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Research Output 1978 2019

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Article
2019
6 Citations (Scopus)

Functional Genomics Reveals Synthetic Lethality between Phosphogluconate Dehydrogenase and Oxidative Phosphorylation

Sun, Y., Bandi, M., Lofton, T., Smith, M., Bristow, C. A., Carugo, A., Rogers, N., Leonard, P., Chang, Q., Mullinax, R., Han, J., Shi, X., Seth, S., Meyers, B. A., Miller, M., Miao, L., Ma, X., Feng, N., Giuliani, V., Geck Do, M. & 18 others, Czako, B., Palmer, W. S., Mseeh, F., Asara, J. M., Jiang, Y., Morlacchi, P., Zhao, S., Peoples, M., Tieu, T. N., Warmoes, M. O., Lorenzi, P. L., Muller, F. L., DePinho, R. A., Draetta, G. F., Toniatti, C., Jones, P., Heffernan, T. P. & Marszalek, J. R., Jan 8 2019, In : Cell Reports. 26, 2, p. 469-482.e5

Research output: Contribution to journalArticle

Open Access
Phosphogluconate Dehydrogenase
Oxidative Phosphorylation
Genomics
Fumarate Hydratase
Mitochondrial Diseases
7 Citations (Scopus)

Metabolic reprogramming toward oxidative phosphorylation identifies a therapeutic target for mantle cell lymphoma

Zhang, L., Yao, Y., Zhang, S., Liu, Y., Guo, H., Ahmed, M., Bell, T., Zhang, H., Han, G., Lorence, E., Badillo, M., Zhou, S., Sun, Y., Di Francesco, M. E., Feng, N., Haun, R., Lan, R., MacKintosh, S. G., Mao, X., Song, X. & 11 others, Zhang, J., Pham, L. V., Lorenzi, P. L., Marszalek, J., Heffernan, T., Draetta, G., Jones, P., Futreal, A., Nomie, K., Wang, L. & Wang, M., Jan 1 2019, In : Science Translational Medicine. 11, 491, eaau1167.

Research output: Contribution to journalArticle

Mantle-Cell Lymphoma
Oxidative Phosphorylation
Neoplasms
Metabolic Networks and Pathways
Electron Transport Complex I
4 Citations (Scopus)

p53 Is a Master Regulator of Proteostasis in SMARCB1-Deficient Malignant Rhabdoid Tumors

Carugo, A., Minelli, R., Sapio, L., Soeung, M., Carbone, F., Robinson, F. S., Tepper, J., Chen, Z., Lovisa, S., Svelto, M., Amin, S., Srinivasan, S., Del Poggetto, E., Loponte, S., Puca, F., Dey, P., Malouf, G. G., Su, X., Li, L., Lopez-Terrada, D. & 16 others, Rakheja, D., Lazar, A. J., Netto, G. J., Rao, P., Sgambato, A., Maitra, A., Tripathi, D. N., Walker, C. L., Karam, J. A., Heffernan, T. P., Viale, A., Roberts, C. W. M., Msaouel, P., Tannir, N. M., Draetta, G. F. & Genovese, G., Feb 11 2019, In : Cancer cell. 35, 2, p. 204-220.e9

Research output: Contribution to journalArticle

Rhabdoid Tumor
Unfolded Protein Response
Drug Repositioning
Neoplasms
Chromatin Assembly and Disassembly
1 Citation (Scopus)

Pooled library screening with multiplexed Cpf1 library

Liu, J., Srinivasan, S., Li, C. Y., Ho, I. L., Rose, J., Shaheen, M. A., Wang, G., Yao, W., Deem, A., Bristow, C., Hart, T. & Draetta, G., Dec 1 2019, In : Nature communications. 10, 1, 3144.

Research output: Contribution to journalArticle

Open Access
Libraries
Screening
screening
Genes
Clustered Regularly Interspaced Short Palindromic Repeats
1 Citation (Scopus)

Predictive signatures inform the effective repurposing of decitabine to treat KRAS-dependent pancreatic ductal adenocarcinoma

Mottini, C., Tomihara, H., Carrella, D., Lamolinara, A., Iezzi, M., Huang, J. K., Amoreo, C. A., Buglioni, S., Manni, I., Robinson, F. S., Minelli, R., Kang, Y., Fleming, J. B., Kim, M. P., Bristow, C. A., Trisciuoglio, D., Iuliano, A., Bufalo, D. D., Bernardo, D. D., Melisi, D. & 4 others, Draetta, G. F., Ciliberto, G., Carugo, A. & Cardone, L., Nov 1 2019, In : Cancer research. 79, 21, p. 5612-5625 14 p.

