• 7021 Citations
  • 50 h-Index
1991 …2019
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Research Output 1991 2019

Article
24 Citations (Scopus)

Identification of activators of erk5 transcriptional activity by high-throughput screening and the role of endothelial ERK5 in vasoprotective effects induced by statins and antimalarial agents

Le, N. T., Takei, Y., Izawa-Ishizawa, Y., Heo, K. S., Lee, H., Smrcka, A. V., Miller, B. L., Ko, K. A., Ture, S., Morrell, C., Fujiwara, K., Akaike, M. & Abe, J. I., Oct 1 2014, In : Journal of Immunology. 193, 7, p. 3803-3815 13 p.

Research output: Contribution to journalArticle

Hydroxymethylglutaryl-CoA Reductase Inhibitors
Antimalarials
Endothelial Cells
Leukocyte Rolling
Hydroxychloroquine
65 Citations (Scopus)

Inhibiting p90 ribosomal S6 kinase prevents Na+-H+ exchanger-mediated cardiac ischemia-reperfusion injury

Maekawa, N., Abe, J. I., Shishido, T., Itoh, S., Ding, B., Sharma, V. K., Sheu, S. S., Blaxall, B. C. & Berk, B. C., May 1 2006, In : Circulation. 113, 21, p. 2516-2523 8 p.

Research output: Contribution to journalArticle

90-kDa Ribosomal Protein S6 Kinases
Ribosomal Protein S6 Kinases
Sodium-Hydrogen Antiporter
Reperfusion Injury
Protein Isoforms
29 Citations (Scopus)

Inhibition of tumor necrosis factor-α-induced SHP-2 phosphatase activity by shear stress: A mechanism to reduce endothelial inflammation

Lerner-Marmarosh, N., Yoshizumi, M., Che, W., Surapisitchat, J., Kawakatsu, H., Akaike, M., Ding, B., Huang, Q., Yan, C., Berk, B. C. & Abe, J. I., Oct 1 2003, In : Arteriosclerosis, thrombosis, and vascular biology. 23, 10, p. 1775-1781 7 p.

Research output: Contribution to journalArticle

Phosphoric Monoester Hydrolases
Tumor Necrosis Factor-alpha
Inflammation
src-Family Kinases
JNK Mitogen-Activated Protein Kinases
5 Citations (Scopus)

Inhibitory effects of trapidil on PDGF signaling in balloon-injured rat carotid artery

Deguchi, J. O., Abe, J., Makuuchi, M. & Takuwa, Y., Nov 19 1999, In : Life Sciences. 65, 26, p. 2791-2799 9 p.

Research output: Contribution to journalArticle

Trapidil
Balloons
Platelet-Derived Growth Factor
Carotid Arteries
Rats
12 Citations (Scopus)

Insulin activates RSK (p90 ribosomal S6 kinase) to trigger a new negative feedback loop that regulates insulin signaling for glucose metabolism

Smadja-Lamère, N., Shum, M., Déléris, P., Roux, P. P., Abe, J. I. & Marette, A., Oct 25 2013, In : Journal of Biological Chemistry. 288, 43, p. 31165-31176 12 p.

Research output: Contribution to journalArticle

90-kDa Ribosomal Protein S6 Kinases
Metabolism
Serine
Insulin
Feedback
157 Citations (Scopus)

Insulin-like growth factor-1 enhances inflammatory responses in endothelial cells: Role of Gab1 and MEKK3 in TNF-α-induced c-Jun and NF-κB activation and adhesion molecule expression

Che, W., Lerner-Marmarosh, N., Huang, Q., Osawa, M., Ohta, S., Yoshizumi, M., Glassman, M., Lee, J. D., Yan, C., Berk, B. C. & Abe, J. I., Jun 14 2002, In : Circulation research. 90, 11, p. 1222-1230 9 p.

