• 1308 Citations
  • 18 h-Index
20002019
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Research Output 2000 2019

  • 1308 Citations
  • 18 h-Index
  • 29 Article
  • 1 Letter
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Article
2019
1 Citation (Scopus)
Adenocarcinoma
Tumor Microenvironment
Myofibroblasts
Therapeutics
Fibroblasts
2018
3 Citations (Scopus)

Identification of cisplatin sensitizers through high-throughput combinatorial screening

Sun, Y., Jiang, W., Lu, W., Song, M., Liu, K., Chen, P., Chang, A., Ling, J., Chiao, P. J., Hu, Y. & Huang, P., Sep 2018, In : International journal of oncology. 53, 3, p. 1237-1246 10 p.

Research output: Contribution to journalArticle

Cisplatin
Topotecan
United States Food and Drug Administration
Antimony Potassium Tartrate
Pharmaceutical Preparations
16 Citations (Scopus)

Immune Cell Production of Interleukin 17 Induces Stem Cell Features of Pancreatic Intraepithelial Neoplasia Cells

Zhang, Y., Zoltan, M., Riquelme, E., Xu, H., Sahin, I., Castro-Pando, S., Montiel, M. F., Chang, K., Jiang, Z., Ling, J., Gupta, S., Horne, W., Pruski, M., Wang, H., Sun, S. C., Lozano, G., Chiao, P., Maitra, A., Leach, S. D., Kolls, J. K. & 4 others, Vilar, E., Wang, T. C., Bailey, J. M. & McAllister, F., Jul 2018, In : Gastroenterology. 155, 1, p. 210-223.e3

Research output: Contribution to journalArticle

Interleukin-17
Stem Cells
Neoplasms
Pancreatic Neoplasms
Pancreas
8 Citations (Scopus)

SOX9 activity is induced by oncogenic Kras to affect MDC1 and MCMs expression in pancreatic cancer

Zhou, H., Qin, Y., Ji, S., Ling, J., Fu, J., Zhuang, Z., Fan, X., Song, L., Yu, X. & Chiao, P. J., Feb 15 2018, In : Oncogene. 37, 7, p. 912-923 12 p.

Research output: Contribution to journalArticle

Pancreatic Neoplasms
DNA Damage
Adenocarcinoma
Maintenance
Mediator Complex
2 Citations (Scopus)

Suppression of stromal-derived Dickkopf-3 (DKK3) inhibits tumor progression and prolongs survival in pancreatic ductal adenocarcinoma

Zhou, L., Husted, H., Moore, T., Lu, M., Deng, D., Liu, Y., Ramachandran, V., Arumugam, T., Niehrs, C., Wang, H., Chiao, P., Ling, J., Curran, M. A., Maitra, A., Hung, M. C., Lee, J. E., Logsdon, C. D. & Hwang, R. F., Oct 24 2018, In : Science Translational Medicine. 10, 464, eaat3487.

Research output: Contribution to journalArticle

Adenocarcinoma
Survival
Neoplasms
Pancreatic Stellate Cells
Growth
2017
17 Citations (Scopus)

Mutant Kras- and p16-regulated NOX4 activation overcomes metabolic checkpoints in development of pancreatic ductal adenocarcinoma

Ju, H. Q., Ying, H., Tian, T., Ling, J., Fu, J., Lu, Y., Wu, M., Yang, L., Achreja, A., Chen, G., Zhuang, Z., Wang, H., Nagrath, D., Yao, J., Hung, M. C., DePinho, R. A., Huang, P., Xu, R. H. & Chiao, P. J., Feb 24 2017, In : Nature communications. 8, 14437.

Research output: Contribution to journalArticle

Adenocarcinoma
Chemical activation
activation
NAD
deactivation
4 Citations (Scopus)

NEMO peptide inhibits the growth of pancreatic ductal adenocarcinoma by blocking NF-κB activation

Zhuang, Z., Li, H., Lee, H., Aguilar, M., Gocho, T., Ju, H., Iida, T., Ling, J., Fu, J., Wu, M., Sun, Y., Lu, Y. & Chiao, P. J., Dec 28 2017, In : Cancer Letters. 411, p. 44-56 13 p.

