John Frederick de Groot

Professor

  • 8935 Citations
  • 41 h-Index
19972019
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Research Output 1997 2019

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Article
2019
7 Citations (Scopus)

Buparlisib in patients with recurrent glioblastoma harboring phosphatidylinositol 3-kinase pathway activation: An open-label, multicenter, multi-arm, phase II trial

Wen, P. Y., Touat, M., Alexander, B. M., Mellinghoff, I. K., Ramkissoon, S., McCluskey, C. S., Pelton, K., Haidar, S., Basu, S. S., Gaffey, S. C., Brown, L. E., Martinez-Ledesma, J. E., Wu, S., Kim, J., Wei, W., Park, M. A., Huse, J. T., Kuhn, J. G., Rinne, M. L., Colman, H. & 24 others, Agar, N. Y. R., Omuro, A. M., DeAngelis, L. M., Gilbert, M. R., de Groot, J. F., Cloughesy, T. F., Chi, A. S., Roberts, T. M., Zhao, J. J., Lee, E. Q., Nayak, L., Heath, J. R., Horky, L. L., Batchelor, T. T., Beroukhim, R., Chang, S. M., Ligon, A. H., Dunn, I. F., Koul, D., Young, G. S., Prados, M. D., Reardon, D. A., Alfred Yung, W. K. & Ligon, K. L., Mar 20 2019, In : Journal of Clinical Oncology. 37, 9, p. 741-750 10 p.

Research output: Contribution to journalArticle

Phosphatidylinositol 3-Kinase
Glioblastoma
Neoplasms
Pharmacokinetics
NVP-BKM120
1 Citation (Scopus)

Clinical trial participation of patients with glioblastoma at The University of Texas MD Anderson Cancer Center

Harrison, R., Anderson, M. D., Cachia, D., Kamiya Matsuoka, C., Weathers, S-P., O'Brien, B. J., Penas-Prado, M., Yung, W. K. A., Wu, J., Yuan, Y. & de Groot, J. F., May 1 2019, In : European Journal of Cancer. 112, p. 83-93 11 p.

Research output: Contribution to journalArticle

Patient Participation
Glioblastoma
Clinical Trials
Neoplasms
Clinical Protocols

Effect of health disparities on overall survival of patients with glioblastoma

Mandel, J. J., Youssef, M., Nam, J., Patel, A. J., Jalali, A., Ludmir, E. B., Liu, D., Wu, J., Armstrong, G., Huse, J., Bondy, M. & de Groot, J. F., Apr 15 2019, In : Journal of neuro-oncology. 142, 2, p. 365-374 10 p.

Research output: Contribution to journalArticle

Glioblastoma
Survival
Health
Standard of Care
County Hospitals
5 Citations (Scopus)

Inhibition of Nuclear PTEN Tyrosine Phosphorylation Enhances Glioma Radiation Sensitivity through Attenuated DNA Repair

Ma, J., Benitez, J. A., Li, J., Miki, S., Ponte de Albuquerque, C., Galatro, T., Orellana, L., Zanca, C., Reed, R., Boyer, A., Koga, T., Varki, N. M., Fenton, T. R., Nagahashi Marie, S. K., Lindahl, E., Gahman, T. C., Shiau, A. K., Zhou, H., DeGroot, J., Sulman, E. P. & 4 others, Cavenee, W. K., Kolodner, R. D., Chen, C. C. & Furnari, F. B., Mar 18 2019, In : Cancer cell. 35, 3, p. 504-518.e7

Research output: Contribution to journalArticle

Radiation Tolerance
Glioma
DNA Repair
Tyrosine
Phosphorylation
34 Citations (Scopus)

Neoadjuvant anti-PD-1 immunotherapy promotes a survival benefit with intratumoral and systemic immune responses in recurrent glioblastoma

Cloughesy, T. F., Mochizuki, A. Y., Orpilla, J. R., Hugo, W., Lee, A. H., Davidson, T. B., Wang, A. C., Ellingson, B. M., Rytlewski, J. A., Sanders, C. M., Kawaguchi, E. S., Du, L., Li, G., Yong, W. H., Gaffey, S. C., Cohen, A. L., Mellinghoff, I. K., Lee, E. Q., Reardon, D. A., O'Brien, B. J. & 10 others, Butowski, N. A., Nghiemphu, P. L., Clarke, J. L., Arrillaga-Romany, I. C., Colman, H., Kaley, T. J., de Groot, J. F., Liau, L. M., Wen, P. Y. & Prins, R. M., Mar 1 2019, In : Nature medicine. 25, 3, p. 477-486 10 p.