Research output: Contribution to journalArticle

Open Access
decitabine
Adenocarcinoma
Pancreatic Neoplasms
Drug Repositioning
Neoplasms
6 Citations (Scopus)

Pre-existing Functional Heterogeneity of Tumorigenic Compartment as the Origin of Chemoresistance in Pancreatic Tumors

Seth, S., Li, C. Y., Ho, I. L., Corti, D., Loponte, S., Sapio, L., Del Poggetto, E., Yen, E. Y., Robinson, F. S., Peoples, M., Karpinets, T., Deem, A. K., Kumar, T., Song, X., Jiang, S., Kang, Y., Fleming, J., Kim, M., Zhang, J., Maitra, A. & 7 others, Heffernan, T. P., Giuliani, V., Genovese, G., Futreal, A., Draetta, G. F., Carugo, A. & Viale, A., Feb 5 2019, In : Cell Reports. 26, 6, p. 1518-1532.e9

Research output: Contribution to journalArticle

Open Access
Tumors
Neoplasms
gemcitabine
Bearings (structural)
Cells
2018
71 Citations (Scopus)

An inhibitor of oxidative phosphorylation exploits cancer vulnerability

Molina, J. R., Sun, Y., Protopopova, M., Gera, S., Bandi, M., Bristow, C., McAfoos, T., Morlacchi, P., Ackroyd, J., Agip, A. N. A., Al-Atrash, G., Asara, J., Bardenhagen, J., Carrillo, C. C., Carroll, C., Chang, E., Ciurea, S., Cross, J. B., Czako, B., Deem, A. & 46 others, Daver, N., De Groot, J. F., Dong, J. W., Feng, N., Gao, G., Gay, J., Do, M. G., Greer, J., Giuliani, V., Han, J., Han, L., Henry, V. K., Hirst, J., Huang, S., Jiang, Y., Kang, Z., Khor, T., Konoplev, S., Lin, Y. H., Liu, G., Lodi, A., Lofton, T., Ma, H., Mahendra, M., Matre, P., Mullinax, R., Peoples, M., Petrocchi, A., Rodriguez-Canale, J., Serreli, R., Shi, T., Smith, M., Tabe, Y., Theroff, J., Tiziani, S., Xu, Q., Zhang, Q., Muller, F., Depinho, R. A., Toniatti, C., Draetta, G. F., Heffernan, T. P., Konopleva, M., Jones, P., Di Francesco, M. E. & Marszalek, J. R., Jul 1 2018, In : Nature medicine. 24, 7, p. 1036-1046 11 p.

Research output: Contribution to journalArticle

Oxidative Phosphorylation
Tumors
Acute Myeloid Leukemia
Brain Neoplasms
Brain
1 Citation (Scopus)

Collapsing the tumor ecosystem: Preventing adaptive response to treatment by inhibiting transcription

Carugo, A. & Draetta, G. F., Jan 2018, In : Cancer discovery. 8, 1, p. 17-19 3 p.

Research output: Contribution to journalArticle

Ecosystem
Genetic Therapy
Neoplasms
Therapeutics
Pharmaceutical Preparations
10 Citations (Scopus)

High-resolution clonal mapping of multi-organ metastasis in triple negative breast cancer

Echeverria, G. V., Powell, E., Seth, S., Ge, Z., Carugo, A., Bristow, C., Peoples, M., Robinson, F., Qiu, H., Shao, J., Jeter-Jones, S. L., Zhang, X., Ramamoorthy, V., Cai, S., Wu, W., Draetta, G., Moulder, S. L., Symmans, W. F., Chang, J. T., Heffernan, T. P. & 1 others, Piwnica-Worms, H., Dec 1 2018, In : Nature communications. 9, 1, 5079.

Research output: Contribution to journalArticle

Triple Negative Breast Neoplasms
metastasis
breast
organs
Tumors
2017
11 Citations (Scopus)

EZH2 modifies sunitinib resistance in renal cell carcinoma by kinome reprogramming

Adelaiye-Ogala, R., Budka, J., Damayanti, N. P., Arrington, J., Ferris, M., Hsu, C. C., Chintala, S., Orillion, A., Miles, K. M., Shen, L., Elbanna, M., Ciamporcero, E., Arisa, S., Pettazzoni, P., Draetta, G. F., Seshadri, M., Hancock, B., Radovich, M., Kota, J., Buck, M. & 9 others, Keilhack, H., McCarthy, B. P., Persohn, S. A., Territo, P. R., Zang, Y., Irudayaraj, J., Tao, W. A., Hollenhorst, P. & Pili, R., Dec 1 2017, In : Cancer research. 77, 23, p. 6651-6666 16 p.

