If you made any changes in Pure, your changes will be visible here soon.

Research Output 1984 2020

Filter
Article
2020
2 Citations (Scopus)

The WNT receptor ROR2 drives the interaction of multiple myeloma cells with the microenvironment through AKT activation

Frenquelli, M., Caridi, N., Antonini, E., Storti, F., Viganò, V., Gaviraghi, M., Occhionorelli, M., Bianchessi, S., Bongiovanni, L., Spinelli, A., Marcatti, M., Belloni, D., Ferrero, E., Karki, S., Brambilla, P., Martinelli-Boneschi, F., Colla, S., Ponzoni, M., DePinho, R. A. & Tonon, G., Jan 1 2020, In : Leukemia. 34, 1, p. 257-270 14 p.

Research output: Contribution to journalArticle

Cellular Microenvironment
Multiple Myeloma
Bone Marrow
Phosphatidylinositol 3-Kinases
Neoplasms
2019
2 Citations (Scopus)

FoxO1 regulates leptin-induced mood behavior by targeting tyrosine hydroxylase

Son, D. H., Doan, K. V., Yang, D. J., Sun, J. S., Kim, S. K., Kang, N., Kang, J. Y., Paik, J. H., DePinho, R. A., Choi, Y. H., Shin, D. M. & Kim, K. W., Feb 2019, In : Metabolism: clinical and experimental. 91, p. 43-52 10 p.

Research output: Contribution to journalArticle

Tyrosine 3-Monooxygenase
Leptin
STAT3 Transcription Factor
Dopaminergic Neurons
Anti-Anxiety Agents
6 Citations (Scopus)

Functional Genomics Reveals Synthetic Lethality between Phosphogluconate Dehydrogenase and Oxidative Phosphorylation

Sun, Y., Bandi, M., Lofton, T., Smith, M., Bristow, C. A., Carugo, A., Rogers, N., Leonard, P., Chang, Q., Mullinax, R., Han, J., Shi, X., Seth, S., Meyers, B. A., Miller, M., Miao, L., Ma, X., Feng, N., Giuliani, V., Geck Do, M. & 18 others, Czako, B., Palmer, W. S., Mseeh, F., Asara, J. M., Jiang, Y., Morlacchi, P., Zhao, S., Peoples, M., Tieu, T. N., Warmoes, M. O., Lorenzi, P. L., Muller, F. L., DePinho, R. A., Draetta, G. F., Toniatti, C., Jones, P., Heffernan, T. P. & Marszalek, J. R., Jan 8 2019, In : Cell Reports. 26, 2, p. 469-482.e5

Research output: Contribution to journalArticle

Open Access
Phosphogluconate Dehydrogenase
Oxidative Phosphorylation
Genomics
Fumarate Hydratase
Mitochondrial Diseases
18 Citations (Scopus)

KRAS-IRF2 Axis Drives Immune Suppression and Immune Therapy Resistance in Colorectal Cancer

Liao, W., Overman, M. J., Boutin, A. T., Shang, X., Zhao, D., Dey, P., Li, J., Wang, G., Lan, Z., Li, J., Tang, M., Jiang, S., Ma, X., Chen, P., Katkhuda, R., Korphaisarn, K., Chakravarti, D., Chang, A., Spring, D. J., Chang, Q. & 7 others, Zhang, J., Maru, D. M., Maeda, D. Y., Zebala, J. A., Kopetz, S., Wang, Y. A. & DePinho, R. A., Apr 15 2019, In : Cancer cell. 35, 4, p. 559-572.e7

Research output: Contribution to journalArticle

Interferon Regulatory Factor-2
Colorectal Neoplasms
Therapeutics
Tumor Microenvironment
Patient Selection
5 Citations (Scopus)

Symbiotic Macrophage-Glioma Cell Interactions Reveal Synthetic Lethality in PTEN-Null Glioma

