Ehsan Irajizad

2023

A blood-based metabolomic signature predictive of risk for pancreatic cancer

Irajizad, E., Kenney, A., Tang, T., Vykoukal, J., Wu, R., Murage, E., Dennison, J. B., Sans, M., Long, J. P., Loftus, M., Chabot, J. A., Kluger, M. D., Kastrinos, F., Brais, L., Babic, A., Jajoo, K., Lee, L. S., Clancy, T. E., Ng, K., Bullock, A., & 7 othersGenkinger, J. M., Maitra, A., Do, K. A., Yu, B., Wolpin, B. M., Hanash, S. & Fahrmann, J. F., Sep 19 2023, In: Cell Reports Medicine. 4, 9, 101194.

Research output: Contribution to journal › Article › peer-review

Open Access

7 Scopus citations

A Nasal Inflammatory Cytokine Signature Is Associated with Early Graft-versus-Host Disease of the Lung after Allogeneic Hematopoietic Cell Transplantation: Proof of Concept

Ostrin, E. J., Rider, N. L., Alousi, A. M., Irajizad, E., Li, L., Peng, Q., Kim, S. T., Bashoura, L., Arain, M. H., Noor, L. Z., Patel, N., Mehta, R., Popat, U. R., Hosing, C., Jenq, R. R., Rondon, G., Hanash, S. M., Paczesny, S., Shpall, E. J., Champlin, R. E., & 2 othersDickey, B. F. & Sheshadri, A., 2023, In: ImmunoHorizons. 7, 6, p. 421-430 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

A unified mediation analysis framework for integrative cancer proteogenomics with clinical outcomes

Huang, L., Long, J. P., Irajizad, E., Doecke, J. D., Do, K. A. & Ha, M. J., Jan 1 2023, In: Bioinformatics. 39, 1, btad023.

Research output: Contribution to journal › Article › peer-review

Open Access

Blood-based Proteomic Signatures Associated With MEN1-related Duodenopancreatic Neuroendocrine Tumor Progression

Fahrmann, J. F., Wasylishen, A., Pieterman, C. R. C., Irajizad, E., Vykoukal, J., Wu, R., Dennison, J. B., Peterson, C. B., Zhao, H., Do, K. A., Halperin, D. M., Agarwal, S. K., Blau, J. E., Jha, S., Rivero, J. D., Nilubol, N., Walter, M. F., Welch, J. M., Weinstein, L. S., Vriens, M. R., & 6 othersvan Leeuwaarde, R. S., van Treijen, M. J. C., Valk, G. D., Perrier, N. D., Hanash, S. M. & Katayama, H., Nov 17 2023, In: The Journal of clinical endocrinology and metabolism. 108, 12, p. 3260-3271 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

1 Scopus citations

Kynureninase Upregulation Is a Prominent Feature of NFR2-Activated Cancers and Is Associated with Tumor Immunosuppression and Poor Prognosis

León-Letelier, R. A., Abdel Sater, A. H., Chen, Y., Park, S., Wu, R., Irajizad, E., Dennison, J. B., Katayama, H., Vykoukal, J. V., Hanash, S., Ostrin, E. J. & Fahrmann, J. F., Feb 2023, In: Cancers. 15, 3, 834.

Research output: Contribution to journal › Article › peer-review

Open Access

5 Scopus citations

Modulating a prebiotic food source influences inflammation and immune-regulating gut microbes and metabolites: insights from the BE GONE trial

Zhang, X., Irajizad, E., Hoffman, K. L., Fahrmann, J. F., Li, F., Seo, Y. D., Browman, G. J., Dennison, J. B., Vykoukal, J., Luna, P. N., Siu, W., Wu, R., Murage, E., Ajami, N. J., McQuade, J. L., Wargo, J. A., Long, J. P., Do, K. A., Lampe, J. W., Basen-Engquist, K. M., & 6 othersOkhuysen, P. C., Kopetz, S., Hanash, S. M., Petrosino, J. F., Scheet, P. & Daniel, C. R., Dec 2023, In: EBioMedicine. 98, 104873.

Research output: Contribution to journal › Article › peer-review

Open Access

1 Scopus citations

Mortality Benefit of a Blood-Based Biomarker Panel for Lung Cancer on the Basis of the Prostate, Lung, Colorectal, and Ovarian Cohort

Irajizad, E., Fahrmann, J. F., Marsh, T., Vykoukal, J., Dennison, J. B., Long, J. P., Do, K. A., Feng, Z., Hanash, S. & Ostrin, E. J., Sep 20 2023, In: Journal of Clinical Oncology. 41, 27, p. 4360-4368 9 p.