Research output: Contribution to journalArticle

Somatomedins
Endothelial Cells
Tumor Necrosis Factor-alpha
Transcriptional Activation
Blood Vessels
45 Citations (Scopus)

L-arginine inhibits neointimal formation following balloon injury

Taguchi, J., Abe, J., Okazaki, H., Takuwa, Y. & Kurokawa, K., Jan 1 1993, In : Life Sciences. 53, 23

Research output: Contribution to journalArticle

Balloons
Arginine
Nitric Oxide
Wounds and Injuries
Blood pressure
2 Citations (Scopus)

MAGI1 as a link between endothelial activation and ER stress drives atherosclerosis

Abe, J-I., Ko, K. A., Kotla, S., Wang, Y., Paez-Mayorga, J., Shin, I. J., Imanishi, M., Vu, H. T., Tao, Y., Leiva-Juarez, M. M., Thomas, T. N., Medina, J. L., Won, J. H., Fujii, Y., Giancursio, C. J., McBeath, E., Shin, J-H., Guzman, L., Abe, R. J., Taunton, J. & 6 others, Mochizuki, N., Faubion, W., Cooke, J. P., Fujiwara, K., Evans, S. E. & Le, N-T., Apr 4 2019, In : JCI Insight. 4, 7

Research output: Contribution to journalArticle

Endoplasmic Reticulum Stress
Atherosclerosis
Endothelial Cells
Activating Transcription Factor 6
90-kDa Ribosomal Protein S6 Kinases
54 Citations (Scopus)

Mitochondrial Dok-4 recruits Src kinase and regulates NF-κB activation in endothelial cells

Itoh, S., Lemay, S., Osawa, M., Che, W., Duan, Y., Tompkins, A., Brookes, P. S., Sheu, S. S. & Abe, J. I., Jul 15 2005, In : Journal of Biological Chemistry. 280, 28, p. 26383-26396 14 p.

Research output: Contribution to journalArticle

src-Family Kinases
Endothelial cells
Phosphotransferases
Endothelial Cells
Chemical activation
31 Citations (Scopus)

MK2 SUMOylation regulates actin filament remodeling and subsequent migration in endothelial cells by inhibiting MK2 kinase and HSP27 phosphorylation

Chang, E., Heo, K. S., Woo, C. H., Lee, H., Le, N. T., Thomas, T. N., Fujiwara, K. & Abe, J. I., Feb 24 2011, In : Blood. 117, 8, p. 2527-2537 11 p.

Research output: Contribution to journalArticle

Sumoylation
Phosphorylation
Endothelial cells
Actin Cytoskeleton
Actins
118 Citations (Scopus)

Molecular Cloning of Mouse ERK5/BMK1 Splice Variants and Characterization of ERK5 Functional Domains

Yan, C., Luo, H., Lee, J. D., Abe, J. I. & Berk, B. C., Apr 6 2001, In : Journal of Biological Chemistry. 276, 14, p. 10870-10878 9 p.

Research output: Contribution to journalArticle

Mitogen-Activated Protein Kinase 7
Cloning
Molecular Cloning
Complementary DNA
Phosphotransferases
14 Citations (Scopus)

Myocardial reperfusion can be predicted by myoglobin/creatine kinase ratio of a single blood sample obtained at the time of admission

Abe, J., Yamaguchi, T., Isshiki, T., Naka, H., Taguchi, J., Ishizaka, N., Kurokawa, K., Saeki, F., Ishizaka, Y., Ui, K., Ikari, Y., Somitsu, Y., Hashimoto, H. & Kashida, M., Aug 1993, In : American Heart Journal. 126, 2, p. 279-285 7 p.

Research output: Contribution to journalArticle

Myocardial Reperfusion
Myoglobin
Creatine Kinase
Myocardial Infarction
Reperfusion
2 Citations (Scopus)

Neuronal Hyaline Inclusions Observed in an Autopsy Case of Behçet's Disease

Iihara, K., Abe, J. & Murakami, T., Jun 1992, In : Pathology International. 42, 6, p. 432-439 8 p.

