John Frederick de Groot

Professor

  • 8935 Citations
  • 41 h-Index
19972019
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Research Output 1997 2019

2019

Are we AKT-ually getting closer to making targeted therapy successful in breast cancer brain metastases?

Majd, N., Weathers, S. P. & De Groot, J., Nov 4 2019, In : Neuro-oncology. 21, 11, p. 1344-1345 2 p.

Research output: Contribution to journalEditorial

Brain Neoplasms
Breast Neoplasms
Neoplasm Metastasis
Therapeutics
7 Citations (Scopus)

Buparlisib in patients with recurrent glioblastoma harboring phosphatidylinositol 3-kinase pathway activation: An open-label, multicenter, multi-arm, phase II trial

Wen, P. Y., Touat, M., Alexander, B. M., Mellinghoff, I. K., Ramkissoon, S., McCluskey, C. S., Pelton, K., Haidar, S., Basu, S. S., Gaffey, S. C., Brown, L. E., Martinez-Ledesma, J. E., Wu, S., Kim, J., Wei, W., Park, M. A., Huse, J. T., Kuhn, J. G., Rinne, M. L., Colman, H. & 24 others, Agar, N. Y. R., Omuro, A. M., DeAngelis, L. M., Gilbert, M. R., de Groot, J. F., Cloughesy, T. F., Chi, A. S., Roberts, T. M., Zhao, J. J., Lee, E. Q., Nayak, L., Heath, J. R., Horky, L. L., Batchelor, T. T., Beroukhim, R., Chang, S. M., Ligon, A. H., Dunn, I. F., Koul, D., Young, G. S., Prados, M. D., Reardon, D. A., Alfred Yung, W. K. & Ligon, K. L., Mar 20 2019, In : Journal of Clinical Oncology. 37, 9, p. 741-750 10 p.

Research output: Contribution to journalArticle

Phosphatidylinositol 3-Kinase
Glioblastoma
Neoplasms
Pharmacokinetics
NVP-BKM120
1 Citation (Scopus)

Clinical trial participation of patients with glioblastoma at The University of Texas MD Anderson Cancer Center

Harrison, R., Anderson, M. D., Cachia, D., Kamiya Matsuoka, C., Weathers, S-P., O'Brien, B. J., Penas-Prado, M., Yung, W. K. A., Wu, J., Yuan, Y. & de Groot, J. F., May 1 2019, In : European Journal of Cancer. 112, p. 83-93 11 p.

Research output: Contribution to journalArticle

Patient Participation
Glioblastoma
Clinical Trials
Neoplasms
Clinical Protocols
1 Citation (Scopus)

Disparities along the glioblastoma clinical trials landscape

Ludmir, E. B., Mandel, J. J., McAleer, M. F. & de Groot, J. F., Feb 14 2019, In : Neuro-oncology. 21, 2, p. 285-286 2 p.

Research output: Contribution to journalLetter

Open Access
Glioblastoma
Clinical Trials

Effect of health disparities on overall survival of patients with glioblastoma

Mandel, J. J., Youssef, M., Nam, J., Patel, A. J., Jalali, A., Ludmir, E. B., Liu, D., Wu, J., Armstrong, G., Huse, J., Bondy, M. & de Groot, J. F., Apr 15 2019, In : Journal of neuro-oncology. 142, 2, p. 365-374 10 p.

Research output: Contribution to journalArticle

Glioblastoma
Survival
Health
Standard of Care
County Hospitals
1 Citation (Scopus)

Erratum: Inhibition of Nuclear PTEN Tyrosine Phosphorylation Enhances Glioma Radiation Sensitivity through Attenuated DNA Repair (Cancer Cell (2019)35(3)(504–518.e7), (S1535610819300546), (10.1016/j.ccell.2019.01.020))

Ma, J., Benitez, J. A., Li, J., Miki, S., Ponte de Albuquerque, C., Galatro, T., Orellana, L., Zanca, C., Reed, R., Boyer, A., Koga, T., Varki, N. M., Fenton, T. R., Nagahashi Marie, S. K., Lindahl, E., Gahman, T. C., Shiau, A. K., Zhou, H., de Groot, J. F., Sulman, E. P. & 4 others, Cavenee, W. K., Kolodner, R. D., Chen, C. C. & Furnari, F. B., May 13 2019, In : Cancer cell. 35, 5, 1 p.

