• 15100 Citations
  • 75 h-Index
1973 …2019
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Research Output 1973 2019

46 Citations (Scopus)

3'-end formation of mouse pre-rRNA involves both transcription termination and a specific processing reaction.

Kuhn, A. & Grummt, I., Feb 1989, In : Genes & development. 3, 2, p. 224-231 8 p.

Research output: Contribution to journalArticle

RNA Precursors
RNA Polymerase I
Cell-Free System
Guanine
Ribosomal DNA
54 Citations (Scopus)
Open Access
RNA Polymerase I
Cell-Free System
Nucleic Acid Repetitive Sequences
Ribosomal DNA
rRNA Genes
165 Citations (Scopus)

Acetylation of TAFI68, a subunit of TIF-IB/SL1, activates RNA polymerase I transcription

Muth, V., Nadaud, S., Grummt, I. & Voit, R., Mar 15 2001, In : EMBO Journal. 20, 6, p. 1353-1362 10 p.

Research output: Contribution to journalArticle

RNA Polymerase I
Acetylation
Transcription
Ribosomal DNA
TATA-Box Binding Protein
33 Citations (Scopus)

Acetylation of UBF changes during the cell cycle and regulates the interaction of UBF with RNA polymerase I

Meraner, J., Lechner, M., Loidl, A., Goralik-Schramel, M., Voit, R., Grummt, I. & Loidl, P., May 8 2006, In : Nucleic acids research. 34, 6, p. 1798-1806 9 p.

Research output: Contribution to journalArticle

RNA Polymerase I
Acetylation
Cell Cycle
RNA Precursors
G1 Phase
106 Citations (Scopus)

Actin and myosin as transcription factors

Grummt, I., Apr 1 2006, In : Current Opinion in Genetics and Development. 16, 2, p. 191-196 6 p.

Research output: Contribution to journalReview article

Myosins
Actins
Transcription Factors
DNA-Directed RNA Polymerases
Nuclear RNA
60 Citations (Scopus)

Activation of an endogenous suicide response after perturbation of rRNA synthesis leads to neurodegeneration in mice

Parlato, R., Kreiner, G., Erdmann, G., Rieker, C., Stotz, S., Savenkova, E., Berger, S., Grummt, I. & Schútz, G., Nov 26 2008, In : Journal of Neuroscience. 28, 48, p. 12759-12764 6 p.

Research output: Contribution to journalArticle

Suicide
Transcription Factors
RNA Polymerase I
Neurons
rRNA Genes
97 Citations (Scopus)
Casein Kinase II
Phosphorylation
Site-Directed Mutagenesis
Protein Kinases
Serine
113 Citations (Scopus)

Activation of RNA Polymerase I Transcription by Cockayne Syndrome Group B Protein and Histone Methyltransferase G9a

Yuan, X., Feng, W., Imhof, A., Grummt, I. & Zhou, Y., Aug 17 2007, In : Molecular cell. 27, 4, p. 585-595 11 p.

Research output: Contribution to journalArticle

Protein Methyltransferases
Cockayne Syndrome
RNA Polymerase I
RNA Precursors
Ribosomal DNA
88 Citations (Scopus)

A growth-dependent transcription initiation factor (TIF-IA) interacting with RNA polymerase I regulates mouse ribosomal RNA synthesis

Schnapp, A., Pfleiderer, C., Rosenbauer, H. & Grummt, I., Sep 7 1990, In : EMBO Journal. 9, 9, p. 2857-2863 7 p.

Research output: Contribution to journalArticle

RNA Polymerase I
Peptide Initiation Factors
Ribosomal RNA
Transcription
Ribosomal DNA
326 Citations (Scopus)

A kinetic framework for a mammalian RNA polymerase in vivo

Dundr, M., Hoffmann-Rohrer, U., Hu, Q., Grummt, I., Rothblum, L. I., Phair, R. D. & Misteli, T., Nov 22 2002, In : Science. 298, 5598, p. 1623-1626 4 p.

Research output: Contribution to journalArticle

RNA Polymerase I
DNA-Directed RNA Polymerases
Cell Nucleus
Genes
Intravital Microscopy
44 Citations (Scopus)

Alu element-containing RNAs maintain nucleolar structure and function

Caudron-Herger, M., Pankert, T., Seiler, J., Németh, A., Voit, R., Grummt, I. & Rippe, K., Nov 12 2015, In : EMBO Journal. 34, 22, p. 2758-2774 17 p.

