• 3554 Citations
  • 30 h-Index
20022019
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Research Output 2002 2019

  • 3554 Citations
  • 30 h-Index
  • 46 Article
  • 2 Chapter
  • 1 Comment/debate
  • 1 Review article
2019
10 Citations (Scopus)

Human papillomavirus and the landscape of secondary genetic alterations in oral cancers

Gillison, M., Akagi, K., Xiao, W., Jiang, B., Pickard, R. K. L., Li, J., Swanson, B. J., Agrawal, A. D., Zucker, M., Stache-Crain, B., Emde, A. K., Geiger, H. M., Robine, N., Coombes, K. R. & Symer, D. E., Jan 1 2019, In : Genome Research. 29, 1, p. 1-17 17 p.

Research output: Contribution to journalArticle

Mouth Neoplasms
Squamous Cell Carcinoma
Neoplasms
TNF Receptor-Associated Factor 3
Cytosine Deaminase

Identification of Rare Variants Predisposing to Thyroid Cancer

Wang, Y., Liyanarachchi, S., Miller, K. E., Nieminen, T. T., Comiskey, D. F., Li, W., Brock, P., Symer, D. E., Akagi, K., Delap, K. E., He, H., Koboldt, D. C. & De La Chapelle, A., Jul 2019, In : Thyroid. 29, 7, p. 946-955 10 p.

Research output: Contribution to journalArticle

Thyroid Neoplasms
Neoplasm Genes
Genome
Penetrance
Genetic Association Studies
8 Citations (Scopus)

Variations in HPV function are associated with survival in squamous cell carcinoma

Gleber-Netto, F. O., Rao, X., Guo, T., Xi, Y., Gao, M., Shen, L., Erikson, K., Kalu, N. N., Ren, S., Xu, G., Fisch, K. M., Akagi, K., Seiwert, T., Gillison, M., Frederick, M. J., Johnson, F. M., Wang, J., Myers, J. N., Califano, J., Skinner, H. D. & 1 others, Pickering, C. R., Jan 10 2019, In : JCI Insight. 4, 1, e124762.

Research output: Contribution to journalArticle

Open Access
Squamous Cell Carcinoma
Survival
Neoplasms
Radiotherapy
Morbidity
2018
11 Citations (Scopus)

HPV integration hijacks and multimerizes a cellular enhancer to generate a viral-cellular super-enhancer that drives high viral oncogene expression

Warburton, A., Redmond, C. J., Dooley, K. E., Fu, H., Gillison, M. L., Akagi, K., Symer, D. E., Aladjem, M. I. & McBride, A. A., Jan 2018, In : PLoS genetics. 14, 1, e1007179.

Research output: Contribution to journalArticle

Papillomaviridae
oncogenes
Oncogenes
Chromatin
chromatin
3 Citations (Scopus)

Metaplastic breast cancer in a patient with neurofibromatosis type 1 and somatic loss of heterozygosity

Suarez-Kelly, L. P., Akagi, K., Reeser, J. W., Samorodnitsky, E., Reeder, M., Smith, A., Roychowdhury, S., Symer, D. E. & Carson, W. E., Apr 1 2018, In : Cold Spring Harbor Molecular Case Studies. 4, 2, a002352.

Research output: Contribution to journalArticle

Open Access
Neurofibromatosis 1
Loss of Heterozygosity
Breast Neoplasms
Nucleotides
Allelic Imbalance
2017
9 Citations (Scopus)

Chromatin states shape insertion profiles of the piggyBac, Tol2 and Sleeping Beauty transposons and murine leukemia virus

Yoshida, J., Akagi, K., Misawa, R., Kokubu, C., Takeda, J. & Horie, K., Mar 2 2017, In : Scientific Reports. 7, 43613.