Research output: Contribution to journalArticle

Glioblastoma
Immunotherapy
T-cells
Tumors
Survival
3 Citations (Scopus)

Phase 1 lead-in to a phase 2 factorial study of temozolomide plus memantine, mefloquine, and metformin as postradiation adjuvant therapy for newly diagnosed glioblastoma

Maraka, S., Groves, M. D., Mammoser, A. G., Melguizo-Gavilanes, I., Conrad, C. A., Tremont-Lukats, I. W., Loghin, M. E., O'Brien, B. J., Puduvalli, V. K., Sulman, E. P., Hess, K. R., Aldape, K. D., Gilbert, M. R., de Groot, J. F., Alfred Yung, W. K. & Penas-Prado, M., Feb 1 2019, In : Cancer. 125, 3, p. 424-433 10 p.

Research output: Contribution to journalArticle

temozolomide
Mefloquine
Memantine
Metformin
Glioblastoma

Prospective clinical sequencing of adult glioma

Zheng, S., Alfaro-Munoz, K., Wei, W., Wang, X., Wang, F., Eterovic, A. K., Shaw, K. R. M., Meric-Bernstam, F., Fuller, G. N., Chen, K., Verhaak, R. G., Mills, G. B., Yung, W. K. A., Weathers, S. P. & De Groot, J. F., Jan 1 2019, In : Molecular cancer therapeutics. 18, 5, p. 991-1000 10 p.

Research output: Contribution to journalArticle

Glioma
Glioblastoma
Mutation
Neoplasms
temozolomide
7 Citations (Scopus)

The molecular landscape of glioma in patients with Neurofibromatosis 1

D’Angelo, F., Ceccarelli, M., Tala, Garofano, L., Zhang, J., Frattini, V., Caruso, F. P., Lewis, G., Alfaro, K. D., Bauchet, L., Berzero, G., Cachia, D., Cangiano, M., Capelle, L., de Groot, J., DiMeco, F., Ducray, F., Farah, W., Finocchiaro, G., Goutagny, S. & 27 others, Kamiya-Matsuoka, C., Lavarino, C., Loiseau, H., Lorgis, V., Marras, C. E., McCutcheon, I., Nam, D. H., Ronchi, S., Saletti, V., Seizeur, R., Slopis, J., Suñol, M., Vandenbos, F., Varlet, P., Vidaud, D., Watts, C., Tabar, V., Reuss, D. E., Kim, S. K., Meyronet, D., Mokhtari, K., Salvador, H., Bhat, K. P., Eoli, M., Sanson, M., Lasorella, A. & Iavarone, A., Jan 1 2019, In : Nature medicine. 25, 1, p. 176-187 12 p.

Research output: Contribution to journalArticle

Neurofibromatosis 1
Glioma
Tumors
Genes
Isocitrate Dehydrogenase

Treatment strategies for glioblastoma in older patients: age is just a number

Youssef, M., Ludmir, E. B., Mandel, J. J., Patel, A. J., Jalali, A., Treiber, J., Wu, J., McAleer, M. F. & de Groot, J. F., Nov 1 2019, In : Journal of neuro-oncology. 145, 2, p. 357-364 8 p.

Research output: Contribution to journalArticle

temozolomide
Glioblastoma
Radiotherapy
Therapeutics
Survival
2018
8 Citations (Scopus)

A coclinical radiogenomic validation study: Conserved magnetic resonance radiomic appearance of periostin-expressing glioblastoma in patients and xenograft models

Zinn, P. O., Singh, S. K., Kotrotsou, A., Hassan, I., Thomas, G., Luedi, M. M., Elakkad, A., Elshafeey, N., Idris, T., Mosley, J., Gumin, J., Fuller, G. N., De Groot, J. F., Baladandayuthapani, V., Sulman, E. P., Kumar, A. J., Sawaya, R., Lang, F. F., Piwnica-Worms, D. & Colen, R. R., Dec 15 2018, In : Clinical Cancer Research. 24, 24, p. 6288-6299 12 p.

Research output: Contribution to journalArticle

Validation Studies
Glioblastoma
Heterografts
Magnetic Resonance Spectroscopy
Area Under Curve
48 Citations (Scopus)

