Ken Chen

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Ken Chen

Professor

 https://orcid.org/0000-0003-4013-5279

    • 6767 Bertner Ave, Mitchell Basic Science Research Building

      77030 Houston

      United States

    Calculated based on number of publications stored in Pure and citations from Scopus
    20022024

    Research activity per year

    Search results

    • 2012

      Clonal Architecture of Secondary Acute Myeloid Leukemia

      Walter, M. J., Shen, D., Ding, L., Shao, J., Koboldt, D. C., Chen, K., Larson, D. E., McLellan, M. D., Dooling, D., Abbott, R., Fulton, R., Magrini, V., Schmidt, H., Kalicki-Veizer, J., O'Laughlin, M., Fan, X., Grillot, M., Witowski, S., Heath, S., Frater, J. L., & 9 othersEades, W., Tomasson, M., Westervelt, P., Dipersio, J. F., Link, D. C., Mardis, E. R., Ley, T. J., Wilson, R. K. & Graubert, T. A., Mar 22 2012, In: New England Journal of Medicine. 366, 12, p. 1090-1098 9 p.

      Research output: Contribution to journal › Article › peer-review

      Open Access
      641 Scopus citations

    • Clonal evolution in relapsed acute myeloid leukaemia revealed by whole-genome sequencing

      Ding, L., Ley, T. J., Larson, D. E., Miller, C. A., Koboldt, D. C., Welch, J. S., Ritchey, J. K., Young, M. A., Lamprecht, T., McLellan, M. D., McMichael, J. F., Wallis, J. W., Lu, C., Shen, D., Harris, C. C., Dooling, D. J., Fulton, R. S., Fulton, L. L., Chen, K., Schmidt, H., & 19 othersKalicki-Veizer, J., Magrini, V. J., Cook, L., McGrath, S. D., Vickery, T. L., Wendl, M. C., Heath, S., Watson, M. A., Link, D. C., Tomasson, M. H., Shannon, W. D., Payton, J. E., Kulkarni, S., Westervelt, P., Walter, M. J., Graubert, T. A., Mardis, E. R., Wilson, R. K. & Dipersio, J. F., Jan 26 2012, In: Nature. 481, 7382, p. 506-510 5 p.

      Research output: Contribution to journal › Article › peer-review

      1630 Scopus citations

    • Genomic landscape of non-small cell lung cancer in smokers and never-smokers

      Govindan, R., Ding, L., Griffith, M., Subramanian, J., Dees, N. D., Kanchi, K. L., Maher, C. A., Fulton, R., Fulton, L., Wallis, J., Chen, K., Walker, J., McDonald, S., Bose, R., Ornitz, D., Xiong, D., You, M., Dooling, D. J., Watson, M., Mardis, E. R., & 1 othersWilson, R. K., Sep 14 2012, In: Cell. 150, 6, p. 1121-1134 14 p.

      Research output: Contribution to journal › Article › peer-review

      975 Scopus citations

    • Massively parallel sequencing approaches for characterization of structural variation

      Koboldt, D. C., Larson, D. E., Chen, K., Ding, L. & Wilson, R. K., 2012, Genomic Structural Variants: Methods and Protocols. Feuk, L. (ed.). p. 369-384 16 p. (Methods in Molecular Biology; vol. 838).

      Research output: Chapter in Book/Report/Conference proceeding › Chapter

      41 Scopus citations

    • Somaticsniper: Identification of somatic point mutations in whole genome sequencing data

      Larson, D. E., Harris, C. C., Chen, K., Koboldt, D. C., Abbott, T. E., Dooling, D. J., Ley, T. J., Mardis, E. R., Wilson, R. K. & Ding, L., Feb 2012, In: Bioinformatics. 28, 3, p. 311-317 7 p., btr665.

      Research output: Contribution to journal › Article › peer-review

      447 Scopus citations

    • The origin and evolution of mutations in acute myeloid leukemia

      Welch, J. S., Ley, T. J., Link, D. C., Miller, C. A., Larson, D. E., Koboldt, D. C., Wartman, L. D., Lamprecht, T. L., Liu, F., Xia, J., Kandoth, C., Fulton, R. S., McLellan, M. D., Dooling, D. J., Wallis, J. W., Chen, K., Harris, C. C., Schmidt, H. K., Kalicki-Veizer, J. M., Lu, C., & 34 othersZhang, Q., Lin, L., O'Laughlin, M. D., McMichael, J. F., Delehaunty, K. D., Fulton, L. A., Magrini, V. J., McGrath, S. D., Demeter, R. T., Vickery, T. L., Hundal, J., Cook, L. L., Swift, G. W., Reed, J. P., Alldredge, P. A., Wylie, T. N., Walker, J. R., Watson, M. A., Heath, S. E., Shannon, W. D., Varghese, N., Nagarajan, R., Payton, J. E., Baty, J. D., Kulkarni, S., Klco, J. M., Tomasson, M. H., Westervelt, P., Walter, M. J., Graubert, T. A., Dipersio, J. F., Ding, L., Mardis, E. R. & Wilson, R. K., Jul 20 2012, In: Cell. 150, 2, p. 264-278 15 p.

