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1988 …2019
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Research Output 1988 2019

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Article
2019
18 Citations (Scopus)
Open Access
Melanoma
Dermatologists
Sensitivity and Specificity
ROC Curve
Learning

Between Minimal and Greater Than Minimal Risk: How Research Participants and Oncologists Assess Data-Sharing and the Risk of Re-identification in Genomic Research

Schleidgen, S., Husedzinovic, A., Ose, D., Schickhardt, C., von Kalle, C. & Winkler, E. C., Mar 15 2019, In : Philosophy and Technology. 32, 1, p. 39-55 17 p.

Research output: Contribution to journalArticle

Disclosure
Physicians
Entity
Governance
Sound
12 Citations (Scopus)

Comparing artificial intelligence algorithms to 157 German dermatologists: the melanoma classification benchmark

Brinker, T. J., Hekler, A., Hauschild, A., Berking, C., Schilling, B., Enk, A. H., Haferkamp, S., Karoglan, A., von Kalle, C., Weichenthal, M., Sattler, E., Schadendorf, D., Gaiser, M. R., Klode, J. & Utikal, J. S., Apr 1 2019, In : European Journal of Cancer. 111, p. 30-37 8 p.

Research output: Contribution to journalArticle

Open Access
Benchmarking
Artificial Intelligence
Melanoma
ROC Curve
Sensitivity and Specificity
5 Citations (Scopus)

Deep learning outperformed 11 pathologists in the classification of histopathological melanoma images

Hekler, A., Utikal, J. S., Enk, A. H., Solass, W., Schmitt, M., Klode, J., Schadendorf, D., Sondermann, W., Franklin, C., Bestvater, F., Flaig, M. J., Krahl, D., von Kalle, C., Fröhling, S. & Brinker, T. J., Sep 2019, In : European Journal of Cancer. 118, p. 91-96 6 p.

Research output: Contribution to journalArticle

Open Access
Melanoma
Learning
Sensitivity and Specificity
Nevi and Melanomas
Nevus
16 Citations (Scopus)

Deep learning outperformed 136 of 157 dermatologists in a head-to-head dermoscopic melanoma image classification task

Collaborators, May 2019, In : European Journal of Cancer. 113, p. 47-54 8 p.

Research output: Contribution to journalArticle

Open Access
Melanoma
Learning
Sensitivity and Specificity
Physicians
Dermatologists
5 Citations (Scopus)

Deep neural networks are superior to dermatologists in melanoma image classification

Brinker, T. J., Hekler, A., Enk, A. H., Berking, C., Haferkamp, S., Hauschild, A., Weichenthal, M., Klode, J., Schadendorf, D., Holland-Letz, T., von Kalle, C., Fröhling, S., Schilling, B. & Utikal, J. S., Sep 1 2019, In : European Journal of Cancer. 119, p. 11-17 7 p.

Research output: Contribution to journalArticle

Open Access
Melanoma
Nevi and Melanomas
Confidence Intervals
Biopsy
Sensitivity and Specificity
4 Citations (Scopus)

Defective homologous recombination DNA repair as therapeutic target in advanced chordoma

Gröschel, S., Hübschmann, D., Raimondi, F., Horak, P., Warsow, G., Fröhlich, M., Klink, B., Gieldon, L., Hutter, B., Kleinheinz, K., Bonekamp, D., Marschal, O., Chudasama, P., Mika, J., Groth, M., Uhrig, S., Krämer, S., Heining, C., Heilig, C. E., Richter, D. & 19 others, Reisinger, E., Pfütze, K., Eils, R., Wolf, S., von Kalle, C., Brandts, C., Scholl, C., Weichert, W., Richter, S., Bauer, S., Penzel, R., Schröck, E., Stenzinger, A., Schlenk, R. F., Brors, B., Russell, R. B., Glimm, H., Schlesner, M. & Fröhling, S., Dec 1 2019, In : Nature communications. 10, 1, 1635.

Research output: Contribution to journalArticle

Open Access
Chordoma
Recombinational DNA Repair
ribose
adenosine diphosphate
genome
2 Citations (Scopus)

Enhanced classifier training to improve precision of a convolutional neural network to identify images of skin lesions

Brinker, T. J., Hekler, A., Enk, A. H. & von Kalle, C., Jun 2019, In : PloS one. 14, 6, e0218713.

Research output: Contribution to journalArticle

Open Access
skin lesions
neural networks
Skin
Classifiers
image analysis

Identification and characterization of a BRAF fusion oncoprotein with retained autoinhibitory domains

Weinberg, F., Griffin, R., Fröhlich, M., Heining, C., Braun, S., Spohr, C., Iconomou, M., Hollek, V., Röring, M., Horak, P., Kreutzfeldt, S., Warsow, G., Hutter, B., Uhrig, S., Neumann, O., Reuss, D., Heiland, D. H., von Kalle, C., Weichert, W., Stenzinger, A. & 4 others, Brors, B., Glimm, H., Fröhling, S. & Brummer, T., Jan 1 2019, (Accepted/In press) In : Oncogene.