Research output: Contribution to journalComment/debate

Open Access
Radiation Tolerance
Glioma
DNA Repair
Tyrosine
Phosphorylation
5 Citations (Scopus)

Inhibition of Nuclear PTEN Tyrosine Phosphorylation Enhances Glioma Radiation Sensitivity through Attenuated DNA Repair

Ma, J., Benitez, J. A., Li, J., Miki, S., Ponte de Albuquerque, C., Galatro, T., Orellana, L., Zanca, C., Reed, R., Boyer, A., Koga, T., Varki, N. M., Fenton, T. R., Nagahashi Marie, S. K., Lindahl, E., Gahman, T. C., Shiau, A. K., Zhou, H., DeGroot, J., Sulman, E. P. & 4 others, Cavenee, W. K., Kolodner, R. D., Chen, C. C. & Furnari, F. B., Mar 18 2019, In : Cancer cell. 35, 3, p. 504-518.e7

Research output: Contribution to journalArticle

Radiation Tolerance
Glioma
DNA Repair
Tyrosine
Phosphorylation

Letter: When less is more: Dexamethasone dosing for brain tumors

Lim-Fat, M. J., Bi, W. L., Lo, J., Lee, E. Q., Ahluwalia, M. S., Batchelor, T. T., Chang, S. M., Chiocca, E. A., Chukwueke, U., Cloughesy, T. F., Colman, H., Deangelis, L. M., Galanis, E., Gilbert, M. R., De Groot, J. F., Lassman, A. B., Liau, L. M., Mason, W., McFaline-Figueroa, J. R., Mehta, M. P. & 5 others, Mellinghoff, I. K., Nabors, L. B., Nayak, L., Reardon, D. A. & Wen, P. Y., Sep 1 2019, In : Clinical Neurosurgery. 85, 3, p. E607-E608 nyz186.

Research output: Contribution to journalLetter

Brain Neoplasms
Dexamethasone
34 Citations (Scopus)

Neoadjuvant anti-PD-1 immunotherapy promotes a survival benefit with intratumoral and systemic immune responses in recurrent glioblastoma

Cloughesy, T. F., Mochizuki, A. Y., Orpilla, J. R., Hugo, W., Lee, A. H., Davidson, T. B., Wang, A. C., Ellingson, B. M., Rytlewski, J. A., Sanders, C. M., Kawaguchi, E. S., Du, L., Li, G., Yong, W. H., Gaffey, S. C., Cohen, A. L., Mellinghoff, I. K., Lee, E. Q., Reardon, D. A., O'Brien, B. J. & 10 others, Butowski, N. A., Nghiemphu, P. L., Clarke, J. L., Arrillaga-Romany, I. C., Colman, H., Kaley, T. J., de Groot, J. F., Liau, L. M., Wen, P. Y. & Prins, R. M., Mar 1 2019, In : Nature medicine. 25, 3, p. 477-486 10 p.

Research output: Contribution to journalArticle

Glioblastoma
Immunotherapy
T-cells
Tumors
Survival
3 Citations (Scopus)

Phase 1 lead-in to a phase 2 factorial study of temozolomide plus memantine, mefloquine, and metformin as postradiation adjuvant therapy for newly diagnosed glioblastoma

Maraka, S., Groves, M. D., Mammoser, A. G., Melguizo-Gavilanes, I., Conrad, C. A., Tremont-Lukats, I. W., Loghin, M. E., O'Brien, B. J., Puduvalli, V. K., Sulman, E. P., Hess, K. R., Aldape, K. D., Gilbert, M. R., de Groot, J. F., Alfred Yung, W. K. & Penas-Prado, M., Feb 1 2019, In : Cancer. 125, 3, p. 424-433 10 p.

Research output: Contribution to journalArticle

temozolomide
Mefloquine
Memantine
Metformin
Glioblastoma

Prospective clinical sequencing of adult glioma

Zheng, S., Alfaro-Munoz, K., Wei, W., Wang, X., Wang, F., Eterovic, A. K., Shaw, K. R. M., Meric-Bernstam, F., Fuller, G. N., Chen, K., Verhaak, R. G., Mills, G. B., Yung, W. K. A., Weathers, S. P. & De Groot, J. F., Jan 1 2019, In : Molecular cancer therapeutics. 18, 5, p. 991-1000 10 p.

