Eugenie S Kleinerman

Professor

  • 6767 Bertner Ave, Mitchell Basic Science Research Building

    77030 Houston

    United States

  • 7311 Citations
  • 47 h-Index
1974 …2019
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Research Output 1974 2019

2019
3 Citations (Scopus)

Alpha particle radium 223 dichloride in high-risk osteosarcoma: A phase i dose escalation trial

Subbiah, V., Anderson, P. M., Kairemo, K., Hess, K., Huh, W. W., Ravi, V., Daw, N. C., Somaiah, N., Ludwig, J. A., Benjamin, R. S., Chawla, S., Hong, D. S., Meric-Bernstam, F., Ravizzini, G., Kleinerman, E., Macapinlac, H. & Rohren, E., Jan 1 2019, In : Clinical Cancer Research. 25, 13, p. 3802-3810 9 p.

Research output: Contribution to journalArticle

Open Access
Alpha Particles
Radium
Osteosarcoma
Neoplasm Metastasis
Technetium Tc 99m Medronate
Anthracyclines
Osteosarcoma
Stroke Volume
Survivors
Young Adult

Vascular modulation through exercise improves chemotherapy efficacy in Ewing sarcoma

Morrell, M. B. G., Alvarez-Florez, C., Zhang, A., Kleinerman, E. S., Savage, H., Marmonti, E., Park, M., Shaw, A. & Schadler, K. L., Sep 1 2019, In : Pediatric Blood and Cancer. 66, 9, e27835.

Research output: Contribution to journalArticle

Open Access
Ewing's Sarcoma
Blood Vessels
Drug Therapy
Exercise
Doxorubicin
2018
6 Citations (Scopus)

Aerobic exercise during early murine doxorubicin exposure mitigates cardiac toxicity

Wang, F., Iskra, B., Kleinerman, E. S., Alvarez-Florez, C., Andrews, T., Shaw, A., Chandra, J., Schadler, K. L. & Aune, G. J., Jan 1 2018, In : Journal of Pediatric Hematology/Oncology. 40, 3, p. 208-215 8 p.

Research output: Contribution to journalArticle

Doxorubicin
Exercise
Nude Mice
Cardiotoxicity
Neoplasms

Aerosol Gemcitabine after Amputation Inhibits Osteosarcoma Lung Metastases but Not Wound Healing

Kleinerman, E. S., Yu, L., Dao, J., Hayes-Jordan, A., Lindsey, B., Kawedia, J. D., Stewart, J. & Gordon, N., Jan 1 2018, In : Sarcoma. 2018, 3143096.

Research output: Contribution to journalArticle

gemcitabine
Osteosarcoma
Aerosols
Amputation
Wound Healing
2 Citations (Scopus)

Analysis of hsp27 and the autophagy marker LC3B þ puncta following preoperative chemotherapy identifies high-risk osteosarcoma patients

Livingston, J. A., Wang, W-L., Tsai, J. W., Lazar, A., Leung, C. H., Lin, H., Advani, S., Daw Bitar, N., Santiago-O'Farrill, J., Hollomon, M., Gordon, N. & Kleinerman, E. S., Jun 1 2018, In : Molecular cancer therapeutics. 17, 6, p. 1315-1323 9 p.

Research output: Contribution to journalArticle

HSP27 Heat-Shock Proteins
Autophagy
Osteosarcoma
Light
Drug Therapy
14 Citations (Scopus)

Anti-PD-1 therapy redirects macrophages from an M2 to an M1 phenotype inducing regression of OS lung metastases

Dhupkar, P., Gordon, N., Stewart, J. & Kleinerman, E. S., Jun 2018, In : Cancer medicine. 7, 6, p. 2654-2664 11 p.

Research output: Contribution to journalArticle

Osteosarcoma
Macrophages
Neoplasm Metastasis
Phenotype
Lung
3 Citations (Scopus)
Exercise
Pediatrics
Diet
Neoplasms
Pediatric Obesity
5 Citations (Scopus)

MiR-20a regulates FAS expression in osteosarcoma cells by modulating FAS promoter activity and can be therapeutically targeted to inhibit lung metastases

Yang, Y., Huang, G., Zhou, Z., Fewell, J. G. & Kleinerman, E. S., Jan 1 2018, In : Molecular cancer therapeutics. 17, 1, p. 130-139 10 p.

