Guillermo Garcia-Manero

1991

LA REACCION EN CADENA DE LA DNA-POLIMERASA (RPC): UNA NUEVA TECNICA DE ANALISIS MOLECULAR PARA EL ESTUDIO DEL CANCER

Translated title of the contribution: 'In vitro' effects of several agents in transplantable melanomasGarcia-Manero, G., Domine, M., Delgado, C., Cunningham, J. M. & Francis, G. E., 1991, In: Oncologia. 14, 11, p. 501-516 16 p.

Research output: Contribution to journal › Review article › peer-review

1992

DAUNOMICINA INHIBE LA ACTIVIDAD DE ENCADENAMIENTO DE LA ENZIMA DNA-TOPOISOMERASA II EN UN SISTEMA IN VITRO

Translated title of the contribution: Daunomizine, inhibits the catenation activity of DNA-topoisomerase II in an 'in vitro' systemGarcia-Manero, G. & Domine, M., 1992, In: Oncologia. 15, 7, p. 305-310 6 p.

Research output: Contribution to journal › Article › peer-review

1997

Colocalization of tissue transglutaminase and stress fibers in human vascular smooth muscle cells and human umbilical vein endothelial cells

Chowdhury, Z. A., Barsigian, C., Chalupowicz, G. D., Bach, T. L., Garcia-Manero, G. & Martinez, J., Feb 25 1997, In: Experimental Cell Research. 231, 1, p. 38-49 12 p.

Research output: Contribution to journal › Article › peer-review

45 Scopus citations

Does lymph node dissection still have a role in cancer therapy?

Sorensen, S. C., Garcia-Manero, G., Mastrangelo, M. J., Soltan, A., Friedland, D. M., Ruiz-Arguelles, G. J. & Gomez-Almaguer, D., 1997, In: Seminars in oncology. 24, 3, p. 33-34+39+41

Research output: Contribution to journal › Article › peer-review

1999

Pulmonary hypertension in patients with myelofibrosis secondary to myeloproliferative diseases

García-Manero, G., Schuster, S. J., Patrick, H. & Martinez, J., 1999, In: American journal of hematology. 60, 2, p. 130-135 6 p.

Research output: Contribution to journal › Article › peer-review

Open Access

79 Scopus citations

Should autologous or allogeneic stem-cell therapy be a part of consolidation therapy for all cases of adult acute myelogenous leukemia?

Garcia-Manero, G., Schuster, S. J., Agha, M. E. & Friedland, D. M., 1999, In: Seminars in oncology. 26, 1, p. xvi-xvii+xxi/xxii

Research output: Contribution to journal › Review article › peer-review

2000

The hyper-CVAD regimen in adult acute lymphocytic leukemia

Garcia-Manero, G. & Kantarjian, H. M., 2000, In: Hematology/Oncology Clinics of North America. 14, 6, p. 1381-1396 16 p.

Research output: Contribution to journal › Article › peer-review

54 Scopus citations

2001

Chromosomal abnormalities in chronic lymphocytic leukemia [3]

Garcia-Manero, G., Döhner, H., Stilgenbauer, S. & Lichter, P., Apr 19 2001, In: New England Journal of Medicine. 344, 16, p. 1254-1255 2 p.

Research output: Contribution to journal › Letter › peer-review

2 Scopus citations

Mylotarg™ (gemtuzumab ozogamicin) therapy is associated with hepatic venoocclusive disease in patients who have not received stem cell transplantation

Giles, F. J., Kantarjian, H. M., Kornblau, S. M., Thomas, D. A., Garcia-Manero, G., Waddelow, T. A., David, C. L., Phan, A. T., Colburn, D. E., Rashid, A. & Estey, E. H., Jul 15 2001, In: Cancer. 92, 2, p. 406-413 8 p.

Research output: Contribution to journal › Article › peer-review

247 Scopus citations

Phase I study of Irofulven (MGI 114), an acylfulvene illudin analog, in patients with acute leukemia

Giles, F., Cortes, J., Garcia-Manero, G., Kornblau, S., Estey, E., Kwari, M., Murgo, A. & Kantarjian, H., 2001, In: Investigational New Drugs. 19, 1, p. 13-20 8 p.