Research output: Contribution to journalArticle

gemcitabine
Adenocarcinoma
Peptides
Growth
Pancreatic Neoplasms
2016
42 Citations (Scopus)

IL1 receptor antagonist inhibits pancreatic cancer growth by abrogating NF-κB activation

Zhuang, Z., Ju, H. Q., Aguilar, M., Gocho, T., Li, H., Iida, T., Lee, H., Fan, X., Zhou, H., Ling, J., Li, Z., Fu, J., Wu, M., Li, M., Melisi, D., Iwakura, Y., Xu, K., Fleming, J. B. & Chiao, P. J., Mar 15 2016, In : Clinical Cancer Research. 22, 6, p. 1432-1444 13 p.

Research output: Contribution to journalArticle

gemcitabine
Interleukin-1 Receptors
Pancreatic Neoplasms
Adenocarcinoma
Growth
15 Citations (Scopus)

Transforming growth factor-β limits secretion of lumican by activated stellate cells within primary pancreatic adenocarcinoma tumors

Kang, YA., Roife, D., Lee, Y., Lv, H., Suzuki, R., Ling, J., Rios Perez, M. V., Li, X., Dai, B., Pratt, M., Truty, M. J., Chatterjee, D., Wang, H., Thomas, R. M., Wang, Y., Koay, E. J., Chiao, P. J., Katz, M. H. & Fleming, J. B., Oct 1 2016, In : Clinical Cancer Research. 22, 19, p. 4934-4946 13 p.

Research output: Contribution to journalArticle

Transforming Growth Factors
Adenocarcinoma
Collagen
Neoplasms
Pancreatic Stellate Cells
2014
27 Citations (Scopus)

Cooperativity of oncogenic K-ras and downregulated p16/INK4A in human pancreatic tumorigenesis

Chang, Z., Ju, H., Ling, J., Zhuang, Z., Li, Z., Wang, H., Fleming, J. B., Freeman, J. W., Yu, D., Huang, P. & Chiao, P. J., Jul 16 2014, In : PloS one. 9, 7, e101452.

Research output: Contribution to journalArticle

Cyclin-Dependent Kinase Inhibitor p16
carcinogenesis
Carcinogenesis
Down-Regulation
Nestin
18 Citations (Scopus)

SMAD4 regulates cell motility through transcription of N-cadherin in human pancreatic ductal epithelium

Kang, YA., Ling, J., Suzuki, R., Roife, D., Chopin-Laly, X., Truty, M. J., Chatterjee, D., Wang, H., Thomas, R. M., Katz, M. H., Chiao, P. J. & Fleming, J. B., Sep 29 2014, In : PloS one. 9, 9, e107948.

Research output: Contribution to journalArticle

transforming growth factors
cadherins
Transforming Growth Factors
Cadherins
Transcription
2012
17 Citations (Scopus)

Constitutive activation of p38 MAPK in tumor cells contributes to osteolytic bone lesions in multiple myeloma

Yang, J., He, J., Wang, J., Cao, Y., Ling, J., Qian, J., Lu, Y., Li, H., Zheng, Y., Lan, Y., Hong, S., Matthews, J., Starbuck, M. W., Navone, N. M., Orlowski, R. Z., Lin, P., Kwak, L. W. & Yi, Q., Sep 1 2012, In : Leukemia. 26, 9, p. 2114-2123 10 p.

Research output: Contribution to journalArticle

p38 Mitogen-Activated Protein Kinases
Multiple Myeloma
Bone and Bones
Neoplasms
SCID Mice
267 Citations (Scopus)

Kras G12D-Induced IKK2/β/NF-κB Activation by IL-1α and p62 Feedforward Loops Is Required for Development of Pancreatic Ductal Adenocarcinoma

Ling, J., Kang, Y., Zhao, R., Xia, Q., Lee, D. F., Chang, Z., Li, J., Peng, B., Fleming, J. B., Wang, H., Liu, J., Lemischka, I. R., Hung, M. C. & Chiao, P. J., Jan 17 2012, In : Cancer cell. 21, 1, p. 105-120 16 p.

Research output: Contribution to journalArticle

Interleukin-1
Adenocarcinoma
Transcription Factor AP-1
Pancreas
Mutation
2011
7 Citations (Scopus)

Kras, Pten, NF-κB, and inflammation: Dangerous liaisons

Chiao, P. J. & Ling, J., Jul 18 2011, In : Cancer discovery. 1, 2, p. 103-105 3 p.