Research output: Contribution to journalArticle

Glioma
Glioblastoma
Mutation
Neoplasms
temozolomide
7 Citations (Scopus)

The molecular landscape of glioma in patients with Neurofibromatosis 1

D’Angelo, F., Ceccarelli, M., Tala, Garofano, L., Zhang, J., Frattini, V., Caruso, F. P., Lewis, G., Alfaro, K. D., Bauchet, L., Berzero, G., Cachia, D., Cangiano, M., Capelle, L., de Groot, J., DiMeco, F., Ducray, F., Farah, W., Finocchiaro, G., Goutagny, S. & 27 others, Kamiya-Matsuoka, C., Lavarino, C., Loiseau, H., Lorgis, V., Marras, C. E., McCutcheon, I., Nam, D. H., Ronchi, S., Saletti, V., Seizeur, R., Slopis, J., Suñol, M., Vandenbos, F., Varlet, P., Vidaud, D., Watts, C., Tabar, V., Reuss, D. E., Kim, S. K., Meyronet, D., Mokhtari, K., Salvador, H., Bhat, K. P., Eoli, M., Sanson, M., Lasorella, A. & Iavarone, A., Jan 1 2019, In : Nature medicine. 25, 1, p. 176-187 12 p.

Research output: Contribution to journalArticle

Neurofibromatosis 1
Glioma
Tumors
Genes
Isocitrate Dehydrogenase

The path forward for anti-programmed death-1 therapy in gliomas

Majd, N., Kamiya-Matsuoka, C. & De Groot, J., Jan 1 2019, (Accepted/In press) In : Current Opinion in Neurology.

Research output: Contribution to journalReview article

Glioblastoma
Glioma
Cell Death
Therapeutics
Immunotherapy

Treatment strategies for glioblastoma in older patients: age is just a number

Youssef, M., Ludmir, E. B., Mandel, J. J., Patel, A. J., Jalali, A., Treiber, J., Wu, J., McAleer, M. F. & de Groot, J. F., Nov 1 2019, In : Journal of neuro-oncology. 145, 2, p. 357-364 8 p.

Research output: Contribution to journalArticle

temozolomide
Glioblastoma
Radiotherapy
Therapeutics
Survival
2018
8 Citations (Scopus)

A coclinical radiogenomic validation study: Conserved magnetic resonance radiomic appearance of periostin-expressing glioblastoma in patients and xenograft models

Zinn, P. O., Singh, S. K., Kotrotsou, A., Hassan, I., Thomas, G., Luedi, M. M., Elakkad, A., Elshafeey, N., Idris, T., Mosley, J., Gumin, J., Fuller, G. N., De Groot, J. F., Baladandayuthapani, V., Sulman, E. P., Kumar, A. J., Sawaya, R., Lang, F. F., Piwnica-Worms, D. & Colen, R. R., Dec 15 2018, In : Clinical Cancer Research. 24, 24, p. 6288-6299 12 p.

Research output: Contribution to journalArticle

Validation Studies
Glioblastoma
Heterografts
Magnetic Resonance Spectroscopy
Area Under Curve
21 Citations (Scopus)

Adaptive global innovative learning environment for glioblastoma: GBM AGILE

GBM AGILE Network, Feb 15 2018, In : Clinical Cancer Research. 24, 4, p. 737-743 7 p.

Research output: Contribution to journalReview article

Glioblastoma
Learning
Biomarkers
Therapeutics
Random Allocation
48 Citations (Scopus)

An inhibitor of oxidative phosphorylation exploits cancer vulnerability

Molina, J. R., Sun, Y., Protopopova, M., Gera, S., Bandi, M., Bristow, C., McAfoos, T., Morlacchi, P., Ackroyd, J., Agip, A. N. A., Al-Atrash, G., Asara, J., Bardenhagen, J., Carrillo, C. C., Carroll, C., Chang, E., Ciurea, S., Cross, J. B., Czako, B., Deem, A. & 46 others, Daver, N., De Groot, J. F., Dong, J. W., Feng, N., Gao, G., Gay, J., Do, M. G., Greer, J., Giuliani, V., Han, J., Han, L., Henry, V. K., Hirst, J., Huang, S., Jiang, Y., Kang, Z., Khor, T., Konoplev, S., Lin, Y. H., Liu, G., Lodi, A., Lofton, T., Ma, H., Mahendra, M., Matre, P., Mullinax, R., Peoples, M., Petrocchi, A., Rodriguez-Canale, J., Serreli, R., Shi, T., Smith, M., Tabe, Y., Theroff, J., Tiziani, S., Xu, Q., Zhang, Q., Muller, F., Depinho, R. A., Toniatti, C., Draetta, G. F., Heffernan, T. P., Konopleva, M., Jones, P., Di Francesco, M. E. & Marszalek, J. R., Jul 1 2018, In : Nature medicine. 24, 7, p. 1036-1046 11 p.

