Giulio Draetta

2024

Clonal dominance defines metastatic dissemination in pancreatic cancer

Ho, I. L., Li, C. Y., Wang, F., Zhao, L., Liu, J., Yen, E. Y., Dyke, C. A., Shah, R., Liu, Z., Çetin, A. O., Chu, Y., Citron, F., Attanasio, S., Corti, D., Darbaniyan, F., Del Poggetto, E., Loponte, S., Liu, J., Soeung, M. & Chen, Z. & 21 others, Jiang, S., Jiang, H., Inoue, A., Gao, S., Deem, A., Feng, N., Ying, H., Kim, M., Giuliani, V., Genovese, G., Zhang, J., Futreal, A., Maitra, A., Heffernan, T., Wang, L., Do, K. A., Gargiulo, G., Draetta, G., Carugo, A., Lin, R. & Viale, A., Mar 15 2024, In: Science Advances. 10, 11, eadd9342.

Research output: Contribution to journal › Article › peer-review

Open Access

2 Scopus citations

The KRAS mutational spectrum and its clinical implications in pancreatic cancer

Perelli, L., Genovese, G. & Draetta, G. F., Sep 9 2024, In: Cancer cell. 42, 9, p. 1494-1496 3 p.

Research output: Contribution to journal › Comment/debate › peer-review

2023

Clinical Characteristics and Cause of Death Among Hospitalized Decedents With Cancer and COVID-19

D3CODE Team Collaborators, Mar 2023, In: Mayo Clinic Proceedings. 98, 3, p. 451-457 7 p.

Research output: Contribution to journal › Article › peer-review

Open Access

2 Scopus citations

Ether phospholipids are required for mitochondrial reactive oxygen species homeostasis

Chen, Z., Ho, I. L., Soeung, M., Yen, E. Y., Liu, J., Yan, L., Rose, J. L., Srinivasan, S., Jiang, S., Edward Chang, Q., Feng, N., Gay, J. P., Wang, Q., Wang, J., Lorenzi, P. L., Veillon, L. J., Wei, B., Weinstein, J. N., Deem, A. K. & Gao, S. & 7 others, Genovese, G., Viale, A., Yao, W., Lyssiotis, C. A., Marszalek, J. R., Draetta, G. F. & Ying, H., Dec 2023, In: Nature communications. 14, 1, 2194.

Research output: Contribution to journal › Article › peer-review

Open Access

12 Scopus citations

Interferon signaling promotes tolerance to chromosomal instability during metastatic evolution in renal cancer

Perelli, L., Carbone, F., Zhang, L., Huang, J. K., Le, C., Khan, H., Citron, F., Del Poggetto, E., Gutschner, T., Tomihara, H., Soeung, M., Minelli, R., Srinivasan, S., Peoples, M., Lam, T. N. A., Lundgren, S., Xia, R., Zhu, C., Mohamed, A. M. T. & Zhang, J. & 24 others, Sircar, K., Sgambato, A., Gao, J. J., Jonasch, E., Draetta, G. F., Futreal, A., Bakouny, Z., Van Allen, E. M., Choueiri, T., Signoretti, S., Msaouel, P., Litchfield, K., Turajlic, S., Wang, L., Chen, Y. B., Di Natale, R. G., Hakimi, A. A., Giuliani, V., Heffernan, T. P., Viale, A., Bristow, C. A., Tannir, N. M., Carugo, A. & Genovese, G., Jul 2023, In: Nature Cancer. 4, 7, p. 984-1000 17 p.

Research output: Contribution to journal › Article › peer-review

Open Access

14 Scopus citations

Interstitial lung abnormalities after hospitalization for COVID-19 in patients with cancer: A prospective cohort study

D3CODE Team, Sep 2023, In: Cancer medicine. 12, 17, p. 17753-17765 13 p.

Research output: Contribution to journal › Article › peer-review

Open Access

3 Scopus citations

SMARCB1 regulates the hypoxic stress response in sickle cell trait

Soeung, M., Perelli, L., Chen, Z., Dondossola, E., Ho, I. L., Carbone, F., Zhang, L., Khan, H., Le, C. N., Zhu, C., Peoples, M. D., Feng, N., Jiang, S., Zacharias, N. M., Minelli, R., Shapiro, D. D., Deem, A. K., Gao, S., Cheng, E. H. & Lucchetti, D. & 9 others, Walker, C. L., Carugo, A., Giuliani, V., Heffernan, T. P., Viale, A., Tannir, N. M., Draetta, G. F., Msaouel, P. & Genovese, G., May 23 2023, In: Proceedings of the National Academy of Sciences of the United States of America. 120, 21, e2209639120.