Research output: Contribution to journalArticle

Hyalin
Lewy Bodies
Autopsy
Parkinson Disease
Oral Ulcer
35 Citations (Scopus)

Novel role of C terminus of Hsc70-interacting protein (CHIP) ubiquitin ligase on inhibiting cardiac apoptosis and dysfunction via regulating ERK5-mediated degradation of inducible cAMP early repressor

Woo, C. H., Le, N. T., Shishido, T., Chang, E., Lee, H., Heo, K. S., Mickelsen, D. M., Lu, Y., McClain, C., Spangenberg, T., Yan, C., Molina, C. A., Yang, J., Patterson, C. & Abe, J. I., Dec 1 2010, In : FASEB Journal. 24, 12, p. 4917-4928 12 p.

Research output: Contribution to journalArticle

HSC70 Heat-Shock Proteins
Ubiquitin-Protein Ligases
Ligases
Ubiquitin
Apoptosis
14 Citations (Scopus)

p160 Bcr mediates platelet-derived growth factor activation of extracellular signal-regulated kinase in vascular smooth muscle cells

Che, W., Abe, J. I., Yoshizumi, M., Huang, Q., Glassman, M., Ohta, S., Melaragno, M. G., Poppa, V., Yan, C., Lerner-Marmarosh, N., Zhang, C., Wu, Y., Arlinghaus, R. & Berk, B. C., Sep 18 2001, In : Circulation. 104, 12, p. 1399-1406 8 p.

Research output: Contribution to journalArticle

Platelet-Derived Growth Factor
Extracellular Signal-Regulated MAP Kinases
Vascular Smooth Muscle
Smooth Muscle Myocytes
Phosphotransferases
127 Citations (Scopus)

p38 Kinase is a negative regulator of angiotensin II signal transduction in vascular smooth muscle cells effects on Na+/H+ exchange and ERK1/2

Kusuhara, M., Takahashi, E., Peterson, T. E., Abe, J., Ishida, M., Han, J., Ulevitch, R. & Berk, B. C., Oct 19 1998, In : Circulation Research. 83, 8, p. 824-831 8 p.

Research output: Contribution to journalArticle

Mitogen-Activated Protein Kinase 3
Mitogen-Activated Protein Kinase 1
Vascular Smooth Muscle
Angiotensin II
Smooth Muscle Myocytes
18 Citations (Scopus)

P62 binding to protein kinase C ζ regulates tumor necrosis factor α-induced apoptotic pathway in endothelial cells

Kim, G. Y., Nigro, P., Fujiwara, K., Abe, J. I. & Berk, B. C., Dec 1 2012, In : Arteriosclerosis, thrombosis, and vascular biology. 32, 12, p. 2974-2980 7 p.

Research output: Contribution to journalArticle

Protein Kinase C
Carrier Proteins
Endothelial Cells
Tumor Necrosis Factor-alpha
Caspase 3
198 Citations (Scopus)

p90(RSK) is a serum-stimulated Na+/H+ exchanger isoform-1 kinase. Regulatory phosphorylation of serine 703 of Na+/H+ exchanger isoform-1

Takáhashi, E., Abe, J., Gallis, B., Aebersold, R., Spring, D. J., Krebs, E. G. & Berk, B. C., Jul 16 1999, In : Journal of Biological Chemistry. 274, 29, p. 20206-20214 9 p.

Research output: Contribution to journalArticle

90-kDa Ribosomal Protein S6 Kinases
Sodium-Hydrogen Antiporter
Phosphorylation
Serine
Protein Isoforms
6 Citations (Scopus)

P90 ribosomal S6 kinase regulates activity of the renin-angiotensin system: A pathogenic mechanism for ischemia-reperfusion injury

Shi, X., Yan, C., Nadtochiy, S. M., Abe, J., Brookes, P. S. & Berk, B. C., Aug 1 2011, In : Journal of Molecular and Cellular Cardiology. 51, 2, p. 272-275 4 p.

