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Dive into the research topics where Pijus Mandal is active. These topic labels come from the works of this person. Together they form a unique fingerprint.
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Structure-Guided Development of NRAS G12D Inhibitors Based on a 5-Azaindole Core
Cox, J. B., Nair, V., Mandal, P., Reyna, N., Tran, T., Mustachio, L. M., Bardenhagen, J., Fawver, J., Shepard, H., Hickey, A. M., Wu, Q., Rodriguez, C., Yu, F., Phan, P., Mendiola, A. J., Johnson, R., Thapar, R., Johnson, T., Jiang, Y. & Cross, J. B. & 6 others, , Feb 12 2026, In: ACS Medicinal Chemistry Letters. 17, 2, p. 425-432 8 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Author Correction: An enolase inhibitor for the targeted treatment of ENO1-deleted cancers (Nature Metabolism, (2020), 2, 12, (1413-1426), 10.1038/s42255-020-00313-3)
Lin, Y. H., Satani, N., Hammoudi, N., Yan, V. C., Barekatain, Y., Khadka, S., Ackroyd, J. J., Georgiou, D. K., Pham, C. D., Arthur, K., Maxwell, D., Peng, Z., Leonard, P. G., Czako, B., Pisaneschi, F., Mandal, P., Sun, Y., Zielinski, R., Pando, S. C. & Wang, X. & 11 others, , Jan 2021, In: Nature Metabolism. 3, 1, p. 122 1 p.Research output: Contribution to journal › Comment/debate › peer-review
Open Access1 Link opens in a new tab Scopus citations -
Discovery of 6-[(3 S,4 S)-4-Amino-3-methyl-2-oxa-8-azaspiro[4.5]decan-8-yl]-3-(2,3-dichlorophenyl)-2-methyl-3,4-dihydropyrimidin-4-one (IACS-15414), a Potent and Orally Bioavailable SHP2 Inhibitor
Czako, B., Sun, Y., McAfoos, T., Cross, J. B., Leonard, P. G., Burke, J. P., Carroll, C. L., Feng, N., Harris, A. L., Jiang, Y., Kang, Z., Kovacs, J. J., Mandal, P., Meyers, B. A., Mseeh, F., Parker, C. A., Yu, S. S., Williams, C. C., Wu, Q. & Di Francesco, M. E. & 5 others, , Oct 28 2021, In: Journal of Medicinal Chemistry. 64, 20, p. 15141-15169 29 p.Research output: Contribution to journal › Article › peer-review
Open Access21 Link opens in a new tab Scopus citations -
Discovery of IACS-9779 and IACS-70465 as Potent Inhibitors Targeting Indoleamine 2,3-Dioxygenase 1 (IDO1) Apoenzyme
Hamilton, M. M., Mseeh, F., McAfoos, T., Leonard, P. G., Reyna, N. J., Harris, A. L., Xu, A., Han, M., Soth, M. J., Czako, B., Theroff, J. P., Mandal, P. K., Burke, J. P., Virgin-Downey, B., Petrocchi, A., Pfaffinger, D., Rogers, N. E., Parker, C. A., Yu, S. S. & Jiang, Y. & 10 others, , Aug 12 2021, In: Journal of Medicinal Chemistry. 64, 15, p. 11302-11329 28 p.Research output: Contribution to journal › Article › peer-review
Open Access27 Link opens in a new tab Scopus citations -
Allosteric SHP2 inhibitor, IACS-13909, overcomes EGFR-dependent and EGFR-independent resistance mechanisms toward osimertinib
Sun, Y., Meyers, B. A., Czako, B., Leonard, P., Mseeh, F., Harris, A. L., Wu, Q., Johnson, S., Parker, C. A., Cross, J. B., Di Francesco, M. E., Bivona, B. J., Bristow, C. A., Burke, J. P., Carrillo, C. C., Carroll, C. L., Chang, Q., Feng, N., Gao, G. & Gera, S. & 25 others, , Nov 1 2020, In: Cancer Research. 80, 21, p. 4840-4853 14 p.Research output: Contribution to journal › Article › peer-review
Open Access76 Link opens in a new tab Scopus citations