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

2022

A Blood-Based Metabolite Panel for Distinguishing Ovarian Cancer from Benign Pelvic Masses

Irajizad, E., Han, C. Y., Celestino, J., Wu, R., Murage, E., Spencer, R., Dennison, J. B., Vykoukal, J., Long, J. P., Do, K. A., Drescher, C., Lu, K., Lu, Z., Bast, R. C., Hanash, S. & Fahrmann, J. F., Nov 1 2022, In: Clinical Cancer Research. 28, 21, p. 4669-4676 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

3 Scopus citations

A Comprehensive Search of Non-Canonical Proteins in Non-Small Cell Lung Cancer and Their Impact on the Immune Response

Irajizad, E., Fahrmann, J. F., Long, J. P., Vykoukal, J., Kobayashi, M., Capello, M., Yu, C. Y., Cai, Y., Hsiao, F. C., Patel, N., Park, S., Peng, Q., Dennison, J. B., Kato, T., Tai, M. C., Taguchi, A., Kadara, H., Wistuba, I. I., Katayama, H., Do, K. A., & 2 othersHanash, S. M. & Ostrin, E. J., Aug 2022, In: International journal of molecular sciences. 23, 16, 8933.

Research output: Contribution to journal › Article › peer-review

Open Access

1 Scopus citations

A polyamine-centric, blood-based metabolite panel predictive of poor response to CAR-T cell therapy in large B cell lymphoma

Fahrmann, J. F., Saini, N. Y., Chia-Chi, C., Irajizad, E., Strati, P., Nair, R., Fayad, L. E., Ahmed, S., Lee, H. J., Iyer, S., Steiner, R., Vykoukal, J., Wu, R., Dennison, J. B., Nastoupil, L., Jain, P., Wang, M., Green, M., Westin, J., Blumenberg, V., & 11 othersDavila, M., Champlin, R., Shpall, E. J., Kebriaei, P., Flowers, C. R., Jain, M., Jenq, R., Stein-Thoeringer, C. K., Subklewe, M., Neelapu, S. S. & Hanash, S., Nov 15 2022, In: Cell Reports Medicine. 3, 11, 100720.

Research output: Contribution to journal › Article › peer-review

Open Access

2 Scopus citations

Application of Artificial Intelligence to Plasma Metabolomics Profiles to Predict Response to Neoadjuvant Chemotherapy in Triple-Negative Breast Cancer

Irajizad, E., Wu, R., Vykoukal, J., Murage, E., Spencer, R., Dennison, J. B., Moulder, S., Ravenberg, E., Lim, B., Litton, J., Tripathym, D., Valero, V., Damodaran, S., Rauch, G. M., Adrada, B., Candelaria, R., White, J. B., Brewster, A., Arun, B., Long, J. P., & 3 othersDo, K. A., Hanash, S. & Fahrmann, J. F., Aug 11 2022, In: Frontiers in Artificial Intelligence. 5, 876100.

Research output: Contribution to journal › Article › peer-review

Open Access

4 Scopus citations

Blood-Based Biomarker Panel for Personalized Lung Cancer Risk Assessment

Fahrmann, J. F., Marsh, T., Irajizad, E., Patel, N., Murage, E., Vykoukal, J., Dennison, J. B., Do, K. A., Ostrin, E., Spitz, M. R., Lam, S., Shete, S., Meza, R., Tammemägi, M. C., Feng, Z. & Hanash, S. M., Mar 10 2022, In: Journal of Clinical Oncology. 40, 8, p. 876-883 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

36 Scopus citations

CES2 sustains HNF4α expression to promote pancreatic adenocarcinoma progression through an epoxide hydrolase-dependent regulatory loop

Chen, Y., Capello, M., Rios Perez, M. V., Vykoukal, J. V., Roife, D., Kang, Y., Prakash, L. R., Katayama, H., Irajizad, E., Fleury, A., Ferri-Borgogno, S., Baluya, D. L., Dennison, J. B., Do, K. A., Fiehn, O., Maitra, A., Wang, H., Chiao, P. J., Katz, M. H. G., Fleming, J. B., & 2 othersHanash, S. M. & Fahrmann, J. F., Feb 2022, In: Molecular Metabolism. 56, 101426.