Research output: Contribution to journalArticle

Oxidative Phosphorylation
Tumors
Acute Myeloid Leukemia
Brain Neoplasms
Brain
270 Citations (Scopus)

Chimeric antigen receptor T-cell therapy-assessment and management of toxicities

Neelapu, S. S., Tummala, S., Kebriaei, P., Wierda, W. G., Gutierrez, C., Locke, F. L., Komanduri, K. V., Lin, Y., Jain, N., Daver, N., Westin, J. R., Gulbis, A. M., Loghin, M. E., de Groot, J. F., Adkins, S., Davis, S. E., Rezvani, K., Hwu, P. & Shpall, E., Jan 1 2018, In : Nature Reviews Clinical Oncology. 15, 1, p. 47-62 16 p.

Research output: Contribution to journalReview article

Antigen Receptors
Cell- and Tissue-Based Therapy
Cytokines
Hemophagocytic Lymphohistiocytosis
Brain Diseases

Ependymomas overexpress chemoresistance and DNA repairrelated proteins

Ferguson, S. D., Zhou, S., Xiu, J., Hashimoto, Y., Sanai, N., Kim, L., Kesari, S., de Groot, J., Spetzler, D. & Heimberger, A. B., Jan 1 2018, In : Oncotarget. 9, 8, p. 7822-7831 10 p.

Research output: Contribution to journalArticle

Ependymoma
DNA
Proteins
Therapeutics
DNA Repair Enzymes
11 Citations (Scopus)

Glioma through the looking GLASS: Molecular evolution of diffuse gliomas and the Glioma Longitudinal Analysis Consortium

Aldape, K., Amin, S. B., Ashley, D. M., Barnholtz-Sloan, J. S., Bates, A. J., Beroukhim, R., Bock, C., Brat, D. J., Claus, E. B., Costello, J. F., de Groot, J. F., Finocchiaro, G., French, P. J., Gan, H. K., Griffith, B., Herold-Mende, C. C., Horbinski, C., Iavarone, A., Kalkanis, S. N., Karabatsou, K. & 36 others, Kim, H., Kouwenhoven, M. C. M., McDonald, K. L., Miletic, H., Nam, D. H., Ng, H. K., Niclou, S. P., Noushmehr, H., Ryan Ormond, D., Poisson, L. M., Reifenberger, G., Roncaroli, F., Sa, J. K., Sillevis Smitt, P. A. E., Smits, M., Souza, C. F., Tabatabai, G., Van Meir, E. G., Verhaak, R. G. W., Watts, C., Wesseling, P., Woehrer, A., Alfred Yung, W. K., Jungk, C., Hau, A. C., van Dyck, E., Westerman, B. A., Yin, J., Abiola, O., Zeps, N., Grimmond, S., Buckland, M., Khasraw, M., Sulman, E. P., Muscat, A. M. & Stead, L., Jun 18 2018, In : Neuro-oncology. 20, 7, p. 873-884 12 p.

Research output: Contribution to journalArticle

Open Access
Molecular Evolution
Glioma
Atlases
Epigenomics
Brain Neoplasms
1 Citation (Scopus)

Highlighting the need for reliable clinical trials in glioblastoma

Mandel, J. J., Youssef, M., Ludmir, E., Yust-Katz, S., Patel, A. J. & de Groot, J. F., Oct 3 2018, In : Expert Review of Anticancer Therapy. 18, 10, p. 1031-1040 10 p.

Research output: Contribution to journalReview article

Glioblastoma
Clinical Trials
Survival
Biomarkers
Therapeutics
5 Citations (Scopus)

Inability of positive phase II clinical trials of investigational treatments to subsequently predict positive phase III clinical trials in glioblastoma

Mandel, J. J., Yust-Katz, S., Patel, A. J., Cachia, D., Liu, DI., Park, M., Yuan, Y., Kent, T. A. & de Groot, J. F., Jan 1 2018, In : Neuro-oncology. 20, 1, p. 113-122 10 p.

Research output: Contribution to journalArticle

Phase III Clinical Trials
Phase II Clinical Trials
Investigational Therapies
Glioblastoma
Standard of Care
29 Citations (Scopus)

Intermediate-risk meningioma: Initial outcomes from NRG Oncology RTOG 0539

Rogers, L., Zhang, P., Vogelbaum, M. A., Perry, A., Ashby, L. S., Modi, J. M., Alleman, A. M., Galvin, J., Brachman, D., Jenrette, J. M., De Groot, J., Bovi, J. A., Werner-Wasik, M., Knisely, J. P. S. & Mehta, M. P., Jul 2018, In : Journal of neurosurgery. 129, 1, p. 35-47 13 p.