An inhibitor of oxidative phosphorylation exploits cancer vulnerability

Molina, J. R., Sun, Y., Protopopova, M., Gera, S., Bandi, M., Bristow, C., McAfoos, T., Morlacchi, P., Ackroyd, J., Agip, A. N. A., Al-Atrash, G., Asara, J., Bardenhagen, J., Carrillo, C. C., Carroll, C., Chang, E., Ciurea, S., Cross, J. B., Czako, B., Deem, A. & 46 others, Daver, N., De Groot, J. F., Dong, J. W., Feng, N., Gao, G., Gay, J., Do, M. G., Greer, J., Giuliani, V., Han, J., Han, L., Henry, V. K., Hirst, J., Huang, S., Jiang, Y., Kang, Z., Khor, T., Konoplev, S., Lin, Y. H., Liu, G., Lodi, A., Lofton, T., Ma, H., Mahendra, M., Matre, P., Mullinax, R., Peoples, M., Petrocchi, A., Rodriguez-Canale, J., Serreli, R., Shi, T., Smith, M., Tabe, Y., Theroff, J., Tiziani, S., Xu, Q., Zhang, Q., Muller, F., Depinho, R. A., Toniatti, C., Draetta, G. F., Heffernan, T. P., Konopleva, M., Jones, P., Di Francesco, M. E. & Marszalek, J. R., Jul 1 2018, In : Nature medicine. 24, 7, p. 1036-1046 11 p.

Research output: Contribution to journalArticle

Oxidative Phosphorylation
Tumors
Acute Myeloid Leukemia
Brain Neoplasms
Brain

Ependymomas overexpress chemoresistance and DNA repairrelated proteins

Ferguson, S. D., Zhou, S., Xiu, J., Hashimoto, Y., Sanai, N., Kim, L., Kesari, S., de Groot, J., Spetzler, D. & Heimberger, A. B., Jan 1 2018, In : Oncotarget. 9, 8, p. 7822-7831 10 p.

Research output: Contribution to journalArticle

Ependymoma
DNA
Proteins
Therapeutics
DNA Repair Enzymes
11 Citations (Scopus)

Glioma through the looking GLASS: Molecular evolution of diffuse gliomas and the Glioma Longitudinal Analysis Consortium

Aldape, K., Amin, S. B., Ashley, D. M., Barnholtz-Sloan, J. S., Bates, A. J., Beroukhim, R., Bock, C., Brat, D. J., Claus, E. B., Costello, J. F., de Groot, J. F., Finocchiaro, G., French, P. J., Gan, H. K., Griffith, B., Herold-Mende, C. C., Horbinski, C., Iavarone, A., Kalkanis, S. N., Karabatsou, K. & 36 others, Kim, H., Kouwenhoven, M. C. M., McDonald, K. L., Miletic, H., Nam, D. H., Ng, H. K., Niclou, S. P., Noushmehr, H., Ryan Ormond, D., Poisson, L. M., Reifenberger, G., Roncaroli, F., Sa, J. K., Sillevis Smitt, P. A. E., Smits, M., Souza, C. F., Tabatabai, G., Van Meir, E. G., Verhaak, R. G. W., Watts, C., Wesseling, P., Woehrer, A., Alfred Yung, W. K., Jungk, C., Hau, A. C., van Dyck, E., Westerman, B. A., Yin, J., Abiola, O., Zeps, N., Grimmond, S., Buckland, M., Khasraw, M., Sulman, E. P., Muscat, A. M. & Stead, L., Jun 18 2018, In : Neuro-oncology. 20, 7, p. 873-884 12 p.

Research output: Contribution to journalArticle

Open Access
Molecular Evolution
Glioma
Atlases
Epigenomics
Brain Neoplasms
5 Citations (Scopus)

Inability of positive phase II clinical trials of investigational treatments to subsequently predict positive phase III clinical trials in glioblastoma

Mandel, J. J., Yust-Katz, S., Patel, A. J., Cachia, D., Liu, DI., Park, M., Yuan, Y., Kent, T. A. & de Groot, J. F., Jan 1 2018, In : Neuro-oncology. 20, 1, p. 113-122 10 p.

Research output: Contribution to journalArticle

Phase III Clinical Trials
Phase II Clinical Trials
Investigational Therapies
Glioblastoma
Standard of Care
29 Citations (Scopus)

Intermediate-risk meningioma: Initial outcomes from NRG Oncology RTOG 0539

Rogers, L., Zhang, P., Vogelbaum, M. A., Perry, A., Ashby, L. S., Modi, J. M., Alleman, A. M., Galvin, J., Brachman, D., Jenrette, J. M., De Groot, J., Bovi, J. A., Werner-Wasik, M., Knisely, J. P. S. & Mehta, M. P., Jul 2018, In : Journal of neurosurgery. 129, 1, p. 35-47 13 p.