Research output: Contribution to journalArticle

Beauty
Murine Leukemia Viruses
Chromatin
Embryonic Stem Cells
Transcription Factors
35 Citations (Scopus)

In vivo genome editing restores dystrophin expression and cardiac function in dystrophic mice

El Refaey, M., Xu, L., Gao, Y., Canan, B. D., Ayodele Adesanya, T. M., Warner, S. C., Akagi, K., Symer, D. E., Mohler, P. J., Ma, J., Janssen, P. M. L. & Han, R., Sep 1 2017, In : Circulation research. 121, 8, p. 923-929 7 p.

Research output: Contribution to journalArticle

Clustered Regularly Interspaced Short Palindromic Repeats
Dystrophin
Dependovirus
Duchenne Muscular Dystrophy
Myocardium
47 Citations (Scopus)

KRAS Allelic Imbalance Enhances Fitness and Modulates MAP Kinase Dependence in Cancer

Burgess, M. R., Hwang, E., Mroue, R., Bielski, C. M., Wandler, A. M., Huang, B. J., Firestone, A. J., Young, A., Lacap, J. A., Crocker, L., Asthana, S., Davis, E. M., Xu, J., Akagi, K., Le Beau, M. M., Li, Q., Haley, B., Stokoe, D., Sampath, D., Taylor, B. S. & 2 others, Evangelista, M. & Shannon, K., Feb 23 2017, In : Cell. 168, 5, p. 817-829.e15

Research output: Contribution to journalArticle

Allelic Imbalance
Mitogen-Activated Protein Kinase Kinases
Phosphotransferases
Acute Myeloid Leukemia
Clustered Regularly Interspaced Short Palindromic Repeats
37 Citations (Scopus)

Merkel cell polyomavirus exhibits dominant control of the tumor genome and transcriptome in virus-associated merkel cell carcinoma

Starrett, G. J., Marcelus, C., Cantalupo, P. G., Katz, J. P., Cheng, J., Akagi, K., Thakuria, M., Rabinowits, G., Wang, L. C., Symer, D. E., Pipas, J. M., Harris, R. S. & Decaprio, J. A., Jan 1 2017, In : mBio. 8, 1, e02079-16.

Research output: Contribution to journalArticle

Merkel cell polyomavirus
Merkel Cell Carcinoma
Transcriptome
Genome
Viruses
2016
46 Citations (Scopus)

Synthetic viability by BRCA2 and PARP1/ARTD1 deficiencies

Ding, X., Chaudhuri, A. R., Callen, E., Pang, Y., Biswas, K., Klarmann, K. D., Martin, B. K., Burkett, S., Cleveland, L., Stauffer, S., Sullivan, T., Dewan, A., Marks, H., Tubbs, A. T., Wong, N., Buehler, E., Akagi, K., Martin, S. E., Keller, J. R., Nussenzweig, A. & 1 others, Sharan, S. K., Aug 8 2016, In : Nature communications. 7, 12425.

Research output: Contribution to journalArticle

viability
Homologous Recombination
inhibitors
ribose
adenosine diphosphate
2015
20 Citations (Scopus)

A germline mutation in SRRM2, a splicing factor gene, is implicated in papillary thyroid carcinoma predisposition

Tomsic, J., He, H., Akagi, K., Liyanarachchi, S., Pan, Q., Bertani, B., Nagy, R., Symer, D. E., Blencowe, B. J. & de la Chapelle, A., Jul 2 2015, In : Scientific reports. 5, 1 p.

Research output: Contribution to journalArticle

Germ-Line Mutation
Serine
Arginine
Alternative Splicing
Exons
36 Citations (Scopus)

Multiple functional variants in long-range enhancer elements contribute to the risk of SNP rs965513 in thyroid cancer

He, H., Li, W., Liyanarachchi, S., Srinivas, M., Wang, Y., Akagi, K., Wang, Y., Wu, D., Wang, Q., Jin, V., Symer, D. E., Shen, R., Phay, J., Nagy, R. & De La Chapelle, A., May 12 2015, In : Proceedings of the National Academy of Sciences of the United States of America. 112, 19, p. 6128-6133 6 p.