Research output: Contribution to journalArticle

Osteosarcoma
3' Untranslated Regions
Down-Regulation
Neoplasm Metastasis
Lung
3 Citations (Scopus)

Phosphorylated heat shock protein 27 as a potential biomarker to predict the role of chemotherapy-induced autophagy in osteosarcoma response to therapy

Santiago-O'Farrill, J. M., Kleinerman, E. S., Hollomon, M. G., Livingston, A., Wang, W. L., Tsai, J. W. & Gordon, N. B., Jan 1 2018, In : Oncotarget. 9, 2, p. 1602-1616 15 p.

Research output: Contribution to journalArticle

HSP27 Heat-Shock Proteins
Autophagy
Osteosarcoma
gemcitabine
Biomarkers
1 Citation (Scopus)

Using the Spleen as an in Vivo Systemic Immune Barometer Alongside Osteosarcoma Disease Progression and Immunotherapy with α-PD-L1

Markel, J. E., Noore, J., Emery, E. J., Bobnar, H. J., Kleinerman, E. S. & Lindsey, B. A., Jan 1 2018, In : Sarcoma. 2018, 8694397.

Research output: Contribution to journalArticle

Osteosarcoma
Immunotherapy
Disease Progression
Spleen
Neoplasms
2017
5 Citations (Scopus)

BMTP-11 is active in preclinical models of human osteosarcoma and a candidate targeted drug for clinical translation

Lewis, V. O., Devarajan, E., Cardó-Vila, M., Thomas, D. G., Kleinerman, E. S., Marchiò, S., Sidman, R. L., Pasqualini, R. & Arap, W., Jul 25 2017, In : Proceedings of the National Academy of Sciences of the United States of America. 114, 30, p. 8065-8070 6 p.

Research output: Contribution to journalArticle

Interleukin-11 Receptors
Osteosarcoma
Pharmaceutical Preparations
gemcitabine
Lung
6 Citations (Scopus)

Effect of entinostat on NK cell-mediated cytotoxicity against osteosarcoma cells and osteosarcoma lung metastasis

Kiany, S., Huang, G. & Kleinerman, E. S., Aug 3 2017, In : OncoImmunology. 6, 8, e1333214.

Research output: Contribution to journalArticle

Osteosarcoma
Natural Killer Cells
Neoplasm Metastasis
Lung
Natural Killer Cell Receptors
1 Citation (Scopus)

Hes4: A potential prognostic biomarker for newly diagnosed patients with high-grade osteosarcoma

McManus, M., Kleinerman, E. S., Yang, Y., Livingston, J. A., Mortus, J., Rivera, R., Zweidler-McKay, P. A. & Schadler, K. L., May 1 2017, In : Pediatric Blood and Cancer. 64, 5, e26318.

Research output: Contribution to journalArticle

Osteosarcoma
Biomarkers
Drug Therapy
Neoplasm Metastasis
Survival
6 Citations (Scopus)
Histone Acetyltransferases
Ligands
T-Lymphocytes
Neoplasms
Genetic Engineering
10 Citations (Scopus)

Interferon gamma induces changes in Natural Killer (NK) cell ligand expression and alters NK cell-mediated lysis of pediatric cancer cell lines

Aquino-López, A., Senyukov, V. V., Vlasic, Z., Kleinerman, E. S. & Lee, D. A., Apr 6 2017, In : Frontiers in immunology. 8, APR, 391.

Research output: Contribution to journalArticle

Natural Killer Cells
Interferon-gamma
Pediatrics
Ligands
Cell Line
2016
7 Citations (Scopus)

Lack of immunomodulatory interleukin-27 enhances oncogenic properties of mutant p53 in vivo

Dibra, D., Mitra, A., Newman, M., Xia, X., Cutrera, J. J., Gagea Iurascu, M., Kleinerman, E. S., Lozano, G. & Li, S., Aug 1 2016, In : Clinical Cancer Research. 22, 15, p. 3876-3883 8 p.

Research output: Contribution to journalArticle

Interleukin-27
Neoplasms
Survival
Protein Stability
p53 Genes
12 Citations (Scopus)

Maximum benefit of chemotherapy for osteosarcoma achieved—what are the next steps?