Chen, P., Zhao, D., Li, J., Liang, X., Li, J., Chang, A., Henry, V. K., Lan, Z., Spring, D. J., Rao, G., Wang, Y. A. & DePinho, R. A., Jun 10 2019, In : Cancer Cell. 35, 6, p. 868-884.e6

Research output: Contribution to journalArticle

Protein-Lysine 6-Oxidase
Glioma
Cell Communication
Glioblastoma
Macrophages

USP21 deubiquitinase promotes pancreas cancer cell stemness via Wnt pathway activation

Hou, P., Ma, X., Zhang, Q., Wu, C. J., Liao, W., Li, J., Wang, H., Zhao, J., Zhou, X., Guan, C., Ackroyd, J., Jiang, S., Zhang, J., Spring, D. J., Alan Wang, Y. & DePinho, R. A., Oct 1 2019, In : Genes and Development. 33, 19-20, p. 1361-1366 6 p.

Research output: Contribution to journalArticle

Open Access
Wnt Signaling Pathway
Pancreatic Neoplasms
Adenocarcinoma
TCF Transcription Factors
Neoplasms
2018
71 Citations (Scopus)

An inhibitor of oxidative phosphorylation exploits cancer vulnerability

Molina, J. R., Sun, Y., Protopopova, M., Gera, S., Bandi, M., Bristow, C., McAfoos, T., Morlacchi, P., Ackroyd, J., Agip, A. N. A., Al-Atrash, G., Asara, J., Bardenhagen, J., Carrillo, C. C., Carroll, C., Chang, E., Ciurea, S., Cross, J. B., Czako, B., Deem, A. & 46 others, Daver, N., De Groot, J. F., Dong, J. W., Feng, N., Gao, G., Gay, J., Do, M. G., Greer, J., Giuliani, V., Han, J., Han, L., Henry, V. K., Hirst, J., Huang, S., Jiang, Y., Kang, Z., Khor, T., Konoplev, S., Lin, Y. H., Liu, G., Lodi, A., Lofton, T., Ma, H., Mahendra, M., Matre, P., Mullinax, R., Peoples, M., Petrocchi, A., Rodriguez-Canale, J., Serreli, R., Shi, T., Smith, M., Tabe, Y., Theroff, J., Tiziani, S., Xu, Q., Zhang, Q., Muller, F., Depinho, R. A., Toniatti, C., Draetta, G. F., Heffernan, T. P., Konopleva, M., Jones, P., Di Francesco, M. E. & Marszalek, J. R., Jul 1 2018, In : Nature medicine. 24, 7, p. 1036-1046 11 p.

Research output: Contribution to journalArticle

Oxidative Phosphorylation
Tumors
Acute Myeloid Leukemia
Brain Neoplasms
Brain
1 Citation (Scopus)

An in vivo screen identifies PYGO2 as a driver for metastatic prostate cancer

Lu, X., Pan, X., Wu, C. J., Zhao, D., Feng, S., Zang, Y., Lee, R., Khadka, S., Amin, S. B., Jin, E. J., Shang, X., Deng, P., Luo, Y., Morgenlander, W. R., Weinrich, J., Lu, X., Jiang, S., Chang, Q., Navone, N. M., Troncoso, P. & 2 others, DePinho, R. A. & Wang, Y. A., Jul 15 2018, In : Cancer research. 78, 14, p. 3823-3833 11 p.

Research output: Contribution to journalArticle

Prostatic Neoplasms
Oncogenes
Neoplasm Metastasis
Biomarkers
Lymph Nodes
10 Citations (Scopus)

FoxO3 an important player in fibrogenesis and therapeutic target for idiopathic pulmonary fibrosis

Al-Tamari, H. M., Dabral, S., Schmall, A., Sarvari, P., Ruppert, C., Paik, J., DePinho, R. A., Grimminger, F., Eickelberg, O., Guenther, A., Seeger, W., Savai, R. & Pullamsetti, S. S., Feb 1 2018, In : EMBO Molecular Medicine. 10, 2, p. 276-293 18 p.