Research output: Contribution to journalArticle

Thyroid Neoplasms
Single Nucleotide Polymorphism
Factor IX
Thyroid Gland
Alleles
2014
26 Citations (Scopus)

An antisense promoter in mouse L1 retrotransposon open reading frame-1 initiates expression of diverse fusion transcripts and limits retrotransposition

Li, J., Kannan, M., Trivett, A. L., Liao, H., Wu, X., Akagi, K. & Symer, D. E., Jan 1 2014, In : Nucleic Acids Research. 42, 7, p. 4546-4562 17 p.

Research output: Contribution to journalArticle

Retroelements
Open Reading Frames
Long Interspersed Nucleotide Elements
DNA Transposable Elements
RNA Polymerase II
165 Citations (Scopus)

Genome-wide analysis of HPV integration in human cancers reveals recurrent, focal genomic instability

Akagi, K., Li, J., Broutian, T. R., Padilla-Nash, H., Xiao, W., Jiang, B., Rocco, J. W., Teknos, T. N., Kumar, B., Wangsa, D., He, D., Ried, T., Symer, D. E. & Gillison, M., Feb 1 2014, In : Genome Research. 24, 2, p. 185-199 15 p.

Research output: Contribution to journalArticle

Genomic Instability
Genome
Neoplasms
Genomic Structural Variation
Genetic Translocation
41 Citations (Scopus)

Loss of oncogenic Notch1 with resistance to a PI3K inhibitor in T-cell leukaemia

Dail, M., Wong, J., Lawrence, J., O'Connor, D., Nakitandwe, J., Chen, S. C., Xu, J., Lee, L. B., Akagi, K., Li, Q., Aster, J. C., Pear, W. S., Downing, J. R., Sampath, D. & Shannon, K., Sep 25 2014, In : Nature. 513, 7519, p. 512-516 5 p.

Research output: Contribution to journalArticle

T-Cell Leukemia
1-Phosphatidylinositol 4-Kinase
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
Notch1 Receptor
Clone Cells
7 Citations (Scopus)

Sleeping beauty mouse models identify candidate genes involved in gliomagenesis

Vyazunova, I., Maklakova, V. I., Berman, S., De, I., Steffen, M. D., Hong, W., Lincoln, H., Morrissy, A. S., Taylor, M. D., Akagi, K., Brennan, C. W., Rodriguez, F. J. & Collier, L. S., Nov 25 2014, In : PloS one. 9, 11, e113489.

Research output: Contribution to journalArticle

Beauty
Glioma
transposons
Genes
animal models
2013
13 Citations (Scopus)
DNA Transposable Elements
Gene Frequency
Gene expression
Genes
Genome
30 Citations (Scopus)

SRGAP1 is a candidate gene for papillary thyroid carcinoma susceptibility

He, H., Bronisz, A., Liyanarachchi, S., Nagy, R., Li, W., Huang, Y., Akagi, K., Saji, M., Kula, D., Wojcicka, A., Sebastian, N., Wen, B., Puch, Z., Kalemba, M., Stachlewska, E., Czetwertynska, M., Dlugosinska, J., Dymecka, K., Ploski, R., Krawczyk, M. & 9 others, Morrison, P. J., Ringel, M. D., Kloos, R. T., Jazdzewski, K., Symer, D. E., Vieland, V. J., Ostrowski, M., Jarzab, B. & De La Chapelle, A., May 1 2013, In : Journal of Clinical Endocrinology and Metabolism. 98, 5, p. E973-E980

Research output: Contribution to journalArticle

Genes
rho GTPase-activating protein
Papillary Thyroid cancer
Association reactions
Aptitude
16 Citations (Scopus)

Ultra-Rare Mutation in Long-Range Enhancer Predisposes to Thyroid Carcinoma with High Penetrance

He, H., Li, W., Wu, D., Nagy, R., Liyanarachchi, S., Akagi, K., Jendrzejewski, J., Jiao, H., Hoag, K., Wen, B., Srinivas, M., Waidyaratne, G., Wang, R., Wojcicka, A., Lattimer, I. R., Stachlewska, E., Czetwertynska, M., Dlugosinska, J., Gierlikowski, W., Ploski, R. & 7 others, Krawczyk, M., Jazdzewski, K., Kere, J., Symer, D. E., Jin, V., Wang, Q. & de la Chapelle, A., May 14 2013, In : PloS one. 8, 5, e61920.