Kleinerman, E., Oct 1 2016, In : The lancet oncology. 17, 10, p. 1340-1342 3 p.

Research output: Contribution to journalComment/debate

Osteosarcoma
Drug Therapy
2015
31 Citations (Scopus)

The narrow-spectrum HDAC inhibitor entinostat enhances NKG2D expression without NK cell toxicity, leading to enhanced recognition of cancer cells

Zhu, S., Denman, C. J., Cobanoglu, Z. S., Kiany, S., Lau, C. C., Gottschalk, S. M., Hughes, D. P. M., Kleinerman, E. S. & Lee, D. A., Jan 1 2015, In : Pharmaceutical Research. 32, 3, p. 779-792 14 p.

Research output: Contribution to journalArticle

Histone Deacetylase Inhibitors
Natural Killer Cells
Toxicity
Tumors
Cytotoxicity
2014
20 Citations (Scopus)
Osteosarcoma
Aerosols
Natural Killer Cells
Interleukin-2
Cell Proliferation
20 Citations (Scopus)
Proto-Oncogene Proteins c-sis
Pericytes
Ewing's Sarcoma
Blood Vessels
Intercellular Signaling Peptides and Proteins
16 Citations (Scopus)
NK Cell Lectin-Like Receptor Subfamily K
Interleukin-12
Doxorubicin
T-Lymphocytes
Neoplasms
5 Citations (Scopus)
Clinical Trials, Phase I
Pediatrics
Neoplasms
Drug Industry
Multivariate Analysis
1 Citation (Scopus)

Current advances in osteosarcoma

Kleinerman, E. S., Jan 1 2014, In : Advances in experimental medicine and biology. 804

Research output: Contribution to journalArticle

Osteosarcoma
Osteosarcoma
Medicine
Biomedical Research
11 Citations (Scopus)

EWS-FLI-1 regulates the neuronal repressor gene REST, which controls Ewing sarcoma growth and vascular morphology

Zhou, Z., Yu, L. & Kleinerman, E. S., Feb 15 2014, In : Cancer. 120, 4, p. 579-588 10 p.

Research output: Contribution to journalArticle

Ewing's Sarcoma
Gene Silencing
Blood Vessels
Growth
Neoplasms
29 Citations (Scopus)

Mifamurtide in metastatic and recurrent osteosarcoma: A patient access study with pharmacokinetic, pharmacodynamic, and safety assessments

Anderson, P. M., Meyers, P., Kleinerman, E. S., Venkatakrishnan, K., Hughes, D. P., Herzog, C. E., Huh, W., Sutphin, R., Vyas, Y. M., Shen, V., Warwick, A., Yeager, N., Oliva, C., Wang, B., Liu, Y. & Chou, A., Feb 1 2014, In : Pediatric Blood and Cancer. 61, 2, p. 238-244 7 p.

Research output: Contribution to journalArticle

Osteosarcoma
Pharmacokinetics
Safety
Survival
mifamurtide
23 Citations (Scopus)

Natural killer cell therapy and aerosol interleukin-2 for the treatment of osteosarcoma lung metastasis

Guma, S. R., Lee, D. A., Yu, L., Gordon, N., Hughes, D., Stewart, J., Wang, W-L. & Kleinerman, E. S., Apr 1 2014, In : Pediatric Blood and Cancer. 61, 4, p. 618-626 9 p.

Research output: Contribution to journalArticle

Osteosarcoma
Cell- and Tissue-Based Therapy
Aerosols
Natural Killer Cells
Interleukin-2
1 Citation (Scopus)

Osteosarcoma: the state of affairs dictates a change. What do we know?

Kleinerman, E. S., Mary, V. & John, A., Jan 1 2014, In : Advances in Experimental Medicine and Biology. 804

Research output: Contribution to journalEditorial

Molecular Targeted Therapy
Bone Neoplasms
Osteosarcoma
Antineoplastic Agents
16 Citations (Scopus)

Participation of the Fas/FasL signaling pathway and the lung microenvironment in the development of osteosarcoma lung metastases

Huang, G., Nishimoto, K., Yang, Y. & Kleinerman, E. S., Jan 1 2014, In : Advances in experimental medicine and biology. 804, p. 203-217 15 p.