Research output: Contribution to journalArticle

Idiopathic Pulmonary Fibrosis
Fibroblasts
Lung
Bleomycin
Fibrosis
15 Citations (Scopus)

FoxO Function Is Essential for Maintenance of Autophagic Flux and Neuronal Morphogenesis in Adult Neurogenesis

Schäffner, I., Minakaki, G., Khan, M. A., Balta, E. A., Schlötzer-Schrehardt, U., Schwarz, T. J., Beckervordersandforth, R., Winner, B., Webb, A. E., DePinho, R. A., Paik, J., Wurst, W., Klucken, J. & Lie, D. C., Sep 19 2018, In : Neuron. 99, 6, p. 1188-1203.e6

Research output: Contribution to journalArticle

Neurogenesis
Morphogenesis
Maintenance
Autophagy
Neurons
4 Citations (Scopus)

STAT3 inhibition combined with CpG immunostimulation activates antitumor immunity to eradicate genetically distinct castration-resistant prostate cancers

Moreira, D., Adamus, T., Zhao, X., Su, Y. L., Zhang, Z., White, S. V., Swiderski, P., Lu, X., DePinho, R. A., Pal, S. K. & Kortylewski, M., Dec 1 2018, In : Clinical Cancer Research. 24, 23, p. 5948-5962 15 p.

Research output: Contribution to journalArticle

Castration
Toll-Like Receptor 9
Immunity
Immunization
Prostatic Neoplasms
3 Citations (Scopus)

SUMOylation of ROR-γt inhibits IL-17 expression and inflammation via HDAC2

Singh, A. K., Khare, P., Obaid, A., Conlon, K. P., Basrur, V., DePinho, R. A. & Venuprasad, K., Oct 30 2018, In : Nature communications. 9, 1, 1 p.

Research output: Contribution to journalArticle

Sumoylation
Interleukin-17
Inflammation
mice
disorders
2017
1 Citation (Scopus)

A tumor vessel-targeting fusion protein elicits a chemotherapeutic bystander effect in pancreatic ductal adenocarcinoma

Chen, C. T., Chen, Y. C., Du, Y., Han, Z., Ying, H., Bouchard, R. R., Hsu, J. L., Hsu, J. M., Mitcham, T. M., Chen, M. K., Sun, H. L., Chang, S. S., Li, D., Chang, P., DePinho, R. A. & Hung, M. C., Jan 1 2017, In : American Journal of Cancer Research. 7, 3, p. 657-672 16 p.

Research output: Contribution to journalArticle

Bystander Effect
Protein Transport
Adenocarcinoma
Flucytosine
Neoplasms
111 Citations (Scopus)

Effective combinatorial immunotherapy for castration-resistant prostate cancer

Lu, X., Horner, J. W., Paul, E., Shang, X., Troncoso, P., Deng, P., Jiang, S., Chang, Q., Spring, D. J., Sharma, P., Zebala, J. A., Maeda, D. Y., Wang, Y. A. & DePinho, R. A., Mar 30 2017, In : Nature. 543, 7647, p. 728-732 5 p.

Research output: Contribution to journalArticle

Castration
Immunotherapy
Prostatic Neoplasms
Cytotoxic T-Lymphocytes
Cell- and Tissue-Based Therapy
69 Citations (Scopus)

Genomic deletion of malic enzyme 2 confers collateral lethality in pancreatic cancer

Dey, P., Baddour, J., Muller, F., Wu, C. C., Wang, H., Liao, W. T., Lan, Z., Chen, A., Gutschner, T., Kang, Y., Fleming, J., Satani, N., Zhao, D., Achreja, A., Yang, L., Lee, J., Chang, E., Genovese, G., Viale, A., Ying, H. & 5 others, Draetta, G., Maitra, A., Wang, Y. A., Nagrath, D. & Depinho, R. A., Feb 2 2017, In : Nature. 542, 7639, p. 119-123 5 p.