Research output: Contribution to journalArticle

Meningioma
Disease-Free Survival
Radiotherapy
Neoplasms
Clinical Protocols
3 Citations (Scopus)

Multi-center study finds postoperative residual non-enhancing component of glioblastoma as a new determinant of patient outcome

Kotrotsou, A., Elakkad, A., Sun, J., Thomas, G. A., Yang, D., Abrol, S., Wei, W., Weinberg, J. S., Bakhtiari, A. S., Kircher, M. F., Luedi, M. M., de Groot, J. F., Sawaya, R., Kumar, A. J., Zinn, P. O. & Colen, R. R., Aug 1 2018, In : Journal of neuro-oncology. 139, 1, p. 125-133 9 p.

Research output: Contribution to journalArticle

Glioblastoma
Survival
Karnofsky Performance Status
Atlases
Neoplasms
6 Citations (Scopus)

Phase II study of cabozantinib in patients with progressive glioblastoma: Subset analysis of patients with prior antiangiogenic therapy

Cloughesy, T. F., Drappatz, J., de Groot, J. F., Prados, M. D., Reardon, D. A., Schiff, D., Chamberlain, M., Mikkelsen, T., Desjardins, A., Ping, J., Holland, J., Weitzman, R. & Wen, P. Y., Jan 22 2018, In : Neuro-oncology. 20, 2, p. 259-267 9 p.

Research output: Contribution to journalArticle

Glioblastoma
Therapeutics
Disease-Free Survival
Safety
Vascular Endothelial Growth Factor Receptor-2
13 Citations (Scopus)

Phase II study of cabozantinib in patients with progressive glioblastoma: Subset analysis of patients naive to antiangiogenic therapy

Wen, P. Y., Drappatz, J., de Groot, J. F., Prados, M. D., Reardon, D. A., Schiff, D., Chamberlain, M., Mikkelsen, T., Desjardins, A., Holland, J., Ping, J., Weitzman, R. & Cloughesy, T. F., Jan 22 2018, In : Neuro-oncology. 20, 2, p. 249-258 10 p.

Research output: Contribution to journalArticle

Glioblastoma
Disease-Free Survival
Therapeutics
Vascular Endothelial Growth Factor Receptor-2
Survival
3 Citations (Scopus)

Profiles of brain metastases: Prioritization of therapeutic targets

Ferguson, S. D., Zheng, S., Xiu, J., Zhou, S., Khasraw, M., Brastianos, P. K., Kesari, S., Hu, J., Rudnick, J., Salacz, M. E., Piccioni, D., Huang, S., Davies, M. A., Glitza, I. C., Heymach, J. V., Zhang, J., Ibrahim, N. K., DeGroot, J. F., McCarty, J., O'Brien, B. J. & 7 others, Sawaya, R., Verhaak, R. G. W., Reddy, S. K., Priebe, W., Gatalica, Z., Spetzler, D. & Heimberger, A. B., Dec 1 2018, In : International Journal of Cancer. 143, 11, p. 3019-3026 8 p.

Research output: Contribution to journalArticle

Neoplasm Metastasis
Brain
Therapeutics
Melanoma
Neoplasms
17 Citations (Scopus)

Prospective Feasibility Trial for Genomics-Informed Treatment in Recurrent and Progressive Glioblastoma

Byron, S. A., Tran, N. L., Halperin, R. F., Phillips, J. J., Kuhn, J. G., de Groot, J. F., Colman, H., Ligon, K. L., Wen, P. Y., Cloughesy, T. F., Mellinghoff, I. K., Butowski, N. A., Taylor, J. W., Clarke, J. L., Chang, S. M., Berger, M. S., Molinaro, A. M., Maggiora, G. M., Peng, S., Nasser, S. & 6 others, Liang, W. S., Trent, J. M., Berens, M. E., Carpten, J. D., Craig, D. W. & Prados, M. D., Jan 15 2018, In : Clinical Cancer Research. 24, 2, p. 295-305 11 p.

Research output: Contribution to journalArticle

Glioblastoma
Genomics
Therapeutics
Exome
RNA Sequence Analysis
6 Citations (Scopus)

Targetable gene fusions associate with the IDH wild-type astrocytic lineage in adult gliomas

Ferguson, S. D., Zhou, S., Huse, J., de Groot, J. F., Xiu, J., Subramaniam, D. S., Mehta, S., Gatalica, Z., Swensen, J., Sanai, N., Spetzler, D. & Heimberger, A. B., Jun 1 2018, In : Journal of Neuropathology and Experimental Neurology. 77, 6, p. 437-442 6 p.

Research output: Contribution to journalArticle

Gene Fusion
Glioma
Astrocytoma
RNA Sequence Analysis
Oligodendroglioma
5 Citations (Scopus)

The polo-like kinase 1 inhibitor volasertib synergistically increases radiation efficacy in glioma stem cells

Dong, J., Park, S. Y., Nguyen, N., Ezhilarasan, R., Martinez-Ledesma, E., Wu, S., Henry, V., Piao, Y., Tiao, N., Brunell, D., Stephan, C., Verhaak, R., Sulman, E., Balasubramaniyan, V. & de Groot, J. F., Jan 1 2018, In : Oncotarget. 9, 12, p. 10497-10509 13 p.