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Salvage therapy for refractory or relapsed acute lymphocytic leukemia

Garcia-Manero, G. & Thomas, D. A., 2001, In: Hematology/Oncology Clinics of North America. 15, 1, p. 163-205 43 p.

Research output: Contribution to journal › Article › peer-review

68 Scopus citations

2002

A phase I study of idarubicin dose escalation with amifostine and high-dose cytarabine in patients with relapsed acute myelogenous leukemia and myelodysplastic syndromes

Garcia-Manero, G., Faderl, S., Giles, F., Thomas, D., Cortes, J., O'Brien, S., Davis, J., Kantarjian, H. M. & Estey, E., 2002, In: Haematologica. 87, 8, p. 804-807 4 p.

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Current therapy of chronic myelogenous leukemia

Garcia-Manero, G., Talpaz, M. & Kantarjian, H. M., 2002, In: Internal Medicine. 41, 4, p. 254-264 11 p.

Research output: Contribution to journal › Review article › peer-review

Open Access

14 Scopus citations

DNA methylation of multiple promoter-associated CpG islands in adult acute lymphocytic leukemia

Garcia-Manero, G., Daniel, J., Smith, T. L., Kornblau, S. M., Lee, M. S., Kantarjian, H. M. & Issa, J. P. J., 2002, In: Clinical Cancer Research. 8, 7, p. 2217-2224 8 p.

Research output: Contribution to journal › Article › peer-review

182 Scopus citations

DNA methylation patterns at relapse in adult acute lymphocytic leukemia

Garcia-Manero, G., Bueso-Ramos, C., Daniel, J., Williamson, J., Kantarjian, H. M. & Issa, J. P. J., 2002, In: Clinical Cancer Research. 8, 6, p. 1897-1903 7 p.

Research output: Contribution to journal › Article › peer-review

65 Scopus citations

Expression profile of 11 proteins and their prognostic significance in patients with chronic lymphocytic leukemia (CLL)

Faderl, S., Keating, M. J., Do, K. A., Liang, S. Y., Kantarjian, H. M., O'Brien, S., Garcia-Manero, G., Manshouri, T. & Albitar, M., 2002, In: Leukemia. 16, 6, p. 1045-1052 8 p.

Research output: Contribution to journal › Review article › peer-review

102 Scopus citations

Fatal hepatic veno-occlusive disease in a phase I study of Mylotarg and Troxatyl in patients with refractory acute myeloid leukemia or myelodysplastic syndrome

Giles, F., Garcia-Manero, G., O'brien, S., Estey, E. & Kantarjian, H., 2002, In: Acta haematologica. 108, 3, p. 164-167 4 p.

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Imatinib mesylate (STI571) therapy for Philadelphia chromosome-positive chronic myelogenous leukemia in blast phase

Kantarjian, H. M., Cortes, J., O'Brien, S., Giles, F. J., Albitar, M., Rios, M. B., Shan, J., Faderl, S., Garcia-Manero, G., Thomas, D. A., Resta, D. & Talpaz, M., May 15 2002, In: Blood. 99, 10, p. 3547-3553 7 p.

Research output: Contribution to journal › Article › peer-review

Open Access

275 Scopus citations

Imatinib mesylate for Philadelphia chromosome-positive, chronic-phase myeloid leukemia after failure of interferon-α: Follow-up results

Kantarjian, H. M., Talpaz, M., O'Brien, S., Smith, T. L., Giles, F. J., Faderl, S., Thomas, D. A., Garcia-Manero, G., Issa, J. P. J., Andreeff, M., Kornblau, S. M., Koller, C., Beran, M., Keating, M., Rios, M. B., Shan, J., Resta, D., Capdeville, R., Hayes, K., Albitar, M., & 2 othersFreireich, E. J. & Cortes, J. E., 2002, In: Clinical Cancer Research. 8, 7, p. 2177-2187 11 p.