Research output: Contribution to journalArticle

YY1 Transcription Factor
penetrance
Penetrance
Chromosomes
Thyroid Neoplasms
2012
272 Citations (Scopus)

Clonal selection drives genetic divergence of metastatic medulloblastoma

Wu, X., Northcott, P. A., Dubuc, A., Dupuy, A. J., Shih, D. J. H., Witt, H., Croul, S., Bouffet, E., Fults, D. W., Eberhart, C. G., Garzia, L., Van Meter, T., Zagzag, D., Jabado, N., Schwartzentruber, J., Majewski, J., Scheetz, T. E., Pfister, S. M., Korshunov, A., Li, X. N. & 12 others, Scherer, S. W., Cho, Y. J., Akagi, K., MacDonald, T. J., Koster, J., McCabe, M. G., Sarver, A. L., Collins, V. P., Weiss, W. A., Largaespada, D. A., Collier, L. S. & Taylor, M. D., Feb 23 2012, In : Nature. 482, 7386, p. 529-533 5 p.

Research output: Contribution to journalArticle

Medulloblastoma
Neoplasm Metastasis
Cerebrospinal Fluid
Neoplasms
Spinal Cord
38 Citations (Scopus)

Mouse endogenous retroviruses can trigger premature transcriptional termination at a distance

Li, J., Akagi, K., Hu, Y., Trivett, A. L., Hlynialuk, C. J. W., Swing, D. A., Volfovsky, N., Morgan, T. C., Golubeva, Y., Stephens, R. M., Smith, D. E. & Symer, D. E., May 1 2012, In : Genome Research. 22, 5, p. 870-884 15 p.

Research output: Contribution to journalArticle

Endogenous Retroviruses
Genes
Gene Expression
Retroelements
Polyadenylation
236 Citations (Scopus)

The bonobo genome compared with the chimpanzee and human genomes

Prüfer, K., Munch, K., Hellmann, I., Akagi, K., Miller, J. R., Walenz, B., Koren, S., Sutton, G., Kodira, C., Winer, R., Knight, J. R., Mullikin, J. C., Meader, S. J., Ponting, C. P., Lunter, G., Higashino, S., Hobolth, A., Dutheil, J., Karakoç, E., Alkan, C. & 21 others, Sajjadian, S., Catacchio, C. R., Ventura, M., Marques-Bonet, T., Eichler, E. E., André, C., Atencia, R., Mugisha, L., Junhold, J., Patterson, N., Siebauer, M., Good, J. M., Fischer, A., Ptak, S. E., Lachmann, M., Symer, D. E., Mailund, T., Schierup, M. H., Andrés, A. M., Kelso, J. & Pääbo, S., Jun 28 2012, In : Nature. 486, 7404, p. 527-531 5 p.

Research output: Contribution to journalArticle

Pan paniscus
Pan troglodytes
Human Genome
Genome
Hominidae
2011
21 Citations (Scopus)

A homozygous mutant embryonic stem cell bank applicable for phenotype-driven genetic screening

Horie, K., Kokubu, C., Yoshida, J., Akagi, K., Isotani, A., Oshitani, A., Yusa, K., Ikeda, R., Huang, Y., Bradley, A. & Takeda, J., Dec 1 2011, In : Nature Methods. 8, 12, p. 1071-1081 11 p.