Research output: Contribution to journalArticle

Glioma
Stem Cells
Radiation
Glioblastoma
Ionizing Radiation
1 Citation (Scopus)

The prognostic value of maximal surgical resection is attenuated in oligodendroglioma subgroups of adult diffuse glioma: a multicenter retrospective study

Ding, X., Wang, Z., Chen, D., Wang, Y., Zhao, Z., Sun, C., Chen, D., Tang, C., Xiong, J., Chen, L., Yao, Z., Liu, Y., Wang, X., Cahill, D. P., de Groot, J. F., Jiang, T., Yao, Y. & Zhou, L., Dec 15 2018, In : Journal of neuro-oncology. 140, 3, p. 591-603 13 p.

Research output: Contribution to journalArticle

Oligodendroglioma
Glioma
Multicenter Studies
Retrospective Studies
Survival
6 Citations (Scopus)

Validation of postoperative residual contrast-enhancing tumor volume as an independent prognostic factor for overall survival in newly diagnosed glioblastoma

Ellingson, B. M., Abrey, L. E., Nelson, S. J., Kaufmann, T. J., Garcia, J., Chinot, O., Saran, F., Nishikawa, R., Henriksson, R., Mason, W. P., Wick, W., Butowski, N., Ligon, K. L., Gerstner, E. R., Colman, H., De Groot, J., Chang, S., Mellinghoff, I., Young, R. J., Alexander, B. M. & 12 others, Colen, R., Taylor, J. W., Arrillaga-Romany, I., Mehta, A., Huang, R. Y., Pope, W. B., Reardon, D., Batchelor, T., Prados, M., Galanis, E., Wen, P. Y. & Cloughesy, T. F., Jan 1 2018, In : Neuro-oncology. 20, 9, p. 1240-1250 11 p.

Research output: Contribution to journalArticle

Glioblastoma
Tumor Burden
Residual Neoplasm
Survival
Methyltransferases
2 Citations (Scopus)

Volumetric response quantified using T1 subtraction predicts long-term survival benefit from cabozantinib monotherapy in recurrent glioblastoma

Ellingson, B. M., Aftab, D. T., Schwab, G. M., Hessel, C., Harris, R. J., Woodworth, D. C., Leu, K., Chakhoyan, A., Raymond, C., Drappatz, J., De Groot, J., Prados, M. D., Reardon, D. A., Schiff, D., Chamberlain, M., Mikkelsen, T., Desjardins, A., Holland, J., Ping, J., Weitzman, R. & 2 others, Wen, P. Y. & Cloughesy, T. F., Jan 1 2018, In : Neuro-oncology. 20, 10, p. 1411-1418 8 p.

Research output: Contribution to journalArticle

Glioblastoma
Tumor Burden
Survival
Proto-Oncogene Proteins c-met
Vascular Endothelial Growth Factor Receptor-2
2017
3 Citations (Scopus)

A relative increase in circulating platelets following chemoradiation predicts for poor survival of patients with glioblastoma

Boonyawan, K., Hess, K. R., Yang, J., Long, L., Wang, Q., Ezhilarasan, R., Auia, A., Alfaro-Munoz, K. D., de Groot, J. F., Bhat, K. P. & Sulman, E. P., Jan 1 2017, In : Oncotarget. 8, 52, p. 90488-90495 8 p.

Research output: Contribution to journalArticle

Glioblastoma
Blood Platelets
temozolomide
Survival
Therapeutics
17 Citations (Scopus)

Diffusion MRI phenotypes predict overall survival benefit from Anti-VEGF monotherapy in recurrent glioblastoma: Converging evidence from phase II trials

Ellingson, B. M., Gerstner, E. R., Smits, M., Huang, R. Y., Colen, R., Abrey, L. E., Aftab, D. T., Schwab, G. M., Hessel, C., Harris, R. J., Chakhoyan, A., Gahrmann, R., Pope, W. B., Leu, K., Raymond, C., Woodworth, D. C., de Groot, J. F., Wen, P. Y., Batchelor, T. T., Van Den Bent, M. J. & 1 others, Cloughesy, T. F., Oct 1 2017, In : Clinical Cancer Research. 23, 19, p. 5745-5756 12 p.