Research output: Contribution to journal › Article › peer-review

Open Access

6 Scopus citations

2022

Immune landscape of a genetically engineered murine model of glioma compared with human glioma

Zamler, D. B., Shingu, T., Kahn, L. M., Huntoon, K., Kassab, C., Ott, M., Tomczak, K., Liu, J., Li, Y., Lai, I., Zorilla-Veloz, R., Yee, C., Rai, K., Kim, B. Y. S., Watowich, S. S., Heimberger, A. B., Draetta, G. F. & Hu, J., Jun 22 2022, In: JCI Insight. 7, 12

Research output: Contribution to journal › Article › peer-review

Open Access

12 Scopus citations

Lineage-coupled clonal capture identifies clonal evolution mechanisms and vulnerabilities of BRAF^V600E inhibition resistance in melanoma

Zhang, Z. Y., Ding, Y., Ezhilarasan, R., Lhakhang, T., Wang, Q., Yang, J., Modrek, A. S., Zhang, H., Tsirigos, A., Futreal, A., Draetta, G. F., Verhaak, R. G. W. & Sulman, E. P., Dec 2022, In: Cell Discovery. 8, 1, 102.

Research output: Contribution to journal › Article › peer-review

Open Access

3 Scopus citations

PGC1α/β Expression Predicts Therapeutic Response to Oxidative Phosphorylation Inhibition in Ovarian Cancer

Ghilardi, C., Moreira-Barbosa, C., Brunelli, L., Ostano, P., Panini, N., Lupi, M., Anastasia, A., Fiordaliso, F., Salio, M., Formenti, L., Russo, M., Arrigoni, E., Chiaradonna, F., Chiorino, G., Draetta, G., Marszalek, J. R., Vellano, C. P., Pastorelli, R., Bani, M. R. & Decio, A. & 1 others, Giavazzi, R., Apr 1 2022, In: Cancer Research. 82, 7, p. 1423-1434 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

14 Scopus citations

Targeting mitochondrial respiration and the BCL2 family in high-grade MYC-associated B-cell lymphoma

Donati, G., Ravà, M., Filipuzzi, M., Nicoli, P., Cassina, L., Verrecchia, A., Doni, M., Rodighiero, S., Parodi, F., Boletta, A., Vellano, C. P., Marszalek, J. R., Draetta, G. F. & Amati, B., Mar 2022, In: Molecular oncology. 16, 5, p. 1132-1152 21 p.

Research output: Contribution to journal › Article › peer-review

Open Access

10 Scopus citations

The NEDD8 pathway as a therapeutic target in HER2-amplified colorectal cancer

Invrea, F., Carugo, A., Arena, S., Draetta, G., Bardelli, A. & Medico, E., Oct 2022, In: European Journal of Cancer. 174, p. S63

Research output: Contribution to journal › Article › peer-review

Open Access

2021

Association of high-intensity exercise with renal medullary carcinoma in individuals with sickle cell trait: Clinical observations and experimental animal studies

Shapiro, D. D., Soeung, M., Perelli, L., Dondossola, E., Surasi, D. S., Tripathi, D. N., Bertocchio, J. P., Carbone, F., Starbuck, M. W., Van Alstine, M. L., Rao, P., Katz, M. H. G., Parker, N. H., Shah, A. Y., Carugo, A., Heffernan, T. P., Schadler, K. L., Logothetis, C., Walker, C. L. & Wood, C. G. & 5 others, Karam, J. A., Draetta, G. F., Tannir, N. M., Genovese, G. & Msaouel, P., Dec 1 2021, In: Cancers. 13, 23, 6022.

Research output: Contribution to journal › Article › peer-review

Open Access

15 Scopus citations

Discovery of 6-[(3 S,4 S)-4-Amino-3-methyl-2-oxa-8-azaspiro[4.5]decan-8-yl]-3-(2,3-dichlorophenyl)-2-methyl-3,4-dihydropyrimidin-4-one (IACS-15414), a Potent and Orally Bioavailable SHP2 Inhibitor

Czako, B., Sun, Y., McAfoos, T., Cross, J. B., Leonard, P. G., Burke, J. P., Carroll, C. L., Feng, N., Harris, A. L., Jiang, Y., Kang, Z., Kovacs, J. J., Mandal, P., Meyers, B. A., Mseeh, F., Parker, C. A., Yu, S. S., Williams, C. C., Wu, Q. & Di Francesco, M. E. & 5 others, Draetta, G., Heffernan, T., Marszalek, J. R., Kohl, N. E. & Jones, P., Oct 28 2021, In: Journal of Medicinal Chemistry. 64, 20, p. 15141-15169 29 p.

Research output: Contribution to journal › Article › peer-review

20 Scopus citations

Epithelial memory of inflammation limits tissue damage while promoting pancreatic tumorigenesis

Del Poggetto, E., Ho, I. L., Balestrieri, C., Yen, E. Y., Zhang, S., Citron, F., Shah, R., Corti, D., Diaferia, G. R., Li, C. Y., Loponte, S., Carbone, F., Hayakawa, Y., Valenti, G., Jiang, S., Sapio, L., Jiang, H., Dey, P., Gao, S. & Deem, A. K. & 13 others, Rose-John, S., Yao, W., Ying, H., Rhim, A. D., Genovese, G., Heffernan, T. P., Maitra, A., Wang, T. C., Wang, L., Draetta, G. F., Carugo, A., Natoli, G. & Viale, A., Sep 17 2021, In: Science. 373, 6561, eabj0486.