Research output: Contribution to journalArticle

Meningioma
Disease-Free Survival
Radiotherapy
Neoplasms
Clinical Protocols

Lower-grade gliomas: The wrong target for bevacizumab

Schiff, D. & De Groot, J. F., Nov 12 2018, In : Neuro-oncology. 20, 12, p. 1559-1560 2 p.

Research output: Contribution to journalEditorial

Glioma
Bevacizumab
3 Citations (Scopus)

Multi-center study finds postoperative residual non-enhancing component of glioblastoma as a new determinant of patient outcome

Kotrotsou, A., Elakkad, A., Sun, J., Thomas, G. A., Yang, D., Abrol, S., Wei, W., Weinberg, J. S., Bakhtiari, A. S., Kircher, M. F., Luedi, M. M., de Groot, J. F., Sawaya, R., Kumar, A. J., Zinn, P. O. & Colen, R. R., Aug 1 2018, In : Journal of neuro-oncology. 139, 1, p. 125-133 9 p.

Research output: Contribution to journalArticle

Glioblastoma
Survival
Karnofsky Performance Status
Atlases
Neoplasms
6 Citations (Scopus)

Phase II study of cabozantinib in patients with progressive glioblastoma: Subset analysis of patients with prior antiangiogenic therapy

Cloughesy, T. F., Drappatz, J., de Groot, J. F., Prados, M. D., Reardon, D. A., Schiff, D., Chamberlain, M., Mikkelsen, T., Desjardins, A., Ping, J., Holland, J., Weitzman, R. & Wen, P. Y., Jan 22 2018, In : Neuro-oncology. 20, 2, p. 259-267 9 p.

Research output: Contribution to journalArticle

Glioblastoma
Therapeutics
Disease-Free Survival
Safety
Vascular Endothelial Growth Factor Receptor-2
13 Citations (Scopus)

Phase II study of cabozantinib in patients with progressive glioblastoma: Subset analysis of patients naive to antiangiogenic therapy

Wen, P. Y., Drappatz, J., de Groot, J. F., Prados, M. D., Reardon, D. A., Schiff, D., Chamberlain, M., Mikkelsen, T., Desjardins, A., Holland, J., Ping, J., Weitzman, R. & Cloughesy, T. F., Jan 22 2018, In : Neuro-oncology. 20, 2, p. 249-258 10 p.

Research output: Contribution to journalArticle

Glioblastoma
Disease-Free Survival
Therapeutics
Vascular Endothelial Growth Factor Receptor-2
Survival
3 Citations (Scopus)

Profiles of brain metastases: Prioritization of therapeutic targets

Ferguson, S. D., Zheng, S., Xiu, J., Zhou, S., Khasraw, M., Brastianos, P. K., Kesari, S., Hu, J., Rudnick, J., Salacz, M. E., Piccioni, D., Huang, S., Davies, M. A., Glitza, I. C., Heymach, J. V., Zhang, J., Ibrahim, N. K., DeGroot, J. F., McCarty, J., O'Brien, B. J. & 7 others, Sawaya, R., Verhaak, R. G. W., Reddy, S. K., Priebe, W., Gatalica, Z., Spetzler, D. & Heimberger, A. B., Dec 1 2018, In : International Journal of Cancer. 143, 11, p. 3019-3026 8 p.

Research output: Contribution to journalArticle

Neoplasm Metastasis
Brain
Therapeutics
Melanoma
Neoplasms
17 Citations (Scopus)

Prospective Feasibility Trial for Genomics-Informed Treatment in Recurrent and Progressive Glioblastoma

Byron, S. A., Tran, N. L., Halperin, R. F., Phillips, J. J., Kuhn, J. G., de Groot, J. F., Colman, H., Ligon, K. L., Wen, P. Y., Cloughesy, T. F., Mellinghoff, I. K., Butowski, N. A., Taylor, J. W., Clarke, J. L., Chang, S. M., Berger, M. S., Molinaro, A. M., Maggiora, G. M., Peng, S., Nasser, S. & 6 others, Liang, W. S., Trent, J. M., Berens, M. E., Carpten, J. D., Craig, D. W. & Prados, M. D., Jan 15 2018, In : Clinical Cancer Research. 24, 2, p. 295-305 11 p.