Research output: Contribution to journalArticle

Diffusion Magnetic Resonance Imaging
Glioblastoma
Vascular Endothelial Growth Factor A
Lomustine
Phenotype
69 Citations (Scopus)

Mutational burden, immune checkpoint expression, and mismatch repair in glioma: Implications for immune checkpoint immunotherapy

Hodges, T. R., Ott, M., Xiu, J., Gatalica, Z., Swensen, J., Zhou, S., Huse, J., de Groot, J. F., Li, S., Overwijk, W., Spetzler, D. & Heimberger, A. B., Aug 1 2017, In : Neuro-oncology. 19, 8, p. 1047-1057 11 p.

Research output: Contribution to journalArticle

DNA Mismatch Repair
Tumor Burden
Glioma
Immunotherapy
Biomarkers
2 Citations (Scopus)

Phase I trial of aflibercept (VEGF trap) with radiation therapy and concomitant and adjuvant temozolomide in patients with high-grade gliomas

Nayak, L., de Groot, J., Wefel, J. S., Cloughesy, T. F., Lieberman, F., Chang, S. M., Omuro, A., Drappatz, J., Batchelor, T. T., DeAngelis, L. M., Gilbert, M. R., Aldape, K. D., Yung, A. W. K., Fisher, J., Ye, X., Chen, A., Grossman, S., Prados, M. & Wen, P. Y., Mar 1 2017, In : Journal of neuro-oncology. 132, 1, p. 181-188 8 p.

Research output: Contribution to journalArticle

temozolomide
Glioma
Vascular Endothelial Growth Factor A
Radiotherapy
Maximum Tolerated Dose
3 Citations (Scopus)

Radiographic patterns of progression with associated outcomes after bevacizumab therapy in glioblastoma patients

Cachia, D., Elshafeey, N. A., Kamiya Matsuoka, C., Hatami, M., Alfaro-Munoz, K. D., Mandel, J. J., Colen, R. & de Groot, J. F., Oct 1 2017, In : Journal of neuro-oncology. 135, 1, p. 75-81 7 p.

Research output: Contribution to journalArticle

Glioblastoma
Survival
Therapeutics
Disease-Free Survival
Bevacizumab
22 Citations (Scopus)

Stabilization of phosphofructokinase 1 platelet isoform by AKT promotes tumorigenesis

Lee, J. H., Liu, R., Li, J., Zhang, C., Wang, Y., Cai, Q., Qian, X., Xia, Y., Zheng, Y., Piao, Y., Chen, Q., De Groot, J. F., Jiang, T. & Lu, Z., Dec 1 2017, In : Nature communications. 8, 1, 906.

Research output: Contribution to journalArticle

Phosphofructokinase-1
Platelets
platelets
Protein Isoforms
Carcinogenesis
7 Citations (Scopus)

Targeting intercellular adhesion molecule-1 prolongs survival in mice bearing bevacizumab-resistant glioblastoma

Piao, Y., Henry, V., Tiao, N., Park, S. Y., Martinez-Ledesma, J., Dong, J. W., Balasubramaniyan, V. & de Groot, J. F., Jan 1 2017, In : Oncotarget. 8, 57, p. 96970-96983 14 p.

Research output: Contribution to journalArticle

Intercellular Adhesion Molecule-1
Glioblastoma
Neoplasms
Glioma
Bevacizumab
2016
21 Citations (Scopus)

A phase II study of bevacizumab and erlotinib after radiation and temozolomide in MGMT unmethylated GBM patients

Raizer, J. J., Giglio, P., Hu, J., Groves, M., Merrell, R., Conrad, C., Phuphanich, S., Puduvalli, V. K., Loghin, M., Paleologos, N., Yuan, Y., Liu, D., Rademaker, A., Yung, W. K., Vaillant, B., Rudnick, J., Chamberlain, M., Vick, N., Grimm, S., Tremont-Lukats, I. W. & 3 others, De Groot, J., Aldape, K. & Gilbert, M. R., Jan 1 2016, In : Journal of neuro-oncology. 126, 1, p. 185-192 8 p.

Research output: Contribution to journalArticle

temozolomide
Glioblastoma
Radiation
Survival
Bevacizumab
11 Citations (Scopus)

A randomized phase I/II study of ABT-888 in combination with temozolomide in recurrent temozolomide resistant glioblastoma: An NRG oncology RTOG group study

Robins, H. I., Zhang, P., Gilbert, M. R., Chakravarti, A., de Groot, J. F., Grimm, S. A., Wang, F., Lieberman, F. S., Krauze, A., Trotti, A. M., Mohile, N., Kee, A. Y. J., Colman, H., Cavaliere, R., Kesari, S., Chmura, S. J. & Mehta, M., Jan 1 2016, In : Journal of neuro-oncology. 126, 2, p. 309-316 8 p.