Research output: Contribution to journalArticle

Renal Cell Carcinoma
Receptor Protein-Tyrosine Kinases
Transferases
Drug Resistance
Heterografts
69 Citations (Scopus)

Genomic deletion of malic enzyme 2 confers collateral lethality in pancreatic cancer

Dey, P., Baddour, J., Muller, F., Wu, C. C., Wang, H., Liao, W. T., Lan, Z., Chen, A., Gutschner, T., Kang, Y., Fleming, J., Satani, N., Zhao, D., Achreja, A., Yang, L., Lee, J., Chang, E., Genovese, G., Viale, A., Ying, H. & 5 others, Draetta, G., Maitra, A., Wang, Y. A., Nagrath, D. & Depinho, R. A., Feb 2 2017, In : Nature. 542, 7639, p. 119-123 5 p.

Research output: Contribution to journalArticle

Pancreatic Neoplasms
Enzymes
NADP
Reactive Oxygen Species
Adenocarcinoma
31 Citations (Scopus)

ILF2 Is a Regulator of RNA Splicing and DNA Damage Response in 1q21-Amplified Multiple Myeloma

Marchesini, M., Ogoti, Y., Fiorini, E., Aktas Samur, A., Nezi, L., D'Anca, M., Storti, P., Samur, M. K., Ganan Gomez, I., Fulciniti, M. T., Mistry, N., Jiang, S., Bao, N., Marchica, V., Neri, A., Bueso-Ramos, C. E., Wu, C. J., Zhang, L., Liang, H., Peng, X. & 9 others, Giuliani, N., Draetta, G., Dwyer, K. C., Kantarjian, H. M., Munshi, N., Orlowski, R., Garcia-Manero, G., DePinho, R. A. & Colla, S., Jul 10 2017, In : Cancer cell. 32, 1, p. 88-100.e6

Research output: Contribution to journalArticle

RNA Splicing
Multiple Myeloma
DNA Damage
Disease Resistance
Genomic Instability
15 Citations (Scopus)

PRKCI promotes immune suppression in ovarian cancer

Sarkar, S., Bristow, C. A., Dey, P., Rai, K., Perets, R., Ramirez-Cardenas, A., Malasi, S., Huang-Hobbs, E., Haemmerle, M., Wu, S. Y., McGuire, M., Protopopov, A., Jiang, S., Liu, J. F., Hirsch, M. S., Chang, Q., Lazar, A. J., Sood, A. K., Drapkin, R., DePinho, R. & 2 others, Draetta, G. & Chin, L., Jan 1 2017, In : Genes and Development. 31, 11, p. 1109-1121 13 p.

Research output: Contribution to journalArticle

Ovarian Neoplasms
T-Lymphocytes
Tumor Microenvironment
Fallopian Tubes
Carcinoma in Situ
30 Citations (Scopus)

Synthetic vulnerabilities of mesenchymal subpopulations in pancreatic cancer

Genovese, G., Carugo, A., Tepper, J., Robinson, F. S., Li, L., Svelto, M., Nezi, L., Corti, D., Minelli, R., Pettazzoni, P., Gutschner, T., Wu, C. C., Seth, S., Akdemir, K. C., Leo, E., Amin, S., Molin, M. D., Ying, H., Kwong, L. N., Colla, S. & 23 others, Takahashi, K., Ghosh, P., Giuliani, V., Muller, F., Dey, P., Jiang, S., Garvey, J., Liu, C. G., Zhang, J., Heffernan, T. P., Toniatti, C., Fleming, J. B., Goggins, M. G., Wood, L. D., Sgambato, A., Agaimy, A., Maitra, A., Roberts, C. W. M., Wang, H., Viale, A., DePinho, R. A., Draetta, G. F. & Chin, L., Feb 16 2017, In : Nature. 542, 7641, p. 362-366 5 p.

Research output: Contribution to journalArticle

Pancreatic Neoplasms
Adenocarcinoma
Endoplasmic Reticulum Stress
Neoplasms
Unfolded Protein Response
2016
38 Citations (Scopus)

Identification of potent and selective MTH1 inhibitors

Petrocchi, A., Leo, E., Reyna, N. J., Hamilton, M. M., Shi, X., Parker, C. A., Mseeh, F., Bardenhagen, J. P., Leonard, P., Cross, J. B., Huang, S., Jiang, Y., Cardozo, M., Draetta, G., Marszalek, J. R., Toniatti, C., Jones, P. & Lewis, R. T., Jan 1 2016, In : Bioorganic and Medicinal Chemistry Letters. 26, 6, p. 1503-1507 5 p.

