• 9371 Citations
  • 44 h-Index
1993 …2019
If you made any changes in Pure, your changes will be visible here soon.

Fingerprint Fingerprint is based on mining the text of the experts' scientific documents to create an index of weighted terms, which defines the key subjects of each individual researcher.

  • 1 Similar Profiles
Histone Deacetylases Medicine & Life Sciences
Neuroblastoma Medicine & Life Sciences
Neoplasms Medicine & Life Sciences
Histone Deacetylase Inhibitors Medicine & Life Sciences
Medulloblastoma Medicine & Life Sciences
Pediatrics Medicine & Life Sciences
Astrocytoma Medicine & Life Sciences
Therapeutics Medicine & Life Sciences

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Research Output 1993 2019

The enzyme activity of histone deacetylase 8 is modulated by a redox-switch

Jänsch, N., Meyners, C., Muth, M., Kopranovic, A., Witt, O., Oehme, I. & Meyer-Almes, F. J., Jan 1 2019, In : Redox Biology. 20, p. 60-67 8 p.

Research output: Contribution to journalArticle

Histone Deacetylases
Enzyme activity
Oxidation-Reduction
Switches
Enzymes
1 Citations

A kinome-wide RNAi screen identifies ALK as a target to sensitize neuroblastoma cells for HDAC8-inhibitor treatment

Shen, J., Najafi, S., Stäble, S., Fabian, J., Koeneke, E., Kolbinger, F. R., Wrobel, J. K., Meder, B., Distel, M., Heimburg, T., Sippl, W., Jung, M., Peterziel, H., Kranz, D., Boutros, M., Westermann, F., Witt, O. & Oehme, I., Mar 7 2018, (Accepted/In press) In : Cell death and differentiation. p. 1-18 18 p.

Research output: Contribution to journalArticle

RNA Interference
Neuroblastoma
Cell Line
Therapeutics
Local Area Networks
2 Citations

BRAF V600E status alone is not sufficient as a prognostic biomarker in pediatric low-grade glioma

Jones, D. T. W., Witt, O. & Pfister, S. M., Jan 1 2018, In : Journal of Clinical Oncology. 36, 1, 1 p.

Research output: Contribution to journalLetter

Glioma
Biomarkers
Pediatrics

Correction: The landscape of genomic alterations across childhood cancers (Nature (2018) DOI: 10.1038/nature25480)

Gröbner, S. N., Worst, B. C., Weischenfeldt, J., Buchhalter, I., Kleinheinz, K., Rudneva, V. A., Johann, P. D., Balasubramanian, G. P., Segura-Wang, M., Brabetz, S., Bender, S., Hutter, B., Sturm, D., Pfaff, E., Hübschmann, D., Zipprich, G., Heinold, M., Eils, J., Lawerenz, C., Erkek, S. & 64 othersLambo, S., Waszak, S., Blattmann, C., Borkhardt, A., Kuhlen, M., Eggert, A., Fulda, S., Gessler, M., Wegert, J., Kappler, R., Baumhoer, D., Burdach, S., Kirschner-Schwabe, R., Kontny, U., Kulozik, A. E., Lohmann, D., Hettmer, S., Eckert, C., Bielack, S., Nathrath, M., Niemeyer, C., Richter, G. H., Schulte, J., Siebert, R., Westermann, F., Molenaar, J. J., Vassal, G., Witt, H., Burkhardt, B., Kratz, C. P., Witt, O., Van Tilburg, C. M., Kramm, C. M., Fleischhack, G., Dirksen, U., Rutkowski, S., Frühwald, M., Von Hoff, K., Wolf, S., Klingebiel, T., Koscielniak, E., Landgraf, P., Koster, J., Resnick, A. C., Zhang, J., Liu, Y., Zhou, X., Waanders, A. J., Zwijnenburg, D. A., Raman, P., Brors, B., Weber, U. D., Northcott, P. A., Pajtler, K. W., Kool, M., Piro, R. M., Korbel, J. O., Schlesner, M., Eils, R., Jones, D. T. W., Lichter, P., Chavez, L., Zapatka, M. & Pfister, S. M., Jul 19 2018, In : Nature. 559, 7714, p. E10

Research output: Contribution to journalComment/debate

Neurobiology
Research
Neoplasms
57 Citations

DNA methylation-based classification of central nervous system tumours

Capper, D., Jones, D. T. W., Sill, M., Hovestadt, V., Schrimpf, D., Sturm, D., Koelsche, C., Sahm, F., Chavez, L., Reuss, D. E., Kratz, A., Wefers, A. K., Huang, K., Pajtler, K. W., Schweizer, L., Stichel, D., Olar, A., Engel, N. W., Lindenberg, K., Harter, P. N. & 123 othersBraczynski, A. K., Plate, K. H., Dohmen, H., Garvalov, B. K., Coras, R., Hölsken, A., Hewer, E., Bewerunge-Hudler, M., Schick, M., Fischer, R., Beschorner, R., Schittenhelm, J., Staszewski, O., Wani, K., Varlet, P., Pages, M., Temming, P., Lohmann, D., Selt, F., Witt, H., Milde, T., Witt, O., Aronica, E., Giangaspero, F., Rushing, E., Scheurlen, W., Geisenberger, C., Rodriguez, F. J., Becker, A., Preusser, M., Haberler, C., Bjerkvig, R., Cryan, J., Farrell, M., Deckert, M., Hench, J., Frank, S., Serrano, J., Kannan, K., Tsirigos, A., Brück, W., Hofer, S., Brehmer, S., Seiz-Rosenhagen, M., Hänggi, D., Hans, V., Rozsnoki, S., Hansford, J. R., Kohlhof, P., Kristensen, B. W., Lechner, M., Lopes, B., Mawrin, C., Ketter, R., Kulozik, A., Khatib, Z., Heppner, F., Koch, A., Jouvet, A., Keohane, C., Mühleisen, H., Mueller, W., Pohl, U., Prinz, M., Benner, A., Zapatka, M., Gottardo, N. G., Driever, P. H., Kramm, C. M., Müller, H. L., Rutkowski, S., Von Hoff, K., Frühwald, M. C., Gnekow, A., Fleischhack, G., Tippelt, S., Calaminus, G., Monoranu, C. M., Perry, A., Jones, C., Jacques, T. S., Radlwimmer, B., Gessi, M., Pietsch, T., Schramm, J., Schackert, G., Westphal, M., Reifenberger, G., Wesseling, P., Weller, M., Collins, V. P., Blümcke, I., Bendszus, M., Debus, J., Huang, A., Jabado, N., Northcott, P. A., Paulus, W., Gajjar, A., Robinson, G. W., Taylor, M. D., Jaunmuktane, Z., Ryzhova, M., Platten, M., Unterberg, A., Wick, W., Karajannis, M. A., Mittelbronn, M., Acker, T., Hartmann, C., Aldape, K., Schüller, U., Buslei, R., Lichter, P., Kool, M., Herold-Mende, C., Ellison, D. W., Hasselblatt, M., Snuderl, M., Brandner, S., Korshunov, A., von Deimling, A. & Pfister, S. M., Mar 22 2018, In : Nature. 555, 7697, p. 469-474 6 p.

Research output: Contribution to journalArticle

Central Nervous System Neoplasms
DNA Methylation
Neoplasms
Observer Variation
Age Groups