Research output: Contribution to journalArticle

temozolomide
Glioblastoma
Appointments and Schedules
Maximum Tolerated Dose
Survival
12 Citations (Scopus)

A randomized phase II trial of standard dose bevacizumab versus low dose bevacizumab plus lomustine (CCNU) in adults with recurrent glioblastoma

Weathers, S-P., Han, X., Liu, D. D., Conrad, C. A., Gilbert, M. R., Loghin, M. E., O'Brien, B. J., Penas-Prado, M., Puduvalli, V. K., Tremont-Lukats, I., Colen, R., Yung, W. K. A. & de Groot, J. F., Sep 1 2016, In : Journal of neuro-oncology. 129, 3, p. 487-494 8 p.

Research output: Contribution to journalArticle

Lomustine
Glioblastoma
Disease-Free Survival
temozolomide
Bevacizumab
9 Citations (Scopus)

Cdc2-like kinase 2 is a key regulator of the cell cycle via FOXO3a/p27 in glioblastoma

Park, S. Y., Piao, Y., Thomas, C., Fuller, G. N. & de Groot, J. F., May 1 2016, In : Oncotarget. 7, 18, p. 26793-26805 13 p.

Research output: Contribution to journalArticle

Glioblastoma
Cell Cycle
Phosphotransferases
Protein Array Analysis
Survival
8 Citations (Scopus)

Demonstration of DCE-MRI as an early pharmacodynamic biomarker of response to VEGF Trap in glioblastoma

O’Neill, A. F., Qin, L., Wen, P. Y., de Groot, J. F., Van den Abbeele, A. D. & Yap, J. T., Dec 1 2016, In : Journal of neuro-oncology. 130, 3, p. 495-503 9 p.

Research output: Contribution to journalArticle

Glioblastoma
Positron-Emission Tomography
Biomarkers
Magnetic Resonance Imaging
temozolomide
42 Citations (Scopus)

Immune checkpoint blockade as a potential therapeutic target: Surveying CNS malignancies

Garber, S. T., Hashimoto, Y., Weathers, S-P., Xiu, J., Gatalica, Z., Verhaak, R. G. W., Zhou, S., Fuller, G. N., Khasraw, M., de Groot, J. F., Reddy, S. K., Spetzler, D. & Heimberger, A. B., Oct 1 2016, In : Neuro-Oncology. 18, 10, p. 1357-1366 10 p.

Research output: Contribution to journalArticle

Tumor-Infiltrating Lymphocytes
Ligands
Glioma
Neoplasms
Methyltransferases
12 Citations (Scopus)

Impact of IDH1 mutation status on outcome in clinical trials for recurrent glioblastoma

Mandel, J. J., Cachia, D., Liu, D., Wilson, C., Aldape, K., Fuller, G. N. & de Groot, J. F., Aug 1 2016, In : Journal of neuro-oncology. 129, 1, p. 147-154 8 p.

Research output: Contribution to journalArticle

Glioblastoma
Clinical Trials
Mutation
Recurrence
Disease-Free Survival
101 Citations (Scopus)

Orally administered colony stimulating factor 1 receptor inhibitor PLX3397 in recurrent glioblastoma: An Ivy Foundation Early Phase Clinical Trials Consortium phase II study

Butowski, N., Colman, H., de Groot, J. F., Omuro, A. M., Nayak, L., Wen, P. Y., Cloughesy, T. F., Marimuthu, A., Haidar, S., Perry, A., Huse, J., Phillips, J., West, B. L., Nolop, K. B., Hsu, H. H., Ligon, K. L., Molinaro, A. M. & Prados, M., Apr 1 2016, In : Neuro-oncology. 18, 4, p. 557-564 8 p.

Research output: Contribution to journalArticle

Colony-Stimulating Factor Receptors
Phase II Clinical Trials
Macrophage Colony-Stimulating Factor
Glioblastoma
Microglia
25 Citations (Scopus)

Periostin (POSTN) regulates tumor resistance to antiangiogenic therapy in glioma models

Park, S. Y., Piao, Y., Jeong, K. J., Dong, J. & de Groot, J. F., Sep 1 2016, In : Molecular cancer therapeutics. 15, 9, p. 2187-2197 11 p.

Research output: Contribution to journalArticle

Glioma
Vascular Endothelial Growth Factor A
Neoplasms
Stem Cells
Therapeutics
2015
16 Citations (Scopus)

Adult brainstem gliomas: Correlation of clinical and molecular features

Theeler, B. J., Ellezam, B., Melguizo-Gavilanes, I., de Groot, J. F., Mahajan, A., Aldape, K. D., Bruner, J. M. & Puduvalli, V. K., Jun 15 2015, In : Journal of the Neurological Sciences. 353, 1-2, p. 92-97 6 p.