      Research output: Contribution to journal › Article › peer-review

      1257 Scopus citations

    • Whole-genome analysis informs breast cancer response to aromatase inhibition

      Ellis, M. J., Ding, L., Shen, D., Luo, J., Suman, V. J., Wallis, J. W., Van Tine, B. A., Hoog, J., Goiffon, R. J., Goldstein, T. C., Ng, S., Lin, L., Crowder, R., Snider, J., Ballman, K., Weber, J., Chen, K., Koboldt, D. C., Kandoth, C., Schierding, W. S., & 39 othersMcMichael, J. F., Miller, C. A., Lu, C., Harris, C. C., McLellan, M. D., Wendl, M. C., Deschryver, K., Allred, D. C., Esserman, L., Unzeitig, G., Margenthaler, J., Babiera, G. V., Marcom, P. K., Guenther, J. M., Leitch, M., Hunt, K., Olson, J., Tao, Y., Maher, C. A., Fulton, L. L., Fulton, R. S., Harrison, M., Oberkfell, B., Du, F., Demeter, R., Vickery, T. L., Elhammali, A., Piwnica-Worms, H., McDonald, S., Watson, M., Dooling, D. J., Ota, D., Chang, L. W., Bose, R., Ley, T. J., Piwnica-Worms, D., Stuart, J. M., Wilson, R. K. & Mardis, E. R., Jun 21 2012, In: Nature. 486, 7403, p. 353-360 8 p.

      Research output: Contribution to journal › Article › peer-review

      857 Scopus citations
    • 2011

      CREST maps somatic structural variation in cancer genomes with base-pair resolution

      Wang, J., Mullighan, C. G., Easton, J., Roberts, S., Heatley, S. L., Ma, J., Rusch, M. C., Chen, K., Harris, C. C., Ding, L., Holmfeldt, L., Payne-Turner, D., Fan, X., Wei, L., Zhao, D., Obenauer, J. C., Naeve, C., Mardis, E. R., Wilson, R. K., Downing, J. R., & 1 othersZhang, J., Aug 2011, In: Nature Methods. 8, 8, p. 652-654 3 p.

      Research output: Contribution to journal › Article › peer-review

      Open Access
      393 Scopus citations

    • Identification of a novel TP53 cancer susceptibility mutation through whole-genome sequencing of a patient with therapy-related AML

      Link, D. C., Schuettpelz, L. G., Shen, D., Wang, J., Walter, M. J., Kulkarni, S., Payton, J. E., Ivanovich, J., Goodfellow, P. J., Le Beau, M., Koboldt, D. C., Dooling, D. J., Fulton, R. S., Bender, R. H. F., Fulton, L. L., Delehaunty, K. D., Fronick, C. C., Appelbaum, E. L., Schmidt, H., Abbott, R., & 12 othersO'Laughlin, M., Chen, K., McLellan, M. D., Varghese, N., Nagarajan, R., Heath, S., Graubert, T. A., Ding, L., Ley, T. J., Zambetti, G. P., Wilson, R. K. & Mardis, E. R., Apr 20 2011, In: JAMA. 305, 15, p. 1568-1576 9 p.