Research output: Contribution to journalArticle

90-kDa Ribosomal Protein S6 Kinases
Ribosomal Protein S6 Kinases
Renin-Angiotensin System
Reperfusion Injury
Renin
33 Citations (Scopus)

P90RSK targets the ERK5-CHIP ubiquitin E3 ligase activity in diabetic hearts and promotes cardiac apoptosis and dysfunction

Le, N. T., Takei, Y., Shishido, T., Woo, C. H., Chang, E., Heo, K. S., Lee, H., Lu, Y., Morrell, C., Oikawa, M., McClain, C., Wang, X., Tournier, C., Molina, C. A., Taunton, J., Yan, C., Fujiwara, K., Patterson, C., Yang, J. & Abe, J. I., Feb 17 2012, In : Circulation research. 110, 4, p. 536-550 15 p.

Research output: Contribution to journalArticle

Ubiquitin-Protein Ligases
Apoptosis
Ligases
Ubiquitin
Myocardial Infarction
17 Citations (Scopus)

PDE1C deficiency antagonizes pathological cardiac remodeling and dysfunction

Knight, W. E., Chen, S., Zhang, Y., Oikawa, M., Wu, M., Zhou, Q., Miller, C. L., Cai, Y., Mickelsen, D. M., Moravec, C., Small, E. M., Abe, J. & Yan, C., Nov 8 2016, In : Proceedings of the National Academy of Sciences of the United States of America. 113, 45, p. E7116-E7125

Research output: Contribution to journalArticle

Phosphoric Diester Hydrolases
Cardiac Myocytes
Fibroblasts
Cardiomegaly
Apoptosis
5 Citations (Scopus)

PDZK1 prevents neointima formation via suppression of breakpoint cluster region kinase in vascular smooth muscle

Lee, W. R., Sacharidou, A., Behling-Kelly, E., Oltmann, S. C., Zhu, W., Ahmed, M., Gerard, R. D., Hui, D. Y., Abe, J. I., Shaul, P. W. & Mineo, C., Apr 17 2015, In : PloS one. 10, 4, e0124494.

Research output: Contribution to journalArticle

Neointima
Vascular Smooth Muscle
blood vessels
smooth muscle
Muscle
57 Citations (Scopus)

Perlecan proteolysis induces an α2β1 integrin- and Src family kinase-dependent anti-apoptotic pathway in fibroblasts in the absence of focal adhesion kinase activation

Laplante, P., Raymond, M. A., Labelle, A., Abe, J. I., Iozzo, R. V. & Hébert, M. J., Oct 13 2006, In : Journal of Biological Chemistry. 281, 41, p. 30383-30392 10 p.

Research output: Contribution to journalArticle

Proteolysis
Focal Adhesion Protein-Tyrosine Kinases
src-Family Kinases
Fibroblasts
Integrins
15 Citations (Scopus)

Phosphorylation of protein inhibitor of activated STAT1 (PIAS1) by MAPK-activated protein kinase-2 inhibits endothelial inflammation via increasing both PIAS1 transrepression and SUMO E3 ligase activity

Heo, K. S., Chang, E., Takei, Y., Le, N. T., Woo, C. H., Sullivan, M. A., Morrell, C., Fujiwara, K. & Abe, J. I., Feb 1 2013, In : Arteriosclerosis, thrombosis, and vascular biology. 33, 2, p. 321-329 9 p.

Research output: Contribution to journalArticle

Ubiquitin-Protein Ligases
Ubiquitin
Mitogen-Activated Protein Kinases
Protein Kinases
Phosphorylation
50 Citations (Scopus)

PKCζ decreases eNOS protein stability via inhibitory phosphorylation of ERK5

Nigro, P., Abe, J., Woo, C. H., Satoh, K., McClain, C., O'Dell, M. R., Lee, H., Lim, J. H., Li, J. D., Heo, K., Fujiwara, K. & Berk, B. C., Sep 16 2010, In : Blood. 116, 11, p. 1971-1979 9 p.

