Changying Jiang

2024

The HSP90-MYC-CDK9 network drives therapeutic resistance in mantle cell lymphoma

Yan, F., Jiang, V., Jordan, A., Che, Y., Liu, Y., Cai, Q., Xue, Y., Li, Y., McIntosh, J., Chen, Z., Vargas, J., Nie, L., Yao, Y., Lee, H. H., Wang, W., Bigcal, J. N. R., Badillo, M., Meena, J., Flowers, C., Zhou, J., & 3 othersZhao, Z., Simon, L. M. & Wang, M., Dec 2024, In: Experimental Hematology and Oncology. 13, 1, 14.

Research output: Contribution to journal › Article › peer-review

Open Access

2023

Cotargeting of BTK and MALT1 overcomes resistance to BTK inhibitors in mantle cell lymphoma

Jiang, V. C., Liu, Y., Lian, J., Huang, S., Jordan, A., Cai, Q., Lin, R., Yan, F., McIntosh, J., Li, Y., Che, Y., Chen, Z., Vargas, J., Badillo, M., Bigcal, J. N., Lee, H. H., Wang, W., Yao, Y., Nie, L., Flowers, C. R., & 1 othersWang, M., Feb 1 2023, In: Journal of Clinical Investigation. 133, 3, e165694.

Research output: Contribution to journal › Article › peer-review

Open Access

9 Scopus citations

Dual targeting of CDK4/6 and Bcl-2 exhibits a potent antitumor effect on mantle cell lymphoma

Che, Y., Liu, Y., Li, Y., McIntosh, J. M., Jordan, A., Yan, F., Wang, W., Nie, L., Lee, H. H., Jin, J., Yao, Y., Zhao, Z., Jiang, V. C. & Wang, M., Jul 25 2023, In: Blood Advances. 7, 14, p. 3361-3365 5 p.

Research output: Contribution to journal › Article › peer-review

Open Access

2 Scopus citations

Pirtobrutinib and venetoclax combination overcomes resistance to targeted and chimeric antigen receptor T-cell therapy in aggressive mantle cell lymphoma

Liu, Y., Yan, F., Jiang, V. C., Li, Y., Che, Y., McIntosh, J., Jordan, A., Hou, I., Nie, L., Jin, J., Wang, W., Lee, H. H., Yao, Y. & Wang, M., May 2023, In: Haematologica. 108, 5, p. 1412-1416 5 p.

Research output: Contribution to journal › Letter › peer-review

Open Access

2 Scopus citations

Potentiation of apoptosis in drug-resistant mantle cell lymphoma cells by MCL-1 inhibitor involves downregulation of inhibitor of apoptosis proteins

Li, Y., Lee, H. H., Jiang, V. C., Che, Y., McIntosh, J., Jordan, A., Vargas, J., Zhang, T., Yan, F., Simmons, M. E., Wang, W., Nie, L., Yao, Y., Jain, P., Wang, M. & Liu, Y., Nov 2023, In: Cell Death and Disease. 14, 11, 714.

Research output: Contribution to journal › Article › peer-review

Open Access

Targeting glutaminase is therapeutically effective in ibrutinib-resistant mantle cell lymphoma

Li, L., Nie, L., Jordan, A., Cai, Q., Liu, Y., Li, Y., Che, Y., Vargas, J., Chen, Z., Leeming, A., Wang, W., Yao, Y., Wang, M. & Jiang, V. C., Jun 2023, In: Haematologica. 108, 6, p. 1616-1627 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

5 Scopus citations

2022

Dual targeting of PI3K and BCL-2 overcomes ibrutinib resistance in aggressive mantle cell lymphoma

Ye, H., Huang, S., Liu, Y., Chen, Z., Wang, M. & Jiang, V. C., May 2022, In: Journal of Cellular and Molecular Medicine. 26, 10, p. 3068-3073 6 p.