      Research output: Contribution to journal › Article › peer-review

      Open Access
      139 Scopus citations

    • Mapping copy number variation by population-scale genome sequencing

      Mills, R. E., Walter, K., Stewart, C., Handsaker, R. E., Chen, K., Alkan, C., Abyzov, A., Yoon, S. C., Ye, K., Cheetham, R. K., Chinwalla, A., Conrad, D. F., Fu, Y., Grubert, F., Hajirasouliha, I., Hormozdiari, F., Iakoucheva, L. M., Iqbal, Z., Kang, S., Kidd, J. M., & 352 othersKonkel, M. K., Korn, J., Khurana, E., Kural, D., Lam, H. Y. K., Leng, J., Li, R., Li, Y., Lin, C. Y., Luo, R., Mu, X. J., Nemesh, J., Peckham, H. E., Rausch, T., Scally, A., Shi, X., Stromberg, M. P., Sütz, A. M., Urban, A. E., Walker, J. A., Wu, J., Zhang, Y., Zhang, Z. D., Batzer, M. A., Ding, L., Marth, G. T., McVean, G., Sebat, J., Snyder, M., Wang, J., Ye, K., Eichler, E. E., Gerstein, M. B., Hurles, M. E., Lee, C., McCarroll, S. A., Korbel, J. O., Collins, F. S., Altshuler, D. L., Durbin, R. M., Abecasis, G. R., Bentley, D. R., Chakravarti, A., Clark, A. G., De La Vega, F. M., Donnelly, P., Egholm, M., Flicek, P., Gabriel, S. B., Gibbs, R. A., Knoppers, B. M., Lander, E. S., Lehrach, H., Mardis, E. R., Nickerson, D. A., Peltonen, L., Schafer, A. J., Sherry, S. T., Wilson, R. K., Deiros, D., Metzker, M., Muzny, D., Reid, J., Wheeler, D., Li, J., Jian, M., Li, G., Liang, H., Tian, G., Wang, B., Wang, W., Yang, H., Zhang, X., Zheng, H., Ambrogio, L., Bloom, T., Cibulskis, K., Fennell, T. J., Jaffe, D. B., Shefler, E., Sougnez, C. L., Gormley, N., Humphray, S., Kingsbury, Z., Koko-Gonzales, P., Stone, J., McKernan, K. J., Costa, G. L., Ichikawa, J. K., Lee, C. C., Sudbrak, R., Borodina, T. A., Dahl, A., Davydov, A. N., Marquardt, P., Mertes, F., Nietfeld, W., Rosenstiel, P., Schreiber, S., Soldatov, A. V., Timmermann, B., Tolzmann, M., Affourtit, J., Ashworth, D., Attiya, S., Bachorski, M., Buglione, E., Burke, A., Caprio, A., Celone, C., Clark, S., Conners, D., Desany, B., Gu, L., Guccione, L., Kao, K., Kebbel, A., Knowlton, J., Labrecque, M., McDade, L., Mealmaker, C., Minderman, M., Nawrocki, A., Niazi, F., Pareja, K., Ramenani, R., Riches, D., Song, W., Turcotte, C., Wang, S., Dooling, D., Fulton, L., Fulton, R., Weinstock, G., Burton, J., Carter, D. M., Churcher, C., Coffey, A., Cox, A., Palotie, A., Quail, M., Skelly, T., Stalker, J., Swerdlow, H. P., Turner, D., De Witte, A., Giles, S., Bainbridge, M., Challis, D., Sabo, A., Yu, F., Yu, J., Fang, X., Guo, X., Tai, S., Wu, H., Zheng, X., Zhou, Y., Garrison, E. P., Huang, W., Indap, A., Lee, W. P., Leong, W. F., Quinlan, A. R., Ward, A. N., Daly, M. J., DePristo, M. A., Ball, A. D., Banks, E., Browning, B. L., Garimella, K. V., Grossman, S. R., Hanna, M., Hartl, C., Kernytsky, A. M., Korn, J. M., Li, H., Maguire, J. R., McKenna, A., Nemesh, J. C., Philippakis, A. A., Poplin, R. E., Price, A., Rivas, M. A., Sabeti, P. C., Schaffner, S. F., Shlyakhter, I. A., Cooper, D. N., Ball, E. V., Mort, M., Phillips, A. D., Stenson, P. D., Makarov, V., Bustamante, C. D., Boyko, A., Degenhardt, J., Gravel, S., Gutenkunst, R. N., Kaganovich, M., Keinan, A., Lacroute, P., Ma, X., Reynolds, A., Clarke, L., Cunningham, F., Herrero, J., Keenen, S., Kulesha, E., Leinonen, R., McLaren, W. M., Radhakrishnan, R., Smith, R. E., Zalunin, V., Zheng-Bradley, X., Stütz, A. M., Bauer, M., Cox, T., Eberle, M., James, T., Kahn, S., Murray, L., Hyland, F. C., Manning, J. M., McLaughlin, S. F., Sakarya, O., Sun, Y. A., Tsung, E. F., Albrecht, M. W., Amstislavskiy, V. S., Herwig, R., Parkhomchuk, D. V., Agarwala, R., Khouri, H., Morgulis, A. O., Paschall, J. E., Phan, L. D., Rotmistrovsky, K. E., Sanders, R. D., Shumway, M. F., Xiao, C., Auton, A., Lunter, G., Marchini, J. L., Moutsianas, L., Myers, S., Tumian, A., Knight, J., Winer, R., Craig, D. W., Beckstrom-Sternberg, S. M., Christoforides, A., Kurdoglu, A. A., Pearson, J. V., Sinari, S. A., Tembe, W. D., Haussler, D., Hinrichs, A. S., Katzman, S. J., Kern, A., Kuhn, R. M., Przeworski, M., Hernandez, R. D., Howie, B., Kelley, J. L., Melton, S. C., Anderson, P., Blackwell, T., Chen, W., Cookson, W. O., Ding, J., Kang, H. M., Lathrop, M., Liang, L., Moffatt, M. F., Scheet, P., Sidore, C., Zhan, X., Zöllner, S., Awadalla, P., Casals, F., Idaghdour, Y., Keebler, J., Stone, E. A., Zilversmit, M., Jorde, L., Xing, J., Aksay, G., Sahinalp, S. C., Sudmant, P. H., Koboldt, D. C., McLellan, M. D., Wallis, J. W., Wendl, M. C., Zhang, Q., Albers, C. A., Ayub, Q., Balasubramaniam, S., Barrett, J. C., Chen, Y., Danecek, P., Dermitzakis, E. T., Hu, M., Huang, N., Jin, H., Jostins, L., Keane, T. M., Le, S. Q., Lindsay, S., Long, Q., MacArthur, D. G., Montgomery, S. B., Parts, L., Tyler-Smith, C., Balasubramanian, S., Bjornson, R., Du, J., Habegger, L., Haraksingh, R., Jee, J., Lam, H. Y., Jeng, J., Zhang, Z., Bank, E., Yoon, S., Kidd, J., Coafra, C., Dinh, H., Kovar, C., Lee, S., Nazareth, L., Wilkinson, J., Khouri, H. M., Scott, C., Gharani, N., Kaye, J. S., Kent, A., Li, T., McGuire, A. L., Ossorio, P. N., Rotimi, C. N., Su, Y., Toji, L. H., Brooks, L. D., Felsenfeld, A. L., McEwen, J. E., Abdallah, A., Juenger, C. R., Clemm, N. C., Duncanson, A., Green, E. D., Guyer, M. S. & Peterson, J. L., Feb 3 2011, In: Nature. 470, 7332, p. 59-65 7 p.

