• 6953 Citations
  • 49 h-Index
1991 …2019
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Research Output 1991 2019

Article
102 Citations (Scopus)

14-3-3 Binding to Na+/H+ Exchanger Isoform-1 is Associated with Serum-dependent Activation of Na+/H+ Exchange

Lehoux, S., Abe, J. I., Florian, J. A. & Berk, B. C., May 11 2001, In : Journal of Biological Chemistry. 276, 19, p. 15794-15800 7 p.

Research output: Contribution to journalArticle

Sodium-Hydrogen Antiporter
Ion exchange
Protein Isoforms
Chemical activation
Serum
51 Citations (Scopus)

A crucial role for p90RSK-mediated reduction of ERK5 transcriptional activity in endothelial dysfunction and atherosclerosis

Le, N. T., Heo, K., Takei, Y., Lee, H., Woo, C. H., Chang, E., McClain, C., Hurley, C., Wang, X., Li, F., Xu, H., Morrell, C., Sullivan, M. A., Cohen, M. S., Serafimova, I. M., Taunton, J., Fujiwara, K. & Abe, J., Jan 29 2013, In : Circulation. 127, 4, p. 486-499 14 p.

Research output: Contribution to journalArticle

Mitogen-Activated Protein Kinase 7
90-kDa Ribosomal Protein S6 Kinases
Atherosclerosis
Endothelial Cells
Ketones
31 Citations (Scopus)

Activation of big MAP kinase 1 (BMK1/ERK5) inhibits cardiac injury after myocardial ischemia and reperfusion

Cameron, S. J., Itoh, S., Baines, C. P., Zhang, C., Ohta, S., Che, W., Glassman, M., Lee, J. D., Yan, C., Yang, J. & Abe, J., May 21 2004, In : FEBS Letters. 566, 1-3, p. 255-260 6 p.

Research output: Contribution to journalArticle

Mitogen-Activated Protein Kinase 7
Myocardial Reperfusion
Transgenic Mice
Reperfusion
Myocardial Ischemia
42 Citations (Scopus)

Activation of extracellular signal-regulated kinase 5 reduces cardiac apoptosis and dysfunction via inhibition of a phosphodiesterase 3A/inducible cAMP early repressor feedback loop

Yan, C., Ding, B., Shishido, T., Woo, C. H., Itoh, S., Jeon, K. I., Liu, W., Xu, H., McClain, C., Molina, C. A., Blaxall, B. C. & Abe, J., Mar 1 2007, In : Circulation research. 100, 4, p. 510-519 10 p.

Research output: Contribution to journalArticle

Mitogen-Activated Protein Kinase 7
Type 3 Cyclic Nucleotide Phosphodiesterases
Apoptosis
Somatomedins
Cardiac Myocytes
77 Citations (Scopus)

Activation of mitogen-activated protein kinases and p90 ribosomal S6 kinase in failing human hearts with dilated cardiomyopathy

Takeishi, Y., Huang, Q., Abe, J. I., Che, W., Lee, J. D., Kawakatsu, H., Hoit, B. D., Berk, B. C. & Walsh, R. A., Jan 10 2002, In : Cardiovascular Research. 53, 1, p. 131-137 7 p.

Research output: Contribution to journalArticle

90-kDa Ribosomal Protein S6 Kinases
Mitogen-Activated Protein Kinase 7
Dilated Cardiomyopathy
Mitogen-Activated Protein Kinases
Phosphotransferases
43 Citations (Scopus)

Adenovirus-mediated overexpression of diacylglycerol kinase-ζ inhibits endothelin-1-induced cardiomyocyte hypertrophy

Takahashi, H., Takeishi, Y., Seidler, T., Arimoto, T., Akiyama, H., Hozumi, Y., Koyama, Y., Shishido, T., Tsunoda, Y., Niizeki, T., Nozaki, N., Abe, J. I., Hasenfuss, G., Goto, K. & Kubota, I., Mar 29 2005, In : Circulation. 111, 12, p. 1510-1516 7 p.