Research output: Contribution to journalArticle

Genetic Testing
Embryonic Stem Cells
Stem cells
Mutagenesis
Screening

Bioinformatics of high-throughput insertional mutagenesis

Akagi, K., Yi, M., Roayaei, J. & Stephens, R. M., Dec 1 2011, Insertional Mutagenesis Strategies in Cancer Genetics. Springer New York, p. 167-188 22 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Mutagenesis
Insertional Mutagenesis
Bioinformatics
Computational Biology
Pipelines

Erratum: Tumor suppressor BRCA1 epigenetically controls oncogenic microRNA-155 (Nature Medicine (2011) 17 (1275-1282))

Chang, S., Wang, R. H., Akagi, K., Kim, K. A., Martin, B. K., Cavallone, L., Haines, D. C., Basik, M., Mai, P., Poggi, E., Isaacs, C., Looi, L. M., Mun, K. S., Greene, M. H., Byers, S. W., Teo, S. H., Deng, C. X. & Sharan, S. K., Nov 1 2011, In : Nature medicine. 17, 11, 1 p.

Research output: Contribution to journalComment/debate

81 Citations (Scopus)

Hematopoiesis and leukemogenesis in mice expressing oncogenic Nras G12D from the endogenous locus

Li, Q., Haigis, K. M., McDaniel, A., Harding-Theobald, E., Kogan, S. C., Akagi, K., Wong, J. C. Y., Braun, B. S., Wolff, L., Jacks, T. & Shannon, K., Feb 10 2011, In : Blood. 117, 6, p. 2022-2032 11 p.

Research output: Contribution to journalArticle

ras Proteins
Hematopoiesis
Guanosine Triphosphate
Myeloproliferative Disorders
Hematopoietic Stem Cells
130 Citations (Scopus)

Mutations in U4atac snRNA, a component of the minor spliceosome, in the developmental disorder MOPD i

He, H., Liyanarachchi, S., Akagi, K., Nagy, R., Li, J., Dietrich, R. C., Li, W., Sebastian, N., Wen, B., Xin, B., Singh, J., Yan, P., Alder, H., Haan, E., Wieczorek, D., Albrecht, B., Puffenberger, E., Wang, H., Westman, J. A., Padgett, R. A. & 2 others, Symer, D. E. & De La Chapelle, A., Apr 8 2011, In : Science. 332, 6026, p. 238-240 3 p.

Research output: Contribution to journalArticle

Spliceosomes
Small Nuclear RNA
Mutation
Introns
Multiple Abnormalities
152 Citations (Scopus)

Tumor suppressor BRCA1 epigenetically controls oncogenic microRNA-155

Chang, S., Wang, R. H., Akagi, K., Kim, K. A., Martin, B. K., Cavallone, L., Haines, D. C., Basik, M., Mai, P., Poggi, E., Isaacs, C., Looi, L. M., Mun, K. S., Greene, M. H., Byers, S. W., Teo, S. H., Deng, C. X. & Sharan, S. K., Oct 1 2011, In : Nature medicine. 17, 10, p. 1275-1282 8 p.

Research output: Contribution to journalArticle

MicroRNAs
Tumors
Neoplasms
DNA Repair
Repair
2010
5 Citations (Scopus)

An integrated genetic-genomic approach for the identification of novel cancer loci in mice sensitized to c-Myc-induced apoptosis

Mendrysa, S. M., Akagi, K., Roayaei, J., Lien, W. H., Copeland, N. G., Jenkins, N. A. & Eisenman, R. N., Dec 1 2010, In : Genes and Cancer. 1, 5, p. 465-479 15 p.

Research output: Contribution to journalArticle

Neoplasm Genes
Apoptosis
Neoplasms
Insertional Mutagenesis
Growth
49 Citations (Scopus)

Mutant Ikzf1, KrasG12D, and Notch1 cooperate in T lineage leukemogenesis and modulate responses to targeted agents

Dail, M., Li, Q., McDaniel, A., Wong, J., Akagi, K., Huang, B., Kang, H. C., Kogan, S. C., Shokat, K., Wolff, L., Braun, B. S. & Shannon, K., Mar 16 2010, In : Proceedings of the National Academy of Sciences of the United States of America. 107, 11, p. 5106-5111 6 p.