Research output: Contribution to journalArticle

Oncogene Proteins
Mitogen-Activated Protein Kinase Kinases
Phosphorylation
Proteins
Membranes
8 Citations (Scopus)

Pathologist-level classification of histopathological melanoma images with deep neural networks

Hekler, A., Utikal, J. S., Enk, A. H., Berking, C., Klode, J., Schadendorf, D., Jansen, P., Franklin, C., Holland-Letz, T., Krahl, D., von Kalle, C., Fröhling, S. & Brinker, T. J., Jul 1 2019, In : European Journal of Cancer. 115, p. 79-83 5 p.

Research output: Contribution to journalArticle

Open Access
Melanoma
Nevus
Confidence Intervals
Learning
Nevi and Melanomas
4 Citations (Scopus)

Prediction of melanoma evolution in melanocytic nevi via artificial intelligence: A call for prospective data

Sondermann, W., Utikal, J. S., Enk, A. H., Schadendorf, D., Klode, J., Hauschild, A., Weichenthal, M., French, L. E., Berking, C., Schilling, B., Haferkamp, S., Fröhling, S., von Kalle, C. & Brinker, T. J., Sep 1 2019, In : European Journal of Cancer. 119, p. 30-34 5 p.

Research output: Contribution to journalArticle

Open Access
Pigmented Nevus
Artificial Intelligence
Melanoma
Nevus
Mobile Applications

Process evaluation of a medical student-delivered smoking prevention program for secondary schools: protocol for the education against tobacco cluster randomized trial

Brinker, T. J., Buslaff, F., Suhre, J. L., Silchmüller, M. P., Divizieva, E., Wilhelm, J., Hillebrand, G., Penka, D., Gaim, B., Swoboda, S., Baumermann, S., Walther, J. W., Brieske, C. M., Jakob, L., Baumert, H. M., Anhuef, O., Schmidt, S. M., Alfitian, J., Batra, A., Taha, L. & 21 others, Mons, U., Hofmann, F. J., Haney, A. C., Haney, C. M., Schaible, S., Tran, T. A., Beißwenger, H., Stark, T., Groneberg, D. A., Seeger, W., Srivastava, A., Gall, H., Holzapfel, J., Rigotti, N. A., Baudson, T. G., Enk, A. H., Fröhling, S., von Kalle, C., Bernardes-Souza, B., De Oliveira Santos Pereira, R. M. & Thomas, R., Apr 1 2019, In : Journal of medical Internet research. 21, 4, e13508.

Research output: Contribution to journalArticle

Open Access
Medical Students
Tobacco
Smoking
Education
Students
4 Citations (Scopus)

Superior skin cancer classification by the combination of human and artificial intelligence

Hekler, A., Utikal, J. S., Enk, A. H., Hauschild, A., Weichenthal, M., Maron, R. C., Berking, C., Haferkamp, S., Klode, J., Schadendorf, D., Schilling, B., Holland-Letz, T., Izar, B., von Kalle, C., Fröhling, S., Brinker, T. J., Schmitt, L., Peitsch, W. K., Hoffmann, F., Becker, J. C. & 81 others, Drusio, C., Jansen, P., Lodde, G., Sammet, S., Sondermann, W., Ugurel, S., Zader, J., Enk, A., Salzmann, M., Schäfer, S., Schäkel, K., Winkler, J., Wölbing, P., Asper, H., Bohne, A. S., Brown, V., Burba, B., Deffaa, S., Dietrich, C., Dietrich, M., Drerup, K. A., Egberts, F., Erkens, A. S., Greven, S., Harde, V., Jost, M., Kaeding, M., Kosova, K., Lischner, S., Maagk, M., Messinger, A. L., Metzner, M., Motamedi, R., Rosenthal, A. C., Seidl, U., Stemmermann, J., Torz, K., Velez, J. G., Haiduk, J., Alter, M., Bär, C., Bergenthal, P., Gerlach, A., Holtorf, C., Karoglan, A., Kindermann, S., Kraas, L., Felcht, M., Gaiser, M. R., Klemke, C. D., Kurzen, H., Leibing, T., Müller, V., Reinhard, R. R., Utikal, J., Winter, F., Eicher, L., Hartmann, D., Heppt, M., Kilian, K., Krammer, S., Lill, D., Niesert, A. C., Oppel, E., Sattler, E., Senner, S., Wallmichrath, J., Wolff, H., Gesierich, A., Giner, T., Glutsch, V., Kerstan, A., Presser, D., Schrüfer, P., Schummer, P., Stolze, I., Weber, J., Drexler, K., Mickler, M., Stauner, C. T. & Thiem, A., Oct 2019, In : European Journal of Cancer. 120, p. 114-121 8 p.

Research output: Contribution to journalArticle

Open Access
Artificial Intelligence
Skin Neoplasms
Artificial Skin
Nevi and Melanomas
Learning
1 Citation (Scopus)

Systematic comparative study of computational methods for T-cell receptor sequencing data analysis

Afzal, S., Gil-Farina, I., Gabriel, R., Ahmad, S., Von Kalle, C., Schmidt, M. & Fronza, R., Jan 1 2019, In : Briefings in bioinformatics. 20, 1, p. 1-13 13 p.