Research output: Contribution to journal › Article › peer-review

Open Access

1 Scopus citations

Targeting FcγRIIB by antagonistic antibody BI-1206 improves the efficacy of rituximab-based therapies in aggressive mantle cell lymphoma

Jiang, V. C., Liu, Y., Jordan, A., Leeming, A., McIntosh, J., Huang, S., Zhang, R., Cai, Q., Chen, Z., Li, Y., Che, Y., Nie, L., Karlsson, I., Mårtensson, L., Kovacek, M., Teige, I., Frendéus, B. & Wang, M., Dec 2022, In: Journal of Hematology and Oncology. 15, 1, 42.

Research output: Contribution to journal › Letter › peer-review

Open Access

4 Scopus citations

TIGIT is the central player in T-cell suppression associated with CAR T-cell relapse in mantle cell lymphoma

Jiang, V. C., Hao, D., Jain, P., Li, Y., Cai, Q., Yao, Y., Nie, L., Liu, Y., Jin, J., Wang, W., Lee, H. H., Che, Y., Dai, E., Han, G., Wang, R., Rai, K., Futreal, A., Flowers, C., Wang, L. & Wang, M., Dec 2022, In: Molecular cancer. 21, 1, 185.

Research output: Contribution to journal › Article › peer-review

Open Access

22 Scopus citations

2021

Inhibition of B-cell receptor signaling disrupts cell adhesion in mantle cell lymphoma via RAC2

Wu, W., Wang, W., Franzen, C. A., Guo, H., Lee, J., Li, Y., Sukhanova, M., Sheng, D., Venkataraman, G., Ming, M., Lu, P., Gao, A., Xia, C., Li, J., Zhang, L. L., Jiang, V. C., Wang, M. L., Andrade, J., Zhou, X. & Lynn Wang, Y., Jan 12 2021, In: Blood Advances. 5, 1, p. 185-197 13 p.

Research output: Contribution to journal › Article › peer-review

Open Access

11 Scopus citations

Longitudinal single-cell profiling reveals molecular heterogeneity and tumor-immune evolution in refractory mantle cell lymphoma

Zhang, S., Jiang, V. C., Han, G., Hao, D., Lian, J., Liu, Y., Zhang, R., McIntosh, J., Wang, R., Dang, M., Dai, E., Wang, Y., Santos, D., Badillo, M., Leeming, A., Chen, Z., Hartig, K., Bigcal, J., Zhou, J., Kanagal-Shamanna, R., & 17 othersOk, C. Y., Lee, H., Steiner, R. E., Zhang, J., Song, X., Nair, R., Ahmed, S., Rodriquez, A., Thirumurthi, S., Jain, P., Wagner-Bartak, N., Hill, H., Nomie, K., Flowers, C., Futreal, A., Wang, L. & Wang, M., Dec 1 2021, In: Nature communications. 12, 1, 2877.

Research output: Contribution to journal › Article › peer-review

Open Access

33 Scopus citations

The antibody drug conjugate VLS-101 targeting ROR1 is effective in CAR T-resistant mantle cell lymphoma

Jiang, V. C., Liu, Y., Jordan, A., McIntosh, J., Li, Y., Che, Y., Jessen, K. A., Lannutti, B. J. & Wang, M., Dec 2021, In: Journal of Hematology and Oncology. 14, 1, 132.

Research output: Contribution to journal › Letter › peer-review

Open Access

17 Scopus citations

2020

Efficacy of venetoclax in high risk relapsed mantle cell lymphoma (MCL) - outcomes and mutation profile from venetoclax resistant MCL patients

Zhao, S., Kanagal-Shamanna, R., Navsaria, L., Ok, C. Y., Zhang, S., Nomie, K., Han, G., Hao, D., Hill, H. A., Jiang, C., Yao, Y., Nastoupil, L., Westin, J., Fayad, L., Nair, R., Steiner, R., Ahmed, S., Samaniego, F., Iyer, S. P., Oriabure, O., & 21 othersChen, W., Song, X., Zhang, J., Badillo, M., Moghrabi, O., Aranda, J., Tang, G., Yin, C. C., Patel, K., Medeiros, L. J., Li, S., Vega, F., Thirumurthi, S., Xu, G., Neelapu, S., Flowers, C. R., Romaguera, J., Fowler, N., Wang, L., Wang, M. L. & Jain, P., Jun 1 2020, In: American journal of hematology. 95, 6, p. 623-629 7 p.

