• 14984 Citations
  • 74 h-Index
1973 …2019
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Research Output 1973 2019

2019
3 Citations (Scopus)

Detection of RNA-DNA binding sites in long noncoding RNAs

Kuo, C. C., Hänzelmann, S., Sentürk Cetin, N., Frank, S., Zajzon, B., Derks, J. P., Akhade, V. S., Ahuja, G., Kanduri, C., Grummt, I., Kurian, L. & Costa, I. G., Apr 8 2019, In : Nucleic acids research. 47, 6, p. e32

Research output: Contribution to journalArticle

Open Access
Long Noncoding RNA
Binding Sites
RNA
DNA
Genes

Experimental approaches to investigate the role of helicase acetylation in regulating r-loop stability

Song, C. & Grummt, I., Jan 1 2019, Methods in Molecular Biology. Humana Press Inc., p. 237-253 17 p. (Methods in Molecular Biology; vol. 1983).

Research output: Chapter in Book/Report/Conference proceedingChapter

Nucleic Acid Heteroduplexes
RNA Helicases
Genomic Instability
Single-Stranded DNA
Acetylation
11 Citations (Scopus)

GADD45A binds R-loops and recruits TET1 to CpG island promoters

Arab, K., Karaulanov, E., Musheev, M., Trnka, P., Schäfer, A., Grummt, I. & Niehrs, C., Feb 1 2019, In : Nature Genetics. 51, 2, p. 217-223 7 p.

Research output: Contribution to journalLetter

CpG Islands
DNA Damage
Antisense RNA
DNA
Growth
1 Citation (Scopus)

Isolation and genome-wide characterization of cellular DNA:RNA triplex structures

Cetin, N. S., Kuo, C. C., Ribarska, T., Li, R., Costa, I. G. & Grummt, I., Jan 1 2019, In : Nucleic acids research. 47, 5, p. 2306-2321 16 p.

Research output: Contribution to journalArticle

Open Access
Genome
RNA
DNA
triplex DNA
Small Nuclear RNA
2 Citations (Scopus)

lncRNA KHPS1 Activates a Poised Enhancer by Triplex-Dependent Recruitment of Epigenomic Regulators

Blank-Giwojna, A., Postepska-Igielska, A. & Grummt, I., Mar 12 2019, In : Cell Reports. 26, 11, p. 2904-2915.e4

Research output: Contribution to journalArticle

Open Access
Long Noncoding RNA
Epigenomics
RNA
Antisense RNA
Transcription

Stop-and-Go: Dynamics of Nucleolar Transcription During the Cell Cycle

Iyer-Bierhoff, A. & Grummt, I., May 1 2019, In : Epigenetics Insights. 12

Research output: Contribution to journalComment/debate

Open Access
Transcription
Methylation
Chromatin
Cell Cycle
Ribosomal DNA
2018
21 Citations (Scopus)

Dynamic regulation of nucleolar architecture

Németh, A. & Grummt, I., Jun 1 2018, In : Current Opinion in Cell Biology. 52, p. 105-111 7 p.

Research output: Contribution to journalReview article

Ribonucleoproteins
Nuclear Proteins
Cell Cycle Checkpoints
Ribosomes
Chromatin
11 Citations (Scopus)

lncRNA PAPAS tethered to the rDNA enhancer recruits hypophosphorylated CHD4/NuRD to repress rRNA synthesis at elevated temperatures

Zhao, Z., Sentürk, N., Song, C. & Grummt, I., Jun 1 2018, In : Genes and Development. 32, 11-12, p. 836-848 13 p.

Research output: Contribution to journalArticle

Long Noncoding RNA
Nucleosomes
RNA Precursors
Ribosomal DNA
Temperature
5 Citations (Scopus)

Purine– and pyrimidine–triple-helix-forming oligonucleotides recognize qualitatively different target sites at the ribosomal DNA locus

Maldonado, R., Filarsky, M., Grummt, I. & Längst, G., Mar 1 2018, In : RNA. 24, 3, p. 371-380 10 p.