Research output: Contribution to journalArticle

T-cells
Computational methods
T-Cell Antigen Receptor
Complementarity Determining Regions
Technology
5 Citations (Scopus)

Systematic outperformance of 112 dermatologists in multiclass skin cancer image classification by convolutional neural networks

Maron, R. C., Weichenthal, M., Utikal, J. S., Hekler, A., Berking, C., Hauschild, A., Enk, A. H., Haferkamp, S., Klode, J., Schadendorf, D., Jansen, P., Holland-Letz, T., Schilling, B., von Kalle, C., Fröhling, S., Gaiser, M. R., Hartmann, D., Gesierich, A., Kähler, K. C., Wehkamp, U. & 82 others, Karoglan, A., Bär, C., Brinker, T. J., Schmitt, L., Peitsch, W. K., Hoffmann, F., Becker, J. C., Drusio, C., Lodde, G., Sammet, S., Sondermann, W., Ugurel, S., Zader, J., Enk, A., Salzmann, M., Schäfer, S., Schäkel, K., Winkler, J., Wölbing, P., Asper, H., Bohne, A. S., Brown, V., Burba, B., Deffaa, S., Dietrich, C., Dietrich, M., Drerup, K. A., Egberts, F., Erkens, A. S., Greven, S., Harde, V., Jost, M., Kaeding, M., Kosova, K., Lischner, S., Maagk, M., Messinger, A. L., Metzner, M., Motamedi, R., Rosenthal, A. C., Seidl, U., Stemmermann, J., Torz, K., Velez, J. G., Haiduk, J., Alter, M., Bergenthal, P., Gerlach, A., Holtorf, C., Kindermann, S., Kraas, L., Felcht, M., Klemke, C. D., Kurzen, H., Leibing, T., Müller, V., Reinhard, R. R., Utikal, J., Winter, F., Eicher, L., Heppt, M., Kilian, K., Krammer, S., Lill, D., Niesert, A. C., Oppel, E., Sattler, E., Senner, S., Wallmichrath, J., Wolff, H., Giner, T., Glutsch, V., Kerstan, A., Presser, D., Schrüfer, P., Schummer, P., Stolze, I., Weber, J., Drexler, K., Mickler, M., Stauner, C. T. & Thiem, A., Sep 2019, In : European Journal of Cancer. 119, p. 57-65 9 p.

Research output: Contribution to journalArticle

Open Access
Skin Neoplasms
Confidence Intervals
Nevi and Melanomas
Early Detection of Cancer
Sensitivity and Specificity
2018
7 Citations (Scopus)

A face-aging app for smoking cessation in a waiting room setting: Pilot study in an HIV outpatient clinic

Brinker, T. J., Brieske, C. M., Esser, S., Klode, J., Mons, U., Batra, A., Rüther, T., Seeger, W., Enk, A. H., Von Kalle, C., Berking, C., Heppt, M. V., Gatzka, M. V., Bernardes-Souza, B., Schlenk, R. F. & Schadendorf, D., Aug 2018, In : Journal of medical Internet research. 20, 8, e10976.

Research output: Contribution to journalArticle

Smoking Cessation
Ambulatory Care Facilities
HIV
Smoking
Health Personnel
3 Citations (Scopus)

A face-aging smoking prevention/cessation intervention for nursery school students in Germany: An appearance-focused interventional study

Brinker, T. J., Alfitian, J., Seeger, W., Groneberg, D. A., von Kalle, C., Enk, A. H., Herth, F. J. F., Kreuter, M., Bauer, C. M., Gatzka, M. & Suhre, J. L., Aug 4 2018, In : International Journal of Environmental Research and Public Health. 15, 8, 1656.

Research output: Contribution to journalArticle

Nursery Schools
Smoking Cessation
Germany
Nursing Students
Students
4 Citations (Scopus)

A skin cancer prevention facial-aging mobile app for secondary schools in Brazil: Appearance-focused interventional study

Brinker, T. J., Heckl, M., Gatzka, M., Heppt, M. V., Rodrigues, H. R., Schneider, S., Sondermann, W., de Almeida e Silva, C., Kirchberger, M. C., Klode, J., Enk, A. H., Knispel, S., von Kalle, C., Stoffels, I., Schadendorf, D., Nakamura, Y., Esser, S., Assis, A. & Breno, B. S., Mar 2018, In : Journal of medical Internet research. 20, 3, p. e60

Research output: Contribution to journalArticle

Mobile Applications
Skin Neoplasms
Brazil
Pupil
Medical Students
22 Citations (Scopus)

Drug-perturbation-based stratification of blood cancer

Dietrich, S., Oleś, M., Lu, J., Sellner, L., Anders, S., Velten, B., Wu, B., Hüllein, J., Liberio, M. D. S., Walther, T., Wagner, L., Rabe, S., Ghidelli-Disse, S., Bantscheff, M., Oleś, A. K., Słabicki, M., Mock, A., Oakes, C. C., Wang, S., Oppermann, S. & 31 others, Lukas, M., Kim, V., Sill, M., Benner, A., Jauch, A., Sutton, L. A., Young, E., Rosenquist, R., Liu, X., Jethwa, A., Lee, K. S., Lewis, J., Putzker, K., Lutz, C., Rossi, D., Mokhir, A., Oellerich, T., Zirlik, K., Herling, M., Nguyen-Khac, F., Plass, C., Andersson, E., Mustjoki, S., Von Kalle, C., Ho, A. D., Hensel, M., Dürig, J., Ringshausen, I., Zapatka, M., Huber, W. & Zenz, T., Jan 2 2018, In : Journal of Clinical Investigation. 128, 1, p. 427-445 19 p.