      Research output: Contribution to journal › Article › peer-review

      Open Access
      858 Scopus citations

    • Sequencing a mouse acute promyelocytic leukemia genome reveals genetic events relevant for disease progression

      Wartman, L. D., Larson, D. E., Xiang, Z., Ding, L., Chen, K., Lin, L., Cahan, P., Klco, J. M., Welch, J. S., Li, C., Payton, J. E., Uy, G. L., Varghese, N., Ries, R. E., Hoock, M., Koboldt, D. C., McLellan, M. D., Schmidt, H., Fulton, R. S., Abbott, R. M., & 12 othersCook, L., McGrath, S. D., Fan, X., Dukes, A. F., Vickery, T., Kalicki, J., Lamprecht, T. L., Graubert, T. A., Tomasson, M. H., Mardis, E. R., Wilson, R. K. & Ley, T. J., Apr 1 2011, In: Journal of Clinical Investigation. 121, 4, p. 1445-1455 11 p.

      Research output: Contribution to journal › Article › peer-review

      86 Scopus citations

    • Use of whole-genome sequencing to diagnose a cryptic fusion oncogene

      Welch, J. S., Westervelt, P., Ding, L., Larson, D. E., Klco, J. M., Kulkarni, S., Wallis, J., Chen, K., Payton, J. E., Fulton, R. S., Veizer, J., Schmidt, H., Vickery, T. L., Heath, S., Watson, M. A., Tomasson, M. H., Link, D. C., Graubert, T. A., DiPersio, J. F., Mardis, E. R., & 2 othersLey, T. J. & Wilson, R. K., Apr 20 2011, In: JAMA. 305, 15, p. 1577-1584 8 p.

      Research output: Contribution to journal › Article › peer-review

      Open Access
      220 Scopus citations
    • 2010

      A map of human genome variation from population-scale sequencing

      Altshuler, D. L., Durbin, R. M., Abecasis, G. R., Bentley, D. R., Chakravarti, A., Clark, A. G., Collins, F. S., De La Vega, F. M., Donnelly, P., Egholm, M., Flicek, P., Gabriel, S. B., Gibbs, R. A., Knoppers, B. M., Lander, E. S., Lehrach, H., Mardis, E. R., McVean, G. A., Nickerson, D. A., Peltonen, L., & 348 othersSchafer, A. J., Sherry, S. T., Wang, J., Wilson, R. K., Deiros, D., Metzker, M., Muzny, D., Reid, J., Wheeler, D., Wang, S. J., Li, J., Jian, M., Li, G., Li, R., Liang, H., Tian, G., Wang, B., Wang, J., Wang, W., Yang, H., Zhang, X., Zheng, H., Ambrogio, L., Bloom, T., Cibulskis, K., Fennell, T. J., Jaffe, D. B., Shefler, E., Sougnez, C. L., Bentley, I. D. R., Gormley, N., Humphray, S., Kingsbury, Z., Koko-Gonzales, P., Stone, J., Mc Kernan, K. J., Costa, G. L., Ichikawa, J. K., Lee, C. C., Sudbrak, R., Borodina, T. A., Dahl, A., Davydov, A. N., Marquardt, P., Mertes, F., Nietfeld, W., Rosenstiel, P., Schreiber, S., Soldatov, A. V., Timmermann, B., Tolzmann, M., Affourtit, J., Ashworth, D., Attiya, S., Bachorski, M., Buglione, E., Burke, A., Caprio, A., Celone, C., Clark, S., Conners, D., Desany, B., Gu, L., Guccione, L., Kao, K., Kebbel, A., Knowlton, J., Labrecque, M., McDade, L., Mealmaker, C., Minderman, M., Nawrocki, A., Niazi, F., Pareja, K., Ramenani, R., Riches, D., Song, W., Turcotte, C., Wang, S., Dooling, D., Fulton, L., Fulton, R., Weinstock, G., Burton, J., Carter, D. M., Churcher, C., Coffey, A., Cox, A., Palotie, A., Quail, M., Skelly, T., Stalker, J., Swerdlow, H. P., Turner, D., De Witte, A., Giles, S., Bainbridge, M., Challis, D., Sabo, A., Yu, F., Yu, J., Fang, X., Guo, X., Li, Y., Luo, R., Tai, S., Wu, H., Zheng, H., Zheng, X., Zhou, Y., Marth, G. T., Garrison, E. P., Huang, W., Indap, A., Kural, D., Lee, W. P., Leong, W. F., Quinlan, A. R., Stewart, C., Stromberg, M. P., Ward, A. N., Wu, J., Lee, C., Mills, R. E., Shi, X., Daly, M. J., DePristo, M. A., Ball, A. D., Banks, E., Browning, B. L., Garimella, K. V., Grossman, S. R., Handsaker, R. E., Hanna, M., Hartl, C., Kernytsky, A. M., Korn, J. M., Li, H., Maguire, J. R., McKenna, A., Nemesh, J. C., Philippakis, A. A., Poplin, R. E., Price, A., Rivas, M. A., Sabeti, P. C., Schaffner, S. F., Shlyakhter, I. A., Cooper, D. N., Ball, E. V., Mort, M., Phillips, A. D., Stenson, P. D., Sebat, J., Makarov, V., Ye, K., Yoon, S. C., Bustamante, C. D., Boyko, A., Degenhardt, J., Gravel, S., Gutenkunst, R. N., Kaganovich, M., Keinan, A., Lacroute, P., Ma, X., Reynolds, A., Clarke, L., Cunningham, F., Herrero, J., Keenen, S., Kulesha, E., Leinonen, R., McLaren, W. M., Radhakrishnan, R., Smith, R. E., Zalunin, V., Korbel, J. O., Stütz, A. M., Humphray, I. S., Bauer, M., Cheetham, R. K., Cox, T., Eberle, M., James, T., Kahn, S., Murray, L., Ye, K., Fu, Y., Hyland, F. C. L., Manning, J. M., Stephen, F. M., Peckham, H. E., Sakarya, O., Sun, Y. A., Tsung, E. F., Mark, A. B., Konkel, M. K., Walker, J. A., Albrecht, M. W., Amstislavskiy, V. S., Herwig, R., Parkhomchuk, D. V., Agarwala, R., Khouri, H. M., Morgulis, A. O., Paschall, J. E., Phan, L. D., Rotmistrovsky, K. E., Sanders, R. D., Shumway, M. F., Xiao, C., Gil, A. M., Auton, A., Iqbal, Z., Lunter, G., Marchini, J. L., Moutsianas, L., Myers, S., Tumian, A., Knight, J., Winer, R., Craig, D. W., Beckstrom-Sternberg, S. M., Christoforides, A., Kurdoglu, A. A., Pearson, J. V., Sinari, S. A., Tembe, W. D., Haussler, D., Hinrichs, A. S., Katzman, S. J., Kern, A., Kuhn, R. M., Przeworski, M., Hernandez, R. D., Howie, B., Kelley, J. L., Melton, S. C., Li, Y., Anderson, P., Blackwell, T., Chen, W., Cookson, W. O., Ding, J., Kang, H. M., Lathrop, M., Liang, L., Moffatt, M. F., Scheet, P., Sidore, C., Snyder, M., Zhan, X., Zöllner, S., Awadalla, P., Casals, F., Idaghdour, Y., Keebler, J., Stone, E. A., Zilversmit, M., Jorde, L., Xing, J., Eichler, E. E., Aksay, G., Alkan, C., Hajirasouliha, I., Hormozdiari, F., Kidd, J. M., CenkSahinalp, S., Sudmant, P. H., Chen, K., Chinwalla, A., Ding, L., Koboldt, D. C., McLellan, M. D., Wallis, J. W., Wendl, M. C., Zhang, Q., Albers, C. A., Ayub, Q., Balasubramaniam, S., Barrett, J. C., Chen, Y., Conrad, D. F., Danecek, P., Dermitzakis, E. T., Hu, M., Huang, N., Matt, E. H., Jin, H., Jostins, L., Keane, T. M., Quang Le, S., Lindsay, S., Long, Q., MacArthur, D. G., Montgomery, S. B., Parts, L., Chris Tyler-Smith, T-S., Walter, K., Zhang, Y., Gerstein, M. B., Snyder, M., Abyzov, A., Balasubramanian, S., Bjornson, R., Grubert, F., Habegger, L., Haraksingh, R., Khurana, E., Lam, H. Y. K., Leng, J., Mu, X. J., Urban, A. E., Zhang, Z., McCarroll, S. A., Zheng-Bradley, X., Batzer, M. A., Hurles, M. E., Du, J., Jee, J., Coafra, C., Dinh, H., Kovar, C., Lee, S., Nazareth, L., Wilkinson, J., Coffey, A., Scott, C., Tyler-Smith, C., Gharani, N., Kaye, J. S., Kent, A., Li, T., McGuire, A. L., Ossorio, P. N., Rotimi, C. N., Su, Y., Toji, L. H., Felsenfeld, A. L., McEwen, J. E., Abdallah, A., Juenger, C. R., Clemm, N. C., Duncanson, A., Green, E. D., Guyer, M. S. & Peterson, J. L., Oct 28 2010, In: Nature. 467, 7319, p. 1061-1073 13 p.