Research output: Contribution to journalArticle

Oncology
Microsomes
Permeability
2-aminopyrimidine
34 Citations (Scopus)

In Vivo Functional Platform Targeting Patient-Derived Xenografts Identifies WDR5-Myc Association as a Critical Determinant of Pancreatic Cancer

Carugo, A., Genovese, G., Seth, S., Nezi, L., Rose, J. L., Bossi, D., Cicalese, A., Shah, P. K., Viale, A., Pettazzoni, P. F., Akdemir, K. C., Bristow, C. A., Robinson, F. S., Tepper, J., Sanchez, N., Gupta, S., Estecio, M. R., Giuliani, V., Dellino, G. I., Riva, L. & 16 others, Yao, W., Di Francesco, M. E., Green, T., D'Alesio, C., Corti, D., Kang, Y., Jones, P., Wang, H., Fleming, J. B., Maitra, A., Pelicci, P. G., Chin, L., DePinho, R. A., Lanfrancone, L., Heffernan, T. P. & Draetta, G. F., Jun 1 2016, In : Cell Reports. 16, 1, p. 133-147 15 p.

Research output: Contribution to journalArticle

Pancreatic Neoplasms
Heterografts
Tumors
Adenocarcinoma
Methyltransferases
20 Citations (Scopus)

In Vivo genetic screens of patient-derived tumors revealed unexpected frailty of the transformed phenotype

Bossi, D., Cicalese, A., Dellino, G. I., Luzi, L., Riva, L., D’Alesio, C., Diaferia, G. R., Carugo, A., Cavallaro, E., Piccioni, R., Barberis, M., Mazzarol, G., Testori, A., Punzi, S., Pallavicini, I., Tosti, G., Giacó, L., Melloni, G., Heffernan, T. P., Natoli, G. & 4 others, Draetta, G. F., Minucci, S., Pelicci, P. & Lanfrancone, L., Jun 2016, In : Cancer discovery. 6, 6, p. 650-663 14 p.

Research output: Contribution to journalArticle

Phenotype
Neoplasms
Genes
Neoplasm Genes
Growth
82 Citations (Scopus)

Post-translational Regulation of Cas9 during G1 Enhances Homology-Directed Repair

Gutschner, T., Haemmerle, M., Genovese, G., Draetta, G. F. & Chin, L., Feb 16 2016, In : Cell Reports. 14, 6, p. 1555-1566 12 p.

Research output: Contribution to journalArticle

Cell Cycle
Repair
Geminin
Clustered Regularly Interspaced Short Palindromic Repeats
Protein Engineering
61 Citations (Scopus)

Structure-Guided Design of IACS-9571, a Selective High-Affinity Dual TRIM24-BRPF1 Bromodomain Inhibitor

Palmer, W. S., Poncet-Montange, G., Liu, G., Petrocchi, A., Reyna, N., Subramanian, G., Theroff, J., Yau, A., Kost-Alimova, M., Bardenhagen, J. P., Leo, E., Shepard, H. E., Tieu, T. N., Shi, X., Zhan, Y., Zhao, S., Barton, M. C., Draetta, G., Toniatti, C., Jones, P. & 2 others, Geck Do, M. & Andersen, J. N., Feb 25 2016, In : Journal of Medicinal Chemistry. 59, 4, p. 1440-1454 15 p.

Research output: Contribution to journalArticle

Leukemia
Proteins
Histone Acetyltransferases
Zinc Fingers
Gene Expression Regulation
2015
14 Citations (Scopus)

Development of novel cellular histone-binding and chromatin-displacement assays for bromodomain drug discovery

Zhan, Y., Kost-Alimova, M., Shi, X., Leo, E., Bardenhagen, J. P., Shepard, H. E., Appikonda, S., Vangamudi, B., Zhao, S., Tieu, T. N., Jiang, S., Heffernan, T. P., Marszalek, J. R., Toniatti, C., Draetta, G., Tyler, J., Barton, M., Jones, P., Palmer, W. S., Geck Do, M. K. & 1 others, Andersen, J. N., Sep 21 2015, In : Epigenetics and Chromatin. 8, 1, 37.

Research output: Contribution to journalArticle

Drug Discovery
Histones
Chromatin
Proteins
Epigenomics
37 Citations (Scopus)

Genetic events that limit the efficacy of MEK and RTK inhibitor therapies in a mouse model of KRAS-driven pancreatic cancer

Pettazzoni, P., Viale, A., Shah, P., Carugo, A., Ying, H., Wang, H., Genovese, G., Seth, S., Minelli, R., Green, T., Huang-Hobbs, E., Corti, D., Sanchez, N., Nezi, L., Marchesini, M., Kapoor, A., Yao, W., Di Francesco, M. E., Petrocchi, A., Deem, A. K. & 9 others, Scott, K., Colla, S., Mills, G. B., Fleming, J. B., Heffernan, T. P., Jones, P., Toniatti, C., Depinho, R. A. & Draetta, G. F., Mar 15 2015, In : Cancer research. 75, 6, p. 1091-1101 11 p.