Research output: Contribution to journalArticle

Ribosomal DNA
Oligonucleotides
Base Composition
Gene Expression Regulation
Computational Biology
2 Citations (Scopus)

SIRT7-Dependent Deacetylation of Fibrillarin Controls Histone H2A Methylation and rRNA Synthesis during the Cell Cycle

Iyer-Bierhoff, A., Krogh, N., Tessarz, P., Ruppert, T., Nielsen, H. & Grummt, I., Dec 11 2018, In : Cell Reports. 25, 11, p. 2946-2954.e5

Research output: Contribution to journalArticle

Methylation
Histones
Cell Cycle
Cells
Acetylation
2017

Ribosomes Dance to a Daily Rhythm

Iyer, A. & Grummt, I., Aug 1 2017, In : Trends in Biochemical Sciences. 42, 8, p. 585-587 3 p.

Research output: Contribution to journalShort survey

Ribosomes
Cell Size
Liver
Proteins
22 Citations (Scopus)

SIRT7 and the DEAD-box helicase DDX21 cooperate to resolve genomic R loops and safeguard genome stability

Song, C., Hotz-Wagenblatt, A., Voit, R. & Grummt, I., Jul 1 2017, In : Genes and Development. 31, 13, p. 1370-1381 12 p.

Research output: Contribution to journalArticle

Genomic Instability
Acetylation
Estrogens
Nucleic Acid Heteroduplexes
RNA Helicases
14 Citations (Scopus)

SIRT7-dependent deacetylation of CDK9 activates RNA polymerase II transcription

Blank, M. F., Chen, S., Poetz, F., Schnölzer, M., Voit, R. & Grummt, I., Mar 17 2017, In : Nucleic acids research. 45, 5, p. 2675-2686 12 p.

Research output: Contribution to journalArticle

Positive Transcriptional Elongation Factor B
RNA Polymerase II
Small Nucleolar RNA
Small Nuclear Ribonucleoproteins
RNA Polymerase I
20 Citations (Scopus)

The seven faces of SIRT7

Blank, M. F. & Grummt, I., Mar 15 2017, In : Transcription. 8, 2, p. 67-74 8 p.

Research output: Contribution to journalReview article

Cell proliferation
Cell Cycle Checkpoints
Ribosomes
NAD
Carcinogenesis
2016
17 Citations (Scopus)

Heat shock represses rRNA synthesis by inactivation of TIF-IA and lncRNA-dependent changes in nucleosome positioning

Zhao, Z., Dammert, M. A., Hoppe, S., Bierhoff, H. & Grummt, I., Sep 30 2016, In : Nucleic acids research. 44, 17, p. 8144-8152 9 p.

Research output: Contribution to journalArticle

Long Noncoding RNA
Nucleosomes
RNA Precursors
Shock
Hot Temperature
15 Citations (Scopus)

LncRNA-Induced Nucleosome Repositioning Reinforces Transcriptional Repression of rRNA Genes upon Hypotonic Stress

Zhao, Z., Dammert, M. A., Grummt, I. & Bierhoff, H., Mar 1 2016, In : Cell Reports. 14, 8, p. 1876-1882 7 p.

Research output: Contribution to journalArticle

Nucleosomes
Osmotic Pressure
Ribosomal DNA
rRNA Genes
Genes
34 Citations (Scopus)

SIRT7-dependent deacetylation of the U3-55k protein controls pre-rRNA processing

Chen, S., Blank, M. F., Iyer, A., Huang, B., Wang, L., Grummt, I. & Voit, R., Feb 12 2016, In : Nature communications. 7, 10734.

Research output: Contribution to journalArticle

ribonucleic acids
Ribosomal RNA
proteins
Processing
Proteins
2015
43 Citations (Scopus)

Alu element-containing RNAs maintain nucleolar structure and function

Caudron-Herger, M., Pankert, T., Seiler, J., Németh, A., Voit, R., Grummt, I. & Rippe, K., Nov 12 2015, In : EMBO Journal. 34, 22, p. 2758-2774 17 p.