Research output: Contribution to journalArticle

Glioblastoma
Genomics
Therapeutics
Exome
RNA Sequence Analysis
8 Citations (Scopus)
Glioblastoma
Pharmaceutical Preparations
Neoplasms
Clinical Trials
Pharmacology
6 Citations (Scopus)

Targetable gene fusions associate with the IDH wild-type astrocytic lineage in adult gliomas

Ferguson, S. D., Zhou, S., Huse, J., de Groot, J. F., Xiu, J., Subramaniam, D. S., Mehta, S., Gatalica, Z., Swensen, J., Sanai, N., Spetzler, D. & Heimberger, A. B., Jun 1 2018, In : Journal of Neuropathology and Experimental Neurology. 77, 6, p. 437-442 6 p.

Research output: Contribution to journalArticle

Gene Fusion
Glioma
Astrocytoma
RNA Sequence Analysis
Oligodendroglioma
5 Citations (Scopus)

The polo-like kinase 1 inhibitor volasertib synergistically increases radiation efficacy in glioma stem cells

Dong, J., Park, S. Y., Nguyen, N., Ezhilarasan, R., Martinez-Ledesma, E., Wu, S., Henry, V., Piao, Y., Tiao, N., Brunell, D., Stephan, C., Verhaak, R., Sulman, E., Balasubramaniyan, V. & de Groot, J. F., Jan 1 2018, In : Oncotarget. 9, 12, p. 10497-10509 13 p.

Research output: Contribution to journalArticle

Glioma
Stem Cells
Radiation
Glioblastoma
Ionizing Radiation
1 Citation (Scopus)

The prognostic value of maximal surgical resection is attenuated in oligodendroglioma subgroups of adult diffuse glioma: a multicenter retrospective study

Ding, X., Wang, Z., Chen, D., Wang, Y., Zhao, Z., Sun, C., Chen, D., Tang, C., Xiong, J., Chen, L., Yao, Z., Liu, Y., Wang, X., Cahill, D. P., de Groot, J. F., Jiang, T., Yao, Y. & Zhou, L., Dec 15 2018, In : Journal of neuro-oncology. 140, 3, p. 591-603 13 p.

Research output: Contribution to journalArticle

Oligodendroglioma
Glioma
Multicenter Studies
Retrospective Studies
Survival
1 Citation (Scopus)

Treatment of Glioblastoma in the Elderly

Harrison, R. & de Groot, J. F., Aug 1 2018, In : Drugs and Aging. 35, 8, p. 707-718 12 p.

Research output: Contribution to journalReview article

Glioblastoma
temozolomide
Therapeutics
Population
Radiotherapy
6 Citations (Scopus)

Validation of postoperative residual contrast-enhancing tumor volume as an independent prognostic factor for overall survival in newly diagnosed glioblastoma

Ellingson, B. M., Abrey, L. E., Nelson, S. J., Kaufmann, T. J., Garcia, J., Chinot, O., Saran, F., Nishikawa, R., Henriksson, R., Mason, W. P., Wick, W., Butowski, N., Ligon, K. L., Gerstner, E. R., Colman, H., De Groot, J., Chang, S., Mellinghoff, I., Young, R. J., Alexander, B. M. & 12 others, Colen, R., Taylor, J. W., Arrillaga-Romany, I., Mehta, A., Huang, R. Y., Pope, W. B., Reardon, D., Batchelor, T., Prados, M., Galanis, E., Wen, P. Y. & Cloughesy, T. F., Jan 1 2018, In : Neuro-oncology. 20, 9, p. 1240-1250 11 p.

Research output: Contribution to journalArticle

Glioblastoma
Tumor Burden
Residual Neoplasm
Survival
Methyltransferases
2 Citations (Scopus)

Volumetric response quantified using T1 subtraction predicts long-term survival benefit from cabozantinib monotherapy in recurrent glioblastoma

Ellingson, B. M., Aftab, D. T., Schwab, G. M., Hessel, C., Harris, R. J., Woodworth, D. C., Leu, K., Chakhoyan, A., Raymond, C., Drappatz, J., De Groot, J., Prados, M. D., Reardon, D. A., Schiff, D., Chamberlain, M., Mikkelsen, T., Desjardins, A., Holland, J., Ping, J., Weitzman, R. & 2 others, Wen, P. Y. & Cloughesy, T. F., Jan 1 2018, In : Neuro-oncology. 20, 10, p. 1411-1418 8 p.