Research output: Contribution to journal › Article › peer-review

Open Access

121 Scopus citations

Loss of ARID1A Promotes Epithelial–Mesenchymal Transition and Sensitizes Pancreatic Tumors to Proteotoxic Stress ^A C

Tomihara, H., Carbone, F., Perelli, L., Huang, J. K., Soeung, M., Rose, J. L., Robinson, F. S., Deribe, Y. L., Feng, N., Takeda, M., Inoue, A., Poggetto, E. D., Deem, A. K., Maitra, A., Msaouel, P., Tannir, N. M., Draetta, G. F., Viale, A., Heffernan, T. P. & Bristow, C. A. & 2 others, Carugo, A. & Genovese, G., Jan 15 2021, In: Cancer Research. 81, 2, p. 332-343 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

28 Scopus citations

Medium-chain acyl-coa dehydrogenase protects mitochondria from lipid peroxidation in glioblastoma

Puca, F., Yu, F., Bartolacci, C., Pettazzoni, P., Carugo, A., Huang-Hobbs, E., Liu, J., Zanca, C., Carbone, F., Del Poggetto, E., Gumin, J., Dasgupta, P., Seth, S., Srinivasan, S., Lang, F. F., Sulman, E. P., Lorenzi, P. L., Tan, L., Shan, M. & Tolstyka, Z. P. & 9 others, Kachman, M., Zhang, L., Gao, S., Deem, A. K., Genovese, G., Scaglioni, P. P., Lyssiotis, C. A., Viale, A. & Draetta, G. F., Nov 2021, In: Cancer discovery. 11, 11, p. 2904-2923 20 p.

Research output: Contribution to journal › Article › peer-review

Open Access

31 Scopus citations

miR-9 modulates and predicts the response to radiotherapy and EGFR inhibition in HNSCC

Citron, F., Segatto, I., Musco, L., Pellarin, I., Rampioni Vinciguerra, G. L., Franchin, G., Fanetti, G., Miccichè, F., Giacomarra, V., Lupato, V., Favero, A., Concina, I., Srinivasan, S., Avanzo, M., Castiglioni, I., Barzan, L., Sulfaro, S., Petrone, G., Viale, A. & Draetta, G. F. & 3 others, Vecchione, A., Belletti, B. & Baldassarre, G., Jul 7 2021, In: EMBO Molecular Medicine. 13, 7, e12872.

Research output: Contribution to journal › Article › peer-review

Open Access

20 Scopus citations

Oxidative phosphorylation is a metabolic vulnerability in chemotherapy-resistant triple-negative breast cancer

Evans, K. W., Yuca, E., Scott, S. S., Zhao, M., Arango, N. P., Cruz Pico, C. X., Saridogan, T., Shariati, M., Class, C. A., Bristow, C. A., Vellano, C. P., Zheng, X., Gonzalez-Angulo, A. M., Su, X., Tapia, C., Chen, K., Akcakanat, A., Lim, B., Tripathy, D. & Yap, T. A. & 6 others, Di Francesco, M. E., Draetta, G. F., Jones, P., Heffernan, T. P., Marszalek, J. R. & Meric-Bernstam, F., Nov 1 2021, In: Cancer Research. 81, 21, p. 5572-5581 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

84 Scopus citations

PRMT1-dependent regulation of RNA metabolism and DNA damage response sustains pancreatic ductal adenocarcinoma

Giuliani, V., Miller, M. A., Liu, C. Y., Hartono, S. R., Class, C. A., Bristow, C. A., Suzuki, E., Sanz, L. A., Gao, G., Gay, J. P., Feng, N., Rose, J. L., Tomihara, H., Daniele, J. R., Peoples, M. D., Bardenhagen, J. P., Geck Do, M. K., Chang, Q. E., Vangamudi, B. & Vellano, C. & 18 others, Ying, H., Deem, A. K., Do, K. A., Genovese, G., Marszalek, J. R., Kovacs, J. J., Kim, M., Fleming, J. B., Guccione, E., Viale, A., Maitra, A., Emilia Di Francesco, M., Yap, T. A., Jones, P., Draetta, G., Carugo, A., Chedin, F. & Heffernan, T. P., Dec 1 2021, In: Nature communications. 12, 1, 4626.

Research output: Contribution to journal › Article › peer-review

Open Access

37 Scopus citations

Sequential Administration of XPO1 and ATR Inhibitors Enhances Therapeutic Response in TP53-mutated Colorectal Cancer

Inoue, A., Robinson, F. S., Minelli, R., Tomihara, H., Rizi, B. S., Rose, J. L., Kodama, T., Srinivasan, S., Harris, A. L., Zuniga, A. M., Mullinax, R. A., Ma, X., Seth, S., Daniele, J. R., Peoples, M. D., Loponte, S., Akdemir, K. C., Khor, T. O., Feng, N. & Roszik, J. & 15 others, Sobieski, M. M., Brunell, D., Stephan, C., Giuliani, V., Deem, A. K., Shingu, T., Deribe, Y. L., Menter, D. G., Heffernan, T. P., Viale, A., Bristow, C. A., Kopetz, S., Draetta, G. F., Genovese, G. & Carugo, A., Jul 2021, In: Gastroenterology. 161, 1, p. 196-210 15 p.