Research output: Contribution to journalArticle

Diacylglycerol Kinase
Endothelin-1
Cardiac Myocytes
Adenoviridae
Hypertrophy
145 Citations (Scopus)
Retinoblastoma Genes
Angiogenesis Inhibitors
Cyclin-Dependent Kinases
Endothelial Cells
Phosphorylation
49 Citations (Scopus)

Angiographic follow-up after successful percutaneous coronary angioplasty for chronic total coronary occlusion: Experience in 110 consecutive patients

Ishizaka, N., Issiki, T., Saeki, F., Ishizaka, Y., Ikari, Y., Abe, J., Soumitsu, Y., Hashimoto, H., Masaki, K. & Yamaguchi, T., Jan 1 1994, In : American Heart Journal. 127, 1, p. 8-12 5 p.

Research output: Contribution to journalArticle

Coronary Balloon Angioplasty
Coronary Occlusion
Angioplasty
Angiography
Coronary Artery Disease
25 Citations (Scopus)

Angiotensin converting enzyme inhibitors or DuP753 prevent neointimal formation following balloon injury with single topical or multiple systemic application

Taguchi, J., Abe, J., Okazaki, H., Ochiai, M., Ohno, M., Takuwa, Y. & Kurokawa, K., Oct 29 1993, In : Biochemical and biophysical research communications. 196, 2, p. 969-974 6 p.

Research output: Contribution to journalArticle

Balloons
Angiotensin-Converting Enzyme Inhibitors
UCON 50-HB-5100
Angiotensin II
Wounds and Injuries
46 Citations (Scopus)

Angiotensin II stimulates p90(rsk) in vascular smooth muscle cells: A potential Na+-H+ exchanger kinase

Takahashi, E., Abe, J. & Berk, B. C., Jan 1 1997, In : Circulation Research. 81, 2, p. 268-273 6 p.

Research output: Contribution to journalArticle

90-kDa Ribosomal Protein S6 Kinases
Sodium-Hydrogen Antiporter
Vascular Smooth Muscle
Angiotensin II
Smooth Muscle Myocytes

Angiotensin II Stimulates p90rsk2 in vascular smooth muscle cells: A potential Na+/H+ exchanger kinase

Takahashi, E., Abe, J. I. & Berk, B. C., Dec 1 1997, In : FASEB Journal. 11, 3, p. A500

Research output: Contribution to journalArticle

Sodium-Hydrogen Antiporter
Vascular Smooth Muscle
Angiotensin II
Smooth Muscle Myocytes
Muscle
92 Citations (Scopus)

A positive feedback loop of phosphodiesterase 3 (PDE3) and inducible cAMP early repressor (ICER) leads to cardiomyocyte apoptosis

Ding, B., Abe, J. I., Wei, H., Xu, H., Che, W., Aizawa, T., Liu, W., Molina, C. A., Sadoshima, J., Blaxall, B. C., Berk, B. C. & Yan, C., Oct 11 2005, In : Proceedings of the National Academy of Sciences of the United States of America. 102, 41, p. 14771-14776 6 p.

Research output: Contribution to journalArticle

Type 3 Cyclic Nucleotide Phosphodiesterases
Phosphoric Diester Hydrolases
Cardiac Myocytes
Apoptosis
Up-Regulation
9 Citations (Scopus)

Axl modulates immune activation of smooth muscle cells in vein graft remodeling

Batchu, S. N., Xia, J., Ko, K. A., Doyley, M. M., Abe, J. I., Morrell, C. N. & Korshunov, V. A., Sep 18 2015, In : American Journal of Physiology - Heart and Circulatory Physiology. 309, 6, p. H1048-H1058

Research output: Contribution to journalArticle

Smooth Muscle Myocytes
Veins
Transplants
Blood Vessels
STAT1 Transcription Factor
5 Citations (Scopus)

Bcr in vascular smooth muscle cells involvement of Ras and Raf-1 activation by Bcr

Abe, J. I., Che, W., Yoshizumi, M., Huang, Q., Glassman, M., Ohta, S., Wu, Y., Arlinghaus, R. & Berk, B. C., Jan 1 2001, In : Annals of the New York Academy of Sciences. 947, p. 341-343 3 p.

Research output: Contribution to journalArticle

Vascular Smooth Muscle
Smooth Muscle Myocytes
Muscle
Phosphotransferases
Chemical activation
29 Citations (Scopus)

Bcr kinase activation by angiotensin II inhibits peroxisome proliferator-activated receptor γ transcriptional activity in vascular smooth muscle cells

Alexis, J. D., Wang, N., Che, W., Lerner-Marmarosh, N., Sahni, A., Korshunov, V. A., Zou, Y., Ding, B., Yan, C., Berk, B. C. & Abe, J. I., Jan 2 2009, In : Circulation research. 104, 1, p. 69-78 10 p.