Research output: Contribution to journalArticle

Alu Elements
RNA Polymerase II
RNA Polymerase I
RNA Precursors
RNA
45 Citations (Scopus)

A Metabolic Throttle Regulates the Epigenetic State of rDNA

Grummt, I. & Ladurner, A. G., May 16 2008, In : Cell. 133, 4, p. 577-580 4 p.

Research output: Contribution to journalShort survey

Ribosomal DNA
Epigenomics
NAD
Cell Physiological Phenomena
Histone Deacetylases
102 Citations (Scopus)

Amino acid starvation affects the initiation frequency of nucleolar RNA polymerase

Grummt, I., Smith, V. A. & Grummt, F., Mar 1976, In : Cell. 7, 3, p. 439-445 7 p.

Research output: Contribution to journalArticle

Cell Nucleolus
DNA-Directed RNA Polymerases
Starvation
Amino Acids
RNA
36 Citations (Scopus)

A model for the topology of active ribosomal RNA genes

Denissov, S., Lessard, F., Mayer, C., Stefanovsky, V., Van Driel, M., Grummt, I., Moss, T. & Stunnenberg, H. G., Mar 1 2011, In : EMBO reports. 12, 3, p. 231-237 7 p.

Research output: Contribution to journalArticle

Ribosomal RNA
rRNA Genes
Genes
Topology
Chromatin Immunoprecipitation
107 Citations (Scopus)

AMP-activated protein kinase adapts rRNA synthesis to cellular energy supply

Hoppe, S., Bierhoff, H., Cado, I., Weber, A., Tiebe, M., Grummt, I. & Voit, R., Oct 20 2009, In : Proceedings of the National Academy of Sciences of the United States of America. 106, 42, p. 17781-17786 6 p.

Research output: Contribution to journalArticle

AMP-Activated Protein Kinases
Pol1 Transcription Initiation Complex Proteins
Down-Regulation
Adenosine Monophosphate
Serine
49 Citations (Scopus)

A neuroprotective phase precedes striatal degeneration upon nucleolar stress

Kreiner, G., Bierhoff, H., Armentano, M., Rodriguez-Parkitna, J., Sowodniok, K., Naranjo, J. R., Bonfanti, L., Liss, B., Schütz, G., Grummt, I. & Parlato, R., Nov 1 2013, In : Cell death and differentiation. 20, 11, p. 1455-1464 10 p.

Research output: Contribution to journalArticle

Corpus Striatum
Huntington Disease
Neurons
Peptide Initiation Factors
Transcription Factors
44 Citations (Scopus)

A novel promoter in the mouse rDNA spacer is active in vivo and in vitro.

Kuhn, A. & Grummt, I., Nov 1987, In : The EMBO journal. 6, 11, p. 3487-3492 6 p.

Research output: Contribution to journalArticle

RNA Precursors
Ribosomal DNA
Genes
Genetic Promoter Regions
Transcription
9 Citations (Scopus)

A novel RNA binding surface of the TAM domain of TIP5/BAZ2A mediates epigenetic regulation of rRNA genes

Anosova, I., Melnik, S., Tripsianes, K., Kateb, F., Grummt, I. & Sattler, M., Apr 3 2015, In : Nucleic acids research. 43, 10, p. 5208-5220 13 p.

Research output: Contribution to journalArticle

rRNA Genes
Epigenomics
Untranslated RNA
RNA
Chromatin Assembly and Disassembly
29 Citations (Scopus)

An undecamer DNA sequence directs termination of human ribosomal gene transcription

Pfleiderer, C., Smid, A., Bartsch, I. & Grummt, I., Aug 25 1990, In : Nucleic acids research. 18, 16, p. 4727-4736 10 p.

Research output: Contribution to journalArticle

RNA Polymerase I
Genes
Ribosomal DNA
Transcription Initiation Site
DNA-Binding Proteins
81 Citations (Scopus)

A repeated 18 bp sequence motif in the mouse rDNA spacer mediates binding of a nuclear factor and transcription termination

Grummt, I., Rosenbauer, H., Niedermeyer, I., Maier, U. & Öhrlein, A., Jun 20 1986, In : Cell. 45, 6, p. 837-846 10 p.