Research output: Contribution to journalArticle

Mutation
Pharmaceutical Preparations
B-Cell Chronic Lymphocytic Leukemia
Neoplasms
Trisomy
2 Citations (Scopus)

Enhanced Control of Oncolytic Measles Virus Using MicroRNA Target Sites

Leber, M. F., Baertsch, M. A., Anker, S. C., Henkel, L., Singh, H. M., Bossow, S., Engeland, C. E., Barkley, R., Hoyler, B., Albert, J., Springfeld, C., Jäger, D., von Kalle, C. & Ungerechts, G., Jun 29 2018, In : Molecular Therapy - Oncolytics. 9, p. 30-40 11 p.

Research output: Contribution to journalArticle

Oncolytic Viruses
Measles virus
MicroRNAs
Viruses
Neoplasms

Facial-aging mobile apps for smoking prevention in secondary schools in Brazil: Appearance-focused interventional study

Bernardes-Souza, B., De Assis Pires, F. P. A., Madeira, G. M., Da Cunha Rodrigues, T. F., Gatzka, M., Heppt, M. V., Omlor, A. J., Enk, A. H., Groneberg, D. A., Seeger, W., Von Kalle, C., Berking, C., Pinto Corrêa, P. C. R., Suhre, J. L., Alfitian, J., Assis, A. & Brinker, T. J., Jul 2018, In : Journal of medical Internet research. 20, 7, e10234.

Research output: Contribution to journalArticle

Mobile Applications
Brazil
Smoking
Cell Phones
Medical Students
127 Citations (Scopus)

Gene therapy in patients with transfusion-dependent β-thalassemia

Thompson, A. A., Walters, M. C., Kwiatkowski, J., Rasko, J. E. J., Ribeil, J. A., Hongeng, S., Magrin, E., Schiller, G. J., Payen, E., Semeraro, M., Moshous, D., Lefrere, F., Puy, H., Bourget, P., Magnani, A., Caccavelli, L., Diana, J. S., Suarez, F., Monpoux, F., Brousse, V. & 27 others, Poirot, C., Brouzes, C., Meritet, J. F., Pondarré, C., Beuzard, Y., Chrétien, S., Lefebvre, T., Teachey, D. T., Anurathapan, U., Ho, P. J., Von Kalle, C., Kletzel, M., Vichinsky, E., Soni, S., Veres, G., Negre, O., Ross, R. W., Davidson, D., Petrusich, A., Sandler, L., Asmal, M., Hermine, O., De Montalembert, M., Hacein-Bey-Abina, S., Blanche, S., Leboulch, P. & Cavazzana, M., Apr 19 2018, In : New England Journal of Medicine. 378, 16, p. 1479-1493 15 p.

Research output: Contribution to journalArticle

Thalassemia
Genetic Therapy
Hemoglobins
Genotype
Busulfan
22 Citations (Scopus)

Integrative genomic and transcriptomic analysis of leiomyosarcoma

Chudasama, P., Mughal, S. S., Sanders, M. A., Hübschmann, D., Chung, I., Deeg, K. I., Wong, S. H., Rabe, S., Hlevnjak, M., Zapatka, M., Ernst, A., Kleinheinz, K., Schlesner, M., Sieverling, L., Klink, B., Schröck, E., Hoogenboezem, R. M., Kasper, B., Heilig, C. E., Egerer, G. & 21 others, Wolf, S., Von Kalle, C., Eils, R., Stenzinger, A., Weichert, W., Glimm, H., Gröschel, S., Kopp, H. G., Omlor, G., Lehner, B., Bauer, S., Schimmack, S., Ulrich, A., Mechtersheimer, G., Rippe, K., Brors, B., Hutter, B., Renner, M., Hohenberger, P., Scholl, C. & Fröhling, S., Dec 1 2018, In : Nature communications. 9, 1, 144.