Research output: Contribution to journalArticle

Precursor Cell Lymphoblastic Leukemia-Lymphoma
Pharmacological Biomarkers
Amyloid Precursor Protein Secretases
Insertional Mutagenesis
Mitogen-Activated Protein Kinase Kinases
36 Citations (Scopus)

Sleeping beauty-mediated somatic mutagenesis implicates CSF1 in the formation of high-grade astrocytomas

Bender, A. M., Collier, L. S., Rodriguez, F. J., Tieu, C., Larson, J. D., Halder, C., Mahlum, E., Kollmeyer, T. M., Akagi, K., Sarkar, G., Largaespada, D. A. & Jenkins, R. B., May 1 2010, In : Cancer research. 70, 9, p. 3557-3565 9 p.

Research output: Contribution to journalArticle

Beauty
Astrocytoma
Mutagenesis
Insertional Mutagenesis
Neoplasms
22 Citations (Scopus)

Use of chromosome engineering to model a segmental deletion of chromosome band 7q22 found in myeloid malignancies

Wong, J. C. Y., Zhang, Y., Lieuw, K. H., Tran, M. T., Forgo, E., Weinfurtner, K., Alzamora, P., Kogan, S. C., Akagi, K., Wolff, L., Le Beau, M. M., Killeen, N. & Shannon, K., Jun 3 2010, In : Blood. 115, 22, p. 4524-4532 9 p.

Research output: Contribution to journalArticle

Chromosome Deletion
Chromosomes
Tumors
Genes
Tumor Suppressor Genes
2009
146 Citations (Scopus)

A conditional transposon-based insertional mutagenesis screen for genes associated with mouse hepatocellular carcinoma

Keng, V. W., Villanueva, A., Chiang, D. Y., Dupuy, A. J., Ryan, B. J., Matise, I., Silverstein, K. A. T., Sarver, A., Starr, T. K., Akagi, K., Tessarollo, L., Collier, L. S., Powers, S., Lowe, S. W., Jenkins, N. A., Copeland, N. G., Llovet, J. M. & Largaespada, D. A., Mar 1 2009, In : Nature biotechnology. 27, 3, p. 264-274 11 p.

Research output: Contribution to journalArticle

Mutagenesis
Insertional Mutagenesis
Hepatocellular Carcinoma
Genes
Tissue
9 Citations (Scopus)

Gene targeting in mouse embryonic stem cells

Tessarollo, L., Palko, M. E., Akagi, K. & Coppola, V., Dec 1 2009, Gene Knockout Protocols: Second Edition. Kuhn, R. & Wurst, W. (eds.). p. 141-164 24 p. (Methods in Molecular Biology; vol. 530).

Research output: Chapter in Book/Report/Conference proceedingChapter

Gene Targeting
Mutation
Genome
Technology
Informatics
60 Citations (Scopus)

Identification of PDE4D as a proliferation promoting factor in prostate cancer using a Sleeping beauty transposon-based somatic mutagenesis screen

Rahrmann, E. P., Collier, L. S., Knutson, T. P., Doyal, M. E., Kuslak, S. L., Green, L. E., Malinowski, R. L., Roethe, L., Akagi, K., Waknitz, M., Huang, W., Largaespada, D. A. & Marker, P. C., May 15 2009, In : Cancer research. 69, 10, p. 4388-4397 10 p.

Research output: Contribution to journalArticle

Beauty
Mutagenesis
Prostatic Neoplasms
Neoplasm Genes
Prostate
39 Citations (Scopus)

Jmjd2c histone demethylase enhances the expression of Mdm2 oncogene

Ishimura, A., Terashima, M., Kimura, H., Akagi, K., Suzuki, Y., Sugano, S. & Suzuki, T., Nov 13 2009, In : Biochemical and biophysical research communications. 389, 2, p. 366-371 6 p.