Research output: Contribution to journal › Article › peer-review

Open Access

51 Scopus citations

Genomic profiles and clinical outcomes of de novo blastoid/pleomorphic MCL are distinct from those of transformed MCL

Jain, P., Zhang, S., Kanagal-Shamanna, R., Ok, C. Y., Nomie, K., Gonzalez, G. N., Gonzalez-Pagan, O., Hill, H. A., Lee, H. J., Fayad, L., Westin, J., Nastoupil, L., Hagemeister, F., Chen, W., Oriabure, O., Badillo, M., Jiang, C., Yixin, Y., Li, S., Tang, G., & 22 othersYin, C. C., Patel, K. P., Medeiros, L. J., Nair, R., Ahmed, S., Iyer, S. P., Thirumurthi, S., Champlin, R., Xu, G., Tinsu, P., Santos, D., Wang, R., Han, G., Zhang, J., Song, X., Neelapu, S., Romaguera, J., Futreal, A., Flowers, C., Fowler, N., Wang, L. & Wang, M. L., Mar 24 2020, In: Blood Advances. 4, 6, p. 1038-1050 13 p.

Research output: Contribution to journal › Article › peer-review

Open Access

43 Scopus citations

2019

Dual inhibition of PI3K signaling and histone deacetylation halts proliferation and induces lethality in mantle cell lymphoma

Guo, H., Zeng, D., Zhang, H., Bell, T., Yao, J., Liu, Y., Huang, S., Li, C. J., Lorence, E., Zhou, S., Gong, T., Jiang, C., Ahmed, M., Yao, Y., Nomie, K. J., Zhang, L. & Wang, M., Mar 14 2019, In: Oncogene. 38, 11, p. 1802-1814 13 p.

Research output: Contribution to journal › Article › peer-review

17 Scopus citations

Pleiotropic action of novel Bruton's tyrosine kinase inhibitor BGB-3111 in mantle cell lymphoma

Li, C. J., Jiang, C., Liu, Y., Bell, T., Ma, W., Ye, Y., Huang, S., Guo, H., Zhang, H., Wang, L., Wang, J., Nomie, K., Zhang, L. & Wang, M., Feb 2019, In: Molecular cancer therapeutics. 18, 2, p. 267-277 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

20 Scopus citations

Repurposing auranofin to treat TP53-mutated or PTEN-deleted refractory B-cell lymphoma

Wang, J., Wang, J., Lopez, E., Guo, H., Zhang, H., Liu, Y., Chen, Z., Huang, S., Zhou, S., Leeming, A., Zhang, R. J., Jung, D., Shi, H., Grundman, H., Doakes, D., Cui, K., Jiang, C., Ahmed, M., Nomie, K., Fang, B., & 3 othersWang, M., Yao, Y. & Zhang, L., Dec 1 2019, In: Blood cancer journal. 9, 12, 95.

Research output: Contribution to journal › Letter › peer-review

Open Access

20 Scopus citations

TMEM43-S358L mutation enhances NF-κB-TGFβ signal cascade in arrhythmogenic right ventricular dysplasia/cardiomyopathy

Zheng, G., Jiang, C., Li, Y., Yang, D., Ma, Y., Zhang, B., Li, X., Zhang, P., Hu, X., Zhao, X., Du, J. & Lin, X., Feb 1 2019, In: Protein and Cell. 10, 2, p. 104-119 16 p.