Research output: Contribution to journal › Article › peer-review

128 Scopus citations

Imatinib mesylate therapy for relapse after allogeneic stem cell transplantation for chronic myelogenous leukemia

Kantarjian, H. M., O'Brien, S., Cortes, J. E., Giralt, S. A., Rios, M. B., Shan, J., Giles, F. J., Thomas, D. A., Faderl, S., De Lima, M., Garcia-Manero, G., Champlin, R., Arlinghaus, R. & Talpaz, M., Sep 1 2002, In: Blood. 100, 5, p. 1590-1595 6 p.

Research output: Contribution to journal › Article › peer-review

Open Access

151 Scopus citations

Lack of p21^CIP1 DNA methylation in acute lymphocytic leukemia [2] (multiple letters)

Shen, L. L., Kondo, Y., Issa, J. P., Garcia-Manero, G., Roman-Gomez, J., Castillejo, J. A., Torres, A. & Jimenez, A., Nov 1 2002, In: Blood. 100, 9, p. 3432-3434 3 p.

Research output: Contribution to journal › Letter › peer-review

15 Scopus citations

Neutrophilic-chronic myeloid leukemia: Low levels of p230 BCR/ABL mRNA and undetectable p230 BCR/ABL protein may predict an indolent course

Verstovsek, S., Lin, H., Kantarjian, H., Saglio, G., De Micheli, D., Pane, F., Garcia-Manero, G., Intrieri, M., Rotoli, B., Salvatore, F., Guo, J. Q., Talpaz, M., Specchia, G., Pizzolo, G., Liberati, A. M., Cortes, J., Quackenbush, R. C. & Arlinghaus, R. B., May 1 2002, In: Cancer. 94, 9, p. 2416-2425 10 p.

Research output: Contribution to journal › Article › peer-review

60 Scopus citations

New investigational strategies in patients with myelodysplastic syndromes

Garcia-Manero, G. & Kantarjian, H. M., Jan 1 2002, The Myelodysplastic Syndromes: Pathobiology and Clinical Management. CRC Press, p. 399-420 22 p.

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Phase I and pharmacokinetic study of DX-8951f (exatecan mesylate), a hexacyclic camptothecin, on a daily-times-five schedule in patients with advanced leukemia

Giles, F. J., Cortes, J. E., Thomas, D. A., Garcia-Manero, G., Faderl, S., Jeha, S., De Jager, R. L. & Kantarjian, H. M., 2002, In: Clinical Cancer Research. 8, 7, p. 2134-2141 8 p.

Research output: Contribution to journal › Article › peer-review

25 Scopus citations

Phase II study of troxacitabine, a novel dioxolane nucleoside analog, in patients with refractory leukemia

Giles, F. J., Garcia-Manero, G., Cortes, J. E., Baker, S. D., Miller, C. B., O'Brien, S. M., Thomas, D. A., Andreeff, M., Bivins, C., Jolivet, J. & Kantarjian, H. M., Feb 1 2002, In: Journal of Clinical Oncology. 20, 3, p. 656-664 9 p.

Research output: Contribution to journal › Article › peer-review

73 Scopus citations

Philadelphia chromosome-positive acute lymphoblastic leukemia - Current concepts and future perspectives

Faderl, S., Garcia-Manero, G., Thomas, D. A. & Kantarjian, H. M., 2002, In: Reviews in Clinical and Experimental Hematology. 6, 2, p. 142-160 19 p.

Research output: Contribution to journal › Review article › peer-review

46 Scopus citations

Simultaneous homoharringtonine and interferon-α in the treatment of patients with chronic-phase chronic myelogenous leukemia

O'Brien, S., Talpaz, M., Cortes, J., Shan, J., Giles, F. J., Faderl, S., Thomas, D., Garcia-Manero, G., Mallard, S., BethRios, M., Koller, C., Kornblau, S., Andreeff, M., Murgo, A., Keating, M. & Kantarjian, H. M., Apr 1 2002, In: Cancer. 94, 7, p. 2024-2032 9 p.