Research output: Contribution to journal › Article › peer-review

Open Access

10 Scopus citations

CLL-532 Changes in Proteome of CLL (Chronic Lymphocytic Leukemia) Lymphocytes During Investigator-Initiated Trial of Ibrutinib Alone and in Combination With Venetoclax in Treatment-Naïve Patients With CLL

Timofeeva, N., Jain, N., Irajizad, E., Aslan, B., Katayama, H., Cai, Y., Ayres, M., Iles, L., Vykoukal, J., Dennison, J., Hanash, S., Wierda, W. & Gandhi, V., Oct 2022, In: Clinical Lymphoma, Myeloma and Leukemia. 22, p. S283

Research output: Contribution to journal › Article › peer-review

Mutational Activation of the NRF2 Pathway Upregulates Kynureninase Resulting in Tumor Immunosuppression and Poor Outcome in Lung Adenocarcinoma

Fahrmann, J. F., Tanaka, I., Irajizad, E., Mao, X., Dennison, J. B., Murage, E., Casabar, J., Mayo, J., Peng, Q., Celiktas, M., Vykoukal, J. V., Park, S., Taguchi, A., Delgado, O., Tripathi, S. C., Katayama, H., Soto, L. M. S., Rodriguez-Canales, J., Behrens, C., Wistuba, I., & 2 othersHanash, S. & Ostrin, E. J., May 1 2022, In: Cancers. 14, 10, 2543.

Research output: Contribution to journal › Article › peer-review

Open Access

15 Scopus citations

Novel UHRF1-MYC Axis in Acute Lymphoblastic Leukemia

Park, S., Sater, A. H. A., Fahrmann, J. F., Irajizad, E., Cai, Y., Katayama, H., Vykoukal, J., Kobayashi, M., Dennison, J. B., Garcia-Manero, G., Mullighan, C. G., Gu, Z., Konopleva, M. & Hanash, S., Sep 2022, In: Cancers. 14, 17, 4262.

Research output: Contribution to journal › Article › peer-review

Open Access

1 Scopus citations

2021

A Blood-based Polyamine Signature Associated with MEN1 Duodenopancreatic Neuroendocrine Tumor Progression

Fahrmann, J. F., Wasylishen, A. R., Pieterman, C. R. C., Irajizad, E., Vykoukal, J., Murage, E., Wu, R., Dennison, J. B., Krishna, H., Peterson, C. B., Lozano, G., Zhao, H., Do, K. A., Halperin, D. M., Agarwal, S. K., Blau, J. E., Del Rivero, J., Nilubol, N., Walter, M. F., Welch, J. M., & 7 othersWeinstein, L. S., Vriens, M. R., Van Leeuwaarde, R. S., Van Treijen, M. J. C., Valk, G. D., Perrier, N. D. & Hanash, S. M., Dec 1 2021, In: Journal of Clinical Endocrinology and Metabolism. 106, 12, p. E4969-E4980

Research output: Contribution to journal › Article › peer-review

Open Access

11 Scopus citations

A myc-driven plasma polyamine signature for early detection of ovarian cancer

Fahrmann, J. F., Irajizad, E., Kobayashi, M., Vykoukal, J., Dennison, J. B., Murage, E., Wu, R., Long, J. P., Do, K. A., Celestino, J., Lu, K. H., Lu, Z., Bast, R. C. & Hanash, S., Feb 2021, In: Cancers. 13, 4, p. 1-22 22 p., 913.

Research output: Contribution to journal › Article › peer-review

Open Access

14 Scopus citations

Lead-Time Trajectory of CA19-9 as an Anchor Marker for Pancreatic Cancer Early Detection

Fahrmann, J. F., Schmidt, C. M., Mao, X., Irajizad, E., Loftus, M., Zhang, J., Patel, N., Vykoukal, J., Dennison, J. B., Long, J. P., Do, K. A., Zhang, J., Chabot, J. A., Kluger, M. D., Kastrinos, F., Brais, L., Babic, A., Jajoo, K., Lee, L. S., Clancy, T. E., & 7 othersNg, K., Bullock, A., Genkinger, J., Yip-Schneider, M. T., Maitra, A., Wolpin, B. M. & Hanash, S., Mar 2021, In: Gastroenterology. 160, 4, p. 1373-1383.e6

Research output: Contribution to journal › Article › peer-review

74 Scopus citations

Plasma based protein signatures associated with small cell lung cancer

Fahrmann, J. F., Katayama, H., Irajizad, E., Chakraborty, A., Kato, T., Mao, X., Park, S., Murage, E., Rusling, L., Yu, C. Y., Cai, Y., Hsiao, F. C., Dennison, J. B., Tran, H., Ostrin, E., Wilson, D. O., Yuan, J. M., Vykoukal, J. & Hanash, S., Aug 2021, In: Cancers. 13, 16, 3972.