      Research output: Contribution to journal › Article › peer-review

      Open Access
      6190 Scopus citations

    • Diversity of human copy number variation and multicopy genes

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      Research output: Contribution to journal › Article › peer-review

      Open Access
      525 Scopus citations

    • Genome remodelling in a basal-like breast cancer metastasis and xenograft

      Ding, L., Ellis, M. J., Li, S., Larson, D. E., Chen, K., Wallis, J. W., Harris, C. C., McLellan, M. D., Fulton, R. S., Fulton, L. L., Abbott, R. M., Hoog, J., Dooling, D. J., Koboldt, D. C., Schmidt, H., Kalicki, J., Zhang, Q., Chen, L., Lin, L., Wendl, M. C., & 49 othersMcMichael, J. F., Magrini, V. J., Cook, L., McGrath, S. D., Vickery, T. L., Appelbaum, E., Deschryver, K., Davies, S., Guintoli, T., Lim, L., Crowder, R., Tao, Y., Snider, J. E., Smith, S. M., Dukes, A. F., Sanderson, G. E., Pohl, C. S., Delehaunty, K. D., Fronick, C. C., Pape, K. A., Reed, J. S., Robinson, J. S., Hodges, J. S., Schierding, W., Dees, N. D., Shen, D., Locke, D. P., Wiechert, M. E., Eldred, J. M., Peck, J. B., Oberkfell, B. J., Lolofie, J. T., Du, F., Hawkins, A. E., Oĝlaughlin, M. D., Bernard, K. E., Cunningham, M., Elliott, G., Mason, M. D., Thompson, D. M., Ivanovich, J. L., Goodfellow, P. J., Perou, C. M., Weinstock, G. M., Aft, R., Watson, M., Ley, T. J., Wilson, R. K. & Mardis, E. R., Apr 15 2010, In: Nature. 464, 7291, p. 999-1005 7 p.