Research output: Contribution to journalArticle

Mitogen-Activated Protein Kinase 7
Phosphorylation
Protein Stability
Nitric Oxide Synthase Type III
Protein Kinase C
52 Citations (Scopus)

PKCζ mediates disturbed flow-induced endothelial apoptosis via p53 SUMOylation

Heo, K. S., Lee, H., Nigro, P., Thomas, T., Le, N. T., Chang, E., McClain, C., Reinhart-King, C. A., King, M. R., Berk, B. C., Fujiwara, K., Woo, C. H. & Abe, J. I., May 30 2011, In : Journal of Cell Biology. 193, 5, p. 867-884 18 p.

Research output: Contribution to journalArticle

Sumoylation
Protein Kinase C
Apoptosis
Endothelial Cells
Atherosclerosis
17 Citations (Scopus)

Platelet extracellular regulated protein kinase 5 is a redox switch and triggers maladaptive platelet responses and myocardial infarct expansion

Cameron, S. J., Ture, S. K., Mickelsen, D., Chakrabarti, E., Modjeski, K. L., McNitt, S., Seaberry, M., Field, D. J., Le, N. T., Abe, J. I. & Morrell, C. N., Jan 1 2015, In : Circulation. 132, 1, p. 47-58 12 p.

Research output: Contribution to journalArticle

Protein Kinases
Oxidation-Reduction
Blood Platelets
Myocardial Infarction
Platelet Activation
28 Citations (Scopus)

Pleckstrin Homology and Phosphotyrosine-binding Domain-dependent Membrane Association and Tyrosine Phosphorylation of Dok-4, an Inhibitory Adapter Molecule Expressed in Epithelial Cells

Bedirian, A., Baldwin, C., Abe, J., Takano, T. & Lemay, S., Apr 30 2004, In : Journal of Biological Chemistry. 279, 18, p. 19335-19349 15 p.

Research output: Contribution to journalArticle

Phosphotyrosine
Phosphorylation
Tyrosine
Epithelial Cells
Membranes
88 Citations (Scopus)

Protease-activated receptor-1 contributes to cardiac remodeling and hypertrophy

Pawlinski, R., Tencati, M., Hampton, C. R., Shishido, T., Bullard, T. A., Casey, L. M., Andrade-Gordon, P., Kotzsch, M., Spring, D., Luther, T., Abe, J. I., Pohlman, T. H., Verrier, E. D., Blaxall, B. C. & Mackman, N., Nov 1 2007, In : Circulation. 116, 20, p. 2298-2306 9 p.

Research output: Contribution to journalArticle

PAR-1 Receptor
Cardiomegaly
Cardiac Myocytes
Hypertrophy
Reperfusion Injury
26 Citations (Scopus)

Protein kinase C-α and protein kinase C-ε are required for Grb2-associated binder-1 tyrosine phosphorylation in response to platelet-derived growth factor

Saito, Y., Hojo, Y., Tanimoto, T., Abe, J. I. & Berk, B. C., Jun 28 2002, In : Journal of Biological Chemistry. 277, 26, p. 23216-23222 7 p.

Research output: Contribution to journalArticle

Phosphorylation
Platelet-Derived Growth Factor
Type C Phospholipases
Protein Kinase C
Binders
120 Citations (Scopus)

Reactive oxygen species activate p90 ribosomal S6 kinase via Fyn and Ras

Jun-Ichi, A., Okuda, M., Huang, Q., Yoshizumi, M. & Berk, B. C., Jan 21 2000, In : Journal of Biological Chemistry. 275, 3, p. 1739-1748 10 p.