Research output: Contribution to journalArticle

Pancreatic Neoplasms
Inflammation
Phosphatidylinositol 3-Kinases
Molecular Biology
Up-Regulation
96 Citations (Scopus)

Modulation of pancreatic cancer chemoresistance by inhibition of TAK1

Melisi, D., Xia, Q., Paradiso, G., Ling, J., Moccia, T., Carbone, C., Budillon, A., Abbruzzese, J. L. & Chiao, P. J., Aug 3 2011, In : Journal of the National Cancer Institute. 103, 15, p. 1190-1204 15 p.

Research output: Contribution to journalArticle

gemcitabine
Pancreatic Neoplasms
Phosphotransferases
oxaliplatin
irinotecan
2010
32 Citations (Scopus)

Defective feedback regulation of NF-κB underlies Sjögren's syndrome in mice with mutated κB enhancers of the IκBα promoter

Peng, B., Ling, J., Lee, A. J., Wang, Z., Chang, Z., Jin, W., Kang, Y., Zhang, R., Shim, D., Wang, H., Fleming, J. B., Zheng, H., Sun, S. C. & Chiao, P. J., Aug 24 2010, In : Proceedings of the National Academy of Sciences of the United States of America. 107, 34, p. 15193-15198 6 p.

Research output: Contribution to journalArticle

T-Lymphocytes
Septic Shock
Genes
Autoimmune Diseases
Hypersensitivity
48 Citations (Scopus)

Long-range function of an intergenic retrotransposon

Pi, W., Zhu, X., Wu, M., Wang, Y., Fulzele, S., Eroglu, A., Ling, J. & Tuan, D., Jul 20 2010, In : Proceedings of the National Academy of Sciences of the United States of America. 107, 29, p. 12992-12997 6 p.

Research output: Contribution to journalArticle

Retroelements
Terminal Repeat Sequences
Endogenous Retroviruses
Globins
Genes
2009
28 Citations (Scopus)

Oral poly(ADP-ribose) polymerase-1 inhibitor BSI-401 has antitumor activity and synergizes with oxaliplatin against pancreatic cancer, preventing acute neurotoxicity

Melisi, D., Ossovskaya, V., Cihui, Z., Rosa, R., Jianhua, L., Dougherty, P. M., Sherman, B. M., Abbruzzese, J. L. & Chiao, P. J., Oct 15 2009, In : Clinical Cancer Research. 15, 20, p. 6367-6377 11 p.

Research output: Contribution to journalArticle

oxaliplatin
Pancreatic Neoplasms
Nude Mice
DNA Damage
Poly (ADP-Ribose) Polymerase-1
2007
60 Citations (Scopus)

A facilitated tracking and transcription mechanism of long-range enhancer function

Zhu, X., Ling, J., Zhang, L., Pi, W., Wu, M. & Tuan, D., Aug 1 2007, In : Nucleic acids research. 35, 16, p. 5532-5544 13 p.

Research output: Contribution to journalArticle

Globins
DNA
DNA Polymerase II
Locus Control Region
Genes
207 Citations (Scopus)

Reduction of TRAIL-Induced Mcl-1 and cIAP2 by c-Myc or Sorafenib Sensitizes Resistant Human Cancer Cells to TRAIL-Induced Death

Ricci, M. S., Kim, S. H., Ogi, K., Plastaras, J. P., Ling, J., Wang, W., Jin, Z., Liu, Y. Y., Dicker, D. T., Chiao, P. J., Flaherty, K. T., Smith, C. D. & El-Deiry, W. S., Jul 10 2007, In : Cancer cell. 12, 1, p. 66-80 15 p.

Research output: Contribution to journalArticle

Apoptosis
Neoplasms
Heterografts
Mitochondria
sorafenib
2005
44 Citations (Scopus)

The HS2 enhancer of the β-globin locus control region initiates synthesis of non-coding, polyadenylated RNAs independent of a cis-linked globin promoter

Ling, J., Baibakov, B., Pi, W., Emerson, B. M. & Tuan, D., Jul 29 2005, In : Journal of Molecular Biology. 350, 5, p. 883-896 14 p.