      Research output: Contribution to journal › Article › peer-review

      1012 Scopus citations
    • 2009

      BreakDancer: An algorithm for high-resolution mapping of genomic structural variation

      Chen, K., Wallis, J. W., McLellan, M. D., Larson, D. E., Kalicki, J. M., Pohl, C. S., McGrath, S. D., Wendl, M. C., Zhang, Q., Locke, D. P., Shi, X., Fulton, R. S., Ley, T. J., Wilson, R. K., Ding, L. & Mardis, E. R., 2009, In: Nature Methods. 6, 9, p. 677-681 5 p.

      Research output: Contribution to journal › Article › peer-review

      Open Access
      1109 Scopus citations

    • CMDS: A population-based method for identifying recurrent DNA copy number aberrations in cancer from high-resolution data

      Zhang, Q., Ding, L., Larson, D. E., Koboldt, D. C., McLellan, M. D., Chen, K., Shi, X., Kraja, A., Mardis, E. R., Wilson, R. K., Borecki, I. B. & Province, M. A., Dec 23 2009, In: Bioinformatics. 26, 4, p. 464-469 6 p.

      Research output: Contribution to journal › Article › peer-review

      54 Scopus citations

    • Recurring mutations found by sequencing an acute myeloid leukemia genome

      Mardis, E. R., Ding, L., Dooling, D. J., Larson, D. E., McLellan, M. D., Chen, K., Koboldt, D. C., Fulton, R. S., Delehaunty, K. D., McGrath, S. D., Fulton, L. A., Locke, D. P., Magrini, V. J., Abbott, R. M., Vickery, T. L., Reed, J. S., Robinson, J. S., Wylie, T., Smith, S. M., Carmichael, L., & 38 othersEldred, J. M., Harris, C. C., Walker, J., Peck, J. B., Du, F., Dukes, A. F., Sanderson, G. E., Brummett, A. M., Clark, E., McMichael, J. F., Meyer, R. J., Schindler, J. K., Pohl, C. S., Wallis, J. W., Shi, X., Lin, L., Schmidt, H., Tang, Y., Haipek, C., Wiechert, M. E., Ivy, J. V., Kalicki, J., Elliott, G., Ries, R. E., Payton, J. E., Westervelt, P., Tomasson, M. H., Watson, M. A., Baty, J., Heath, S., Shannon, W. D., Nagarajan, R., Link, D. C., Walter, M. J., Graubert, T. A., DiPersio, J. F., Wilson, R. K. & Ley, T. J., Sep 10 2009, In: New England Journal of Medicine. 361, 11, p. 1058-1066 9 p.

      Research output: Contribution to journal › Article › peer-review

      Open Access
      1890 Scopus citations

    • VarScan: Variant detection in massively parallel sequencing of individual and pooled samples

      Koboldt, D. C., Chen, K., Wylie, T., Larson, D. E., McLellan, M. D., Mardis, E. R., Weinstock, G. M., Wilson, R. K. & Ding, L., 2009, In: Bioinformatics. 25, 17, p. 2283-2285 3 p.

      Research output: Contribution to journal › Article › peer-review

      960 Scopus citations
    • 2008

      Comprehensive genomic characterization defines human glioblastoma genes and core pathways

      McLendon, R., Friedman, A., Bigner, D., Van Meir, E. G., Brat, D. J., Mastrogianakis, G. M., Olson, J. J., Mikkelsen, T., Lehman, N., Aldape, K., Yung, W. K. A., Bogler, O., Weinstein, J. N., VandenBerg, S., Berger, M., Prados, M., Muzny, D., Morgan, M., Scherer, S., Sabo, A., & 211 othersNazareth, L., Lewis, L., Hall, O., Zhu, Y., Ren, Y., Alvi, O., Yao, J., Hawes, A., Jhangiani, S., Fowler, G., San Lucas, A., Kovar, C., Cree, A., Dinh, H., Santibanez, J., Joshi, V., Gonzalez-Garay, M. L., Miller, C. A., Milosavljevic, A., Donehower, L., Wheeler, D. A., Gibbs, R. A., Cibulskis, K., Sougnez, C., Fennell, T., Mahan, S., Wilkinson, J., Ziaugra, L., Onofrio, R., Bloom, T., Nicol, R., Ardlie, K., Baldwin, J., Gabriel, S., Lander, E. S., Ding, L., Fulton, R. S., McLellan, M. D., Wallis, J., Larson, D. E., Shi, X., Abbott, R., Fulton, L., Chen, K., Koboldt, D. C., Wendl, M. C., Meyer, R., Tang, Y., Lin, L., Osborne, J. R., Dunford-Shore, B. H., Miner, T. L., Delehaunty, K., Markovic, C., Swift, G., Courtney, W., Pohl, C., Abbott, S., Hawkins, A., Leong, S., Haipek, C., Schmidt, H., Wiechert, M., Vickery, T., Scott, S., Dooling, D. J., Chinwalla, A., Weinstock, G. M., Mardis, E. R., Wilson, R. K., Getz, G., Winckler, W., Verhaak, R. G. W., Lawrence, M. S., O'Kelly, M., Robinson, J., Alexe, G., Beroukhim, R., Carter, S., Chiang, D., Gould, J., Gupta, S., Korn, J., Mermel, C., Mesirov, J., Monti, S., Nguyen, H., Parkin, M., Reich, M., Stransky, N., Weir, B. A., Garraway, L., Golub, T., Meyerson, M., Chin, L., Protopopov, A., Zhang, J., Perna, I., Aronson, S., Sathiamoorthy, N., Ren, G., Yao, J., Wiedemeyer, W. R., Kim, H., Sek, W. K., Xiao, Y., Kohane, I. S., Seidman, J., Park, P. J., Kucherlapati, R., Laird, P. W., Cope, L., Herman, J. G., Weisenberger, D. J., Pan, F., Van Den Berg, D., Van Neste, L., Joo, M. Y., Schuebel, K. E., Baylin, S. B., Absher, D. M., Li, J. Z., Southwick, A., Brady, S., Aggarwal, A., Chung, T., Sherlock, G., Brooks, J. D., Myers, R. M., Spellman, P. T., Purdom, E., Jakkula, L. R., Lapuk, A. V., Marr, H., Dorton, S., Yoon, G. C., Han, J., Ray, A., Wang, V., Durinck, S., Robinson, M., Wang, N. J., Vranizan, K., Peng, V., Van Name, E., Fontenay, G. V., Ngai, J., Conboy, J. G., Parvin, B., Feiler, H. S., Speed, T. P., Gray, J. W., Brennan, C., Socci, N. D., Olshen, A., Taylor, B. S., Lash, A., Schultz, N., Reva, B., Antipin, Y., Stukalov, A., Gross, B., Cerami, E., Wei, Q. W., Qin, L. X., Seshan, V. E., Villafania, L., Cavatore, M., Borsu, L., Viale, A., Gerald, W., Sander, C., Ladanyi, M., Perou, C. M., Hayes, D. N., Topal, M. D., Hoadley, K. A., Qi, Y., Balu, S., Shi, Y., Wu, J., Penny, R., Bittner, M., Shelton, T., Lenkiewicz, E., Morris, S., Beasley, D., Sanders, S., Kahn, A., Sfeir, R., Chen, J., Nassau, D., Feng, L., Hickey, E., Barker, A., Gerhard, D. S., Vockley, J., Compton, C., Vaught, J., Fielding, P., Ferguson, M. L., Schaefer, C., Zhang, J., Madhavan, S., Buetow, K. H., Collins, F., Good, P., Guyer, M., Ozenberger, B., Peterson, J. & Thomson, E., Oct 23 2008, In: Nature. 455, 7216, p. 1061-1068 8 p.