Research output: Contribution to journalArticle

Mitogen-Activated Protein Kinase Kinases
Receptor Protein-Tyrosine Kinases
Pancreatic Neoplasms
Adenocarcinoma
Apoptosis
9 Citations (Scopus)

Redox-Mediated Suberoylanilide Hydroxamic Acid Sensitivity in Breast Cancer

Chiaradonna, F., Barozzi, I., Miccolo, C., Bucci, G., Palorini, R., Fornasari, L., Botrugno, O. A., Pruneri, G., Masullo, M., Passafaro, A., Galimberti, V. E., Fantin, V. R., Richon, V. M., Pece, S., Viale, G., Di Fiore, P. P., Draetta, G., Pelicci, P. G., Minucci, S. & Chiocca, S., Jul 1 2015, In : Antioxidants and Redox Signaling. 23, 1, p. 15-29 15 p.

Research output: Contribution to journalArticle

Oxidation-Reduction
Tumors
Cells
Breast Neoplasms
Genes
87 Citations (Scopus)

The SMARCA2/4 ATPase domain surpasses the bromodomain as a drug target in SWI/SNF-mutant cancers: Insights from cDNA rescue and PFI-3 inhibitor studies

Vangamudi, B., Paul, T. A., Shah, P. K., Kost-Alimova, M., Nottebaum, L., Shi, X., Zhan, Y., Leo, E., Mahadeshwar, H. S., Protopopov, A., Futreal, A., Tieu, T. N., Peoples, M., Heffernan, T. P., Marszalek, J. R., Toniatti, C., Petrocchi, A., Verhelle, D., Owen, D. R., Draetta, G. & 4 others, Jones, P., Palmer, W. S., Sharma, S. & Andersen, J. N., Sep 15 2015, In : Cancer research. 75, 18, p. 3865-3878 14 p.

Research output: Contribution to journalArticle

Adenosine Triphosphatases
Complementary DNA
Chromatin
Pharmaceutical Preparations
Neoplasms
2014
441 Citations (Scopus)

Oncogene ablation-resistant pancreatic cancer cells depend on mitochondrial function

Viale, A., Pettazzoni, P., Lyssiotis, C. A., Ying, H., Sánchez, N., Marchesini, M., Carugo, A., Green, T., Seth, S., Giuliani, V., Kost-Alimova, M., Muller, F., Colla, S., Nezi, L., Genovese, G., Deem, A. K., Kapoor, A., Yao, W., Brunetto, E., Kang, Y. & 10 others, Yuan, M., Asara, J. M., Wang, Y. A., Heffernan, T. P., Kimmelman, A. C., Wang, H., Fleming, J. B., Cantley, L. C., DePinho, R. A. & Draetta, G. F., Oct 30 2014, In : Nature. 514, 7524, p. 628-632 5 p.

Research output: Contribution to journalArticle

Pancreatic Neoplasms
Oncogenes
Neoplasms
Adenocarcinoma
Oxidative Phosphorylation
28 Citations (Scopus)

Oncology drug discovery: Planning a turnaround

Toniatti, C., Jones, P., Graham, H., Pagliara, B. & Draetta, G., Jan 1 2014, In : Cancer discovery. 4, 4, p. 397-404 8 p.

Research output: Contribution to journalArticle

Drug Discovery
Drug Approval
Drug Evaluation
Cytotoxins
Therapeutics
289 Citations (Scopus)

Yap1 activation enables bypass of oncogenic KRAS addiction in pancreatic cancer

Kapoor, A., Yao, W., Ying, H., Hua, S., Liewen, A., Wang, Q., Zhong, Y., Wu, C. J., Sadanandam, A., Hu, B., Chang, Q., Chu, G. C., Al-Khalil, R., Jiang, S., Xia, H., Fletcher-Sananikone, E., Lim, C., Horwitz, G. I., Viale, A., Pettazzoni, P. & 10 others, Sanchez, N., Wang, H., Protopopov, A., Zhang, J., Heffernan, T., Johnson, R. L., Chin, L., Wang, Y. A., Draetta, G. & Depinho, R. A., Jul 3 2014, In : Cell. 158, 1, p. 185-197 13 p.

Research output: Contribution to journalArticle

Pancreatic Neoplasms
Tumors
Adenocarcinoma
Chemical activation
E2F Transcription Factors
2012
18 Citations (Scopus)

Investigative pathology: Leading the post-genomic revolution

Berman, D. M., Bosenberg, M. W., Orwant, R. L., Thurberg, B. L., Draetta, G., Fletcher, C. D. M. & Loda, M., Jan 1 2012, In : Laboratory Investigation. 92, 1, p. 4-8 5 p.