Research output: Contribution to journal › Article › peer-review

Open Access

24 Scopus citations

Synthetic lethality screening highlights colorectal cancer vulnerability to concomitant blockade of nedd8 and egfr pathways

Invrea, F., Punzi, S., Petti, C., Minelli, R., Peoples, M. D., Bristow, C. A., Vurchio, V., Corrado, A., Bragoni, A., Marchiò, C., Bertotti, A., Trusolino, L., Bardelli, A., Isella, C., Carugo, A., Draetta, G. F. & Medico, E., Aug 1 2021, In: Cancers. 13, 15, 3805.

Research output: Contribution to journal › Article › peer-review

Open Access

9 Scopus citations

Targeting the αv integrin/TGF-β axis improves natural killer cell function against glioblastoma stem cells

Shaim, H., Shanley, M., Basar, R., Daher, M., Gumin, J., Zamler, D. B., Uprety, N., Wang, F., Huang, Y., Gabrusiewicz, K., Miao, Q., Dou, J., Alsuliman, A., Kerbauy, L. N., Acharya, S., Mohanty, V., Mendt, M., Li, S., Lu, J. J. & Wei, J. & 30 others, Fowlkes, N. W., Gokdemir, E., Ensley, E. L., Kaplan, M., Kassab, C., Li, L., Ozcan, G., Banerjee, P. P., Shen, Y., Gilbert, A. L., Jones, C. M., Bdiwi, M., Nunez-Cortes, A. K., Liu, E., Yu, J., Imahashi, N., Muniz-Feliciano, L., Li, Y., Hu, J., Draetta, G., Marin, D., Yu, D., Mielke, S., Eyrich, M., Champlin, R. E., Chen, K., Lang, F. F., Shpall, E. J., Heimberger, A. B. & Rezvani, K., Jul 2021, In: Journal of Clinical Investigation. 131, 14, e142116.

Research output: Contribution to journal › Article › peer-review

Open Access

148 Scopus citations

2020

Accumulation of long-chain fatty acids in the tumor microenvironment drives dysfunction in intrapancreatic cd8+ t cells

Manzo, T., Prentice, B. M., Anderson, K. G., Raman, A., Schalck, A., Codreanu, G. S., Nava Lauson, C. B., Tiberti, S., Raimondi, A., Jones, M. A., Reyzer, M., Bates, B. M., Spraggins, J. M., Patterson, N. H., McLean, J. A., Rai, K., Tacchetti, C., Tucci, S., Wargo, J. A. & Rodighiero, S. & 8 others, Clise-Dwyer, K., Sherrod, S. D., Kim, M., Navin, N. E., Caprioli, R. M., Greenberg, P. D., Draetta, G. & Nezi, L., Aug 3 2020, In: Journal of Experimental Medicine. 217, 8, e20191920.

Research output: Contribution to journal › Article › peer-review

Open Access

190 Scopus citations

Allosteric SHP2 inhibitor, IACS-13909, overcomes EGFR-dependent and EGFR-independent resistance mechanisms toward osimertinib

Sun, Y., Meyers, B. A., Czako, B., Leonard, P., Mseeh, F., Harris, A. L., Wu, Q., Johnson, S., Parker, C. A., Cross, J. B., Di Francesco, M. E., Bivona, B. J., Bristow, C. A., Burke, J. P., Carrillo, C. C., Carroll, C. L., Chang, Q., Feng, N., Gao, G. & Gera, S. & 25 others, Giuliani, V., Huang, J. K., Jiang, Y., Kang, Z., Kovacs, J. J., Liu, C. Y., Lopez, A. M., Ma, X., Mandal, P. K., McAfoos, T., Miller, M. A., Mullinax, R. A., Peoples, M., Ramamoorthy, V., Seth, S., Spencer, N. D., Suzuki, E., Williams, C. C., Yu, S. S., Zuniga, A. M., Draetta, G. F., Marszalek, J. R., Heffernan, T. P., Kohl, N. E. & Jones, P., Nov 1 2020, In: Cancer Research. 80, 21, p. 4840-4853 14 p.

Research output: Contribution to journal › Article › peer-review

Open Access

59 Scopus citations

Discovery of IACS-9439, a Potent, Exquisitely Selective, and Orally Bioavailable Inhibitor of CSF1R

Czako, B., Marszalek, J. R., Burke, J. P., Mandal, P., Leonard, P. G., Cross, J. B., Mseeh, F., Jiang, Y., Chang, E. Q., Suzuki, E., Kovacs, J. J., Feng, N., Gera, S., Harris, A. L., Liu, Z., Mullinax, R. A., Pang, J., Parker, C. A., Spencer, N. D. & Yu, S. S. & 7 others, Wu, Q., Tremblay, M. R., Mikule, K., Wilcoxen, K., Heffernan, T. P., Draetta, G. F. & Jones, P., Sep 10 2020, In: Journal of Medicinal Chemistry. 63, 17, p. 9888-9911 24 p.