      Research output: Contribution to journal › Article › peer-review

      6166 Scopus citations

    • DNA sequencing of a cytogenetically normal acute myeloid leukaemia genome

      Ley, T. J., Mardis, E. R., Ding, L., Fulton, B., McLellan, M. D., Chen, K., Dooling, D., Dunford-Shore, B. H., McGrath, S., Hickenbotham, M., Cook, L., Abbott, R., Larson, D. E., Koboldt, D. C., Pohl, C., Smith, S., Hawkins, A., Abbott, S., Locke, D., Hillier, L. W., & 28 othersMiner, T., Fulton, L., Magrini, V., Wylie, T., Glasscock, J., Conyers, J., Sander, N., Shi, X., Osborne, J. R., Minx, P., Gordon, D., Chinwalla, A., Zhao, Y., Ries, R. E., Payton, J. E., Westervelt, P., Tomasson, M. H., Watson, M., Baty, J., Ivanovich, J., Heath, S., Shannon, W. D., Nagarajan, R., Walter, M. J., Link, D. C., Graubert, T. A., DiPersio, J. F. & Wilson, R. K., Nov 6 2008, In: Nature. 456, 7218, p. 66-72 7 p.

      Research output: Contribution to journal › Article › peer-review

      1048 Scopus citations

    • Somatic mutations affect key pathways in lung adenocarcinoma

      Ding, L., Getz, G., Wheeler, D. A., Mardis, E. R., McLellan, M. D., Cibulskis, K., Sougnez, C., Greulich, H., Muzny, D. M., Morgan, M. B., Fulton, L., Fulton, R. S., Zhang, Q., Wendl, M. C., Lawrence, M. S., Larson, D. E., Chen, K., Dooling, D. J., Sabo, A., Hawes, A. C., & 70 othersShen, H., Jhangiani, S. N., Lewis, L. R., Hall, O., Zhu, Y., Mathew, T., Ren, Y., Yao, J., Scherer, S. E., Clerc, K., Metcalf, G. A., Ng, B., Milosavljevic, A., Gonzalez-Garay, M. L., Osborne, J. R., Meyer, R., Shi, X., Tang, Y., Koboldt, D. C., Lin, L., Abbott, R., Miner, T. L., Pohl, C., Fewell, G., Haipek, C., Schmidt, H., Dunford-Shore, B. H., Kraja, A., Crosby, S. D., Sawyer, C. S., Vickery, T., Sander, S., Robinson, J., Winckler, W., Baldwin, J., Chirieac, L. R., Dutt, A., Fennell, T., Hanna, M., Johnson, B. E., Onofrio, R. C., Thomas, R. K., Tonon, G., Weir, B. A., Zhao, X., Ziaugra, L., Zody, M. C., Giordano, T., Orringer, M. B., Roth, J. A., Spitz, M. R., Wistuba, I. I., Ozenberger, B., Good, P. J., Chang, A. C., Beer, D. G., Watson, M. A., Ladanyi, M., Broderick, S., Yoshizawa, A., Travis, W. D., Pao, W., Province, M. A., Weinstock, G. M., Varmus, H. E., Gabriel, S. B., Lander, E. S., Gibbs, R. A., Meyerson, M. & Wilson, R. K., Oct 23 2008, In: Nature. 455, 7216, p. 1069-1075 7 p.