Research output: Contribution to journal › Article › peer-review

Open Access

31 Scopus citations

2018

The Adaptor Protein CARD9 Protects against Colon Cancer by Restricting Mycobiota-Mediated Expansion of Myeloid-Derived Suppressor Cells

Wang, T., Fan, C., Yao, A., Xu, X., Zheng, G., You, Y., Jiang, C., Zhao, X., Hou, Y., Hung, M. C. & Lin, X., Sep 18 2018, In: Immunity. 49, 3, p. 504-514.e4

Research output: Contribution to journal › Article › peer-review

Open Access

127 Scopus citations

The CD20-specific engineered toxin antibody MT-3724 exhibits lethal effects against mantle cell lymphoma

Huang, S., Jiang, C., Zhang, H., Bell, T., Guo, H., Liu, Y., Yao, Y., Zeng, D., Ahmed, M., Nomie, K., Zhang, L. & Wang, M., Mar 1 2018, In: Blood cancer journal. 8, 3, 33.

Research output: Contribution to journal › Letter › peer-review

Open Access

9 Scopus citations

2017

JNK1 negatively controls antifungal innate immunity by suppressing CD23 expression

Zhao, X., Guo, Y., Jiang, C., Chang, Q., Zhang, S., Luo, T., Zhang, B., Jia, X., Hung, M. C., Dong, C. & Lin, X., Mar 1 2017, In: Nature medicine. 23, 3, p. 337-346 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

77 Scopus citations

Structural optimization elaborates novel potent Akt inhibitors with promising anticancer activity

Liu, Y., Yin, Y., Zhang, Z., Li, C. J., Zhang, H., Zhang, D., Jiang, C., Nomie, K., Zhang, L., Wang, M. L. & Zhao, G., 2017, In: European Journal of Medicinal Chemistry. 138, p. 543-551 9 p.

Research output: Contribution to journal › Article › peer-review

15 Scopus citations

TMEM43/LUMA is a key signaling component mediating EGFR-induced NF-κ B activation and tumor progression

Jiang, C., Zhu, Y., Zhou, Z., Gumin, J., Bengtsson, L., Wu, W., Songyang, Z., Lang, F. F. & Lin, X., May 18 2017, In: Oncogene. 36, 20, p. 2813-2823 11 p.

Research output: Contribution to journal › Article › peer-review

34 Scopus citations

2016

CARMA3 Is a Host Factor Regulating the Balance of Inflammatory and Antiviral Responses against Viral Infection

Jiang, C., Zhou, Z., Quan, Y., Zhang, S., Wang, T., Zhao, X., Morrison, C., Heise, M. T., He, W., Miller, M. S. & Lin, X., Mar 15 2016, In: Cell Reports. 14, 10, p. 2389-2401 13 p.

Research output: Contribution to journal › Article › peer-review

Open Access

23 Scopus citations

Dectin-3 Deficiency Promotes Colitis Development due to Impaired Antifungal Innate Immune Responses in the Gut

Wang, T., Pan, D., Zhou, Z., You, Y., Jiang, C., Zhao, X. & Lin, X., Jun 2016, In: PLoS pathogens. 12, 6, e1005662.

Research output: Contribution to journal › Article › peer-review

Open Access

71 Scopus citations

MALT1 is required for EGFR-induced NF-κB activation and contributes to EGFR-driven lung cancer progression

Pan, D., Jiang, C., Ma, Z., Blonska, M., You, M. J. & Lin, X., Feb 18 2016, In: Oncogene. 35, 7, p. 919-928 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

47 Scopus citations

The CBM complex underwrites NF-κB activation to promote HER2-associated tumor malignancy

Pan, D., Zhu, Y., Zhou, Z., Wang, T., You, H., Jiang, C. & Lin, X., Jan 2016, In: Molecular Cancer Research. 14, 1, p. 93-102 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

32 Scopus citations

2015

Analysis of epidermal growth factor-induced NF-κB signaling

Jiang, C. & Lin, X., 2015, In: Methods in Molecular Biology. 1280, p. 75-102 28 p.