Research output: Contribution to journalArticle

Alu Elements
RNA Polymerase II
RNA Polymerase I
RNA Precursors
RNA
8 Citations (Scopus)

A novel RNA binding surface of the TAM domain of TIP5/BAZ2A mediates epigenetic regulation of rRNA genes

Anosova, I., Melnik, S., Tripsianes, K., Kateb, F., Grummt, I. & Sattler, M., Apr 3 2015, In : Nucleic acids research. 43, 10, p. 5208-5220 13 p.

Research output: Contribution to journalArticle

rRNA Genes
Epigenomics
Untranslated RNA
RNA
Chromatin Assembly and Disassembly
13 Citations (Scopus)

Cooperative Action of Cdk1/cyclin B and SIRT1 Is Required for Mitotic Repression of rRNA Synthesis

Voit, R., Seiler, J. & Grummt, I., May 1 2015, In : PLoS genetics. 11, 5, e1005246.

Research output: Contribution to journalArticle

Cyclin B
cyclins
cooperatives
phosphorylation
transcription (genetics)
70 Citations (Scopus)

LncRNA Khps1 Regulates Expression of the Proto-oncogene SPHK1 via Triplex-Mediated Changes in Chromatin Structure

Postepska-Igielska, A., Giwojna, A., Gasri-Plotnitsky, L., Schmitt, N., Dold, A., Ginsberg, D. & Grummt, I., Nov 19 2015, In : Molecular cell. 60, 4, p. 626-636 11 p.

Research output: Contribution to journalArticle

Long Noncoding RNA
Proto-Oncogenes
Chromatin
Histone Acetyltransferases
Antisense RNA
2014
129 Citations (Scopus)

Long noncoding RNA TARID directs demethylation and activation of the tumor suppressor TCF21 via GADD45A

Arab, K., Park, Y. J., Lindroth, A. M., Schäfer, A., Oakes, C., Weichenhan, D., Lukanova, A., Lundin, E., Risch, A., Meister, M., Dienemann, H., Dyckhoff, G., Herold-Mende, C., Grummt, I., Niehrs, C. & Plass, C., Aug 21 2014, In : Molecular cell. 55, 4, p. 604-614 11 p.

Research output: Contribution to journalArticle

Long Noncoding RNA
Antisense RNA
Thymine DNA Glycosylase
DNA
5-Methylcytosine
33 Citations (Scopus)

Noisy silence: Non-coding RNA and heterochromatin formation at repetitive elements

Bierhoff, H., Postepska-Igielska, A. & Grummt, I., Jan 1 2014, In : Epigenetics. 9, 1, p. 53-61 9 p.

Research output: Contribution to journalReview article

Untranslated RNA
Heterochromatin
Genomic Instability
Genetic Recombination
Chromatin
5 Citations (Scopus)

NoRC silences rRNA genes, telomeres, and centromeres

Postepska-Igielska, A. & Grummt, I., Feb 15 2014, In : Cell Cycle. 13, 4, p. 493-494 2 p.

Research output: Contribution to journalEditorial

58 Citations (Scopus)

Quiescence-Induced LncRNAs Trigger H4K20 Trimethylation and Transcriptional Silencing

Bierhoff, H., Dammert, M. A., Brocks, D., Dambacher, S., Schotta, G. & Grummt, I., May 22 2014, In : Molecular cell. 54, 4, p. 675-682 8 p.

Research output: Contribution to journalArticle

Long Noncoding RNA
Chromatin
Intracisternal A-Particle Genes
Methyltransferases
Growth
2013
49 Citations (Scopus)

A neuroprotective phase precedes striatal degeneration upon nucleolar stress

Kreiner, G., Bierhoff, H., Armentano, M., Rodriguez-Parkitna, J., Sowodniok, K., Naranjo, J. R., Bonfanti, L., Liss, B., Schütz, G., Grummt, I. & Parlato, R., Nov 1 2013, In : Cell death and differentiation. 20, 11, p. 1455-1464 10 p.