Research output: Contribution to journal › Article › peer-review

15 Scopus citations

Discovery of IPN60090, a Clinical Stage Selective Glutaminase-1 (GLS-1) Inhibitor with Excellent Pharmacokinetic and Physicochemical Properties

Soth, M. J., Le, K., Di Francesco, M. E., Hamilton, M. M., Liu, G., Burke, J. P., Carroll, C. L., Kovacs, J. J., Bardenhagen, J. P., Bristow, C. A., Cardozo, M., Czako, B., De Stanchina, E., Feng, N., Garvey, J. R., Gay, J. P., Do, M. K. G., Greer, J., Han, M. & Harris, A. & 27 others, Herrera, Z., Huang, S., Giuliani, V., Jiang, Y., Johnson, S. B., Johnson, T. A., Kang, Z., Leonard, P. G., Liu, Z., McAfoos, T., Miller, M., Morlacchi, P., Mullinax, R. A., Palmer, W. S., Pang, J., Rogers, N., Rudin, C. M., Shepard, H. E., Spencer, N. D., Theroff, J., Wu, Q., Xu, A., Yau, J. A., Draetta, G., Toniatti, C., Heffernan, T. P. & Jones, P., Nov 12 2020, In: Journal of Medicinal Chemistry. 63, 21, p. 12957-12977 21 p.

Research output: Contribution to journal › Article › peer-review

Open Access

59 Scopus citations

2019

Academic discovery of anticancer drugs: Historic and future perspectives

Carugo, A. & Draetta, G. F., 2019, In: Annual Review of Cancer Biology. 3, 1, p. 385-408 24 p.

Research output: Contribution to journal › Review article › peer-review

21 Scopus citations

Critical questions in ovarian cancer research and treatment: Report of an American Association for Cancer Research Special Conference

Bast, R. C., Matulonis, U. A., Sood, A. K., Ahmed, A. A., Amobi, A. E., Balkwill, F. R., Wielgos-Bonvallet, M., Bowtell, D. D. L., Brenton, J. D., Brugge, J. S., Coleman, R. L., Draetta, G. F., Doberstein, K., Drapkin, R. I., Eckert, M. A., Edwards, R. P., Elias, K. M., Ennis, D., Futreal, A. & Gershenson, D. M. & 23 others, Greenberg, R. A., Huntsman, D. G., Ji, J. X. Y., Kohn, E. C., Iavarone, C., Lengyel, E. R., Levine, D. A., Lord, C. J., Lu, Z., Mills, G. B., Modugno, F., Nelson, B. H., Odunsi, K., Pilsworth, J. A., Rottapel, R. K., Powell, D. J., Shen, L., Shih, I. M., Spriggs, D. R., Walton, J., Zhang, K., Zhang, R. & Zou, L., Jun 15 2019, In: Cancer. 125, 12, p. 1963-1972 10 p.

Research output: Contribution to journal › Comment/debate › peer-review

Open Access

41 Scopus citations

Current and future horizons of patient-derived xenograft models in colorectal cancer translational research

Inoue, A., Deem, A. K., Kopetz, S., Heffernan, T. P., Draetta, G. F. & Carugo, A., Sep 2019, In: Cancers. 11, 9, 1321.

Research output: Contribution to journal › Review article › peer-review

Open Access

33 Scopus citations

Erratum: Yap1 Activation Enables Bypass of Oncogenic Kras Addiction in Pancreatic Cancer (Yap1 Activation Enables Bypass of Oncogenic Kras Addiction in Pancreatic Cancer (2014) 158(1) (185–197), (S0092867414007247), (10.1016/j.cell.2014.06.003))

Kapoor, A., Yao, W., Ying, H., Hua, S., Liewen, A., Wang, Q., Zhong, Y., Wu, C.-J., Sadanandam, A., Hu, B., Chang, Q., Chu, G. C., Al-Khalil, R., Jiang, S., Xia, H., Fletcher-Sananikone, E., Lim, C., Horwitz, G. I., Viale, A. & Pettazzoni, P. & 10 others, Sanchez, N., Wang, H., Protopopov, A., Zhang, J., Heffernan, T., Johnson, R. L., Chin, L., Wang, Y. A., Draetta, G. & DePinho, R. A., Nov 14 2019, In: Cell. 179, 5, p. 1239 1 p.