Research output: Contribution to journalArticle

Peroxisome Proliferator-Activated Receptors
Vascular Smooth Muscle
Angiotensin II
Smooth Muscle Myocytes
Phosphotransferases
363 Citations (Scopus)

Big mitogen-activated protein kinase 1 (BMK1) is a redox-sensitive kinase

Abe, J., Kusuhara, M., Ulevitch, R. J., Berk, B. C. & Lee, J. D., Jul 30 1996, In : Journal of Biological Chemistry. 271, 28, p. 16586-16590 5 p.

Research output: Contribution to journalArticle

Mitogen-Activated Protein Kinase 1
Oxidation-Reduction
Phosphotransferases
Mitogen-Activated Protein Kinases
Chemical activation
41 Citations (Scopus)

BMK1/ERK5 is a novel regulator of angiogenesis by destabilizing hypoxia inducible factor 1α

Pi, X., Garin, G., Xie, L., Zheng, Q., Wei, H., Abe, J., Yan, C. & Berk, B. C., Jun 10 2005, In : Circulation Research. 96, 11, p. 1145-1151 7 p.

Research output: Contribution to journalArticle

Hypoxia-Inducible Factor 1
Endothelial Cells
Ubiquitination
Mitogen-Activated Protein Kinase 7
Mitogen-Activated Protein Kinase 1
20 Citations (Scopus)

Ca2+/calmodulin-stimulated PDE1 regulates the beta-catenin/TCF signaling through PP2A B56 gamma subunit in proliferating vascular smooth muscle cells

Jeon, K. I., Jono, H., Miller, C. L., Cai, Y., Lim, S., Liu, X., Gao, P., Abe, J., Li, J. D. & Yan, C., Dec 1 2010, In : FEBS Journal. 277, 24, p. 5026-5039 14 p.

Research output: Contribution to journalArticle

Type 1 Cyclic Nucleotide Phosphodiesterases
TCF Transcription Factors
Protein Phosphatase 2
Catenins
Phosphoric Diester Hydrolases
79 Citations (Scopus)

Cardiac mitochondrial connexin 43 regulates apoptosis

Goubaeva, F., Mikami, M., Giardina, S., Ding, B., Abe, J. & Yang, J., Jan 5 2007, In : Biochemical and biophysical research communications. 352, 1, p. 97-103 7 p.

Research output: Contribution to journalArticle

Connexin 43
Apoptosis
Mitochondria
Muscle Cells
Heptanol
1 Citation (Scopus)

Cardiac Nuclear High-Mobility Group Box 1 Ameliorates Pathological Cardiac Hypertrophy by Inhibiting DNA Damage Response

Takahashi, T., Shishido, T., Kinoshita, D., Watanabe, K., Toshima, T., Sugai, T., Narumi, T., Otaki, Y., Tamura, H., Nishiyama, S., Arimoto, T., Takahashi, H., Miyamoto, T., Watanabe, T., Woo, C. H., Abe, J., Takeishi, Y., Kubota, I. & Watanabe, M., Apr 1 2019, In : JACC: Basic to Translational Science. 4, 2, p. 234-247 14 p.

Research output: Contribution to journalArticle

Open Access
Cardiomegaly
DNA Damage
DNA
NF-kappa B
Angiotensins
39 Citations (Scopus)

Cardiac nuclear high mobility group box 1 prevents the development of cardiac hypertrophy and heart failure

Funayama, A., Shishido, T., Netsu, S., Narumi, T., Kadowaki, S., Takahashi, H., Miyamoto, T., Watanabe, T., Woo, C. H., Abe, J., Kuwahara, K., Nakao, K., Takeishi, Y. & Kubota, I., Sep 1 2013, In : Cardiovascular Research. 99, 4, p. 657-664 8 p.

Research output: Contribution to journalArticle

HMGB1 Protein
Cardiomegaly
Heart Failure
Constriction
Endothelin-1
70 Citations (Scopus)

Cardiac-specific overexpression of diacylglycerol kinase ζ prevents Gq protein-coupled receptor agonist-induced cardiac hypertrophy in transgenic mice

Arimoto, T., Takeishi, Y., Takahashi, H., Shishido, T., Niizeki, T., Koyama, Y., Shiga, R., Nozaki, N., Nakajima, O., Nishimaru, K., Abe, J., Endoh, M., Walsh, R. A., Goto, K. & Kubota, I., Jan 1 2006, In : Circulation. 113, 1, p. 60-66 7 p.