Research output: Contribution to journalArticle

Sequence Deletion
Insertional Mutagenesis
RNA Precursors
Consensus Sequence
Transcription
72 Citations (Scopus)

A TBP-containing multiprotein complex (TIF-IB) mediates transcription specificity of murine RNA polymerase I

Eberhard, D., Tora, L., Egly, J. M. & Grummt, I., Sep 11 1993, In : Nucleic acids research. 21, 18, p. 4180-4186 7 p.

Research output: Contribution to journalArticle

RNA Polymerase I
Multiprotein Complexes
Transcription
RNA
Specificity
37 Citations (Scopus)

ATPase and GTPase Activities Isolated from Rat Liver Ribosomes

Grummt, F., Grummt, I. & Erdmann, V. A., Apr 1974, In : European Journal of Biochemistry. 43, 2, p. 343-348 6 p.

Research output: Contribution to journalArticle

GTP Phosphohydrolases
Ribosomes
Liver
Adenosine Triphosphatases
Rats
85 Citations (Scopus)

A transcription terminator located upstream of the mouse rDNA initiation site affects rRNA synthesis

Grummt, I., Kuhn, A., Bartsch, I. & Rosenbauer, H., Dec 26 1986, In : Cell. 47, 6, p. 901-911 11 p.

Research output: Contribution to journalArticle

RNA Polymerase I
Transcription Initiation Site
RNA Precursors
Transcription
Ribosomal DNA
17 Citations (Scopus)

Autoantibodies to NOR 90/hUBF: Longterm clinical and serological followup in a patient with limited systemic sclerosis suggests an antigen driven immune response

Dagher, J. H., Scheer, U., Voit, R., Grummt, I., Lonzetti, L., Raymond, Y. & Senécal, J. L., Jan 1 2002, In : Journal of Rheumatology. 29, 7, p. 1543-1547 5 p.

Research output: Contribution to journalArticle

Systemic Scleroderma
Histocompatibility Antigens Class II
Autoantibodies
transcription factor UBF
128 Citations (Scopus)
RNA Polymerase I
Mitosis
Cell Cycle
Phosphorylation
Cyclin B
168 Citations (Scopus)

Cellular stress and nucleolar function

Mayer, C. & Grummt, I., Aug 2005, In : Cell Cycle. 4, 8, p. 1036-1038 3 p.

Research output: Contribution to journalShort survey

Down-Regulation
Mitogen-Activated Protein Kinase 9
RNA Polymerase I
Ribosomal RNA
Nuclear Proteins
46 Citations (Scopus)

Characterization of a cloned ribosomal fragment from mouse which contains the 18S coding region and adjacent spacer sequences

Grummt, I., Soellner, C. & Scholz, I., Apr 1 1979, In : Nucleic acids research. 6, 4, p. 1351-1369 19 p.

Research output: Contribution to journalArticle

Mouse
Fragment
Adjacent
Coding
Genes
16 Citations (Scopus)

Chromatin-Specific Regulation of Mammalian rDNA Transcription by Clustered TTF-I Binding Sites

Diermeier, S. D., Németh, A., Rehli, M., Grummt, I. & Längst, G., Sep 1 2013, In : PLoS genetics. 9, 9, e1003786.

Research output: Contribution to journalArticle

Ribosomal DNA
Chromatin
chromatin
binding sites
transcription (genetics)
104 Citations (Scopus)

Cloning and functional characterization of PTRF, a novel protein which induces dissociation of paused ternary transcription complexes

Jansa, P., Mason, S. W., Hoffmann-Rohrer, U. & Grummt, I., May 15 1998, In : EMBO Journal. 17, 10, p. 2855-2864 10 p.

Research output: Contribution to journalArticle

Cloning
Transcription
Organism Cloning
RNA Precursors
RNA Polymerase I
68 Citations (Scopus)
TATA-Binding Protein Associated Factors
RNA Polymerase I
TATA-Box Binding Protein
Organism Cloning
Proteins
308 Citations (Scopus)

c-Myc associates with ribosomal DNA and activates RNA polymerase I transcription

Arabi, A., Wu, S., Ridderstråle, K., Bierhoff, H., Shiue, C., Fatyol, K., Fahlén, S., Hydbring, P., Söderberg, O., Grummt, I., Larsson, L. G. & Wright, A. P. H., Mar 1 2005, In : Nature cell biology. 7, 3, p. 303-310 8 p.

