• 10152 Citations
  • 45 h-Index
1993 …2019
If you made any changes in Pure, your changes will be visible here soon.

Fingerprint Fingerprint is based on mining the text of the experts' scientific documents to create an index of weighted terms, which defines the key subjects of each individual researcher.

Histone Deacetylases Medicine & Life Sciences
Neuroblastoma Medicine & Life Sciences
Neoplasms Medicine & Life Sciences
Histone Deacetylase Inhibitors Medicine & Life Sciences
Pediatrics Medicine & Life Sciences
Medulloblastoma Medicine & Life Sciences
Astrocytoma Medicine & Life Sciences
Therapeutics Medicine & Life Sciences

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Research Output 1993 2019

Brainstem biopsy in pediatric diffuse intrinsic pontine glioma in the era of precision medicine: the INFORM study experience

Pfaff, E., El Damaty, A., Balasubramanian, G. P., Blattner-Johnson, M., Worst, B. C., Stark, S., Witt, H., Pajtler, K. W., van Tilburg, C. M., Witt, R., Milde, T., Jakobs, M., Fiesel, P., Frühwald, M. C., Hernáiz Driever, P., Thomale, U. W., Schuhmann, M. U., Metzler, M., Bochennek, K., Simon, T. & 16 othersDürken, M., Karremann, M., Knirsch, S., Ebinger, M., von Bueren, A. O., Pietsch, T., Herold-Mende, C., Reuss, D. E., Kiening, K., Lichter, P., Eggert, A., Kramm, C. M., Pfister, S. M., Jones, D. T. W., Bächli, H. & Witt, O., Jun 1 2019, In : European Journal of Cancer. 114, p. 27-35 9 p.

Research output: Contribution to journalArticle

Precision Medicine
Glioma
Brain Stem
Pediatrics
Biopsy

Comprehensive Analysis of Chromatin States in Atypical Teratoid/Rhabdoid Tumor Identifies Diverging Roles for SWI/SNF and Polycomb in Gene Regulation

Erkek, S., Johann, P. D., Finetti, M. A., Drosos, Y., Chou, H. C., Zapatka, M., Sturm, D., Jones, D. T. W., Korshunov, A., Rhyzova, M., Wolf, S., Mallm, J. P., Beck, K., Witt, O., Kulozik, A. E., Frühwald, M. C., Northcott, P. A., Korbel, J. O., Lichter, P., Eils, R. & 7 othersGajjar, A., Roberts, C. W. M., Williamson, D., Hasselblatt, M., Chavez, L., Pfister, S. M. & Kool, M., Jan 14 2019, In : Cancer Cell. 35, 1, p. 95-110.e8

Research output: Contribution to journalArticle

Chromatin Immunoprecipitation
Chromatin
Histone Code
Polycomb-Group Proteins
Repressor Proteins

Monitoring futility and efficacy in phase II trials with Bayesian posterior distributions—A calibration approach

Kopp-Schneider, A., Wiesenfarth, M., Witt, R., Edelmann, D., Witt, O. & Abel, U., May 1 2019, In : Biometrical Journal. 61, 3, p. 488-502 15 p.

Research output: Contribution to journalArticle

Beta-binomial Model
Posterior Probability
Decision Rules
Efficacy
Calibration

The enzyme activity of histone deacetylase 8 is modulated by a redox-switch

Jänsch, N., Meyners, C., Muth, M., Kopranovic, A., Witt, O., Oehme, I. & Meyer-Almes, F. J., Jan 1 2019, In : Redox Biology. 20, p. 60-67 8 p.

Research output: Contribution to journalArticle

Histone Deacetylases
Enzyme activity
Oxidation-Reduction
Switches
Enzymes

The Senescence-associated Secretory Phenotype Mediates Oncogene-induced Senescence in Pediatric Pilocytic Astrocytoma

Buhl, J. L., Selt, F., Hielscher, T., Guiho, R., Ecker, J., Sahm, F., Ridinger, J., Riehl, D., Usta, D., Ismer, B., Sommerkamp, A. C., Martinez-Barbera, J. P., Wefers, A. K., Remke, M., Picard, D., Pusch, S., Gronych, J., Oehme, I., van Tilburg, C. M., Kool, M. & 11 othersKuhn, D., Capper, D., von Deimling, A., Schuhmann, M. U., Herold-Mende, C., Korshunov, A., Brummer, T., Pfister, S. M., Jones, D. T. W., Witt, O. & Milde, T., Jan 1 2019, In : Clinical Cancer Research. 25, 6, p. 1851-1866 16 p.

Research output: Contribution to journalArticle

Astrocytoma
Oncogenes
Pediatrics
Phenotype
Cell Aging