Research output: Contribution to journalArticle

Gq-G11 GTP-Binding Protein alpha Subunits
Diacylglycerol Kinase
Cardiomegaly
Transgenic Mice
Diglycerides
52 Citations (Scopus)

Central role of endogenous Toll-like receptor-2 activation in regulating inflammation, reactive oxygen species production, and subsequent neointimal formation after vascular injury

Shishido, T., Nozaki, N., Takahashi, H., Arimoto, T., Niizeki, T., Koyama, Y., Abe, J., Takeishi, Y. & Kubota, I., Jul 14 2006, In : Biochemical and biophysical research communications. 345, 4, p. 1446-1453 8 p.

Research output: Contribution to journalArticle

Toll-Like Receptor 2
Vascular System Injuries
Reactive Oxygen Species
Chemical activation
Inflammation
6 Citations (Scopus)

Coordination of cellular localization-dependent effects of sumoylation in regulating cardiovascular and neurological diseases

Abe, J. I., Sandhu, U. G., Hoang, N. M., Thangam, M., Quintana-Quezada, R. A., Fujiwara, K. & Le, N. T., Feb 1 2017, In : Advances in experimental medicine and biology. 963, p. 337-358 22 p.

Research output: Contribution to journalArticle

Sumoylation
Cardiovascular Diseases
Ubiquitin-Protein Ligases
Mitochondrial Proteins
Proteins
246 Citations (Scopus)

c-Src is required for oxidative stress-mediated activation of big mitogen-activated protein kinase 1 (BMK1)

Abe, J., Takahashi, M., Ishida, M., Lee, J. D. & Berk, B. C., Aug 15 1997, In : Journal of Biological Chemistry. 272, 33, p. 20389-20394 6 p.

Research output: Contribution to journalArticle

Oxidative stress
Mitogen-Activated Protein Kinase 1
Oxidative Stress
Chemical activation
src-Family Kinases
23 Citations (Scopus)

Cyclic nucleotide phosphodiesterase 3A1 protects the heart against ischemia-reperfusion injury

Oikawa, M., Wu, M., Lim, S., Knight, W. E., Miller, C. L., Cai, Y., Lu, Y., Blaxall, B. C., Takeishi, Y., Abe, J. & Yan, C., Nov 1 2013, In : Journal of Molecular and Cellular Cardiology. 64, p. 11-19 9 p.

Research output: Contribution to journalArticle

Type 3 Cyclic Nucleotide Phosphodiesterases
Cyclic Nucleotides
Phosphoric Diester Hydrolases
Reperfusion Injury
Phosphodiesterase 3 Inhibitors
222 Citations (Scopus)

Cyclophilin A enhances vascular oxidative stress and the development of angiotensin II-induced aortic aneurysms

Satoh, K., Nigro, P., Matoba, T., O'Dell, M. R., Cui, Z., Shi, X., Mohan, A., Yan, C., Abe, J., Illig, K. A. & Berk, B. C., Jun 8 2009, In : Nature medicine. 15, 6, p. 649-656 8 p.

Research output: Contribution to journalArticle

Cyclophilin A
Oxidative stress
Aortic Aneurysm
Apolipoproteins E
Angiotensin II
107 Citations (Scopus)

Cyclophilin A is an inflammatory mediator that promotes atherosclerosis in apolipoprotein E-deficient mice

Nigro, P., Satoh, K., O'Dell, M. R., Soe, N. N., Cui, Z., Mohan, A., Abe, J., Alexis, J. D., Sparks, J. D. & Berk, B. C., Jan 17 2011, In : Journal of Experimental Medicine. 208, 1, p. 53-66 14 p.

Research output: Contribution to journalArticle

Cyclophilin A
Apolipoproteins E
Atherosclerosis
Blood Vessels
Vascular Cell Adhesion Molecule-1
133 Citations (Scopus)

Cyclophilin a mediates vascular remodeling by promoting inflammation and vascular smooth muscle cell proliferation

Satoh, K., Matoba, T., Suzuki, J., O'Dell, M. R., Nigro, P., Cui, Z., Mohan, A., Pan, S., Li, L., Jin, Z. G., Yan, C., Abe, J. I. & Berk, B. C., Jun 17 2008, In : Circulation. 117, 24, p. 3088-3098 11 p.

