Hengyu Lyu

2023

KRAS^G12D inhibition reprograms the microenvironment of early and advanced pancreatic cancer to promote FAS-mediated killing by CD8⁺ T cells

Mahadevan, K. K., McAndrews, K. M., LeBleu, V. S., Yang, S., Lyu, H., Li, B., Sockwell, A. M., Kirtley, M. L., Morse, S. J., Moreno Diaz, B. A., Kim, M. P., Feng, N., Lopez, A. M., Guerrero, P. A., Paradiso, F., Sugimoto, H., Arian, K. A., Ying, H., Barekatain, Y., Sthanam, L. K., & 4 othersKelly, P. J., Maitra, A., Heffernan, T. P. & Kalluri, R., Sep 11 2023, In: Cancer cell. 41, 9, p. 1606-1620.e8

Research output: Contribution to journal › Article › peer-review

15 Scopus citations

2022

A functional genomic approach to actionable gene fusions for precision oncology

Li, J., Lu, H., Ng, P. K. S., Pantazi, A., Ip, C. K. M., Jeong, K. J., Amador, B., Tran, R., Tsang, Y. H., Yang, L., Song, X., Dogruluk, T., Ren, X., Hadjipanayis, A., Bristow, C. A., Lee, S., Kucherlapati, M., Parfenov, M., Tang, J., Seth, S., & 17 othersMahadeshwar, H. S., Mojumdar, K., Zeng, D., Zhang, J., Protopopov, A., Seidman, J. G., Creighton, C. J., Lu, Y., Sahni, N., Shaw, K. R., Meric-Bernstam, F., Futreal, A., Chin, L., Scott, K. L., Kucherlapati, R., Mills, G. B. & Liang, H., Feb 2022, In: Science Advances. 8, 6, abm2382.

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

2021

Combinations with allosteric SHP2 inhibitor TNO155 to block receptor tyrosine kinase signaling

Liu, C., Lu, H., Wang, H., Loo, A., Zhang, X., Yang, G., Kowal, C., Delach, S., Wang, Y., Goldoni, S., Hastings, W. D., Wong, K., Gao, H., Meyer, M. J., Moody, S. E., LaMarche, M. J., Engelman, J. A., Williams, J. A., Hammerman, P. S., Abrams, T. J., & 3 othersMohseni, M., Caponigro, G. & Hao, H. X., Jan 1 2021, In: Clinical Cancer Research. 27, 1, p. 342-354 13 p.

Research output: Contribution to journal › Article › peer-review

Open Access

84 Scopus citations

2020

Differential expression of MAGEA6 toggles autophagy to promote pancreatic cancer progression

Tsang, Y. H., Wang, Y., Kong, K., Grzeskowiak, C., Zagorodna, O., Dogruluk, T., Lu, H., Villafane, N., Bhavana, V. H., Moreno, D., Elsea, S. H., Liang, H., Mills, G. B. & Scott, K. L., Apr 2020, In: eLife. 9, e48963.

Research output: Contribution to journal › Article › peer-review

Open Access

19 Scopus citations

Research paper resistance to allosteric SHP2 inhibition in FGFR-driven cancers through rapid feedback activation of FGFR

Lu, H., Liu, C., Huynh, H., Uyen Le, T. B., LaMarche, M. J., Mohseni, M., Engelman, J. A., Hammerman, P. S., Caponigro, G. & Hao, H. X., Jan 21 2020, In: Oncotarget. 11, 3, p. 265-281 17 p.

Research output: Contribution to journal › Article › peer-review

27 Scopus citations

2019

SHP2 inhibition overcomes RTK-mediated pathway reactivation in KRAS-mutant tumors treated with MEK inhibitors

Lu, H., Liu, C., Velazquez, R., Wang, H., Dunkl, L. M., Kazic-Legueux, M., Haberkorn, A., Billy, E., Manchado, E., Brachmann, S. M., Moody, S. E., Engelman, J. A., Hammerman, P. S., Caponigro, G., Mohseni, M. & Hao, H. X., 2019, In: Molecular cancer therapeutics. 18, 7, p. 1323-1334 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

60 Scopus citations

Tumor intrinsic efficacy by SHP2 and RTK inhibitors in KRAS-mutant cancers

Hao, H. X., Wang, H., Liu, C., Kovats, S., Velazquez, R., Lu, H., Pant, B., Shirley, M., Meyer, M. J., Pu, M., Lim, J., Fleming, M., Alexander, L. A., Farsidjani, A., LaMarche, M. J., Moody, S., Silver, S. J., Caponigro, G., Stuart, D. D., Abrams, T. J., & 5 othersHammerman, P. S., Williams, J., Engelman, J. A., Goldoni, S. & Mohseni, M., 2019, In: Molecular cancer therapeutics. 18, 12, p. 2368-2380 13 p.

