSBREAC), Feb 1 2017, In : Breast Cancer Research and Treatment. 162, 1, p. 127-137 11 p.

Research output: Contribution to journalArticle

Breast Neoplasms
Neoplasms
Neoplasm Metastasis
Survival
Extracellular Space
5 Citations (Scopus)

Serum N-glycome alterations in breast cancer during multimodal treatment and follow-up

Saldova, R., Haakensen, V. D., Rødland, E., Walsh, I., Stöckmann, H., Engebraaten, O., Børresen-Dale, A. L. & Rudd, P. M., Oct 2017, In : Molecular oncology. 11, 10, p. 1361-1379 19 p.

Research output: Contribution to journalArticle

Combined Modality Therapy
Breast Neoplasms
Drug Therapy
Serum
Glycosylation
63 Citations (Scopus)

Somatic mutations reveal asymmetric cellular dynamics in the early human embryo

Ju, Y. S., Martincorena, I., Gerstung, M., Petljak, M., Alexandrov, L. B., Rahbari, R., Wedge, D. C., Davies, H. R., Ramakrishna, M., Fullam, A., Martin, S., Alder, C., Patel, N., Gamble, S., O'Meara, S., Giri, DI. D., Sauer, T., Pinder, S. E., Purdie, C. A., Borg, Å. & 21 others, Stunnenberg, H., Van De Vijver, M., Tan, B. K. T., Caldas, C., Tutt, A., Ueno, N. T., Van 'T Veer, L. J., Martens, J. W. M., Sotiriou, C., Knappskog, S., Span, P. N., Lakhani, S. R., Eyfjörd, J. E., Børresen-Dale, A. L., Richardson, A., Thompson, A. M., Viari, A., Hurles, M. E., Nik-Zainal, S., Campbell, P. J. & Stratton, M. R., Mar 30 2017, In : Nature. 543, 7647, p. 714-718 5 p.

Research output: Contribution to journalArticle

Embryonic Structures
Mutation
Embryonic Development
Genome
Inborn Genetic Diseases
10 Citations (Scopus)

The longitudinal transcriptional response to neoadjuvant chemotherapy with and without bevacizumab in breast cancer

Silwal-Pandit, L., Nord, S., Von Der Lippe Gythfeldt, H., Møller, E. K., Fleischer, T., Rødland, E., Krohn, M., Borgen, E., Garred, Ø., Olsen, T., Vu, P., Skjerven, H., Fangberget, A., Holmen, M. M., Schlitchting, E., Wille, E., Stokke, M. N., Vollan, H. K. M., Kristensen, V., Langerød, A. & 6 others, Lundgren, S., Wist, E., Naume, B., Lingjærde, O. C., Børresen-Dale, A. L. & Engebraaten, O., Aug 15 2017, In : Clinical Cancer Research. 23, 16, p. 4662-4670 9 p.

Research output: Contribution to journalArticle

Breast Neoplasms
Drug Therapy
Therapeutics
Arm
Neoplasms
8 Citations (Scopus)

TP53 mutations in breast and ovarian cancer

Silwal-Pandit, L., Langerød, A. & Børresen-Dale, A. L., Jan 2017, In : Cold Spring Harbor Perspectives in Medicine. 7, 1, a026252.

Research output: Contribution to journalArticle

Ovarian Neoplasms
Tumors
Breast Neoplasms
Mutation
Neoplasms
23 Citations (Scopus)

Whole-genome sequencing reveals breast cancers with mismatch repair deficiency

Davies, H., Morganella, S., Purdie, C. A., Jang, S. J., Borgen, E., Russnes, H., Glodzik, D., Zou, X., Viari, A., Richardson, A. L., Børresen-Dale, A. L., Thompson, A., Eyfjord, J. E., Kong, G., Stratton, M. R. & Nik-Zainal, S., Sep 15 2017, In : Cancer research. 77, 18, p. 4755-4762 8 p.

Research output: Contribution to journalArticle

DNA Mismatch Repair
Genome
Breast Neoplasms
Neoplasms
Genes
6 Citations (Scopus)

Widespread alternative exon usage in clinically distinct subtypes of Invasive Ductal Carcinoma

Bjørklund, S. S., Panda, A., Kumar, S., Seiler, M., Robinson, D., Gheeya, J., Yao, M., Alnæs, G. I. G., Toppmeyer, D., Riis, M., Naume, B., Børresen-Dale, A. L., Kristensen, V. N., Ganesan, S. & Bhanot, G., Dec 1 2017, In : Scientific reports. 7, 1, 5568.

Research output: Contribution to journalArticle

Ductal Carcinoma
Exons
Alternative Splicing
Atlases
Neoplasms