Research output: Contribution to journalArticle

Leiomyosarcoma
telomeres
Genes
genes
Tumors
3 Citations (Scopus)

Mapping Active Gene-Regulatory Regions in Human Repopulating Long-Term HSCs

Wünsche, P., Eckert, E. S. P., Holland-Letz, T., Paruzynski, A., Hotz-Wagenblatt, A., Fronza, R., Rath, T., Gil-Farina, I., Schmidt, M., von Kalle, C., Klein, C., Ball, C. R., Herbst, F. & Glimm, H., Jul 5 2018, In : Cell Stem Cell. 23, 1, p. 132-146.e9

Research output: Contribution to journalArticle

Chromosome Mapping
Nucleic Acid Regulatory Sequences
Hematopoietic Stem Cells
Wiskott-Aldrich Syndrome
Genes
1 Citation (Scopus)

Molecular Evidence of Genome Editing in a Mouse Model of Immunodeficiency

Abdul-Razak, H. H., Rocca, C. J., Howe, S. J., Alonso-Ferrero, M. E., Wang, J., Gabriel, R., Bartholomae, C. C., Gan, C. H. V., Garín, M. I., Roberts, A., Blundell, M. P., Prakash, V., Molina-Estevez, F. J., Pantoglou, J., Guenechea, G., Holmes, M. C., Gregory, P. D., Kinnon, C., Von Kalle, C., Schmidt, M. & 3 others, Bueren, J. A., Thrasher, A. J. & Yáñez-Muñoz, R. J., Dec 1 2018, In : Scientific reports. 8, 1, 8214.

Research output: Contribution to journalArticle

Hematopoietic Stem Cells
Severe Combined Immunodeficiency
Hematologic Diseases
Zinc Fingers
T-Lymphocytes
15 Citations (Scopus)

Molecular Evolution of Early-Onset Prostate Cancer Identifies Molecular Risk Markers and Clinical Trajectories

Gerhauser, C., Favero, F., Risch, T., Simon, R., Feuerbach, L., Assenov, Y., Heckmann, D., Sidiropoulos, N., Waszak, S. M., Hübschmann, D., Urbanucci, A., Girma, E. G., Kuryshev, V., Klimczak, L. J., Saini, N., Stütz, A. M., Weichenhan, D., Böttcher, L. M., Toth, R., Hendriksen, J. D. & 35 others, Koop, C., Lutsik, P., Matzk, S., Warnatz, H. J., Amstislavskiy, V., Feuerstein, C., Raeder, B., Bogatyrova, O., Schmitz, E. M., Hube-Magg, C., Kluth, M., Huland, H., Graefen, M., Lawerenz, C., Henry, G. H., Yamaguchi, T. N., Malewska, A., Meiners, J., Schilling, D., Reisinger, E., Eils, R., Schlesner, M., Strand, D. W., Bristow, R. G., Boutros, P. C., von Kalle, C., Gordenin, D., Sültmann, H., Brors, B., Sauter, G., Plass, C., Yaspo, M. L., Korbel, J. O., Schlomm, T. & Weischenfeldt, J., Dec 10 2018, In : Cancer cell. 34, 6, p. 996-1011.e8

Research output: Contribution to journalArticle

Molecular Evolution
Prostatic Neoplasms
Biomarkers
Genome
Gene Expression Profiling
17 Citations (Scopus)

NRG1 fusions in KRAS wild-type pancreatic cancer

Heining, C., Horak, P., Uhrig, S., Codo, P. L., Klink, B., Hutter, B., Fröhlich, M., Bonekamp, D., Richter, D., Steiger, K., Penzel, R., Endris, V., Ehrenberg, K. R., Frank, S., Kleinheinz, K., Toprak, U. H., Schlesner, M., Mandal, R., Schulz, L., Lambertz, H. & 19 others, Fetscher, S., Bitzer, M., Malek, N. P., Horger, M., Giese, N. A., Strobel, O., Hackert, T., Springfeld, C., Feuerbach, L., Bergmann, F., Schröck, E., von Kalle, C., Weichert, W., Scholl, C., Ball, C. R., Stenzinger, A., Brors, B., Fröhling, S. & Glimm, H., Sep 2018, In : Cancer discovery. 8, 9, p. 1087-1095 9 p.

Research output: Contribution to journalArticle

Pancreatic Neoplasms
Adenocarcinoma
Gene Fusion
Neoplasms
Therapeutics
14 Citations (Scopus)

Targeted bite expression by an oncolytic vector augments therapeutic efficacy against solid tumors

Speck, T., Heidbuechel, J. P. W., Veinalde, R., Jaeger, D., Von Kalle, C., Ball, C. R., Ungerechts, G. & Engeland, C. E., May 1 2018, In : Clinical Cancer Research. 24, 9, p. 2128-2137 10 p.

Research output: Contribution to journalArticle

Bites and Stings
Measles virus
T-Lymphocytes
Neoplasms
Therapeutics
2017
6 Citations (Scopus)

GENE-IS: Time-Efficient and Accurate Analysis of Viral Integration Events in Large-Scale Gene Therapy Data

Afzal, S., Wilkening, S., von Kalle, C., Schmidt, M. & Fronza, R., Mar 17 2017, In : Molecular Therapy - Nucleic Acids. 6, p. 133-139 7 p.