Research output: Contribution to journalArticle

gemcitabine
Osteosarcoma
Neoplasm Metastasis
Aerosols
Lung
12 Citations (Scopus)

Pediatric patients with refractory central nervous system tumors: Experiences of a clinical trial combining bevacizumab and temsirolimus

Piha-Paul, S. A., Shin, S. J., Vats, T., Guha-Thakurta, N., Aaron, J., Rytting, M. E., Kleinerman, E. S. & Kurzrock, R., Apr 1 2014, In : Anticancer research. 34, 4, p. 1939-1946 8 p.

Research output: Contribution to journalArticle

Central Nervous System Neoplasms
Clinical Trials
Pediatrics
Glioblastoma
Glioma
60 Citations (Scopus)

Toward a drug development path that targets metastatic progression in osteosarcoma

Khanna, C., Fan, T. M., Gorlick, R., Helman, L. J., Kleinerman, E. S., Adamson, P. C., Houghton, P. J., Tap, W. D., Welch, D. R., Steeg, P. S., Merlino, G., Sorensen, P. H. B., Meltzer, P., Kirsch, D. G., Janeway, K. A., Weigel, B., Randall, L., Withrow, S. J., Paoloni, M., Kaplan, R. & 12 others, Teicher, B. A., Seibel, N. L., Smith, M., Üren, A., Patel, S. R., Trent, J., Savage, S. A., Mirabello, L., Reinke, D., Barkaukas, D. A., Krailo, M. & Bernstein, M., Aug 15 2014, In : Clinical Cancer Research. 20, 16, p. 4200-4209 10 p.

Research output: Contribution to journalReview article

Osteosarcoma
Neoplasm Metastasis
Pharmaceutical Preparations
Expert Testimony
Neoplasms
75 Citations (Scopus)

Universal marker and detection tool for human sarcoma circulating tumor cells

Satelli, A., Mitra, A., Cutrera, J. J., Devarie, M., Xia, X., Ingram, D. R., Dibra, D., Somaiah, N., Torres, K. E., Ravi, V., Ludwig, J. A., Kleinerman, E. S. & Li, S., Mar 15 2014, In : Cancer research. 74, 6, p. 1645-1650 6 p.

Research output: Contribution to journalArticle

Circulating Neoplastic Cells
Sarcoma
Vimentin
Neoplasms
Tumor Biomarkers
2013
9 Citations (Scopus)

Expression of c-FLIP in pulmonary metastases in osteosarcoma patients and human xenografts

Rao-Bindal, K., Rao, C. K., Yu, L. & Kleinerman, E. S., Apr 1 2013, In : Pediatric Blood and Cancer. 60, 4, p. 575-579 5 p.

Research output: Contribution to journalArticle

Osteosarcoma
Heterografts
Neoplasm Metastasis
Lung
Neoplasms
11 Citations (Scopus)

Inhibition of Cdc42-interacting protein 4 (CIP4) impairs osteosarcoma tumor progression

Koshkina, N. V., Yang, G. & Kleinerman, E. S., 2013, In : Current Cancer Drug Targets. 13, 1, p. 48-56 9 p.

Research output: Contribution to journalArticle

cdc42 GTP-Binding Protein
Osteosarcoma
Neoplasms
Down-Regulation
Growth
21 Citations (Scopus)
Camptothecin
Autophagy
Osteosarcoma
Oxidative Stress
Buthionine Sulfoximine
28 Citations (Scopus)
CASP8 and FADD-Like Apoptosis Regulating Protein
Histone Deacetylase Inhibitors
Fas Ligand Protein
Osteosarcoma
Down-Regulation
2012
23 Citations (Scopus)

CAPER-α alternative splicing regulates the expression of vascular endothelial growth factor 165 in Ewing sarcoma cells

Huang, G., Zhou, Z., Wang, H. & Kleinerman, E. S., Apr 15 2012, In : Cancer. 118, 8, p. 2106-2116 11 p.