Research output: Contribution to journalArticle

Pathology
Genome
Human Genome Project
Technology
Precision Medicine
2011
26 Citations (Scopus)

PDK1 attenuation fails to prevent tumor formation in PTEN-deficient transgenic mouse models

Ellwood-Yen, K., Keilhack, H., Kunii, K., Dolinski, B., Connor, Y., Hu, K., Nagashima, K., O'Hare, E., Erkul, Y., Di Bacco, A., Gargano, D., Shomer, N. H., Angagaw, M., Leccese, E., Andrade, P., Hurd, M., Shin, M. K., Vogt, T. F., Northrup, A., Bobkova, E. V. & 9 others, Kasibhatla, S., Bronson, R. T., Scott, M. L., Draetta, G., Richon, V., Kohl, N., Blume-Jensen, P., Andersen, J. N. & Kraus, M., Apr 15 2011, In : Cancer research. 71, 8, p. 3052-3065 14 p.

Research output: Contribution to journalArticle

Phosphatidylinositol 3-Kinases
Transgenic Mice
Phenotype
Doxycycline
Hyperinsulinism
2010
70 Citations (Scopus)

Downregulation of Notch pathway by a γ-secretase inhibitor attenuates akt/mammalian target of rapamycin signaling and glucose uptake in an ERBB2 transgenic breast cancer model

Efferson, C. L., Winkelmann, C. T., Ware, C., Sullivan, T., Giampaoli, S., Tammam, J., Patel, S., Mesiti, G., Reilly, J. F., Gibson, R. E., Buser, C., Yeatman, T., Coppola, D., Winter, C., Clark, E. A., Draetta, G. F., Strack, P. R. & Majumder, P. K., Mar 15 2010, In : Cancer research. 70, 6, p. 2476-2484 9 p.

Research output: Contribution to journalArticle

Amyloid Precursor Protein Secretases
Sirolimus
Down-Regulation
Breast Neoplasms
Glucose
132 Citations (Scopus)

Met activation in non-small cell lung cancer is associated with de novo resistance to EGFR inhibitors and the development of brain metastasis

Benedettini, E., Sholl, L. M., Peyton, M., Reilly, J., Ware, C., Davis, L., Vena, N., Bailey, D., Yeap, B. Y., Fiorentino, M., Ligon, A. H., Pan, B. S., Richon, V., Minna, J. D., Gazdar, A. F., Draetta, G., Bosari, S., Chirieac, L. R., Lutterbach, B. & Loda, M., Jul 2010, In : American Journal of Pathology. 177, 1, p. 415-423 9 p.

Research output: Contribution to journalArticle

Epidermal Growth Factor Receptor
Non-Small Cell Lung Carcinoma
Neoplasm Metastasis
Brain
Protein-Tyrosine Kinases
2009
62 Citations (Scopus)

Down-regulation of the NOTCH pathway mediated by a y-secretase inhibitor induces anti-tumour effects in mouse models of T-cell leukaemia

Tammam, J., Ware, C., Efferson, C., O'Neil, J., Rao, S., Qu, X., Gorenstein, J., Angagaw, M., Kim, H., Kenific, C., Kunii, K., Leach, K. J., Nikov, G., Zhao, J., Dai, X., Hardwick, J., Scott, M., Winter, C., Bristow, L., Elbi, C. & 7 others, Reilly, J. F., Look, T., Draetta, G., Van Der Ploeg, L. H. T., Kohl, N. E., Strack, P. R. & Majumder, P. K., Jan 1 2009, In : British Journal of Pharmacology. 158, 5, p. 1183-1195 13 p.

Research output: Contribution to journalArticle

T-Cell Leukemia
Amyloid Precursor Protein Secretases
Down-Regulation
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
Neoplasms
100 Citations (Scopus)

Inhibition of NOTCH signaling by gamma secretase inhibitor engages the RB pathway and elicits cell cycle exit in T-cell acute lymphoblastic leukemia cells

Rao, S. S., O'Neil, J., Liberator, C. D., Hardwick, J. S., Xudong, D., Zhang, T., Tyminski, E., Yuan, J., Kohl, N. E., Richon, V. M., Van Der Ploeg, L. H. T., Carroll, P. M., Draetta, G. F., Look, A. T., Strack, P. R. & Winter, C. G., Apr 1 2009, In : Cancer research. 69, 7, p. 3060-3068 9 p.