Research output: Contribution to journalArticle

Virus Integration
Genetic Therapy
Genome
Polymerase Chain Reaction
Genes
11 Citations (Scopus)

Genetic subclone architecture of tumor clone-initiating cells in colorectal cancer

Giessler, K. M., Kleinheinz, K., Huebschmann, D., Balasubramanian, G. P., Dubash, T. D., Dieter, S. M., Siegl, C., Herbst, F., Weber, S., Hoffmann, C. M., Fronza, R., Buchhalter, I., Paramasivam, N., Eils, R., Schmidt, M., von Kalle, C., Schneider, M., Ulrich, A., Scholl, C., Fröhling, S. & 5 others, Weichert, W., Brors, B., Schlesner, M., Ball, C. R. & Glimm, H., Jul 1 2017, In : Journal of Experimental Medicine. 214, 7, p. 2073-2087 15 p.

Research output: Contribution to journalArticle

Neoplastic Stem Cells
Colorectal Neoplasms
Clone Cells
Heterografts
Heterologous Transplantation
13 Citations (Scopus)

Genome-wide Specificity of Highly Efficient TALENs and CRISPR/Cas9 for T Cell Receptor Modification

Knipping, F., Osborn, M. J., Petri, K., Tolar, J., Glimm, H., von Kalle, C., Schmidt, M. & Gabriel, R., Mar 17 2017, In : Molecular Therapy - Methods and Clinical Development. 4, p. 213-224 12 p.

Research output: Contribution to journalArticle

Clustered Regularly Interspaced Short Palindromic Repeats
T-Cell Antigen Receptor
Genome
Guide RNA
Integrases
2 Citations (Scopus)

Lentiviral Vector Promoter is Decisive for Aberrant Transcript Formation

Scholz, S. J., Fronza, R., Bartholomä, C. C., Cesana, D., Montini, E., Von Kalle, C., Gil-Farina, I. & Schmidt, M., Oct 1 2017, In : Human gene therapy. 28, 10, p. 875-885 11 p.

Research output: Contribution to journalArticle

RNA Splice Sites
Terminal Repeat Sequences
Post Translational Protein Processing
Transgenes
Genetic Therapy
8 Citations (Scopus)

Mutant KIT as imatinib-sensitive target in metastatic sinonasal carcinoma

Dieter, S. M., Heining, C., Agaimy, A., Huebschmann, D., Bonekamp, D., Hutter, B., Ehrenberg, K. R., Fröhlich, M., Schlesner, M., Scholl, C., Schlemmer, H. P., Wolf, S., Mavratzas, A., Jung, C. S., Gröschel, S., von Kalle, C., Eils, R., Brors, B., Penzel, R., Kriegsmann, M. & 7 others, Reuss, D. E., Schirmacher, P., Stenzinger, A., Federspil, P. A., Weichert, W., Glimm, H. & Fröhling, S., Jan 1 2017, In : Annals of Oncology. 28, 1, p. 142-148 7 p.

Research output: Contribution to journalArticle

Carcinoma
Neoplasms
Exons
Mutation
Gastrointestinal Stromal Tumors
23 Citations (Scopus)

Oncolytic measles virus encoding interleukin-12 mediates potent antitumor effects through T cell activation

Veinalde, R., Grossardt, C., Hartmann, L., Bourgeois-Daigneault, M. C., Bell, J. C., Jäger, D., von Kalle, C., Ungerechts, G. & Engeland, C. E., Apr 3 2017, In : OncoImmunology. 6, 4, e1285992.

Research output: Contribution to journalArticle

Oncolytic Viruses
Measles virus
Interleukin-12
T-Lymphocytes
Immunologic Factors
9 Citations (Scopus)

Patient-derived xenografts of gastrointestinal cancers are susceptible to rapid and delayed B-lymphoproliferation

Dieter, S. M., Giessler, K. M., Kriegsmann, M., Dubash, T. D., Möhrmann, L., Schulz, E. R., Siegl, C., Weber, S., Strakerjahn, H., Oberlack, A., Heger, U., Gao, J., Hartinger, E. M., Oppel, F., Hoffmann, C. M., Ha, N., Brors, B., Lasitschka, F., Ulrich, A., Strobel, O. & 7 others, Schmidt, M., von Kalle, C., Schneider, M., Weichert, W., Ehrenberg, K. R., Glimm, H. & Ball, C. R., Mar 15 2017, In : International Journal of Cancer. 140, 6, p. 1356-1363 8 p.

Research output: Contribution to journalArticle

Gastrointestinal Neoplasms
Heterografts
Neoplasms
Heterologous Transplantation
Carcinoma
32 Citations (Scopus)

Precision oncology based on omics data: The NCT Heidelberg experience

Horak, P., Klink, B., Heining, C., Gröschel, S., Hutter, B., Fröhlich, M., Uhrig, S., Hübschmann, D., Schlesner, M., Eils, R., Richter, D., Pfütze, K., Geörg, C., Meißburger, B., Wolf, S., Schulz, A., Penzel, R., Herpel, E., Kirchner, M., Lier, A. & 11 others, Endris, V., Singer, S., Schirmacher, P., Weichert, W., Stenzinger, A., Schlenk, R. F., Schröck, E., Brors, B., von Kalle, C., Glimm, H. & Fröhling, S., Sep 1 2017, In : International Journal of Cancer. 141, 5, p. 877-886 10 p.