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

2014

C-type lectin receptor Dectin-3 mediates trehalose 6,6′-dimycolate (TDM)-induced Mincle expression through CARD9/Bcl10/MALT1-dependent nuclear factor (NF)-κB activation

Zhao, X. Q., Zhu, L. L., Chang, Q., Jiang, C., You, Y., Luo, T., Jia, X. M. & Lin, X., Oct 24 2014, In: Journal of Biological Chemistry. 289, 43, p. 30052-30062 11 p.

Research output: Contribution to journal › Article › peer-review

92 Scopus citations

2013

C-type lectin receptors dectin-3 and dectin-2 form a heterodimeric pattern-recognition receptor for host defense against fungal infection

Zhu, L. L., Zhao, X. Q., Jiang, C., You, Y., Chen, X. P., Jiang, Y. Y., Jia, X. M. & Lin, X., Aug 22 2013, In: Immunity. 39, 2, p. 324-334 11 p.

Research output: Contribution to journal › Article › peer-review

246 Scopus citations

2012

Regulation of NF-κB by the CARD proteins

Jiang, C. & Lin, X., Mar 2012, In: Immunological Reviews. 246, 1, p. 141-153 13 p.

Research output: Contribution to journal › Review article › peer-review

Open Access

77 Scopus citations

2011

CARMA3 is crucial for EGFR-induced activation of NF-κB and tumor progression

Jiang, T., Grabiner, B., Zhu, Y., Jiang, C., Li, H., You, Y., Lang, J., Hung, M. C. & Lin, X., Mar 15 2011, In: Cancer Research. 71, 6, p. 2183-2192 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

77 Scopus citations

2009

Mutations that increase DNA binding by the processivity factor of herpes simplex virus affect virus production and DNA replication fidelity

Jiang, C., Komazin-Meredith, G., Tian, W., Coen, D. M. & Hwang, C. B. C., Aug 2009, In: Journal of Virology. 83, 15, p. 7573-7580 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

17 Scopus citations

2007

Herpes simplex virus mutants with multiple substitutions affecting DNA binding of UL42 are impaired for viral replication and DNA synthesis

Jiang, C., Hwang, Y. T., Wang, G., Randell, J. C. W., Coen, D. M. & Hwang, C. B. C., Nov 2007, In: Journal of Virology. 81, 21, p. 12077-12079 3 p.

Research output: Contribution to journal › Article › peer-review

Open Access

14 Scopus citations

Mutations that decrease DNA binding of the processivity factor of the herpes simplex virus DNA polymerase reduce viral yield, alter the kinetics of viral DNA replication, and decrease the fidelity of DNA replication

Jiang, C., Hwang, Y. T., Randell, J. C. W., Coen, D. M. & Hwang, C. B. C., Apr 2007, In: Journal of Virology. 81, 7, p. 3495-3502 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

24 Scopus citations

2006

Herpes simplex virus type 1 recombinants without the ori_L sequence replicate DNA with increased fidelity

Jiang, C., Hwang, Y. T. & Hwang, C. B. C., Apr 10 2006, In: Virology. 347, 2, p. 277-285 9 p.

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

2005

Effects of substitutions of arginine residues on the basic surface of herpes simplex virus UL42 support a role for DNA binding in processive DNA synthesis

Randell, J. C. W., Komazin, G., Jiang, C., Hwang, C. B. C. & Coen, D. M., Sep 2005, In: Journal of Virology. 79, 18, p. 12025-12034 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

25 Scopus citations

Genotoxic and endoplasmic reticulum stresses differentially regulate TRB3 expression

Corcoran, C. A., Luo, X., He, Q., Jiang, C., Huang, Y. & Sheikh, M. S., Oct 2005, In: Cancer Biology and Therapy. 4, 10, p. 1063-1067 5 p.

Research output: Contribution to journal › Article › peer-review

Open Access

50 Scopus citations

Changying Jiang

Research output

Search results