Research output: Contribution to journalArticle

Corpus Striatum
Huntington Disease
Neurons
Peptide Initiation Factors
Transcription Factors
16 Citations (Scopus)

Chromatin-Specific Regulation of Mammalian rDNA Transcription by Clustered TTF-I Binding Sites

Diermeier, S. D., Németh, A., Rehli, M., Grummt, I. & Längst, G., Sep 1 2013, In : PLoS genetics. 9, 9, e1003786.

Research output: Contribution to journalArticle

Ribosomal DNA
Chromatin
chromatin
binding sites
transcription (genetics)
73 Citations (Scopus)

Epigenetic control of RNA polymerase I transcription in mammalian cells

Grummt, I. & Längst, G., Mar 1 2013, In : Biochimica et Biophysica Acta - Gene Regulatory Mechanisms. 1829, 3-4, p. 393-404 12 p.

Research output: Contribution to journalReview article

RNA Polymerase I
Transcription
Ribosomal DNA
Epigenomics
Cells

Erratum: The chromatin remodelling complex NoRC safeguards genome stability by heterochromatin formation at telomeres and centromeres (EMBO Reports (2013) 14 (704-710) DOI:10.1038/embor.2013.87)

Postepska-Igielska, A., Krunic, D., Schmitt, N., Greulich-Bode, K. M., Boukamp, P. & Grummt, I., Sep 1 2013, In : EMBO reports. 14, 9, 1 p.

Research output: Contribution to journalComment/debate

Chromatin
Genes
59 Citations (Scopus)

NuRD blocks reprogramming of mouse somatic cells into Pluripotent stem cells

Luo, M., Ling, T., Xie, W., Sun, H., Zhou, Y., Zhu, Q., Shen, M., Zong, L., Lyu, G., Zhao, Y., Ye, T., Gu, J., Tao, W., Lu, Z. & Grummt, I., Jul 1 2013, In : STEM CELLS. 31, 7, p. 1278-1286 9 p.

Research output: Contribution to journalArticle

Pluripotent Stem Cells
Nucleosomes
Induced Pluripotent Stem Cells
Epigenomics
Down-Regulation
86 Citations (Scopus)

Repression of RNA Polymerase I upon Stress Is Caused by Inhibition of RNA-Dependent Deacetylation of PAF53 by SIRT7

Chen, S., Seiler, J., Santiago-Reichelt, M., Felbel, K., Grummt, I. & Voit, R., Nov 7 2013, In : Molecular cell. 52, 3, p. 303-313 11 p.

Research output: Contribution to journalArticle

Sirtuins
RNA Polymerase I
DNA Polymerase I
RNA Precursors
Acetylation
29 Citations (Scopus)

The chromatin remodelling complex NoRC safeguards genome stability by heterochromatin formation at telomeres and centromeres

Postepska-Igielska, A., Krunic, D., Schmitt, N., Greulich-Bode, K. M., Boukamp, P. & Grummt, I., Aug 2013, In : EMBO reports. 14, 8, p. 704-710 7 p.

Research output: Contribution to journalArticle

Chromosomal Instability
Chromatin Assembly and Disassembly
Heterochromatin
Centromere
Genomic Instability
94 Citations (Scopus)

The nucleolus - Guardian of cellular homeostasis and genome integrity

Grummt, I., Dec 1 2013, In : Chromosoma. 122, 6, p. 487-497 11 p.

Research output: Contribution to journalReview article

Ribosomes
Homeostasis
Genome
RNA Polymerase I
Cell Physiological Phenomena
2012
68 Citations (Scopus)

The chromatin remodeling complex NuRD establishes the poised state of rRNA genes characterized by bivalent histone modifications and altered nucleosome positions

Xie, W., Ling, T., Zhou, Y., Feng, W., Zhu, Q., Stunnenberg, H. G., Grummt, I. & Tao, W., May 22 2012, In : Proceedings of the National Academy of Sciences of the United States of America. 109, 21, p. 8161-8166 6 p.