Research output: Contribution to journal › Article › peer-review

60 Scopus citations

Therapy-related myelodysplastic syndrome or acute myelogenous leukemia in patients with acute promyelocytic leukemia (APL) [15]

Garcia-Manero, G., Kantarjian, H. M., Kornblau, S. & Estey, E., Sep 2002, In: Leukemia. 16, 9, p. 1888 1 p.

Research output: Contribution to journal › Letter › peer-review

30 Scopus citations

Treatment of Philadelphia chromosome-positive, accelerated-phase chronic myelogenous leukemia with imatinib mesylate

Kantarjian, H. M., O'Brien, S., Cortes, J. E., Smith, T. L., Rios, M. B., Shan, J., Yang, Y., Giles, F. J., Thomas, D. A., Faderl, S., Garcia-Manero, G., Jeha, S., Wierda, W., Issa, J. P. J., Kornblau, S. M., Keating, M., Resta, D., Capdeville, R. & Talpaz, M., 2002, In: Clinical Cancer Research. 8, 7, p. 2167-2176 10 p.

Research output: Contribution to journal › Article › peer-review

103 Scopus citations

Ursodiol does not prevent hepatic venoocclusive disease associated with Mylotarg therapy [4]

Giles, F., Garcia-Manero, G., Cortes, J., Thomas, D., Kantarjian, H. & Estey, E., Oct 2002, In: Haematologica. 87, 10, p. 1114-1116 3 p.

Research output: Contribution to journal › Letter › peer-review

21 Scopus citations

2003

Aberrant DNA methylation in pediatric patients with acute lymphocytic leukemia

Garcia-Manero, G., Jeha, S., Daniel, J., Williamson, J., Albitar, M., Kantarjian, H. M. & Issa, J. P. J., Feb 1 2003, In: Cancer. 97, 3, p. 695-702 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

56 Scopus citations

Aberrant DNA methylation of p57KIP2 identifies a cell-cycle regulatory pathway with prognostic impact in adult acute lymphocytic leukemia

Shen, L. L., Toyota, M., Kondo, Y., Obata, T., Daniel, S., Pierce, S., Imai, K., Kantarjian, H. M., Issa, J. P. J. & Garcia-Manero, G., May 15 2003, In: Blood. 101, 10, p. 4131-4136 6 p.

Research output: Contribution to journal › Article › peer-review

116 Scopus citations

Adaptive randomized study of idarubicin and cytarabine versus troxacitabine and cytarabine versus troxacitabine and idarubicin in untreated patients 50 years or older with adverse karyotype acute myeloid leukemia

Giles, F. J., Kantarjian, H. M., Cortes, J. E., Garcia-Manero, G., Verstovsek, S., Faderl, S., Thomas, D. A., Ferrajoli, A., O'Brien, S., Wathen, J. K., Xiao, L. C., Berry, D. A. & Estey, E. H., May 1 2003, In: Journal of Clinical Oncology. 21, 9, p. 1722-1727 6 p.

Research output: Contribution to journal › Article › peer-review

84 Scopus citations

Analysis of the impact of imatinib mesylate therapy on the prognosis of patients with philadelphia chromosome-positive chronic myelogenous leukemia treated with interferon-α regimens for early chronic phase

Kantarjian, H., O'Brien, S., Cortes, J., Shan, J., Giles, F., Garcia-Manero, G., Verstovsek, S., Faderl, S., Rios, M. B. & Talpaz, M., Oct 1 2003, In: Cancer. 98, 7, p. 1430-1437 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

20 Scopus citations

A randomized trial of liposomal daunorubicin and cytarabine versus liposomal daunorubicin and topotecan with or without thalidomide as initial therapy for patients with poor prognosis acute myelogenous leukemia or myelodysplastic syndrome

Cortes, J., Kantarjian, H., Albitar, M., Thomas, D., Faderl, S., Koller, C., Garcia-Manero, G., Giles, F., Andreeff, M., O'Brien, S., Keating, M. & Estey, E., Mar 1 2003, In: Cancer. 97, 5, p. 1234-1241 8 p.