Research output: Contribution to journalArticle

90-kDa Ribosomal Protein S6 Kinases
Reactive Oxygen Species
Chemical activation
Fibroblasts
Signal transduction
32 Citations (Scopus)

Reactive oxygen species-induced activation of p90 ribosomal s6 kinase prolongs cardiac repolarization through inhibiting outward K+ channel activity

Lu, Z., Abe, J. I., Taunton, J., Lu, Y., Shishido, T., McClain, C., Yan, C., Xu, S. P., Spangenberg, T. M. & Xu, H., Aug 1 2008, In : Circulation research. 103, 3, p. 269-278 10 p.

Research output: Contribution to journalArticle

90-kDa Ribosomal Protein S6 Kinases
Reactive Oxygen Species
Voltage-Gated Potassium Channels
HEK293 Cells
Reperfusion Injury
90 Citations (Scopus)

Regulation of epidermal growth factor-induced connexin 43 gap junction communication by big mitogen-activated protein kinase 1/ERK5 but not ERK1/2 kinase activation

Cameron, S. J., Malik, S., Akaike, M., Lerner-Marmarosh, N., Yan, C., Lee, J. D., Abe, J. I. & Yang, J., May 16 2003, In : Journal of Biological Chemistry. 278, 20, p. 18682-18688 7 p.

Research output: Contribution to journalArticle

Connexin 43
Mitogen-Activated Protein Kinase 3
Gap Junctions
Mitogen-Activated Protein Kinase 1
Epidermal Growth Factor
97 Citations (Scopus)

Role of Ca2+/calmodulin-stimulated cyclic nucleotide phosphodiesterase 1 in mediating cardiomyocyte hypertrophy

Miller, C. L., Oikawa, M., Cai, Y., Wojtovich, A. P., Nagel, D. J., Xu, X., Xu, H., Florio, V., Rybalkin, S. D., Beavo, J. A., Chen, Y. F., Li, J. D., Blaxall, B. C., Abe, J. I. & Yan, C., Nov 1 2009, In : Circulation research. 105, 10, p. 956-964 9 p.

Research output: Contribution to journalArticle

Cyclic Nucleotides
Phosphoric Diester Hydrolases
Calmodulin
Cardiac Myocytes
Muscle Cells
27 Citations (Scopus)

Role of p90 ribosomal S6 kinase-mediated prorenin-converting enzyme in ischemic and diabetic myocardium

Itoh, S., Ding, B., Shishido, T., Lerner-Marmarosh, N., Wang, N., Maekawa, N., Berk, B. C., Takeishi, Y., Yan, C., Blaxall, B. C. & Abe, J. I., Apr 1 2006, In : Circulation. 113, 14, p. 1787-1798 12 p.

Research output: Contribution to journalArticle

90-kDa Ribosomal Protein S6 Kinases
Myocardium
Renin-Angiotensin System
Angiotensinogen
Enzyme Induction
99 Citations (Scopus)

Role of phosphodiesterase 3 in NO/cGMP-mediated antiinflammatory effects in vascular smooth muscle cells

Aizawa, T., Wei, H., Miano, J. M., Abe, J. I., Berk, B. C. & Yan, C., Sep 5 2003, In : Circulation research. 93, 5, p. 406-413 8 p.

Research output: Contribution to journalArticle

S-Nitroso-N-Acetylpenicillamine
C-Type Natriuretic Peptide
Phosphoric Diester Hydrolases
Vascular Smooth Muscle
Smooth Muscle Myocytes
2 Citations (Scopus)

Senescent Phenotype Induced by p90RSK-NRF2 Signaling Sensitizes Monocytes and Macrophages to Oxidative Stress in HIV-Positive Individuals: Implications for Atherogenesis

Singh, M. V., Kotla, S., Le, N. T., Ko, K. A., Heo, K. S., Wang, Y., Fujii, Y., Thi Vu, H., McBeath, E., Thomas, T. N., Gi, Y. J., Tao, Y., Medina, J. L., Taunton, J., Carson, N., Dogra, V., Doyley, M. M., Tyrell, A., Lu, W., Qiu, X. & 7 others, Stirpe, N. E., Gates, K. J., Hurley, C., Fujiwara, K., Maggirwar, S. B., Schifitto, G. & Abe, J. I., Feb 26 2019, In : Circulation. 139, 9, p. 1199-1216 18 p.