Research output: Contribution to journalArticle

RNA Polymerase I
Ribosomal DNA
Proteasome Endopeptidase Complex
Proto-Oncogene Proteins c-myc
Nuclear RNA
46 Citations (Scopus)

Constitutive and strong association of PAF53 with RNA polymerase I

Seither, P., Zatsepina, O., Hoffmann, M. & Grummt, I., Oct 16 1997, In : Chromosoma. 106, 4, p. 216-225 10 p.

Research output: Contribution to journalArticle

RNA Polymerase I
Ribosomal DNA
Fluorescent Antibody Technique
Growth
Multiprotein Complexes
87 Citations (Scopus)

Control of nucleolar RNA synthesis by the intracellular pool sizes of ATP and GTP

Grummt, I. & Grummt, F., Mar 1976, In : Cell. 7, 3, p. 447-453 7 p.

Research output: Contribution to journalArticle

Guanosine Triphosphate
Adenosine Triphosphate
RNA
Nucleosides
Purine Nucleosides
14 Citations (Scopus)

Cooperative Action of Cdk1/cyclin B and SIRT1 Is Required for Mitotic Repression of rRNA Synthesis

Voit, R., Seiler, J. & Grummt, I., May 1 2015, In : PLoS genetics. 11, 5, e1005246.

Research output: Contribution to journalArticle

Cyclin B
cyclins
cooperatives
phosphorylation
transcription (genetics)
154 Citations (Scopus)

CSB is a component of RNA pol I transcription

Bradsher, J., Auriol, J., De Santis, L. P., Iben, S., Vonesch, J. L., Grummt, I. & Egly, J. M., Oct 1 2002, In : Molecular cell. 10, 4, p. 819-829 11 p.

Research output: Contribution to journalArticle

Cockayne Syndrome
Mutation
Genes
Phenotype
immune RNA
23 Citations (Scopus)

Death-effector domain-containing protein DEDD is an inhibitor of mitotic Cdk1/cyclin B1

Arai, S., Miyake, K., Voit, R., Nemoto, S., Wakeland, E. K., Grummt, I. & Miyazaki, T., Feb 13 2007, In : Proceedings of the National Academy of Sciences of the United States of America. 104, 7, p. 2289-2294 6 p.

Research output: Contribution to journalArticle

Death Domain Receptor Signaling Adaptor Proteins
Cyclin B1
Cell Size
Null Lymphocytes
Cyclins
108 Citations (Scopus)

DEDD, a novel death effector domain-containing protein, targeted to the nucleolus

Stegh, A. H., Schickling, O., Ehret, A., Scaffidi, C., Peterhänsel, C., Hofmann, T. G., Grummt, I., Krammer, P. H. & Peter, M. E., Oct 15 1998, In : EMBO Journal. 17, 20, p. 5974-5986 13 p.

Research output: Contribution to journalArticle

Death Domain Receptor Signaling Adaptor Proteins
Caspase 8
Transcription
RNA Polymerase I
Pol1 Transcription Initiation Complex Proteins
4 Citations (Scopus)

Detection of RNA-DNA binding sites in long noncoding RNAs

Kuo, C. C., Hänzelmann, S., Sentürk Cetin, N., Frank, S., Zajzon, B., Derks, J. P., Akhade, V. S., Ahuja, G., Kanduri, C., Grummt, I., Kurian, L. & Costa, I. G., Apr 8 2019, In : Nucleic acids research. 47, 6, p. e32

Research output: Contribution to journalArticle

Open Access
Long Noncoding RNA
Binding Sites
RNA
DNA
Genes
12 Citations (Scopus)

Development of a species-specific RNA polymerase I-based shRNA expression vector

Brenz Verca, M. S., Weber, P., Mayer, C., Graf, C., Refojo, D., Kühn, R., Grummt, I. & Lutz, B., Jan 1 2007, In : Nucleic acids research. 35, 2, e10.

Research output: Contribution to journalArticle

Small Interfering RNA
Gene Silencing
52 Citations (Scopus)

Different domains of the murine RNA polymerase I-specific termination factor mTTF-I serve distinct functions in transcription termination

Evers, R., Smid, A., Rudloff, U., Lottspeich, F. & Grummt, I., 1995, In : EMBO Journal. 14, 6, p. 1248-1256 9 p.