Research output: Contribution to journalArticle

Ewing's Sarcoma
Alternative Splicing
Vascular Endothelial Growth Factor A
Protein Isoforms
Neoplasms
58 Citations (Scopus)

Genetically modified T cells targeting interleukin-11 receptor α-chain kill human osteosarcoma cells and induce the regression of established osteosarcoma lung metastases

Huang, G., Yu, L., Cooper, L. J. N., Hollomon, M., Huls, H. & Kleinerman, E. S., Jan 1 2012, In : Cancer research. 72, 1, p. 271-281 11 p.

Research output: Contribution to journalArticle

Interleukin-11 Receptors
Interleukins
Osteosarcoma
Neoplasm Metastasis
T-Lymphocytes
124 Citations (Scopus)

miR-20a encoded by the miR-17-92 cluster increases the metastatic potential of osteosarcoma cells by regulating fas expression

Huang, G., Nishimoto, K., Zhou, Z., Hughes, D. & Kleinerman, E. S., Feb 15 2012, In : Cancer research. 72, 4, p. 908-916 9 p.

Research output: Contribution to journalArticle

Osteosarcoma
Down-Regulation
Lung
Neoplasm Metastasis
MicroRNAs
18 Citations (Scopus)
Fas Ligand Protein
Osteosarcoma
Membrane Lipids
Cell Death
CASP8 and FADD-Like Apoptosis Regulating Protein
2011
9 Citations (Scopus)

Bone marrow cells participate in tumor vessel formation that supports the growth of Ewing's sarcoma in the lung

Zhou, Z., Stewart, K. S., Yu, L. & Kleinerman, E. S., May 1 2011, In : Angiogenesis. 14, 2, p. 125-133 9 p.

Research output: Contribution to journalArticle

Ewing's Sarcoma
Bone Marrow Cells
Tumors
Bone
Cells
27 Citations (Scopus)

Delta-like ligand 4-Notch signaling regulates bone marrow-derived pericyte/vascular smooth muscle cell formation

Stewart, K. S., Zhou, Z., Zweidler-McKay, P. & Kleinerman, E. S., Jan 13 2011, In : Blood. 117, 2, p. 719-726 8 p.

Research output: Contribution to journalArticle

Pericytes
Vascular Smooth Muscle
Smooth Muscle Myocytes
Muscle
Bone
19 Citations (Scopus)
Histone Deacetylase Inhibitors
Osteosarcoma
Neoplasm Metastasis
Lung
CD95 Antigens
18 Citations (Scopus)

Epigenetic regulation of apoptosis and cell cycle in osteosarcoma

Kleinerman, E. S. & Rao-Bindal, K., Mar 8 2011, In : Sarcoma. 2011, 679457.

Research output: Contribution to journalArticle

Osteosarcoma
Epigenomics
Cell Cycle
Apoptosis
Histone Code
26 Citations (Scopus)

SDF-1α induces PDGF-B expression and the differentiation of bone marrow cells into pericytes

Hamdan, R., Zhou, Z. & Kleinerman, E. S., Nov 1 2011, In : Molecular Cancer Research. 9, 11, p. 1462-1470 9 p.

Research output: Contribution to journalArticle

Proto-Oncogene Proteins c-sis
Pericytes
Bone Marrow Cells
Ewing's Sarcoma
Tumor Microenvironment
13 Citations (Scopus)
Ewing's Sarcoma
Blood Vessels
Clinical Trials
Vascular Endothelial Growth Factor A
Pediatrics
2010
24 Citations (Scopus)

Aerosol gemcitabine: Preclinical safety and in vivo antitumor activity in osteosarcoma-bearing dogs

Rodriguez, C. O., Crabbs, T. A., Wilson, D. W., Cannan, V. A., Skorupski, K. A., Gordon, N., Koshkina, N., Kleinerman, E. S. & Anderson, P. M., Aug 1 2010, In : Journal of Aerosol Medicine and Pulmonary Drug Delivery. 23, 4, p. 197-206 10 p.

Research output: Contribution to journalArticle

gemcitabine
Osteosarcoma
Aerosols
Dogs
Safety
25 Citations (Scopus)
gemcitabine
Osteosarcoma
Aerosols
Neoplasm Metastasis
Lung
25 Citations (Scopus)
Pericytes
Ewing's Sarcoma
Vascular Smooth Muscle
Smooth Muscle Myocytes
Bone Marrow