Research output: Contribution to journalArticle

Histone Demethylases
Oncogenes
Genes
Chromatin Immunoprecipitation
Tumor Suppressor Genes
13 Citations (Scopus)

MouseIndelDB: A database integrating genomic indel polymorphisms that distinguish mouse strains

Akagi, K., Stephens, R. M., Li, J., Evdokimov, E., Kuehn, M. R., Volfovsky, N. & Symer, D. E., Nov 20 2009, In : Nucleic acids research. 38, SUPPL.1, p. D600-D606 gkp1046.

Research output: Contribution to journalArticle

Databases
Genome
Firearms
Genomics
Names
58 Citations (Scopus)

Murine leukemias with retroviral insertions at Lmo2 are predictive of the leukemias induced in SCID-X1 patients following retroviral gene therapy

Davé, U. P., Akagi, K., Tripathi, R., Cleveland, S. M., Thompson, M. A., Yi, M., Stephens, R., Downing, J. R., Jenkins, N. A. & Copeland, N. G., May 1 2009, In : PLoS Genetics. 5, 5, e1000491.

Research output: Contribution to journalArticle

gene therapy
leukemia
Genetic Therapy
Leukemia
gene
93 Citations (Scopus)

Response and resistance to MEK inhibition in leukaemias initiated by hyperactive Ras

Lauchle, J. O., Kim, D., Le, D. T., Akagi, K., Crone, M., Krisman, K., Warner, K., Bonifas, J. M., Li, Q., Coakley, K. M., Diaz-Flores, E., Gorman, M., Przybranowski, S., Tran, M., Kogan, S. C., Roose, J. P., Copeland, N. G., Jenkins, N. A., Parada, L., Wolff, L. & 2 others, Sebolt-Leopold, J. & Shannon, K., Sep 17 2009, In : Nature. 461, 7262, p. 411-414 4 p.

Research output: Contribution to journalArticle

Mitogen-Activated Protein Kinase Kinases
Leukemia
Acute Myeloid Leukemia
Myeloproliferative Disorders
Neoplasms
37 Citations (Scopus)

Sustained high-level polyclonal hematopoietic marking and transgene expression 4 years after autologous transplantation of rhesus macaques with SIV lentiviral vector-transduced CD34+ cells

Kim, Y. J., Kim, Y. S., Larochelle, A., Renaud, G., Wolfsberg, T. G., Adler, R., Donahue, R. E., Hematti, P., Hong, B. K., Roayaei, J., Akagi, K., Riberdy, J. M., Nienhuis, A. W., Dunbar, C. E. & Persons, D. A., Nov 17 2009, In : Blood. 113, 22, p. 5434-5443 10 p.

Research output: Contribution to journalArticle

Simian Immunodeficiency Virus
Autologous Transplantation
Macaca mulatta
Transgenes
Viruses
52 Citations (Scopus)

Whole-body sleeping beauty mutagenesis can cause penetrant leukemia/lymphoma and rare high-grade glioma without associated embryonic lethality

Collier, L. S., Adams, D. J., Hackett, C. S., Bendzick, L. E., Akagi, K., Davies, M. N., Diers, M. D., Rodriguez, F. J., Bender, A. M., Tieu, C., Matise, I., Dupuy, A. J., Copeland, N. G., Jenkins, N. A., Hodgson, J. G., Weiss, W. A., Jenkins, R. B. & Largaespada, D. A., Nov 1 2009, In : Cancer research. 69, 21, p. 8429-8437 9 p.

Research output: Contribution to journalArticle

Beauty
Glioma
Mutagenesis
Non-Hodgkin's Lymphoma
Neoplasm Genes
2008
61 Citations (Scopus)

Extensive variation between inbred mouse strains due to endogenous L1 retrotransposition

Akagi, K., Li, J., Stephens, R. M., Volfovsky, N. & Symer, D. E., Jun 1 2008, In : Genome Research. 18, 6, p. 869-880 12 p.

Research output: Contribution to journalArticle

Inbred Strains Mice
Retroelements
Genome
Nucleotides
Long Interspersed Nucleotide Elements
2006
117 Citations (Scopus)

Tumor suppressor gene identification using retroviral insertional mutagenesis in Blm-deficient mice

Suzuki, T., Minehata, K. I., Akagi, K., Jenkins, N. A. & Copeland, N. G., Jul 26 2006, In : EMBO Journal. 25, 14, p. 3422-3431 10 p.