Research output: Contribution to journalArticle

RNA Polymerase I
Transcription
DNA
Transcription Factors
myb Genes
57 Citations (Scopus)

Different epigenetic layers engage in complex crosstalk to define the epigenetic state of mammalian rRNA genes

Grummt, I., Apr 15 2007, In : Human molecular genetics. 16, R1, p. R21-R27

Research output: Contribution to journalReview article

Ribosomal DNA
rRNA Genes
Epigenomics
Chromatin
Chromatin Assembly and Disassembly
119 Citations (Scopus)

DNA-dependent protein kinase: A potent inhibitor of transcription by RNA polymerase I

Kuhn, A., Gottlieb, T. M., Jackson, S. P. & Grummt, I., Jan 1 1995, In : Genes and Development. 9, 2, p. 193-203 11 p.

Research output: Contribution to journalArticle

DNA-Activated Protein Kinase
RNA Polymerase I
Cyclic AMP-Dependent Protein Kinases
DNA
Peptide Initiation Factors
15 Citations (Scopus)

DNA sequence encoded repression of rRNA gene transcription in chromatin

Felle, M., Exler, J. H., Merkl, R., Dachauer, K., Brehm, A., Grummt, I. & Längst, G., Apr 25 2010, In : Nucleic acids research. 38, 16, p. 5304-5314 11 p., gkq263.

Research output: Contribution to journalArticle

Nucleosomes
rRNA Genes
Chromatin
Ribosomal DNA
Chromatin Assembly and Disassembly
78 Citations (Scopus)

Drastic rise of intracellular adenosine(5′)tetraphospho(5′)adenosine correlates with onset of DNA synthesis in eukaryotic cells

WEINMANN‐DORSCH, C., HEDL, A., GRUMMT, I., ALBERT, W., FERDINAND, FJ. J., FRIIS, R. R., PIERRON, G., MOLL, W. & GRUMMT, F., Jan 1984, In : European Journal of Biochemistry. 138, 1, p. 179-185 7 p.

Research output: Contribution to journalArticle

Eukaryotic Cells
DNA
S Phase
Cells
G1 Phase
79 Citations (Scopus)
Trans-Activators
DNA
RNA Polymerase I
Peptide Initiation Factors
Proteins
23 Citations (Scopus)

Dynamic regulation of nucleolar architecture

Németh, A. & Grummt, I., Jun 1 2018, In : Current Opinion in Cell Biology. 52, p. 105-111 7 p.

Research output: Contribution to journalReview article

Ribonucleoproteins
Nuclear Proteins
Cell Cycle Checkpoints
Ribosomes
Chromatin
14 Citations (Scopus)

Dynamic subcellular partitioning of the nucleolar transcription factor TIF-IA under ribotoxic stress

Szymański, J., Mayer, C., Hoffmann-Rohrer, U., Kalla, C., Grummt, I. & Weiss, M., Jul 1 2009, In : Biochimica et Biophysica Acta - Molecular Cell Research. 1793, 7, p. 1191-1198 8 p.

Research output: Contribution to journalArticle

Karyopherins
Cytoplasm
Pol1 Transcription Initiation Complex Proteins
MAP Kinase Kinase 4
Osmotic Pressure
11 Citations (Scopus)

Effects of TψCG on the enzymatic binding of eukaryotic and prokaryotic initiator tRNAs to rat liver ribosomes

Grummt, F., Grummt, I., Gross, H. J., Sprinzl, M., Richter, D. & Erdmann, V. A., May 15 1974, In : FEBS Letters. 42, 1, p. 15-17 3 p.

Research output: Contribution to journalArticle

Ultraviolet Spectrophotometry
Bacterial RNA
RNA, Transfer, Met
Nucleic Acid Conformation
Drug Receptors
38 Citations (Scopus)
RNA Polymerase I
Chloramphenicol O-Acetyltransferase
Gene Fusion
Ribosomal DNA
Moloney murine sarcoma virus
76 Citations (Scopus)

Epigenetic control of RNA polymerase I transcription in mammalian cells

Grummt, I. & Längst, G., Mar 1 2013, In : Biochimica et Biophysica Acta - Gene Regulatory Mechanisms. 1829, 3-4, p. 393-404 12 p.

Research output: Contribution to journalReview article

RNA Polymerase I
Transcription
Ribosomal DNA
Epigenomics
Cells