Research output: Contribution to journalArticle

Monocytes
Atherosclerosis
Oxidative Stress
Macrophages
HIV
228 Citations (Scopus)

Src and Cas mediate JNK activation but not ERK1/2 and p38 kinases by reactive oxygen species

Yoshizumi, M., Abe, J. I., Haendeler, J., Huang, Q. & Berk, B. C., Apr 21 2000, In : Journal of Biological Chemistry. 275, 16, p. 11706-11712 7 p.

Research output: Contribution to journalArticle

JNK Mitogen-Activated Protein Kinases
Reactive Oxygen Species
Phosphotransferases
Chemical activation
Mitogen-Activated Protein Kinase 3
108 Citations (Scopus)

Src and multiple MAP kinase activation in cardiac hypertrophy and congestive heart failure under chronic pressure-overload: Comparison with acute mechanical stretch

Takeishi, Y., Huang, Q., Abe, J. I., Glassman, M., Che, W., Lee, J. D., Kawakatsu, H., Lawrence, E. G., Hoit, B. D., Berk, B. C. & Walsh, R. A., Jan 1 2001, In : Journal of Molecular and Cellular Cardiology. 33, 9, p. 1637-1648 12 p.

Research output: Contribution to journalArticle

Cardiomegaly
Mitogen-Activated Protein Kinases
Mitogen-Activated Protein Kinase 7
Heart Failure
Pressure
42 Citations (Scopus)

Src family kinase and adenosine differentially regulate multiple MAP kinases in ischemic myocardium: Modulation of MAP kinases activation by ischemic preconditioning

Takeishi, Y., Huang, Q., Wang, T., Glassman, M., Yoshizumi, M., Baines, C. P., Lee, J. D., Kawakatsu, H., Che, W., Lerner-Marmarosh, N., Zhang, C., Yan, C., Ohta, S., Walsh, R. A., Berk, B. C. & Abe, J. I., Jan 1 2001, In : Journal of Molecular and Cellular Cardiology. 33, 11, p. 1989-2005 17 p.

Research output: Contribution to journalArticle

Ischemic Preconditioning
src-Family Kinases
Mitogen-Activated Protein Kinases
Adenosine
Myocardium
53 Citations (Scopus)

Stimulated activation of platelet-derived growth factor receptor in vivo in balloon-injured arteries: A link between angiotensin II and intimal thickening

Abe, J., Deguchi, J. O., Matsumoto, T., Takuwa, N., Noda, M., Ohno, M., Makuuchi, M., Kurokawa, K. & Takuwa, Y., Jan 1 1997, In : Circulation. 96, 6, p. 1906-1913 8 p.

Research output: Contribution to journalArticle

Tunica Intima
Platelet-Derived Growth Factor Receptors
Angiotensin II
Platelet-Derived Growth Factor
Arteries
29 Citations (Scopus)

STING-IRF3 triggers endothelial inflammation in response to free fatty acid-induced mitochondrial damage in diet-induced obesity

Mao, Y., Luo, W., Zhang, L., Wu, W., Yuan, L., Xu, H., Song, J., Fujiwara, K., Abe, J. I., Lemaire, S. A., Wang, X. L. & Shen, Y. H., May 1 2017, In : Arteriosclerosis, thrombosis, and vascular biology. 37, 5, p. 920-929 10 p.

Research output: Contribution to journalArticle

Interferon Regulatory Factor-3
Nonesterified Fatty Acids
Interferons
Obesity
Diet
65 Citations (Scopus)

Stress and vascular responses: Atheroprotective effect of laminar fluid shear stress in endothelial cells: Possible role of mitogen-activated protein kinases

Yoshizumi, M., Abe, J. I., Tsuchiya, K., Berk, B. C. & Tamaki, T., Mar 1 2003, In : Journal Pharmacological Sciences. 91, 3, p. 172-176 5 p.