Research output: Contribution to journal › Article › peer-review

43 Scopus citations

Chromosomal Abnormalities in Philadelphia Chromosome-Negative Metaphases Appearing during Imatinib Mesylate Therapy in Patients with Philadelphia Chromosome-Positive Chronic Myelogenous Leukemia in Chronic Phase

Medina, J., Kantarjian, H., Talpaz, M., O'Brien, S., Garcia-Manero, G., Giles, F., Rios, M. B., Hayes, K. & Cortes, J., Nov 1 2003, In: Cancer. 98, 9, p. 1905-1911 7 p.

Research output: Contribution to journal › Article › peer-review

115 Scopus citations

Chronic myelogenous leukemia: A review and update of therapeutic strategies

Garcia-Manero, G., Faderl, S., O'Brien, S., Cortes, J., Talpaz, M. & Kantarjian, H. M., Aug 1 2003, In: Cancer. 98, 3, p. 437-457 21 p.

Research output: Contribution to journal › Review article › peer-review

Open Access

72 Scopus citations

Comment on "Chromosomal instability and tumors promoted by DNA hypomethylation" and "Induction of tumors in nice by genomic hypomethylation".

Yang, A. S., Estecio, M. R. H., Garcia-Manero, G., Kantarjian, H. M. & Issa, J. P. J., Nov 14 2003, In: Science. 302, 5648, p. 1153; author reply 1153

Research output: Contribution to journal › Comment/debate › peer-review

72 Scopus citations

DNA methylation in haematological malignancies: The role of decitabine

Hennessy, B. T., Garcia-Manero, G., Kantarjian, H. M. & Giles, F. J., Dec 2003, In: Expert Opinion on Investigational Drugs. 12, 12, p. 1985-1993 9 p.

Research output: Contribution to journal › Review article › peer-review

28 Scopus citations

Dose escalation of imatinib mesylate can overcome resistance to standard-dose therapy in patients with chronic myelogenous leukemia

Kantarjian, H. M., Talpaz, M., O'Brien, S., Giles, F., Garcia-Manero, G., Faded, S., Thomas, D., Shan, J., Rios, M. B. & Cortes, J., Jan 15 2003, In: Blood. 101, 2, p. 473-475 3 p.

Research output: Contribution to journal › Article › peer-review

Open Access

275 Scopus citations

Effects of age on prognosis with imatinib mesylate therapy for patients with Philadelphia chromosome-positive chronic myelogenous leukemia

Cortes, J., Talpaz, M., O'Brien, S., Giles, F., Rios, M. B., Shan, J., Faderl, S., Garcia-Manero, G., Ferrajoli, A., Wierda, W. & Kantarjian, H., Sep 15 2003, In: Cancer. 98, 6, p. 1105-1113 9 p.

Research output: Contribution to journal › Review article › peer-review

85 Scopus citations

Efficacy of the farnesyl transferase inhibitor R115777 in chronic myeloid leukemia and other hematologic malignancies

Cortes, J., Albitar, M., Thomas, D., Giles, F., Kurzrock, R., Thibault, A., Rackoff, W., Koller, C., O'Brien, S., Garcia-Manero, G., Talpaz, M. & Kantarjian, H., Mar 1 2003, In: Blood. 101, 5, p. 1692-1697 6 p.

Research output: Contribution to journal › Article › peer-review

215 Scopus citations

Empirical examination of the neutrophil criterion (>1500 μl^-1) currently needed to declare CR in AML

Estey, E., Giles, F., Cortes, J., Beran, M., Verstovsek, S., Garcia-Manero, G., Faderl, S. & Kantarjian, H., Jun 1 2003, In: Leukemia Research. 27, 6, p. 475-479 5 p.