Research output: Contribution to journalArticle

Cyclophilin A
Cyclophilins
Vascular Smooth Muscle
Smooth Muscle Myocytes
Cell Proliferation
41 Citations (Scopus)

De-sumoylation enzyme of sentrin/sumo-specific protease 2 regulates disturbed flow-induced sumoylation of erk5 and p53 that leads to endothelial dysfunction and atherosclerosis

Heo, K. S., Chang, E., Le, N. T., Cushman, H., Yeh, E. T. H., Fujiwara, K. & Abe, J. I., Mar 15 2013, In : Circulation research. 112, 6, p. 911-923 13 p.

Research output: Contribution to journalArticle

SUMO-1 Protein
Sumoylation
Atherosclerosis
Peptide Hydrolases
Enzymes
74 Citations (Scopus)

Differential regulation of p90 ribosomal S6 kinase and big mitogen- activated protein kinase 1 by ischemia/reperfusion and oxidative stress in perfused guinea pig hearts

Takeishi, Y., Abe, J., Lee, J. D., Kawakatsu, H., Walsh, R. A. & Berk, B. C., Dec 3 1999, In : Circulation research. 85, 12, p. 1164-1172 9 p.

Research output: Contribution to journalArticle

90-kDa Ribosomal Protein S6 Kinases
MAP Kinase Kinase 1
Mitogen-Activated Protein Kinase 1
Reperfusion
Guinea Pigs
28 Citations (Scopus)

Differential Role of MEK5α and MEK5β in BMK1/ERK5 Activation

Cameron, S. J., Abe, J., Malik, S., Che, W. & Yang, J., Jan 9 2004, In : Journal of Biological Chemistry. 279, 2, p. 1506-1512 7 p.

Research output: Contribution to journalArticle

Mitogen-Activated Protein Kinase 1
Mitogen-Activated Protein Kinase 7
Phosphorylation
Phosphotransferases
Chemical activation
32 Citations (Scopus)

Disturbed flow-activated p90RSK kinase accelerates atherosclerosis by inhibiting SENP2 function

Heo, K., Le, N. T., Cushman, H. J., Giancursio, C. J., Chang, E., Woo, C. H., Sullivan, M. A., Taunton, J., Yeh, E., Fujiwara, K. & Abe, J., Jan 1 2015, In : Journal of Clinical Investigation. 125, 3, p. 1299-1310 12 p.

Research output: Contribution to journalArticle

SUMO-1 Protein
Atherosclerosis
Peptide Hydrolases
Phosphotransferases
Threonine
55 Citations (Scopus)

Effects of MEK5/ERK5 association on small ubiquitin-related modification of ERK5: Implications for diabetic ventricular dysfunction after myocardial infarction

Shishido, T., Woo, C. H., Ding, B., McClain, C., Molina, C. A., Yan, C., Yang, J. & Abe, J. I., Jun 6 2008, In : Circulation research. 102, 11, p. 1416-1425 10 p.

Research output: Contribution to journalArticle

Ventricular Dysfunction
Sumoylation
Ubiquitin
Myocardial Infarction
Diabetes Mellitus
180 Citations (Scopus)

Endothelial atheroprotective and anti-inflammatory mechanisms

Berk, B. C., Abe, J., Min, W., Surapisitchat, J. & Yan, C., Jan 1 2001, In : Annals of the New York Academy of Sciences. 947, p. 93-111 19 p.

Research output: Contribution to journalArticle

Endothelial cells
Anti-Inflammatory Agents
Tumor Necrosis Factor-alpha
Endothelial Cells
Phosphotransferases

Endothelial senescence-associated secretory phenotype (SASP) is regulated by Makorin-1 ubiquitin E3 ligase

Kotla, S., Le, N. T., Vu, H. T., Ko, K. A., Gi, Y. J., Thomas, T. N., Giancursio, C., Lusis, A. J., Cooke, J. P., Fujiwara, K. & Abe, J. I., Nov 2019, In : Metabolism: clinical and experimental. 100, 153962.