Research output: Contribution to journal › Comment/debate › peer-review

Open Access

20 Scopus citations

Functional Genomics Reveals Synthetic Lethality between Phosphogluconate Dehydrogenase and Oxidative Phosphorylation

Sun, Y., Bandi, M., Lofton, T., Smith, M., Bristow, C. A., Carugo, A., Rogers, N., Leonard, P., Chang, Q., Mullinax, R., Han, J., Shi, X., Seth, S., Meyers, B. A., Miller, M., Miao, L., Ma, X., Feng, N., Giuliani, V. & Geck Do, M. & 18 others, Czako, B., Palmer, W. S., Mseeh, F., Asara, J. M., Jiang, Y., Morlacchi, P., Zhao, S., Peoples, M., Tieu, T. N., Warmoes, M. O., Lorenzi, P. L., Muller, F. L., DePinho, R. A., Draetta, G. F., Toniatti, C., Jones, P., Heffernan, T. P. & Marszalek, J. R., Jan 8 2019, In: Cell Reports. 26, 2, p. 469-482.e5

Research output: Contribution to journal › Article › peer-review

Open Access

43 Scopus citations

Metabolic reprogramming toward oxidative phosphorylation identifies a therapeutic target for mantle cell lymphoma

Zhang, L., Yao, Y., Zhang, S., Liu, Y., Guo, H., Ahmed, M., Bell, T., Zhang, H., Han, G., Lorence, E., Badillo, M., Zhou, S., Sun, Y., Di Francesco, M. E., Feng, N., Haun, R., Lan, R., MacKintosh, S. G., Mao, X. & Song, X. & 11 others, Zhang, J., Pham, L. V., Lorenzi, P. L., Marszalek, J., Heffernan, T., Draetta, G., Jones, P., Futreal, A., Nomie, K., Wang, L. & Wang, M., 2019, In: Science translational medicine. 11, 491, eaau1167.

Research output: Contribution to journal › Article › peer-review

Open Access

169 Scopus citations

p53 Is a Master Regulator of Proteostasis in SMARCB1-Deficient Malignant Rhabdoid Tumors

Carugo, A., Minelli, R., Sapio, L., Soeung, M., Carbone, F., Robinson, F. S., Tepper, J., Chen, Z., Lovisa, S., Svelto, M., Amin, S., Srinivasan, S., Del Poggetto, E., Loponte, S., Puca, F., Dey, P., Malouf, G. G., Su, X., Li, L. & Lopez-Terrada, D. & 16 others, Rakheja, D., Lazar, A. J., Netto, G. J., Rao, P., Sgambato, A., Maitra, A., Tripathi, D. N., Walker, C. L., Karam, J. A., Heffernan, T. P., Viale, A., Roberts, C. W. M., Msaouel, P., Tannir, N. M., Draetta, G. F. & Genovese, G., Feb 11 2019, In: Cancer cell. 35, 2, p. 204-220.e9

Research output: Contribution to journal › Article › peer-review

Open Access

58 Scopus citations

Pooled library screening with multiplexed Cpf1 library

Liu, J., Srinivasan, S., Li, C. Y., Ho, I. L., Rose, J., Shaheen, M. A., Wang, G., Yao, W., Deem, A., Bristow, C., Hart, T. & Draetta, G., Dec 1 2019, In: Nature communications. 10, 1, 3144.

Research output: Contribution to journal › Article › peer-review

Open Access

33 Scopus citations

Predictive signatures inform the effective repurposing of decitabine to treat KRAS-dependent pancreatic ductal adenocarcinoma

Mottini, C., Tomihara, H., Carrella, D., Lamolinara, A., Iezzi, M., Huang, J. K., Amoreo, C. A., Buglioni, S., Manni, I., Robinson, F. S., Minelli, R., Kang, Y., Fleming, J. B., Kim, M. P., Bristow, C. A., Trisciuoglio, D., Iuliano, A., Bufalo, D. D., Bernardo, D. D. & Melisi, D. & 4 others, Draetta, G. F., Ciliberto, G., Carugo, A. & Cardone, L., Nov 1 2019, In: Cancer Research. 79, 21, p. 5612-5625 14 p.

Research output: Contribution to journal › Article › peer-review

Open Access

14 Scopus citations

Pre-existing Functional Heterogeneity of Tumorigenic Compartment as the Origin of Chemoresistance in Pancreatic Tumors

Seth, S., Li, C. Y., Ho, I. L., Corti, D., Loponte, S., Sapio, L., Del Poggetto, E., Yen, E. Y., Robinson, F. S., Peoples, M., Karpinets, T., Deem, A. K., Kumar, T., Song, X., Jiang, S., Kang, Y., Fleming, J., Kim, M., Zhang, J. & Maitra, A. & 7 others, Heffernan, T. P., Giuliani, V., Genovese, G., Futreal, A., Draetta, G. F., Carugo, A. & Viale, A., Feb 5 2019, In: Cell Reports. 26, 6, p. 1518-1532.e9

Research output: Contribution to journal › Article › peer-review

Open Access

59 Scopus citations

Syndecan 1 is a critical mediator of macropinocytosis in pancreatic cancer

Yao, W., Rose, J. L., Wang, W., Seth, S., Jiang, H., Taguchi, A., Liu, J., Yan, L., Kapoor, A., Hou, P., Chen, Z., Wang, Q., Nezi, L., Xu, Z., Yao, J., Hu, B., Pettazzoni, P. F., Ho, I. L., Feng, N. & Ramamoorthy, V. & 18 others, Jiang, S., Deng, P., Ma, G. J., Den, P., Tan, Z., Zhang, S. X., Wang, H., Wang, Y. A., Deem, A. K., Fleming, J. B., Carugo, A., Heffernan, T. P., Maitra, A., Viale, A., Ying, H., Hanash, S., DePinho, R. A. & Draetta, G. F., Apr 18 2019, In: Nature. 568, 7752, p. 410-414 5 p.

