• 315 Citations
  • 11 h-Index
20092019
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Research Output 2009 2019

  • 315 Citations
  • 11 h-Index
  • 13 Article
  • 2 Review article
  • 1 Comment/debate
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Article
2016
8 Citations (Scopus)

Chaperonin TRiC/CCT modulates the folding and activity of leukemogenic fusion oncoprotein AML1-ETO

Roh, S. H., Kasembeli, M. M., Galaz-Montoya, J. G., Trnka, M., Lau, W. C. Y., Burlingame, A., Chiu, W. & Tweardy, D., Feb 26 2016, In : Journal of Biological Chemistry. 291, 9, p. 4732-4741 10 p.

Research output: Contribution to journalArticle

Chaperonin Containing TCP-1
Chaperonins
Oncogene Proteins
Acute Myeloid Leukemia
Fusion reactions
5 Citations (Scopus)

Chaperonin TRiC/CCT Recognizes Fusion Oncoprotein AML1-ETO through Subunit-Specific Interactions

Roh, S. H., Kasembeli, M. M., Galaz-Montoya, J. G., Chiu, W. & Tweardy, D., Jun 7 2016, In : Biophysical journal. 110, 11, p. 2377-2385 9 p.

Research output: Contribution to journalArticle

Chaperonin Containing TCP-1
Oncogene Proteins
Cryoelectron Microscopy
DNA
Myeloid Cells
18 Citations (Scopus)

PARP Inhibition Suppresses Growth of EGFR-Mutant Cancers by Targeting Nuclear PKM2

Li, N., Feng, L., Liu, H., Wang, J., Kasembeli, M., Tran, M. K., Tweardy, D. J., Lin, S. H. & Chen, J., Apr 26 2016, In : Cell Reports. 15, 4, p. 843-856 14 p.

Research output: Contribution to journalArticle

Tumors
Cells
Poly Adenosine Diphosphate Ribose
Lung Neoplasms
Cell proliferation
12 Citations (Scopus)

Protein stabilization improves STAT3 function in autosomal dominant hyper-IgE syndrome

Bocchini, C. E., Nahmod, K., Katsonis, P., Kim, S., Kasembeli, M. M., Freeman, A., Lichtarge, O., Makedonas, G. & Tweardy, D. J., Dec 29 2016, In : Blood. 128, 26, p. 3061-3072 12 p.

Research output: Contribution to journalArticle

Job Syndrome
geranylgeranylacetone
Immunoglobulin E
Stabilization
STAT3 Transcription Factor
13 Citations (Scopus)

Small-molecule inhibition of STAT3 in radioresistant head and neck squamous cell carcinoma

Bharadwaj, U., Kris Eckols, T., Xu, X., Kasembeli, M. M., Chen, Y., Adachi, M., Song, Y., Mo, Q., Lai, S. Y. & Tweardy, D. J., May 1 2016, In : Oncotarget. 7, 18, p. 26307-26330 24 p.

Research output: Contribution to journalArticle

Heterografts
Cell Line
Neoplasms
Head and Neck Neoplasms
Growth
15 Citations (Scopus)
Triple Negative Breast Neoplasms
Neurokinin-1 Receptors
Cardiac Myocytes
Doxorubicin
Apoptosis
2015
68 Citations (Scopus)

Drug-repositioning screening identified piperlongumine as a direct STAT3 inhibitor with potent activity against breast cancer

Bharadwaj, U., Eckols, T. K., Kolosov, M., Kasembeli, M. M., Adam, A., Torres, D., Zhang, X., Dobrolecki, L. E., Wei, W., Lewis, M. T., Dave, B., Chang, J. C., Landis, M. D., Creighton, C. J., Mancini, M. A. & Tweardy, D., Mar 12 2015, In : Oncogene. 34, 11, p. 1341-1353 13 p.

Research output: Contribution to journalArticle

Drug Repositioning
Preclinical Drug Evaluations
Breast Neoplasms
Neoplasms
Ligands
13 Citations (Scopus)

Rhodium(II) Proximity-Labeling Identifies a Novel Target Site on STAT3 for Inhibitors with Potent Anti-Leukemia Activity

Minus, M. B., Liu, W., Vohidov, F., Kasembeli, M. M., Long, X., Krueger, M. J., Stevens, A., Kolosov, M. I., Tweardy, D. J., Sison, E. A. R., Redell, M. S. & Ball, Z. T., Oct 1 2015, In : Angewandte Chemie - International Edition. 54, 44, p. 13085-13089 5 p.

Research output: Contribution to journalArticle

Rhodium
Labeling
Transducers
Tumors
Phosphotyrosine
11 Citations (Scopus)

Small-molecule targeting of signal transducer and activator of transcription (STAT) 3 to treat non-small cell lung cancer

Lewis, K. M., Bharadwaj, U., Eckols, T. K., Kolosov, M., Kasembeli, M. M., Fridley, C., Siller, R. & Tweardy, D., Nov 1 2015, In : Lung Cancer. 90, 2, p. 182-190 9 p.

Research output: Contribution to journalArticle

STAT3 Transcription Factor
Non-Small Cell Lung Carcinoma
Cell Line
Apoptosis Regulatory Proteins
Growth
2014
28 Citations (Scopus)

Modulation of STAT3 Folding and Function by TRiC/CCT Chaperonin

Kasembeli, M. M., Lau, W. C. Y., Roh, S. H., Eckols, T. K., Frydman, J., Chiu, W. & Tweardy, D., Jan 1 2014, In : PLoS Biology. 12, 4, e1001844.

Research output: Contribution to journalArticle

Chaperonin Containing TCP-1
chaperonins
STAT3 Transcription Factor
transducers (equipment)
transcription (genetics)
6 Citations (Scopus)

Monoclonal antibodies specific for Stat3β reveal its contribution to constitutive Stat3 phosphorylation in breast cancer

Bharadwaj, U., Kasembeli, M. M., Eckols, T. K., Kolosov, M., Lang, P., Christensen, K., Edwards, D. P. & Tweardy, D. J., Dec 1 2014, In : Cancers. 6, 4, p. 2012-2034 23 p.

Research output: Contribution to journalArticle

Protein Isoforms
Monoclonal Antibodies
Phosphorylation
Breast Neoplasms
Biological Phenomena
2009
78 Citations (Scopus)

Chemical probes that competitively and selectively inhibit Stat3 activation

Xu, X., Kasembeli, M. M., Jiang, X., Tweardy, B. J. & Tweardy, D. J., Mar 10 2009, In : PloS one. 4, 3, e4783.

Research output: Contribution to journalArticle

binding sites
Chemical activation
Binding Sites
peptides
Peptides
12 Citations (Scopus)

SH2 domain binding to phosphopeptide ligands: Potential for drug targeting

Kasembeli, M. M., Xu, X. & Tweardy, D., Jan 1 2009, In : Frontiers in Bioscience. 14, 3, p. 1010-1022 13 p.

Research output: Contribution to journalArticle

Phosphopeptides
Phosphotyrosine
src Homology Domains
Drug Delivery Systems
STAT Transcription Factors