Research output: Contribution to journalArticle

Telomeric Repeat Binding Protein 2
Ubiquitin-Protein Ligases
Phenotype
Endothelial Cells
Phosphorylation
2 Citations (Scopus)

Endothelial senescence is induced by phosphorylation and nuclear export of telomeric repeat binding factor 2-interacting protein

Kotla, S., Vu, H. T., Ko, K. A., Wang, Y., Imanishi, M., Heo, K. S., Fujii, Y., Thomas, T. N., Gi, Y. J., Mazhar, H., Paez-Mayorga, J., Shin, J. H., Tao, Y., Giancursio, C. J., Medina, J. L. M., Taunton, J., Lusis, A. J., Cooke, J. P., Fujiwara, K., Le, N. T. & 1 others, Abe, J. I., Jan 1 2019, In : JCI Insight. 4, 9, e124867.

Research output: Contribution to journalArticle

Open Access
Cell Nucleus Active Transport
Phosphorylation
Cell Aging
Endothelial Cells
Apoptosis
17 Citations (Scopus)

Endothelial-to-Osteoblast Conversion Generates Osteoblastic Metastasis of Prostate Cancer

Lin, S-C., Lee, Y-C., Yu, G., Cheng, C. J., Zhou, X., Chu, K., Murshed, M., Le, N. T., Baseler, L., Abe, J., Fujiwara, K., deCrombrugghe, B., Logothetis, C. J., Gallick, G. E., Yu-Lee, L. Y., Maity, S. N. & Lin, S-H., Jun 5 2017, In : Developmental cell. 41, 5, p. 467-480.e3

Research output: Contribution to journalArticle

Osteoblasts
Prostatic Neoplasms
Bone
Neoplasm Metastasis
Endothelial cells
3 Citations (Scopus)

En face preparation of mouse blood vessels

Ko, K. A., Fujiwara, K., Krishnan, S. & Abe, J. I., May 19 2017, In : Journal of Visualized Experiments. 2017, 123, e55460.

Research output: Contribution to journalArticle

Blood vessels
Blood Vessels
Tissue
Histology
Confocal microscopy
35 Citations (Scopus)

ERK1/2 associates with the c-Met-binding domain of growth factor receptor-bound protein 2 (Grb2)-associated binder-1 (Gab1): Role in ERK1/2 and early growth response factor-1 (Egr-1) nuclear accumulation

Osawa, M., Itoh, S., Ohta, S., Huang, Q., Berk, B. C., Marmarosh, N. L., Che, W., Ding, B., Yan, C. & Abe, J. I., Jul 9 2004, In : Journal of Biological Chemistry. 279, 28, p. 29691-29699 9 p.

Research output: Contribution to journalArticle

GRB2 Adaptor Protein
NFI Transcription Factors
Nuclear Localization Signals
Binders
Intercellular Signaling Peptides and Proteins
62 Citations (Scopus)

ERK5 activation inhibits inflammatory responses via peroxisome proliferator-activated receptor δ (PPARδ) stimulation

Woo, C. H., Massett, M. P., Shishido, T., Itoh, S., Ding, B., McClain, C., Che, W., Vulapalli, S. R., Yan, C. & Abe, J. I., Oct 27 2006, In : Journal of Biological Chemistry. 281, 43, p. 32164-32174 11 p.

Research output: Contribution to journalArticle

Peroxisome Proliferator-Activated Receptors
Heme Oxygenase-1
Carbon Monoxide
Chemical activation
Inflammation
24 Citations (Scopus)

ERK5 activation in macrophages promotes efferocytosis and inhibits atherosclerosis

Heo, K. S., Cushman, H. J., Akaike, M., Woo, C. H., Wang, X., Qiu, X., Fujiwara, K. & Abe, J. I., Jul 8 2014, In : Circulation. 130, 2, p. 180-191 12 p.

Research output: Contribution to journalArticle

Macrophage Activation
Atherosclerosis
Macrophages
Atherosclerotic Plaques
Up-Regulation
81 Citations (Scopus)

Extracellular signal-regulated kinase 5 SUMOylation antagonizes shear stress-induced antiinflammatory response and endothelial nitric oxide synthase expression in endothelial cells

Woo, C. H., Shishido, T., McClain, C., Lim, J. H., Li, J. D., Yang, J., Yan, C. & Abe, J., Mar 1 2008, In : Circulation Research. 102, 5, p. 538-545 8 p.