Research output: Contribution to journalArticle

Locus Control Region
Untranslated RNA
Globins
RNA
K562 Cells
35 Citations (Scopus)

The long terminal repeat (LTR) of ERV-9 human endogenous retrovirus binds to NF-Y in the assembly of an active LTR enhancer complex NF-Y/MZF1/GATA-2

Yu, X., Zhu, X., Pi, W., Ling, J., Ko, L., Takeda, Y. & Tuan, D., Oct 21 2005, In : Journal of Biological Chemistry. 280, 42, p. 35184-35194 11 p.

Research output: Contribution to journalArticle

Endogenous Retroviruses
Terminal Repeat Sequences
Erythroid Cells
Nucleotide Motifs
Globins
2004
3 Citations (Scopus)

Dynamic retrotransposition of ERV-9 LTR and L1 in the β-globin gene locus during primate evolution

Ling, J., Zhang, L., Jin, H., Pi, W., Kosteas, T., Anagnou, N. P., Goodman, M. & Tuan, D., Mar 2004, In : Molecular Phylogenetics and Evolution. 30, 3, p. 867-871 5 p.

Research output: Contribution to journalArticle

Endogenous Retroviruses
beta-Globins
primate
Primates
loci
57 Citations (Scopus)

HS2 enhancer function is blocked by a transcriptional terminator inserted between the enhancer and the promoter

Ling, J., Ainol, L., Zhang, L., Yu, X., Pi, W. & Tuan, D., Dec 3 2004, In : Journal of Biological Chemistry. 279, 49, p. 51704-51713 10 p.

Research output: Contribution to journalArticle

Transcription
Globins
Lac Repressors
Erythroid Cells
DNA
29 Citations (Scopus)

The LTR enhancer of ERV-9 human endogenous retrovirus is active in oocytes and progenitor cells in transgenic zebrafish and humans

Pi, W., Yang, Z., Wang, J., Ruan, L., Yu, X., Ling, J., Krantz, S., Isales, C., Conway, S. J., Lin, S. & Tuan, D., Jan 20 2004, In : Proceedings of the National Academy of Sciences of the United States of America. 101, 3, p. 805-810 6 p.

Research output: Contribution to journalArticle

Endogenous Retroviruses
Zebrafish
Oocytes
Stem Cells
Globins
117 Citations (Scopus)

Wound-induced HB-EGF ectodomain shedding and EGFR activation in corneal epithelial cells

Xu, K. P., Ding, Y., Ling, J., Dong, Z. & Yu, F. S. X., Mar 1 2004, In : Investigative Ophthalmology and Visual Science. 45, 3, p. 813-820 8 p.

Research output: Contribution to journalArticle

Epidermal Growth Factor Receptor
Epidermal Growth Factor
Epithelial Cells
Wounds and Injuries
Matrix Metalloproteinase Inhibitors
2003
19 Citations (Scopus)

The ERV-9 LTR enhancer is not blocked by the HS5 insulator and synthesizes through the HS5 site non-coding, long RNAs that regulate LTR enhancer function

Ling, J., Pi, W., Yu, X., Bengra, C., Long, Q., Jin, H., Seyfang, A. & Tuan, D., Aug 1 2003, In : Nucleic acids research. 31, 15, p. 4582-4596 15 p.

Research output: Contribution to journalArticle

Long Noncoding RNA
Endogenous Retroviruses
Terminal Repeat Sequences
Globins
RNA
2002
54 Citations (Scopus)

The solitary long terminal repeats of ERV-9 endogenous retrovirus are conserved during primate evolution and possess enhancer activities in embryonic and hematopoietic cells

Ling, J., Pi, W., Bollag, R., Zeng, S., Keskintepe, M., Saliman, H., Krantz, S., Whitney, B. & Tuan, D., Feb 26 2002, In : Journal of Virology. 76, 5, p. 2410-2423 14 p.

Research output: Contribution to journalArticle

Retroviridae
Endogenous Retroviruses
terminal repeat sequences
Terminal Repeat Sequences
Primates
2000
34 Citations (Scopus)

Stable and unstable transgene integration sites in the human genome: extinction of the Green Fluorescent Protein transgene in K562 cells

Migliaccio, A. R., Bengra, C., Ling, J., Pi, W., Li, C., Zeng, S., Keskintepe, M., Whitney, B., Sanchez, M., Migliaccio, G. & Tuan, D., Oct 3 2000, In : Gene. 256, 1-2, p. 197-214 18 p.

Research output: Contribution to journalArticle

K562 Cells
Human Genome
Green Fluorescent Proteins
Transgenes
Genes