Research output: Contribution to journalArticle

Mutagenesis
Insertional Mutagenesis
Tumor Suppressor Genes
Tumors
Genes
2005
371 Citations (Scopus)

Mammalian mutagenesis using a highly mobile somatic Sleeping Beauty transposon system

Dupuy, A. J., Akagi, K., Largaespada, D. A., Copeland, N. G. & Jenkins, N. A., Jul 14 2005, In : Nature. 436, 7048, p. 221-226 6 p.

Research output: Contribution to journalArticle

Beauty
Mutagenesis
Eukaryota
Neoplasms
Gene Transfer Techniques
133 Citations (Scopus)

Recurrent retroviral vector integration at the Mds1/Evi1 locus in nonhuman primate hematopoietic cells

Calmels, B., Ferguson, C., Laukkanen, M. O., Adler, R., Faulhaber, M., Kim, H. J., Sellers, S., Hematti, P., Schmidt, M., von Kalle, C., Akagi, K., Donahue, R. E. & Dunbar, C. E., Oct 1 2005, In : Blood. 106, 7, p. 2530-2533 4 p.

Research output: Contribution to journalArticle

Gene therapy
Insertional Mutagenesis
Genetic Therapy
Primates
Animals
94 Citations (Scopus)

Region-specific saturation germline mutagenesis in mice using the Sleeping Beauty transposon system

Keng, V. W., Yae, K., Hayakawa, T., Mizuno, S., Uno, Y., Yusa, K., Kokubu, C., Kinoshita, T., Akagi, K., Jenkins, N. A., Copeland, N. G., Horie, K. & Takeda, J., Oct 1 2005, In : Nature Methods. 2, 10, p. 763-769 7 p.

Research output: Contribution to journalArticle

Beauty
Mutagenesis
Genes
Genome
Transposases
2004
264 Citations (Scopus)

RTCGD: Retroviral tagged cancer gene database

Akagi, K., Suzuki, T., Stephens, R. M., Jenkins, N. A. & Copeland, N. G., Jan 1 2004, In : Nucleic Acids Research. 32, DATABASE ISS.

Research output: Contribution to journalReview article

Neoplasm Genes
Databases
Genes
Neoplasms
Clone Cells
2003
53 Citations (Scopus)

Evi3, a common retroviral integration site in murine B-cell lymphoma, encodes an EBFAZ-related Krüppel-like zinc finger protein

Warming, S., Liu, P., Suzuki, T., Akagi, K., Lindtner, S., Pavlakis, G. N., Jenkins, N. A. & Copeland, N. G., Mar 1 2003, In : Blood. 101, 5, p. 1934-1940 7 p.

Research output: Contribution to journalArticle

Zinc Fingers
B-Cell Lymphoma
Zinc
B-Lymphocytes
Cells
2002
8 Citations (Scopus)

Docking protein SNT1 is a critical mediator of fibroblast growth factor signaling during Xenopus embryonic development

Akagi, K., Park, E. K., Mood, K. & Daar, I. O., Feb 11 2002, In : Developmental Dynamics. 223, 2, p. 216-228 13 p.

Research output: Contribution to journalArticle

Fibroblast Growth Factors
Xenopus
Mitogen-Activated Protein Kinases
Embryonic Development
Fibroblast Growth Factor Receptors
344 Citations (Scopus)

New genes involved in cancer identified by retroviral tagging

Suzuki, T., Shen, H., Akagi, K., Morse, H. C., Malley, J. D., Naiman, D. Q., Jenkins, N. A. & Copeland, N. G., Sep 1 2002, In : Nature Genetics. 32, 1, p. 166-174 9 p.

Research output: Contribution to journalArticle

Neoplasm Genes
Genetic Association Studies
Genes
Neoplasms
Myeloid Leukemia