Research output: Contribution to journalArticle

Neoplasms
RNA Sequence Analysis
Exome
Molecular Pathology
Workflow
9 Citations (Scopus)

Shifting cancer care towards Multidisciplinarity: The cancer center certification program of the German cancer society

Kowalski, C., Graeven, U., von Kalle, C., Lang, H., Beckmann, M. W., Blohmer, J. U., Burchardt, M., Ehrenfeld, M., Fichtner, J., Grabbe, S., Hoffmann, H., Iro, H., Post, S., Scharl, A., Schlegel, U., Seufferlein, T., Stummer, W., Ukena, D., Ferencz, J. & Wesselmann, S., Dec 14 2017, In : BMC cancer. 17, 1, 850.

Research output: Contribution to journalArticle

Certification
Neoplasms
Quality of Health Care
Germany
Patient Advocacy
10 Citations (Scopus)

Succession of transiently active tumor-initiating cell clones in human pancreatic cancer xenografts

Ball, C. R., Oppel, F., Ehrenberg, K. R., Dubash, T. D., Dieter, S. M., Hoffmann, C. M., Abel, U., Herbst, F., Koch, M., Werner, J., Bergmann, F., Ishaque, N., Schmidt, M., von Kalle, C., Scholl, C., Fröhling, S., Brors, B., Weichert, W., Weitz, J. & Glimm, H., Jul 2017, In : EMBO Molecular Medicine. 9, 7, p. 918-932 15 p.

Research output: Contribution to journalArticle

Neoplastic Stem Cells
Pancreatic Neoplasms
Heterografts
Clone Cells
Heterologous Transplantation
9 Citations (Scopus)

Targeting fibroblast growth factor receptor 1 for treatment of soft-tissue sarcoma

Chudasama, P., Renner, M., Straub, M., Mughal, S. S., Hutter, B., Kosaloglu, Z., Schweßinger, R., Scheffler, M., Alldinger, I., Schimmack, S., Persigehl, T., Kobe, C., Jäger, D., von Kalle, C., Schirmacher, P., Beckhaus, M. K., Wolf, S., Heining, C., Gröschel, S., Wolf, J. & 7 others, Brors, B., Weichert, W., Glimm, H., Scholl, C., Mechtersheimer, G., Specht, K. & Fröhling, S., Feb 15 2017, In : Clinical Cancer Research. 23, 4, p. 962-973 12 p.

Research output: Contribution to journalArticle

Receptor, Fibroblast Growth Factor, Type 1
Sarcoma
RNA Sequence Analysis
Therapeutics
Comparative Genomic Hybridization
2016
41 Citations (Scopus)

BRAF inhibition in hairy cell leukemia with low-dose vemurafenib

Dietrich, S., Pircher, A., Endris, V., Peyrade, F., Wendtner, C. M., Follows, G. A., Hüllein, J., Jethwa, A., Ellert, E., Walther, T., Liu, X., Dyer, M. J. S., Elter, T., Brummer, T., Zeiser, R., Hermann, M., Herold, M., Weichert, W., Dearden, C., Haferlach, T. & 8 others, Seiffert, M., Hallek, M., Von Kalle, C., Ho, A. D., Gaehler, A., Andrulis, M., Steurer, M. & Zenz, T., Jun 9 2016, In : Blood. 127, 23, p. 2847-2855 9 p.

Research output: Contribution to journalArticle

Hairy Cell Leukemia
Mutation
Lymphoma
Proto-Oncogene Proteins B-raf
Pharmacodynamics
31 Citations (Scopus)

Cooperation of BRAF F595L and mutant HRAS in histiocytic sarcoma provides new insights into oncogenic BRAF signaling

Kordes, M., Röring, M., Heining, C., Braun, S., Hutter, B., Richter, D., Geörg, C., Scholl, C., Gröschel, S., Roth, W., Rosenwald, A., Geissinger, E., von Kalle, C., Jger, D., Brors, B., Weichert, W., Grüllich, C., Glimm, H., Brummer, T. & Fröhling, S., Apr 1 2016, In : Leukemia. 30, 4, p. 937-946 10 p.

Research output: Contribution to journalArticle

Histiocytic Sarcoma
Mutation
Neoplasms
Mitogen-Activated Protein Kinase Kinases
Histiocytosis
67 Citations (Scopus)

Evaluation of TCR gene editing achieved by TALENs, CRISPR/Cas9, and megaTAL nucleases

Osborn, M. J., Webber, B. R., Knipping, F., Lonetree, C. L., Tennis, N., DeFeo, A. P., McElroy, A. N., Starker, C. G., Lee, C., Merkel, S., Lund, T. C., Kelly-Spratt, K. S., Jensen, M. C., Voytas, D. F., Von Kalle, C., Schmidt, M., Gabriel, R., Hippen, K. L., Miller, J. S., Scharenberg, A. M. & 2 others, Tolar, J. & Blazar, B. R., Mar 1 2016, In : Molecular Therapy. 24, 3, p. 570-581 12 p.