Research output: Contribution to journalArticle

Glioblastoma
Tumor Burden
Survival
Proto-Oncogene Proteins c-met
Vascular Endothelial Growth Factor Receptor-2
2017
3 Citations (Scopus)

A relative increase in circulating platelets following chemoradiation predicts for poor survival of patients with glioblastoma

Boonyawan, K., Hess, K. R., Yang, J., Long, L., Wang, Q., Ezhilarasan, R., Auia, A., Alfaro-Munoz, K. D., de Groot, J. F., Bhat, K. P. & Sulman, E. P., Jan 1 2017, In : Oncotarget. 8, 52, p. 90488-90495 8 p.

Research output: Contribution to journalArticle

Glioblastoma
Blood Platelets
temozolomide
Survival
Therapeutics

CATNON interim results: Another triumph of upfront chemotherapy in glioma

Penas-Prado, M. & de Groot, J. F., Oct 1 2017, In : Neuro-oncology. 19, 10, p. 1287-1288 2 p.

Research output: Contribution to journalEditorial

Glioma
Drug Therapy
2 Citations (Scopus)

Cell Signaling Pathways in Brain Tumors

Harrison, R. & de Groot, J. F., Feb 1 2017, In : Topics in Magnetic Resonance Imaging. 26, 1, p. 15-26 12 p.

Research output: Contribution to journalReview article

Brain Neoplasms
Glioblastoma
Biomarkers
Morbidity
Therapeutics
52 Citations (Scopus)

Clinical cancer advances 2017: Annual report on progress against cancer fromthe American Society of Clinical Oncology

Burstein, H. J., Krilov, L., Aragon-Ching, J. P., Baxter, N. N., Chiorean, E. G., Chow, W. A., De Groot, J. F., Devine, S., DuBois, S. G., El-Deiry, W. S., Epstein, A. S., Heymach, J., Jones, J. A., Mayer, D. K., Miksad, R. A., Pennell, N. A., Sabel, M. S., Schilsky, R. L., Schuchter, L. M., Tung, N. & 3 others, Winkfield, K. M., Wirth, L. J. & Dizon, D. S., Apr 20 2017, In : Journal of Clinical Oncology. 35, 12, p. 1341-1367 27 p.

Research output: Contribution to journalReview article

17 Citations (Scopus)

Diffusion MRI phenotypes predict overall survival benefit from Anti-VEGF monotherapy in recurrent glioblastoma: Converging evidence from phase II trials

Ellingson, B. M., Gerstner, E. R., Smits, M., Huang, R. Y., Colen, R., Abrey, L. E., Aftab, D. T., Schwab, G. M., Hessel, C., Harris, R. J., Chakhoyan, A., Gahrmann, R., Pope, W. B., Leu, K., Raymond, C., Woodworth, D. C., de Groot, J. F., Wen, P. Y., Batchelor, T. T., Van Den Bent, M. J. & 1 others, Cloughesy, T. F., Oct 1 2017, In : Clinical Cancer Research. 23, 19, p. 5745-5756 12 p.

Research output: Contribution to journalArticle

Diffusion Magnetic Resonance Imaging
Glioblastoma
Vascular Endothelial Growth Factor A
Lomustine
Phenotype
69 Citations (Scopus)

Mutational burden, immune checkpoint expression, and mismatch repair in glioma: Implications for immune checkpoint immunotherapy

Hodges, T. R., Ott, M., Xiu, J., Gatalica, Z., Swensen, J., Zhou, S., Huse, J., de Groot, J. F., Li, S., Overwijk, W., Spetzler, D. & Heimberger, A. B., Aug 1 2017, In : Neuro-oncology. 19, 8, p. 1047-1057 11 p.

Research output: Contribution to journalArticle

DNA Mismatch Repair
Tumor Burden
Glioma
Immunotherapy
Biomarkers
2 Citations (Scopus)

Phase I trial of aflibercept (VEGF trap) with radiation therapy and concomitant and adjuvant temozolomide in patients with high-grade gliomas

Nayak, L., de Groot, J., Wefel, J. S., Cloughesy, T. F., Lieberman, F., Chang, S. M., Omuro, A., Drappatz, J., Batchelor, T. T., DeAngelis, L. M., Gilbert, M. R., Aldape, K. D., Yung, A. W. K., Fisher, J., Ye, X., Chen, A., Grossman, S., Prados, M. & Wen, P. Y., Mar 1 2017, In : Journal of neuro-oncology. 132, 1, p. 181-188 8 p.