Research output: Contribution to journalArticle

Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
Amyloid Precursor Protein Secretases
Cell Cycle
Mutation
Cyclin-Dependent Kinases
2007
105 Citations (Scopus)

Apoptosis in T Cell Acute Lymphoblastic Leukemia Cells after Cell Cycle Arrest Induced by Pharmacological Inhibition of Notch Signaling

Lewis, H. D., Leveridge, M., Strack, P. R., Haldon, C. D., O'Neil, J., Kim, H., Madin, A., Hannam, J. C., Look, A. T., Kohl, N., Draetta, G., Harrison, T., Kerby, JA. A., Shearman, M. S. & Beher, D., Feb 1 2007, In : Chemistry and Biology. 14, 2, p. 209-219 11 p.

Research output: Contribution to journalArticle

Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
Amyloid Precursor Protein Secretases
T-cells
Cell Cycle Checkpoints
Cells
448 Citations (Scopus)

FBW7 mutations in leukemic cells mediate NOTCH pathway activation and resistance to γ-secretase inhibitors

O'Neil, J., Grim, J., Strack, P., Rao, S., Tibbitts, D., Winter, C., Hardwick, J., Welcker, M., Meijerink, J. P., Pieters, R., Draetta, G., Sears, R., Clurman, B. E. & Look, A. T., Aug 6 2007, In : Journal of Experimental Medicine. 204, 8, p. 1813-1824 12 p.

Research output: Contribution to journalArticle

Amyloid Precursor Protein Secretases
Mutation
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
Cell Line
T-Cell Leukemia
177 Citations (Scopus)

Role for histone deacetylase 1 in human tumor cell proliferation

Senese, S., Zaragoza, K., Minardi, S., Muradore, I., Ronzoni, S., Passafaro, A., Bernard, L., Draetta, G. F., Alcalay, M., Seiser, C. & Chiocca, S., Jul 1 2007, In : Molecular and cellular biology. 27, 13, p. 4784-4795 12 p.

Research output: Contribution to journalArticle

Histone Deacetylases
Cell Proliferation
Neoplasms
Histones
Cell Cycle
313 Citations (Scopus)

SCFFbxl3 controls the oscillation of the circadian clock by directing the degradation of cryptochrome proteins

Busino, L., Bassermann, F., Maiolica, A., Lee, C., Nolan, P. M., Godinho, S. I. H., Draetta, G. F. & Pagano, M., May 11 2007, In : Science. 316, 5826, p. 900-904 5 p.

Research output: Contribution to journalArticle

Cryptochromes
Circadian Clocks
Ubiquitinated Proteins
Ligases
Ubiquitin
2006
57 Citations (Scopus)

Ebp1 is a dsRNA-binding protein associated with ribosomes that modulates eIF2α phosphorylation

Squatrito, M., Mancino, M., Sala, L. & Draetta, G., Jun 9 2006, In : Biochemical and biophysical research communications. 344, 3, p. 859-868 10 p.

Research output: Contribution to journalArticle

Eukaryotic Initiation Factor-2
Phosphorylation
Ribosomes
Carrier Proteins
eIF-2 Kinase
88 Citations (Scopus)

Frequent alterations in the expression of serine/threonine kinases in human cancers

Capra, M., Nuciforo, P. G., Confalonieri, S., Quarto, M., Bianchi, M., Nebuloni, M., Boldorini, R., Pallotti, F., Viale, G., Gishizky, M. L., Draetta, G. F. & Di Fiore, P. P., Aug 15 2006, In : Cancer research. 66, 16, p. 8147-8154 8 p.

Research output: Contribution to journalArticle

Protein-Serine-Threonine Kinases
Phosphotransferases
Neoplasms
Protein Kinases
Protein-Tyrosine Kinases
2005
41 Citations (Scopus)

Transforming growth factor β facilitates β-TrCP-mediated degradation of Cdc25A in a Smad3-dependent manner

Ray, D., Terao, Y., Nimbalkar, D., Chu, L. H., Donzelli, M., Tsutsui, T., Zou, X., Ghosh, A. K., Varga, J., Draetta, G. F. & Kiyokawa, H., Apr 1 2005, In : Molecular and cellular biology. 25, 8, p. 3338-3347 10 p.

Research output: Contribution to journalArticle

Transforming Growth Factors
Ubiquitination
Small Interfering RNA
Mutant Proteins
Ubiquitin
2004
131 Citations (Scopus)

A mechanism for inhibiting the SUMO pathway

Boggio, R., Colombo, R., Hay, R. T., Draetta, G. F. & Chiocca, S., Nov 19 2004, In : Molecular cell. 16, 4, p. 549-561 13 p.

Research output: Contribution to journalArticle

Sumoylation
Biochemical Phenomena
Enzyme Activation
Ubiquitin-Protein Ligases
Transcriptional Activation
11 Citations (Scopus)

Characterization of the BUD31 gene of Saccharomyces cerevisiae

Masciadri, B., Areces, L. B., Carpinelli, P., Foiani, M., Draetta, G. F. & Fiore, F., Aug 6 2004, In : Biochemical and biophysical research communications. 320, 4, p. 1342-1350 9 p.