Research output: Contribution to journalArticle

Histone Code
Chromatin Assembly and Disassembly
Nucleosomes
rRNA Genes
Ribosomal DNA
2011
36 Citations (Scopus)

A model for the topology of active ribosomal RNA genes

Denissov, S., Lessard, F., Mayer, C., Stefanovsky, V., Van Driel, M., Grummt, I., Moss, T. & Stunnenberg, H. G., Mar 1 2011, In : EMBO reports. 12, 3, p. 231-237 7 p.

Research output: Contribution to journalArticle

Ribosomal RNA
rRNA Genes
Genes
Topology
Chromatin Immunoprecipitation
27 Citations (Scopus)

Human Cdc14B promotes progression through mitosis by dephosphorylating Cdc25 and regulating Cdk1/cyclin B activity

Tumurbaatar, I., Cizmecioglu, O., Hoffmann, I., Grummt, I. & Voit, R., Feb 28 2011, In : PloS one. 6, 2, e14711.

Research output: Contribution to journalArticle

Cyclin B
Phosphorylation
cyclins
Chromosomes
Mitosis
93 Citations (Scopus)

Nucleolar disruption in dopaminergic neurons leads to oxidative damage and parkinsonism through repression of mammalian target of rapamycin signaling

Rieker, C., Engblom, D., Kreiner, G., Domanskyi, A., Schober, A., Stotz, S., Neumann, M., Yuan, X., Grummt, I., Schütz, G. & Parlato, R., Jan 12 2011, In : Journal of Neuroscience. 31, 2, p. 453-460 8 p.

Research output: Contribution to journalArticle

Dopaminergic Neurons
Parkinsonian Disorders
Sirolimus
Parkinson Disease
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine
2 Citations (Scopus)

The RNA polymerase i transcription machinery

Voit, R. & Grummt, I., Dec 19 2011, The Nucleolus. Olson, M. & Grosshans, H. (eds.). p. 107-134 28 p. (Protein Reviews; vol. 15).

Research output: Chapter in Book/Report/Conference proceedingChapter

DNA-Directed RNA Polymerases
Transcription
Ribosomes
Machinery
Cell Proliferation
2010
15 Citations (Scopus)

DNA sequence encoded repression of rRNA gene transcription in chromatin

Felle, M., Exler, J. H., Merkl, R., Dachauer, K., Brehm, A., Grummt, I. & Längst, G., Apr 25 2010, In : Nucleic acids research. 38, 16, p. 5304-5314 11 p., gkq263.

Research output: Contribution to journalArticle

Nucleosomes
rRNA Genes
Chromatin
Ribosomal DNA
Chromatin Assembly and Disassembly
305 Citations (Scopus)

Interaction of noncoding RNA with the rDNA promoter mediates recruitment of DNMT3b and silencing of rRNA genes

Schmitz, K. M., Mayer, C., Postepska, A. & Grummt, I., Oct 15 2010, In : Genes and Development. 24, 20, p. 2264-2269 6 p.

Research output: Contribution to journalArticle

Untranslated RNA
Ribosomal DNA
rRNA Genes
RNA
Epigenomics
61 Citations (Scopus)

Intergenic transcripts originating from a subclass of ribosomal DNA repeats silence ribosomal RNA genes in trans

Santoro, R., Schmitz, K. M., Sandoval, J. & Grummt, I., Jan 2010, In : EMBO reports. 11, 1, p. 52-58 7 p.

Research output: Contribution to journalArticle

Ribosomal RNA
Ribosomal DNA
rRNA Genes
Genes
Ribosomal Spacer DNA
20 Citations (Scopus)

Linking rDNA transcription to the cellular energy supply

Grummt, I. & Voit, R., Jan 15 2010, In : Cell Cycle. 9, 2, p. 225-226 2 p.