Research output: Contribution to journalArticle

Clustered Regularly Interspaced Short Palindromic Repeats
T-Lymphocytes
T-Cell Antigen Receptor
Adoptive Immunotherapy
Neoplasm Antigens
21 Citations (Scopus)

Integration of genomics and histology revises diagnosis and enables effective therapy of refractory cancer of unknown primary with PDL1 amplification

Gröschel, S., Bommer, M., Hutter, B., Budczies, J., Bonekamp, D., Heining, C., Horak, P., Fröhlich, M., Uhrig, S., Hübschmann, D., Geörg, C., Richter, D., Pfarr, N., Pfütze, K., Wolf, S., Schirmacher, P., Jäger, D., von Kalle, C., Brors, B., Glimm, H. & 3 others, Weichert, W., Stenzinger, A. & Fröhling, S., Nov 1 2016, In : Cold Spring Harbor Molecular Case Studies. 2, 6, p. a001180

Research output: Contribution to journalArticle

Genomics
Histology
Neoplasms
Triple Negative Breast Neoplasms
Sarcoma
74 Citations (Scopus)

In Vivo Tracking of Human Hematopoiesis Reveals Patterns of Clonal Dynamics during Early and Steady-State Reconstitution Phases

Biasco, L., Pellin, D., Scala, S., Dionisio, F., Basso-Ricci, L., Leonardelli, L., Scaramuzza, S., Baricordi, C., Ferrua, F., Cicalese, M. P., Giannelli, S., Neduva, V., Dow, D. J., Schmidt, M., Von Kalle, C., Roncarolo, M. G., Ciceri, F., Vicard, P., Wit, E., Di Serio, C. & 2 others, Naldini, L. & Aiuti, A., Jul 7 2016, In : Cell Stem Cell. 19, 1, p. 107-119 13 p.

Research output: Contribution to journalArticle

Hematopoiesis
Hematopoietic Stem Cells
Transplants
Genetic Therapy
Wiskott-Aldrich Syndrome
1 Citation (Scopus)

Molekulargenetische Diagnostik - Was wissen die Maschinen? Was wollen wir wissen?

Translated title of the contribution: Molecular genetic diagnostics - What do the machines know? What do we want to know?Bauer, P., Hummel, M., Von Kalle, C., Schmutzler, R., Block, A., Stroth, M., Woopen, C. & Engelke, K., Sep 1 2016, In : Oncology research and treatment. 39, 2, p. 2-23 22 p.

Research output: Contribution to journalArticle

Molecular Pathology
Molecular Biology
54 Citations (Scopus)

Recurrent MET fusion genes represent a drug target in pediatric glioblastoma

for the International Cancer Genome Consortium PedBrain Tumor Project, Nov 1 2016, In : Nature medicine. 22, 11, p. 1314-1320 7 p.

Research output: Contribution to journalArticle

Pediatrics
Gene Fusion
Glioblastoma
Tumors
Fusion reactions
7 Citations (Scopus)

Ultramicroscopy as a novel tool to unravel the tropism of AAV gene therapy vectors in the brain

Alves, S., Bode, J., Bemelmans, A. P., Von Kalle, C., Cartier, N. & Tews, B., Jun 20 2016, In : Scientific reports. 6, 28272.

Research output: Contribution to journalArticle

Tropism
Viral Genes
Genetic Therapy
Brain
Viral Tropism
1 Citation (Scopus)

Zukünftige Aufgaben onkologischer Spitzenzentren in der Forschung

Translated title of the contribution: What functions do oncological centers of excellence have in future research?Heining, C. & von Kalle, C., Mar 1 2016, In : Onkologe. 22, 3, p. 152-157 6 p.

Research output: Contribution to journalArticle

Translational Medical Research
Neoplasms
Certification
Research
Communication
2015
4 Citations (Scopus)

Cell cycle status of CD34 + hemopoietic stem cells determines lentiviral integration in actively transcribed and development-related genes

Papanikolaou, E., Paruzynski, A., Kasampalidis, I., Deichmann, A., Stamateris, E., Schmidt, M., von Kalle, C. & Anagnou, N. P., Apr 10 2015, In : Molecular Therapy. 23, 4, p. 683-696 14 p.

Research output: Contribution to journalArticle

cdc Genes
Cell Cycle
Stem Cells
Insertional Mutagenesis
Genetic Therapy
12 Citations (Scopus)

Engineered dendritic cells from cord blood and adult blood accelerate effector T cell immune reconstitution against HCMV

Daenthanasanmak, A., Salguero, G., Sundarasetty, B. S., Waskow, C., Cosgun, K. N., Guzman, C. A., Riese, P., Gerasch, L., Schneider, A., Ingendoh, A., Messerle, M., Gabaev, I., Woelk, B., Ruggiero, E., Schmidt, M., von Kalle, C., Figueiredo, C., Eiz-Vesper, B., von Kaisenberg, C., Ganser, A. & 1 others, Stripecke, R., Apr 29 2015, In : Molecular Therapy - Methods and Clinical Development. 2, 1 p.

Research output: Contribution to journalArticle

Cytomegalovirus
Fetal Blood
Dendritic Cells
T-Lymphocytes
Cytotoxic T-Lymphocytes