Research output: Contribution to journalArticle

Yeast
Saccharomyces cerevisiae
Genes
Yeasts
Phenotype
95 Citations (Scopus)

EBP1 is a nucleolar growth-regulating protein that is part of pre-ribosomal ribonucleoprotein complexes

Squatrito, M., Mancino, M., Donzelli, M., Areces, L. B. & Draetta, G. F., May 27 2004, In : Oncogene. 23, 25, p. 4454-4465 12 p.

Research output: Contribution to journalArticle

Ribonucleoproteins
Ribosomes
ErbB-3 Receptor
Growth
Cell Proliferation
29 Citations (Scopus)

Hierarchical order of phosphorylation events commits Cdc25A to βTrCP-dependent degradation

Donzelli, M., Busino, L., Chiesa, M., Ganoth, D., Hershko, A. & Draetta, G., 2004, In : Cell Cycle. 3, 4, p. 469-471 3 p.

Research output: Contribution to journalArticle

Phosphorylation
Sequence Homology
S Phase
DNA Damage
Proteins
2003
324 Citations (Scopus)

Degradation of Cdc25A by β-TrCP during S phase and in response to DNA damage

Busino, L., Donzelli, M., Chiesa, M., Guardavaccaro, D., Ganoth, D., Dorrello, N. V., Hershko, A., Pagano, M. & Draetta, G. F., Nov 6 2003, In : Nature. 426, 6962, p. 87-91 5 p.

Research output: Contribution to journalArticle

S Phase Cell Cycle Checkpoints
S Phase
DNA Damage
F-Box Proteins
Cell Cycle
10 Citations (Scopus)

Modulation of p120E4F transcriptional activity by the Gam1 adenoviral early protein

Colombo, R., Draetta, G. F. & Chiocca, S., May 1 2003, In : Oncogene. 22, 17, p. 2541-2547 7 p.

Research output: Contribution to journalArticle

trichostatin A
Transcription Factors
Histone Deacetylase Inhibitors
Adenoviridae
Histones
2002
149 Citations (Scopus)

Dual mode of degradation of Cdc25 A phosphatase

Donzelli, M., Squatrito, M., Ganoth, D., Hershko, A., Pagano, M. & Draetta, G. F., Sep 16 2002, In : EMBO Journal. 21, 18, p. 4875-4884 10 p.

Research output: Contribution to journalArticle

cdc25 Phosphatases
Cullin Proteins
Interphase
Phosphoric Monoester Hydrolases
Cell Cycle
35 Citations (Scopus)

Histone deacetylase 1 inactivation by an adenovirus early gene product

Chiocca, S., Kurtev, V., Colombo, R., Boggio, R., Sciurpi, M. T., Brosch, G., Seiser, C., Draetta, G. F. & Cotten, M., Apr 2 2002, In : Current Biology. 12, 7, p. 594-598 5 p.

Research output: Contribution to journalArticle

Histone Deacetylase 1
histone deacetylase
Adenoviridae
Transcription
Viruses
71 Citations (Scopus)

The adenovirus protein Gam1 interferes with sumoylation of histone deacetylase 1

Colombo, R., Boggio, R., Seiser, C., Draetta, G. F. & Chiocca, S., Nov 1 2002, In : EMBO reports. 3, 11, p. 1062-1068 7 p.

Research output: Contribution to journalArticle

Histone Deacetylase 1
Sumoylation
Adenoviridae
Proteins
Genes
2001
239 Citations (Scopus)

p27 cytoplasmic localization is regulated by phosphorylation on Ser10 and is not a prerequisite for its proteolysis

Rodier, G., Montagnoli, A., Di Marcotullio, L., Coulombe, P., Draetta, G. F., Pagano, M. & Meloche, S., Dec 3 2001, In : EMBO Journal. 20, 23, p. 6672-6682 11 p.

Research output: Contribution to journalArticle

Cyclin-Dependent Kinase 2
Proteolysis
Phosphorylation
Chemical activation
Cyclin-Dependent Kinase Inhibitor p27
109 Citations (Scopus)

Ras-GAP SH3 domain binding protein (G3BP) is a modulator of USP10, a novel human ubiquitin specific protease

Soncini, C., Berdo, I. & Draetta, G., Jan 1 2001, In : Oncogene. 20, 29, p. 3869-3879 11 p.

Research output: Contribution to journalArticle

ras GTPase-Activating Proteins
Ubiquitin-Specific Proteases
src Homology Domains
Ubiquitin
Carrier Proteins