Research output: Contribution to journalShort survey

Ribosomal DNA
51 Citations (Scopus)

Noncoding transcripts in sense and antisense orientation regulate the epigenetic state of ribosomal RNA genes

Bierhoff, H., Schmitz, K., Maass, F., Ye, J. & Grummt, I., Dec 1 2010, In : Cold Spring Harbor Symposia on Quantitative Biology. 75, p. 357-364 8 p.

Research output: Contribution to journalArticle

Ribosomal RNA
Ribosomal DNA
rRNA Genes
Epigenomics
Genes
139 Citations (Scopus)

PHF8 activates transcription of rRNA genes through H3K4me3 binding and H3K9me1/2 demethylation

Feng, W., Yonezawa, M., Ye, J., Jenuwein, T. & Grummt, I., Apr 1 2010, In : Nature Structural and Molecular Biology. 17, 4, p. 445-450 6 p.

Research output: Contribution to journalArticle

rRNA Genes
Fingers
Ribosomal DNA
Proteins
Methylation
105 Citations (Scopus)

The NoRC complex mediates the heterochromatin formation and stability of silent rRNA genes and centromeric repeats

Guetg, C., Lienemann, P., Sirri, V., Grummt, I., Hernandez-Verdun, D., Hottiger, M. O., Fussenegger, M. & Santoro, R., Jul 7 2010, In : EMBO Journal. 29, 13, p. 2135-2146 12 p.

Research output: Contribution to journalArticle

Ribosomal RNA
Heterochromatin
rRNA Genes
Ribosomal DNA
Genes
239 Citations (Scopus)

The RNA polymerase i transcription machinery: An emerging target for the treatment of cancer

Drygin, D., Rice, W. G. & Grummt, I., Feb 10 2010, In : Annual Review of Pharmacology and Toxicology. 50, p. 131-156 26 p.

Research output: Contribution to journalReview article

DNA-Directed RNA Polymerases
Transcription
Machinery
Cells
Cell proliferation
44 Citations (Scopus)

Wisely chosen paths - regulation of rRNA synthesis: Delivered on 30 June 2010 at the 35th FEBS Congress in Gothenburg, Sweden

Grummt, I., Nov 1 2010, In : FEBS Journal. 277, 22, p. 4626-4639 14 p.

Research output: Contribution to journalArticle

Transcription
Ribosomes
rRNA Genes
Sweden
Genes
2009
105 Citations (Scopus)

AMP-activated protein kinase adapts rRNA synthesis to cellular energy supply

Hoppe, S., Bierhoff, H., Cado, I., Weber, A., Tiebe, M., Grummt, I. & Voit, R., Oct 20 2009, In : Proceedings of the National Academy of Sciences of the United States of America. 106, 42, p. 17781-17786 6 p.

Research output: Contribution to journalArticle

AMP-Activated Protein Kinases
Pol1 Transcription Initiation Complex Proteins
Down-Regulation
Adenosine Monophosphate
Serine
14 Citations (Scopus)

Dynamic subcellular partitioning of the nucleolar transcription factor TIF-IA under ribotoxic stress

Szymański, J., Mayer, C., Hoffmann-Rohrer, U., Kalla, C., Grummt, I. & Weiss, M., Jul 1 2009, In : Biochimica et Biophysica Acta - Molecular Cell Research. 1793, 7, p. 1191-1198 8 p.

Research output: Contribution to journalArticle

Karyopherins
Cytoplasm
Pol1 Transcription Initiation Complex Proteins
MAP Kinase Kinase 4
Osmotic Pressure
69 Citations (Scopus)

Reversible acetylation of the chromatin remodelling complex NoRC is required for non-coding RNA-dependent silencing

Zhou, Y., Schmitz, K. M., Mayer, C., Yuan, X., Akhtar, A. & Grummt, I., Jul 6 2009, In : Nature cell biology. 11, 8, p. 1010-1016 7 p.

Research output: Contribution to journalArticle

Untranslated RNA
Chromatin Assembly and Disassembly
Acetylation
RNA Interference
Ribosomal DNA