Research output: Contribution to journal › Article › peer-review

Open Access

2 Scopus citations

Protein citrullination as a source of cancer neoantigens

Katayama, H., Kobayashi, M., Irajizad, E., Sevillarno, A., Patel, N., Mao, X., Rusling, L., Vykoukal, J., Cai, Y., Hsiao, F., Yu, C. Y., Long, J., Liu, J., Esteva, F., Fahrmann, J. & Hanash, S., Jun 10 2021, In: Journal for immunotherapy of cancer. 9, 6, e002549.

Research output: Contribution to journal › Article › peer-review

Open Access

22 Scopus citations

2020

Association between Plasma Diacetylspermine and Tumor Spermine Synthase with Outcome in Triple-Negative Breast Cancer

Fahrmann, J. F., Vykoukal, J., Fleury, A., Tripathi, S., Dennison, J. B., Murage, E., Wang, P., Yu, C. Y., Capello, M., Creighton, C. J., Do, K. A., Long, J. P., Irajizad, E., Peterson, C., Katayama, H., Disis, M. L., Arun, B. & Hanash, S., Jun 1 2020, In: Journal of the National Cancer Institute. 112, 6, p. 607-616 10 p., djz182.

Research output: Contribution to journal › Article › peer-review

Open Access

33 Scopus citations

Caveolin-1-mediated sphingolipid oncometabolism underlies a metabolic vulnerability of prostate cancer

Vykoukal, J., Fahrmann, J. F., Gregg, J. R., Tang, Z., Basourakos, S., Irajizad, E., Park, S., Yang, G., Creighton, C. J., Fleury, A., Mayo, J., Paulucci-Holthauzen, A., Dennison, J. B., Murage, E., Peterson, C. B., Davis, J. W., Kim, J., Hanash, S. & Thompson, T. C., Dec 1 2020, In: Nature communications. 11, 1, 4279.

Research output: Contribution to journal › Article › peer-review

Open Access

47 Scopus citations

Plasma-derived extracellular vesicles convey protein signatures that reflect pathophysiology in lung and pancreatic adenocarcinomas

Fahrmann, J. F., Mao, X., Irajizad, E., Katayama, H., Capello, M., Tanaka, I., Kato, T., Wistuba, I. I., Maitra, A., Ostrin, E. J., Hanash, S. M. & Vykoukal, J., May 2020, In: Cancers. 12, 5, 1147.

Research output: Contribution to journal › Article › peer-review

Open Access

16 Scopus citations

Proteome profiling uncovers an autoimmune response signature that reflects ovarian cancer pathogenesis

Kobayashi, M., Katayama, H., Irajizad, E., Vykoukal, J. V., Fahrmann, J. F., Kundnani, D. L., Yu, C. Y., Cai, Y., Hsiao, F. C., Yang, W. L., Lu, Z., Celestino, J., Long, J. P., Do, K. A., Lu, K. H., Ladd, J. J., Urban, N., Bast, R. C. & Hanash, S. M., Feb 2020, In: Cancers. 12, 2, 485.

Research output: Contribution to journal › Article › peer-review

Open Access

8 Scopus citations

2019

CES2 expression in pancreatic adenocarcinoma is predictive of response to irinotecan and is associated with type 2 diabetes

Capello, M., Fahrmann, J. F., Rios Perez, M. V., Vykoukal, J. V., Irajizad, E., Tripathi, S. C., Roife, D., Bantis, L. E., Kang, Y., Kundnani, D. L., Xu, H., Prakash, L. R., Long, J. P., Katayama, H., Fleury, A., Ferri-Borgogno, S., Baluya, D. L., Dennison, J. B., Aguilar-Bonavides, C., Casabar, J. P., & 10 othersCeliktas, M., Do, K. A., Fiehn, O., Maitra, A., Wang, H., Feng, Z., Chiao, P. J., Katz, M. H., Fleming, J. B. & Hanash, S. M., 2019, In: JCO Precision Oncology. 3, p. 426-436 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access