Research output: Contribution to journalArticle

Mitogen-Activated Protein Kinases
Blood Vessels
Endothelial Cells
Tumor Necrosis Factor-alpha
Umbilical Veins
2 Citations (Scopus)

Sub-cellular localization specific SUMOylation in the heart

Le, N. T., Martin, J. F., Fujiwara, K. & Abe, J. I., Aug 1 2017, In : Biochimica et Biophysica Acta - Molecular Basis of Disease. 1863, 8, p. 2041-2055 15 p.

Research output: Contribution to journalArticle

Sumoylation
Nuclear Proteins
Cardiac Myocytes
Epigenomics
Biological Phenomena
100 Citations (Scopus)

Suppression of neointimal smooth muscle cell accumulation in vivo by antisense cdc2 and cdk2 oligonucleotides in rat carotid artery

Abe, J. I., Zhou, W., Taguchi, J. I., Takuwa, N., Miki, K., Okazaki, H., Kurokawa, K., Kumada, M. & Takuwa, Y., Jan 15 1994, In : Biochemical and biophysical research communications. 198, 1, p. 16-24 9 p.

Research output: Contribution to journalArticle

Tunica Intima
Carotid Arteries
Oligonucleotides
Smooth Muscle Myocytes
Muscle
47 Citations (Scopus)

Targeted deletion of the extracellular signal-regulated protein kinase 5 attenuates hypertrophic response and promotes pressure overload-induced apoptosis in the heart

Kimura, T. E., Jin, J., Zi, M., Prehar, S., Liu, W., Oceandy, D., Abe, J. I., Neyses, L., Weston, A. H., Cartwright, E. J. & Wang, X., Mar 19 2010, In : Circulation research. 106, 5, p. 961-970 10 p.

Research output: Contribution to journalArticle

Mitogen-Activated Protein Kinase 7
Cardiac Myocytes
Protein Kinases
Apoptosis
Pressure
43 Citations (Scopus)

Targeting endogenous platelet-derived growth factor B-chain by adenovirus-mediated gene transfer potently inhibits in vivo smooth muscle proliferation after arterial injury

Deguchi, J., Namba, T., Hamada, H., Nakaoka, T., Abe, J., Sato, O., Miyata, T., Makuuchi, M., Kurokawa, K. & Takuwa, Y., Jun 1 1999, In : Gene Therapy. 6, 6, p. 956-965 10 p.

Research output: Contribution to journalArticle

Proto-Oncogene Proteins c-sis
Adenoviridae
Smooth Muscle
Wounds and Injuries
Platelet-Derived Growth Factor Receptors
88 Citations (Scopus)
Mitogen-Activated Protein Kinase 7
Peroxisome Proliferator-Activated Receptors
Transcriptional Activation
Endothelial Cells
Phosphotransferases
13 Citations (Scopus)

The novel role of the C-terminal region of SHP-2. Involvement of Gab1 and SHP-2 phosphatase activity in Elk-1 activation.

Huang, Q., Lerner-Marmarosh, N., Che, W., Ohta, S., Osawa, M., Yoshizumi, M., Glassman, M., Yan, C., Berk, B. C. & Abe, J. I., Aug 9 2002, In : The Journal of biological chemistry. 277, 32, p. 29330-29341 12 p.

Research output: Contribution to journalArticle

src Homology Domains
Phosphoric Monoester Hydrolases
Chemical activation
Signal transduction
Protein Tyrosine Phosphatases

The Ser/Thr kinase p90RSK promotes kidney fibrosis by modulating fibroblast-epithelial crosstalk

Lin, L., Shi, C., Sun, Z., Le, N. T., Abe, J. I. & Hu, K., Jan 1 2019, In : Journal of Biological Chemistry. 294, 25, p. 9901-9910 10 p.

Research output: Contribution to journalArticle

Fibroblasts
Crosstalk
Fibrosis
Phosphotransferases
Catenins