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Experience with alemtuzumab plus rituximab in patients with relapsed and refractory lymphoid malignancies

Faderl, S., Thomas, D. A., O'Brien, S., Garcia-Manero, G., Kantarjian, H. M., Giles, F. J., Koller, C., Ferrajoli, A., Verstovsek, S., Pro, B., Andreeff, M., Beran, M., Cortes, J., Wierda, W., Tran, N. & Keating, M. J., May 1 2003, In: Blood. 101, 9, p. 3413-3415 3 p.

Research output: Contribution to journal › Article › peer-review

238 Scopus citations

Fractionated cyclophosphamide, vincristine, liposomal daunorubicin, and dexamethasone plus rituximab and granulocyte-macrophage-colony stimulating factor (GM-CSF) alternating with methotrexate and cytarabine plus rituximab and GM-CSF in patients with Richter syndrome or fludarabine-refractory chronic lymphocytic leukemia

Tsimberidou, A. M., Kantarjian, H. M., Cortes, J., Thomas, D. A., Faderl, S., Garcia-Manero, G., Verstovsek, S., Ferrajoli, A., Wierda, W., Alvarado, Y., O'Brien, S. M., Albitar, M., Keating, M. J. & Giles, F. J., Apr 1 2003, In: Cancer. 97, 7, p. 1711-1720 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

103 Scopus citations

Gemtuzumab, fludarabine, cytarabine, and cyclosporine in patients with newly diagnosed acute myelogenous leukemia or high-risk myelodysplastic syndromes

Tsimberidou, A., Estey, E., Cortes, J., Thomas, D., Faderl, S., Verstovsek, S., Garcia-Manero, G., Keating, M., Albitar, M., O'Brien, S., Kantarjian, H. & Giles, F., Mar 15 2003, In: Cancer. 97, 6, p. 1481-1487 7 p.

Research output: Contribution to journal › Article › peer-review

73 Scopus citations

Gemtuzumab ozogamicin, fludarabine, cytarabine and cyclosporine combination regimen in patients with CD33+ primary resistant or relapsed acute myeloid leukemia

Tsimberidou, A., Cortes, J., Thomas, D., Garcia-Manero, G., Verstovsek, S., Faderl, S., Albitar, M., Kantarjian, H., Estey, E. & Giles, F. J., Oct 1 2003, In: Leukemia Research. 27, 10, p. 893-897 5 p.

Research output: Contribution to journal › Article › peer-review

68 Scopus citations

Imatinib Mesylate Therapy Improves Survival in Patients with Newly Diagnosed Philadelphia Chromosome-Positive Chronic Myelogenous Leukemia in the Chronic Phase: Comparison with Historic Data

Kantarjian, H. M., O'Brien, S., Cortes, J., Giles, F. J., Rios, M. B., Shan, J., Faderl, S., Garcia-Manero, G., Ferrajoli, A., Verstovsek, S., Wierda, W., Keating, M. & Talpaz, M., Dec 15 2003, In: Cancer. 98, 12, p. 2636-2642 7 p.

Research output: Contribution to journal › Article › peer-review

Open Access

96 Scopus citations

Imatinib mesylate therapy in newly diagnosed patients with Philadelphia chromosome-positive chronic myelogenous leukemia: High incidence of early complete and major cytogenetic responses

Kantarjian, H. M., Cortes, J. E., O'Brien, S., Giles, F., Garcia-Manero, G., Faderl, S., Thomas, D., Jeha, S., Rios, M. B., Letvak, L., Bochinski, K., Arlinghaus, R. & Talpaz, M., Jan 1 2003, In: Blood. 101, 1, p. 97-100 4 p.

Research output: Contribution to journal › Article › peer-review

Open Access

142 Scopus citations

Metastatic gastric adenocarcinoma following allogeneic stem cell transplantation in a patient with acute myelogenous leukemia [2]

Tsimberidou, A. M., Medina, J., Earl, M., Sierra, M., Shriki, J. E., Bueso-Ramos, C., Giralt, S., Beran, M., Giles, F. J. & Garcia-Manero, G., Mar 2003, In: Bone marrow transplantation. 31, 5, p. 413-414 2 p.

Research output: Contribution to journal › Letter › peer-review

Guillermo Garcia-Manero

Research output

Search results