Research output: Contribution to journal › Article › peer-review

Open Access

136 Scopus citations

YAP1 oncogene is a context-specific driver for pancreatic ductal adenocarcinoma

Tu, B., Yao, J., Ferri-Borgogno, S., Zhao, J., Chen, S., Wang, Q., Yan, L., Zhou, X., Zhu, C., Bang, S., Chang, Q., Bristow, C. A., Kang, Y., Zheng, H., Wang, H., Fleming, J. B., Kim, M., Heffernan, T. P., Draetta, G. F. & Pan, D. & 4 others, Maitra, A., Yao, W., Gupta, S. & Ying, H., Nov 1 2019, In: JCI Insight. 4, 21, e130811.

Research output: Contribution to journal › Article › peer-review

Open Access

46 Scopus citations

2018

Adaptive global innovative learning environment for glioblastoma: GBM AGILE

GBM AGILE Network, Feb 15 2018, In: Clinical Cancer Research. 24, 4, p. 737-743 7 p.

Research output: Contribution to journal › Review article › peer-review

Open Access

152 Scopus citations

An inhibitor of oxidative phosphorylation exploits cancer vulnerability

Molina, J. R., Sun, Y., Protopopova, M., Gera, S., Bandi, M., Bristow, C., McAfoos, T., Morlacchi, P., Ackroyd, J., Agip, A. N. A., Al-Atrash, G., Asara, J., Bardenhagen, J., Carrillo, C. C., Carroll, C., Chang, E., Ciurea, S., Cross, J. B., Czako, B. & Deem, A. & 46 others, Daver, N., De Groot, J. F., Dong, J. W., Feng, N., Gao, G., Gay, J., Do, M. G., Greer, J., Giuliani, V., Han, J., Han, L., Henry, V. K., Hirst, J., Huang, S., Jiang, Y., Kang, Z., Khor, T., Konoplev, S., Lin, Y. H., Liu, G., Lodi, A., Lofton, T., Ma, H., Mahendra, M., Matre, P., Mullinax, R., Peoples, M., Petrocchi, A., Rodriguez-Canale, J., Serreli, R., Shi, T., Smith, M., Tabe, Y., Theroff, J., Tiziani, S., Xu, Q., Zhang, Q., Muller, F., Depinho, R. A., Toniatti, C., Draetta, G. F., Heffernan, T. P., Konopleva, M., Jones, P., Di Francesco, M. E. & Marszalek, J. R., Jul 1 2018, In: Nature medicine. 24, 7, p. 1036-1046 11 p.

Research output: Contribution to journal › Article › peer-review

630 Scopus citations

Collapsing the tumor ecosystem: Preventing adaptive response to treatment by inhibiting transcription

Carugo, A. & Draetta, G. F., Jan 2018, In: Cancer discovery. 8, 1, p. 17-19 3 p.

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

High-resolution clonal mapping of multi-organ metastasis in triple negative breast cancer

Echeverria, G. V., Powell, E., Seth, S., Ge, Z., Carugo, A., Bristow, C., Peoples, M., Robinson, F., Qiu, H., Shao, J., Jeter-Jones, S. L., Zhang, X., Ramamoorthy, V., Cai, S., Wu, W., Draetta, G., Moulder, S. L., Symmans, W. F., Chang, J. T. & Heffernan, T. P. & 1 others, Piwnica-Worms, H., Dec 1 2018, In: Nature communications. 9, 1, 5079.

Research output: Contribution to journal › Article › peer-review

Open Access

95 Scopus citations

2017

EZH2 modifies sunitinib resistance in renal cell carcinoma by kinome reprogramming

Adelaiye-Ogala, R., Budka, J., Damayanti, N. P., Arrington, J., Ferris, M., Hsu, C. C., Chintala, S., Orillion, A., Miles, K. M., Shen, L., Elbanna, M., Ciamporcero, E., Arisa, S., Pettazzoni, P., Draetta, G. F., Seshadri, M., Hancock, B., Radovich, M., Kota, J. & Buck, M. & 9 others, Keilhack, H., McCarthy, B. P., Persohn, S. A., Territo, P. R., Zang, Y., Irudayaraj, J., Tao, W. A., Hollenhorst, P. & Pili, R., Dec 1 2017, In: Cancer Research. 77, 23, p. 6651-6666 16 p.