Research output: Contribution to journal › Article › peer-review

Open Access

29 Scopus citations

2018

Dual Allosteric Inhibition of SHP2 Phosphatase

Fodor, M., Price, E., Wang, P., Lu, H., Argintaru, A., Chen, Z., Glick, M., Hao, H. X., Kato, M., Koenig, R., LaRochelle, J. R., Liu, G., McNeill, E., Majumdar, D., Nishiguchi, G. A., Perez, L. B., Paris, G., Quinn, C. M., Ramsey, T., Sendzik, M., & 6 othersShultz, M. D., Williams, S. L., Stams, T., Blacklow, S. C., Acker, M. G. & LaMarche, M. J., Mar 16 2018, In: ACS Chemical Biology. 13, 3, p. 647-656 10 p.

Research output: Contribution to journal › Article › peer-review

90 Scopus citations

In vivo screening identifies GATAD2B as a metastasis driver in KRAS-driven lung cancer

Grzeskowiak, C. L., Kundu, S. T., Mo, X., Ivanov, A. A., Zagorodna, O., Lu, H., Chapple, R. H., Tsang, Y. H., Moreno, D., Mosqueda, M., Eterovic, K., Fradette, J. J., Ahmad, S., Chen, F., Chong, Z., Chen, K., Creighton, C. J., Fu, H., Mills, G. B., Gibbons, D. L., & 1 othersScott, K. L., Dec 1 2018, In: Nature communications. 9, 1, 2732.

Research output: Contribution to journal › Article › peer-review

Open Access

30 Scopus citations

Systematic Functional Annotation of Somatic Mutations in Cancer

Ng, P. K. S., Li, J., Jeong, K. J., Shao, S., Chen, H., Tsang, Y. H., Sengupta, S., Wang, Z., Bhavana, V. H., Tran, R., Soewito, S., Minussi, D. C., Moreno, D., Kong, K., Dogruluk, T., Lu, H., Gao, J., Tokheim, C., Zhou, D. C., Johnson, A. M., & 20 othersZeng, J., Ip, C. K. M., Ju, Z., Wester, M., Yu, S., Li, Y., Vellano, C. P., Schultz, N., Karchin, R., Ding, L., Lu, Y., Cheung, L. W. T., Chen, K., Shaw, K. R., Meric-Bernstam, F., Scott, K. L., Yi, S., Sahni, N., Liang, H. & Mills, G. B., Mar 12 2018, In: Cancer cell. 33, 3, p. 450-462.e10

Research output: Contribution to journal › Article › peer-review

Open Access

171 Scopus citations

2017

Engineering and functional characterization of fusion genes identifies novel oncogenic drivers of cancer

Lu, H., Villafane, N., Dogruluk, T., Grzeskowiak, C. L., Kong, K., Tsang, Y. H., Zagorodna, O., Pantazi, A., Yang, L., Neill, N. J., Kim, Y. W., Creighton, C. J., Verhaak, R. G., Mills, G. B., Park, P. J., Kucherlapati, R. & Scott, K. L., Jul 1 2017, In: Cancer Research. 77, 13, p. 3502-3512 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

29 Scopus citations

2016

Analyzing Somatic Genome Rearrangements in Human Cancers by Using Whole-Exome Sequencing

Yang, L., Lee, M. S., Lu, H., Oh, D. Y., Kim, Y. J., Park, D., Park, G., Ren, X., Bristow, C. A., Haseley, P. S., Lee, S., Pantazi, A., Kucherlapati, R., Park, W. Y., Scott, K. L., Choi, Y. L. & Park, P. J., May 5 2016, In: American journal of human genetics. 98, 5, p. 843-856 14 p.

Research output: Contribution to journal › Article › peer-review

Open Access

30 Scopus citations

Functional annotation of rare gene aberration drivers of pancreatic cancer

Tsang, Y. H., Dogruluk, T., Tedeschi, P. M., Wardwell-Ozgo, J., Lu, H., Espitia, M., Nair, N., Minelli, R., Chong, Z., Chen, F., Chang, Q. E., Dennison, J. B., Dogruluk, A., Li, M., Ying, H., Bertino, J. R., Gingras, M. C., Ittmann, M., Kerrigan, J., Chen, K., & 4 othersCreighton, C. J., Eterovic, K., Mills, G. B. & Scott, K. L., Jan 25 2016, In: Nature communications. 7, 10500.

Research output: Contribution to journal › Article › peer-review

Open Access

53 Scopus citations

2015

RET fusion as a novel driver of medullary thyroid carcinoma

Grubbs, E. G., Ng, P. K. S., Bui, J., Busaidy, N. L., Chen, K., Lee, J. E., Lu, X., Lu, H., Meric-Bernstam, F., Mills, G. B., Palmer, G., Perrier, N. D., Scott, K. L., Shaw, K. R., Waguespack, S. G., Williams, M. D., Yelensky, R. & Cote, G. J., Mar 1 2015, In: Journal of Clinical Endocrinology and Metabolism. 100, 3, p. 788-793 6 p.

Research output: Contribution to journal › Article › peer-review

60 Scopus citations

Hengyu Lyu

Research output

Search results