Research output: Contribution to journalArticle

Mitogen-Activated Protein Kinase 7
Sumoylation
Nitric Oxide Synthase Type III
Anti-Inflammatory Agents
Endothelial Cells
45 Citations (Scopus)

Flow antagonizes TNF-α signaling in endothelial cells by inhibiting caspase-dependent PKCζ processing

Garin, G., Abe, J. I., Mohan, A., Lu, W., Yan, C., Newby, A. C., Rhaman, A. & Berk, B. C., Jul 1 2007, In : Circulation research. 101, 1, p. 97-105 9 p.

Research output: Contribution to journalArticle

Caspases
Caspase 3
Endothelial Cells
Catalytic Domain
Protein Isoforms
66 Citations (Scopus)

Fluid shear stress activates proline-rich tyrosine kinase via reactive oxygen species-dependent pathway

Tai, L. K., Okuda, M., Abe, J., Yan, C. & Berk, B. C., Nov 1 2002, In : Arteriosclerosis, Thrombosis, and Vascular Biology. 22, 11, p. 1790-1796 7 p.

Research output: Contribution to journalArticle

Proline
Protein-Tyrosine Kinases
Crk-Associated Substrate Protein
Reactive Oxygen Species
Phosphorylation
35 Citations (Scopus)

Fluid shear stress inhibits TNF-mediated JNK activation via MEK5-BMK1 in endothelial cells

Li, L., Tatake, R. J., Natarajan, K., Taba, Y., Garin, G., Tai, C., Leung, E., Surapisitchat, J., Yoshizumi, M., Yan, C., Abe, J. & Berk, B. C., May 23 2008, In : Biochemical and biophysical research communications. 370, 1, p. 159-163 5 p.

Research output: Contribution to journalArticle

Endothelial cells
Shear stress
Endothelial Cells
Tumor Necrosis Factor-alpha
Chemical activation
131 Citations (Scopus)

Functional role of phosphodiesterase 3 in cardiomyocyte apoptosis: Implication in heart failure

Ding, B., Abe, J. I., Wei, H., Huang, Q., Walsh, R. A., Molina, C. A., Zhao, A., Sadoshima, J., Blaxall, B. C., Berk, B. C. & Yan, C., May 17 2005, In : Circulation. 111, 19, p. 2469-2476 8 p.

Research output: Contribution to journalArticle

Phosphoric Diester Hydrolases
Cardiac Myocytes
Heart Failure
Apoptosis
Isoproterenol
178 Citations (Scopus)

Fyn and JAK2 mediate Ras activation by reactive oxygen species

Abe, J. & Berk, B. C., Jul 23 1999, In : Journal of Biological Chemistry. 274, 30, p. 21003-21010 8 p.

Research output: Contribution to journalArticle

Reactive Oxygen Species
Chemical activation
Extracellular Signal-Regulated MAP Kinases
Fibroblasts
Transgenic Mice
19 Citations (Scopus)

High-mobility group box 1-mediated heat shock protein beta 1 expression attenuates mitochondrial dysfunction and apoptosis

Narumi, T., Shishido, T., Otaki, Y., Kadowaki, S., Honda, Y., Funayama, A., Honda, S., Hasegawa, H., Kinoshita, D., Yokoyama, M., Nishiyama, S., Takahashi, H., Arimoto, T., Miyamoto, T., Watanabe, T., Tanaka, A., Woo, C. H., Abe, J., Takeishi, Y. & Kubota, I., May 1 2015, In : Journal of Molecular and Cellular Cardiology. 82, p. 1-12 12 p.

Research output: Contribution to journalArticle

HSP27 Heat-Shock Proteins
Doxorubicin
Cardiac Myocytes
Apoptosis
Shock
22 Citations (Scopus)

Identification of activators of erk5 transcriptional activity by high-throughput screening and the role of endothelial ERK5 in vasoprotective effects induced by statins and antimalarial agents

Le, N. T., Takei, Y., Izawa-Ishizawa, Y., Heo, K., Lee, H., Smrcka, A. V., Miller, B. L., Ko, K. A., Ture, S., Morrell, C., Fujiwara, K., Akaike, M. & Abe, J., Oct 1 2014, In : Journal of Immunology. 193, 7, p. 3803-3815 13 p.

Research output: Contribution to journalArticle

Hydroxymethylglutaryl-CoA Reductase Inhibitors
Antimalarials
Endothelial Cells
Leukocyte Rolling
Hydroxychloroquine