Research output: Contribution to journalArticle

Glioma
Brain Stem
Mutation
Neoplasms
Survival
54 Citations (Scopus)

Clinical actionability enhanced through deep targeted sequencing of solid tumors

Chen, K., Meric-Bernstam, F., Zhao, H., Zhang, Q., Ezzeddine, N., Tang, L. Y., Qi, Y., Mao, Y., Chen, T., Chong, Z., Zhou, W., Zheng, X., Johnson, A., Aldape, K. D., Routbort, M. J., Luthra, R., Kopetz, S., Davies, M. A., De Groot, J., Moulder, S. & 6 others, Vinod, R., Farhangfar, C. J., Shaw, K. M., Mendelsohn, J., Mills, G. B. & Eterovic, A. K., Mar 1 2015, In : Clinical chemistry. 61, 3, p. 544-553 10 p.

Research output: Contribution to journalArticle

High-Throughput Nucleotide Sequencing
Tumors
Mutation
Genes
Neoplasms
189 Citations (Scopus)
Clinical Trials
Genotype
Mutation
Genes
Therapeutics
13 Citations (Scopus)

Interferon-regulatory factor-1 (IRF1) regulates bevacizumab induced autophagy

Liang, J., Piao, Y., Henry, V., Tiao, N. & de Groot, J. F., Jan 1 2015, In : Oncotarget. 6, 31, p. 31479-31492 14 p.

Research output: Contribution to journalArticle

Interferon Regulatory Factor-1
Autophagy
Glioma
Glioblastoma
Heterografts
4 Citations (Scopus)

PC or PCV, that is the question: Primary anaplastic oligodendroglial tumors treated with procarbazine and CCNU with and without vincristine

Webre, C., Shonka, N., Smith, L., Liu, D. & de Groot, J. F., Oct 1 2015, In : Anticancer research. 35, 10, p. 5467-5472 6 p.

Research output: Contribution to journalArticle

Lomustine
Procarbazine
Vincristine
Oligodendroglioma
Neoplasms
17 Citations (Scopus)

Phase 2 study of CT-322, a targeted biologic inhibitor of VEGFR-2 based on a domain of human fibronectin, in recurrent glioblastoma

Schiff, D., Kesari, S., de Groot, J. F., Mikkelsen, T., Drappatz, J., Coyle, T., Fichtel, L., Silver, B., Walters, I. & Reardon, D., Jan 1 2015, In : Investigational New Drugs. 33, 1, p. 247-253 7 p.

Research output: Contribution to journalArticle

Vascular Endothelial Growth Factor Receptor-2
Glioblastoma
Fibronectins
irinotecan
Vascular Endothelial Growth Factor A
19 Citations (Scopus)

Primary and secondary gliosarcomas: clinical, molecular and survival characteristics

Cachia, D., Kamiya Matsuoka, C., Mandel, J. J., Olar, A., Cykowski, M. D., Armstrong, T. S., Fuller, G. N., Gilbert, M. R. & de Groot, J. F., Nov 1 2015, In : Journal of neuro-oncology. 125, 2, p. 401-410 10 p.

Research output: Contribution to journalArticle

Gliosarcoma
Survival
Glioblastoma
Mutation
Disease-Free Survival
25 Citations (Scopus)

Randomized phase II adjuvant factorial study of dose-dense temozolomide alone and in combination with isotretinoin, celecoxib, and/or thalidomide for glioblastoma

Penas-Prado, M., Hess, K. R., Fisch, M. J., Lagrone, L. W., Groves, M. D., Levin, V. A., De Groot, J. F., Puduvalli, V. K., Colman, H., Volas-Redd, G., Giglio, P., Conrad, C. A., Salacz, M. E., Floyd, J. D., Loghin, M. E., Hsu, S. H., Gonzalez, J., Chang, E. L., Woo, S. Y., Mahajan, A. & 3 others, Aldape, K. D., Yung, W. K. A. & Gilbert, M. R., Feb 1 2015, In : Neuro-oncology. 17, 2, p. 266-273 8 p.

Research output: Contribution to journalArticle

Celecoxib
temozolomide
Isotretinoin
Thalidomide
Glioblastoma
2 Citations (Scopus)

Recurrent encephaloclastic cyst induced by intraventricular topotecan

Mella, D. B., Kamiya Matsuoka, C., Liao, B., Tummala, S. & de Groot, J. F., Feb 15 2015, In : Journal of the Neurological Sciences. 349, 1-2, p. 52-53 2 p.

Research output: Contribution to journalArticle

Topotecan
Cysts
Catheters
Drug Therapy
Brain