Research output: Contribution to journal › Article › peer-review

Open Access

66 Scopus citations

Future cancer research priorities in the USA: a Lancet Oncology Commission

Jaffee, E. M., Dang, C. V., Agus, D. B., Alexander, B. M., Anderson, K. C., Ashworth, A., Barker, A. D., Bastani, R., Bhatia, S., Bluestone, J. A., Brawley, O., Butte, A. J., Coit, D. G., Davidson, N. E., Davis, M., DePinho, R. A., Diasio, R. B., Draetta, G., Frazier, A. L. & Futreal, A. & 34 others, Gambhir, S. S., Ganz, P. A., Garraway, L., Gerson, S., Gupta, S., Heath, J., Hoffman, R. I., Hudis, C., Hughes-Halbert, C., Ibrahim, R., Jadvar, H., Kavanagh, B., Kittles, R., Le, Q. T., Lippman, S. M., Mankoff, D., Mardis, E. R., Mayer, D. K., McMasters, K., Meropol, N. J., Mitchell, B., Naredi, P., Ornish, D., Pawlik, T. M., Peppercorn, J., Pomper, M. G., Raghavan, D., Ritchie, C., Schwarz, S. W., Sullivan, R., Wahl, R., Wolchok, J. D., Wong, S. L. & Yung, A., Nov 2017, In: The lancet oncology. 18, 11, p. e653-e706

Research output: Contribution to journal › Review article › peer-review

Open Access

160 Scopus citations

Genomic deletion of malic enzyme 2 confers collateral lethality in pancreatic cancer

Dey, P., Baddour, J., Muller, F., Wu, C. C., Wang, H., Liao, W. T., Lan, Z., Chen, A., Gutschner, T., Kang, Y., Fleming, J., Satani, N., Zhao, D., Achreja, A., Yang, L., Lee, J., Chang, E., Genovese, G., Viale, A. & Ying, H. & 5 others, Draetta, G., Maitra, A., Wang, Y. A., Nagrath, D. & Depinho, R. A., Feb 2 2017, In: Nature. 542, 7639, p. 119-123 5 p.

Research output: Contribution to journal › Article › peer-review

Open Access

197 Scopus citations

How Much Longer Will We Put Up With 100,000 Cancer Drugs?

Workman, P., Draetta, G. F., Schellens, J. H. M. & Bernards, R., Feb 9 2017, In: Cell. 168, 4, p. 579-583 5 p.

Research output: Contribution to journal › Comment/debate › peer-review

Open Access

64 Scopus citations

ILF2 Is a Regulator of RNA Splicing and DNA Damage Response in 1q21-Amplified Multiple Myeloma

Marchesini, M., Ogoti, Y., Fiorini, E., Aktas Samur, A., Nezi, L., D'Anca, M., Storti, P., Samur, M. K., Ganan-Gomez, I., Fulciniti, M. T., Mistry, N., Jiang, S., Bao, N., Marchica, V., Neri, A., Bueso-Ramos, C., Wu, C. J., Zhang, L., Liang, H. & Peng, X. & 9 others, Giuliani, N., Draetta, G., Clise-Dwyer, K., Kantarjian, H., Munshi, N., Orlowski, R., Garcia-Manero, G., DePinho, R. A. & Colla, S., Jul 10 2017, In: Cancer cell. 32, 1, p. 88-100.e6

Research output: Contribution to journal › Article › peer-review

Open Access

117 Scopus citations

PRKCI promotes immune suppression in ovarian cancer

Sarkar, S., Bristow, C. A., Dey, P., Rai, K., Perets, R., Ramirez-Cardenas, A., Malasi, S., Huang-Hobbs, E., Haemmerle, M., Wu, S. Y., McGuire, M., Protopopov, A., Jiang, S., Liu, J. F., Hirsch, M. S., Chang, Q., Lazar, A. J., Sood, A. K., Drapkin, R. & DePinho, R. & 2 others, Draetta, G. & Chin, L., 2017, In: Genes and Development. 31, 11, p. 1109-1121 13 p.

Research output: Contribution to journal › Article › peer-review

Open Access

67 Scopus citations

Synthetic vulnerabilities of mesenchymal subpopulations in pancreatic cancer

Genovese, G., Carugo, A., Tepper, J., Robinson, F. S., Li, L., Svelto, M., Nezi, L., Corti, D., Minelli, R., Pettazzoni, P., Gutschner, T., Wu, C. C., Seth, S., Akdemir, K. C., Leo, E., Amin, S., Molin, M. D., Ying, H., Kwong, L. N. & Colla, S. & 23 others, Takahashi, K., Ghosh, P., Giuliani, V., Muller, F., Dey, P., Jiang, S., Garvey, J., Liu, C. G., Zhang, J., Heffernan, T. P., Toniatti, C., Fleming, J. B., Goggins, M. G., Wood, L. D., Sgambato, A., Agaimy, A., Maitra, A., Roberts, C. W. M., Wang, H., Viale, A., DePinho, R. A., Draetta, G. F. & Chin, L., Feb 16 2017, In: Nature. 542, 7641, p. 362-366 5 p.

Research output: Contribution to journal › Article › peer-review

Open Access

95 Scopus citations

Giulio Draetta

Research output

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