Research output: Contribution to journalArticle

temozolomide
Glioma
Vascular Endothelial Growth Factor A
Radiotherapy
Maximum Tolerated Dose
3 Citations (Scopus)

Radiographic patterns of progression with associated outcomes after bevacizumab therapy in glioblastoma patients

Cachia, D., Elshafeey, N. A., Kamiya Matsuoka, C., Hatami, M., Alfaro-Munoz, K. D., Mandel, J. J., Colen, R. & de Groot, J. F., Oct 1 2017, In : Journal of neuro-oncology. 135, 1, p. 75-81 7 p.

Research output: Contribution to journalArticle

Glioblastoma
Survival
Therapeutics
Disease-Free Survival
Bevacizumab
22 Citations (Scopus)

Stabilization of phosphofructokinase 1 platelet isoform by AKT promotes tumorigenesis

Lee, J. H., Liu, R., Li, J., Zhang, C., Wang, Y., Cai, Q., Qian, X., Xia, Y., Zheng, Y., Piao, Y., Chen, Q., De Groot, J. F., Jiang, T. & Lu, Z., Dec 1 2017, In : Nature communications. 8, 1, 906.

Research output: Contribution to journalArticle

Phosphofructokinase-1
Platelets
platelets
Protein Isoforms
Carcinogenesis
7 Citations (Scopus)

Targeting intercellular adhesion molecule-1 prolongs survival in mice bearing bevacizumab-resistant glioblastoma

Piao, Y., Henry, V., Tiao, N., Park, S. Y., Martinez-Ledesma, J., Dong, J. W., Balasubramaniyan, V. & de Groot, J. F., Jan 1 2017, In : Oncotarget. 8, 57, p. 96970-96983 14 p.

Research output: Contribution to journalArticle

Intercellular Adhesion Molecule-1
Glioblastoma
Neoplasms
Glioma
Bevacizumab
16 Citations (Scopus)

Treatment of glioblastoma

Nam, J. Y. & de Groot, J. F., Oct 1 2017, In : Journal of oncology practice. 13, 10, p. 629-638 10 p.

Research output: Contribution to journalReview article

Glioblastoma
Translational Medical Research
Methyltransferases
Brain Neoplasms
Immunotherapy
2016
21 Citations (Scopus)

A phase II study of bevacizumab and erlotinib after radiation and temozolomide in MGMT unmethylated GBM patients

Raizer, J. J., Giglio, P., Hu, J., Groves, M., Merrell, R., Conrad, C., Phuphanich, S., Puduvalli, V. K., Loghin, M., Paleologos, N., Yuan, Y., Liu, D., Rademaker, A., Yung, W. K., Vaillant, B., Rudnick, J., Chamberlain, M., Vick, N., Grimm, S., Tremont-Lukats, I. W. & 3 others, De Groot, J., Aldape, K. & Gilbert, M. R., Jan 1 2016, In : Journal of neuro-oncology. 126, 1, p. 185-192 8 p.

Research output: Contribution to journalArticle

temozolomide
Glioblastoma
Radiation
Survival
Bevacizumab
11 Citations (Scopus)

A randomized phase I/II study of ABT-888 in combination with temozolomide in recurrent temozolomide resistant glioblastoma: An NRG oncology RTOG group study

Robins, H. I., Zhang, P., Gilbert, M. R., Chakravarti, A., de Groot, J. F., Grimm, S. A., Wang, F., Lieberman, F. S., Krauze, A., Trotti, A. M., Mohile, N., Kee, A. Y. J., Colman, H., Cavaliere, R., Kesari, S., Chmura, S. J. & Mehta, M., Jan 1 2016, In : Journal of neuro-oncology. 126, 2, p. 309-316 8 p.

Research output: Contribution to journalArticle

temozolomide
Glioblastoma
Appointments and Schedules
Maximum Tolerated Dose
Survival
12 Citations (Scopus)

A randomized phase II trial of standard dose bevacizumab versus low dose bevacizumab plus lomustine (CCNU) in adults with recurrent glioblastoma

Weathers, S-P., Han, X., Liu, D. D., Conrad, C. A., Gilbert, M. R., Loghin, M. E., O'Brien, B. J., Penas-Prado, M., Puduvalli, V. K., Tremont-Lukats, I., Colen, R., Yung, W. K. A. & de Groot, J. F., Sep 1 2016, In : Journal of neuro-oncology. 129, 3, p. 487-494 8 p.

Research output: Contribution to journalArticle

Lomustine
Glioblastoma
Disease-Free Survival
temozolomide
Bevacizumab