      Research output: Contribution to journal › Article › peer-review

      2271 Scopus citations
    • 2007

      On the detection of functionally coherent groups of protein domains with an extension to protein annotation

      McLaughlin, W. A., Chen, K., Hou, T. & Wang, W., Oct 16 2007, In: BMC bioinformatics. 8, 390.

      Research output: Contribution to journal › Article › peer-review

      4 Scopus citations

    • PolyScan: An automatic indel and SNP detection approach to the analysis of human resequencing data

      Chen, K., McLellan, M. D., Ding, L., Wendl, M. C., Kasai, Y., Wilson, R. K. & Mardis, E. R., May 2007, In: Genome research. 17, 5, p. 659-666 8 p.

      Research output: Contribution to journal › Article › peer-review

      69 Scopus citations
    • 2006

      Computational analysis and prediction of the binding motif and protein interacting partners of the Abl SH3 domain

      Hou, T., Chen, K., McLaughlin, W. A., Lu, B. & Wang, W., Jan 2006, In: PLoS computational biology. 2, 1, p. 46-55 10 p.

      Research output: Contribution to journal › Article › peer-review

      146 Scopus citations

    • Prediction of binding affinities between the human amphiphysin-1 SH3 domain and its peptide ligands using homology modeling, molecular dynamics and molecular field analysis

      Hou, T., McLaughlin, W., Lu, B., Chen, K. & Wang, W., Jan 2006, In: Journal of Proteome Research. 5, 1, p. 32-43 12 p.

      Research output: Contribution to journal › Article › peer-review

      67 Scopus citations

    • Prosody dependent speech recognition on radio news corpus of American English

      Chen, K., Hasegawa-Johnson, M., Cohen, A., Borys, S., Kim, S. S., Cole, J. & Choi, J. Y., Jan 2006, In: IEEE Transactions on Audio, Speech and Language Processing. 14, 1, p. 232-244 13 p.

      Research output: Contribution to journal › Article › peer-review

      44 Scopus citations
    • 2005

      Landmark-based speech recognition: Report of the 2004 Johns Hopkins summer workshop

      Hasegawa-Johnson, M., Baker, J., Borys, S., Chen, K., Coogan, E., Greenberg, S., Juneja, A., Kirchhoff, K., Livescu, K., Mohan, S., Muller, J., Sonmez, K. & Wang, T., 2005, 2005 IEEE International Conference on Acoustics, Speech, and Signal Processing, ICASSP '05 - Proceedings - Image and Multidimensional Signal Processing Multimedia Signal Processing. Institute of Electrical and Electronics Engineers Inc., p. I213-I216 1415088. (ICASSP, IEEE International Conference on Acoustics, Speech and Signal Processing - Proceedings; vol. I).

      Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

      Open Access
      61 Scopus citations

    • Simultaneous recognition of words and prosody in the Boston University Radio Speech Corpus

      Hasegawa-Johnson, M., Chen, K., Cole, J., Borys, S., Kim, S. S., Cohen, A., Zhang, T., Choi, J. Y., Kim, H., Yoon, T. & Chavarria, S., Jul 2005, In: Speech Communication. 46, 3-4, p. 418-439 22 p.

      Research output: Contribution to journal › Article › peer-review

      40 Scopus citations
    • 2004

      An automatic prosody labeling system using ANN-based syntactic-prosodic model and GMM-based acoustic-prosodic model

      Chen, K., Hasegawa-Johnson, M. & Cohen, A., 2004, In: ICASSP, IEEE International Conference on Acoustics, Speech and Signal Processing - Proceedings. 1, p. I509-I512

      Research output: Contribution to journal › Conference article › peer-review

      85 Scopus citations

    • Automatic recognition of pitch movements using multilayer perception and time-delay recursive neural network

      Kim, S. S., Hasegawa-Johnson, M. & Chen, K., Jul 2004, In: IEEE Signal Processing Letters. 11, 7, p. 645-648 4 p.

      Research output: Contribution to journal › Article › peer-review

      7 Scopus citations

    • Modeling pronunciation variation using artificial neural networks for English spontaneous speech

      Chen, K. & Hasegawa-Johnson, M., 2004, p. 1461-1464. 4 p.

      Research output: Contribution to conference › Paper › peer-review

      8 Scopus citations
    • 2003

      Improving the robustness of prosody dependent language modeling based on prosody syntax dependence

      Chen, K. & Hasegawa-Johnson, M., 2003, 2003 IEEE Workshop on Automatic Speech Recognition and Understanding, ASRU 2003. Institute of Electrical and Electronics Engineers Inc., p. 435-440 6 p. 1318480. (2003 IEEE Workshop on Automatic Speech Recognition and Understanding, ASRU 2003).

      Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

      7 Scopus citations

    • Prosody dependent speech recognition with explicit duration modelling at intonational phrase boundaries

      Chen, K., Borys, S., Hasegawa-Johnson, M. & Cole, J., 2003, p. 393-396. 4 p.

      Research output: Contribution to conference › Paper › peer-review

      12 Scopus citations
    • 2002

      An evaluation of using mutual information for selection of acoustic-features representation of phonemes for speech recognition

      Omar, M. K., Chen, K., Hasegawa-Johnson, M. & Brandman, Y., 2002, p. 2129-2132. 4 p.

      Research output: Contribution to conference › Paper › peer-review

      8 Scopus citations