Research output: Contribution to journalArticle

Pancreatic Neoplasms
Enzymes
NADP
Reactive Oxygen Species
Adenocarcinoma
31 Citations (Scopus)

ILF2 Is a Regulator of RNA Splicing and DNA Damage Response in 1q21-Amplified Multiple Myeloma

Marchesini, M., Ogoti, Y., Fiorini, E., Aktas Samur, A., Nezi, L., D'Anca, M., Storti, P., Samur, M. K., Ganan Gomez, I., Fulciniti, M. T., Mistry, N., Jiang, S., Bao, N., Marchica, V., Neri, A., Bueso-Ramos, C. E., Wu, C. J., Zhang, L., Liang, H., Peng, X. & 9 others, Giuliani, N., Draetta, G., Dwyer, K. C., Kantarjian, H. M., Munshi, N., Orlowski, R., Garcia-Manero, G., DePinho, R. A. & Colla, S., Jul 10 2017, In : Cancer cell. 32, 1, p. 88-100.e6

Research output: Contribution to journalArticle

RNA Splicing
Multiple Myeloma
DNA Damage
Disease Resistance
Genomic Instability
20 Citations (Scopus)

Loss of FOXO1 cooperates with TMPRSS2–ERG overexpression to promote prostate tumorigenesis and cell invasion

Yang, Y., Blee, A. M., Wang, D., An, J., Pan, Y., Yan, Y., Ma, T., He, Y., Dugdale, J., Hou, X., Zhang, J., Weroha, S. J., Zhu, W. G., Wang, Y. A., DePinho, R. A., Xu, W. & Huang, H., Dec 1 2017, In : Cancer research. 77, 23, p. 6524-6537 14 p.

Research output: Contribution to journalArticle

Prostate
Prostatic Neoplasms
Carcinogenesis
Transgenes
Prostatic Intraepithelial Neoplasia
20 Citations (Scopus)

Mutant Kras- and p16-regulated NOX4 activation overcomes metabolic checkpoints in development of pancreatic ductal adenocarcinoma

Ju, H. Q., Ying, H., Tian, T., Ling, J., Fu, J., Lu, Y., Wu, M., Yang, L., Achreja, A., Chen, G., Zhuang, Z., Wang, H., Nagrath, D., Yao, J., Hung, M. C., DePinho, R. A., Huang, P., Xu, R. H. & Chiao, P. J., Feb 24 2017, In : Nature communications. 8, 14437.

Research output: Contribution to journalArticle

Adenocarcinoma
Chemical activation
activation
NAD
deactivation
35 Citations (Scopus)

Oncogenic Kras drives invasion and maintains metastases in colorectal cancer

Boutin, A. T., Liao, W. T., Wang, M., Hwang, S. S., Karpinets, T. V., Cheung, H., Chu, G. C., Jiang, S., Hu, J., Chang, K., Vilar, E., Song, X., Zhang, J., Kopetz, S., Futreal, A., Wang, Y. A., Kwong, L. N. & DePinho, R. A., Feb 15 2017, In : Genes and Development. 31, 4, p. 370-382 13 p.

Research output: Contribution to journalArticle

Colorectal Neoplasms
Neoplasm Metastasis
Alleles
Neoplasms
Exome
9 Citations (Scopus)

Opposing roles of TGFβ and BMP signaling in prostate cancer development

Lu, X., Jin, E. J., Cheng, X., Feng, S., Shang, X., Deng, P., Jiang, S., Chang, Q., Rahmy, S., Chaudhary, S., Lu, X., Zhao, R., Wang, Y. A. & Depinho, R. A., Dec 1 2017, In : Genes and Development. 31, 23-24, p. 2337-2342 6 p.

Research output: Contribution to journalArticle

Bone Morphogenetic Proteins
Transforming Growth Factors
Prostatic Neoplasms
Type II Bone Morphogenetic Protein Receptors
Growth Factor Receptors
4 Citations (Scopus)

PAF promotes stemness and radioresistance of glioma stem cells

Ong, D. S. T., Hu, B., Ho, Y. W., Sauvé, C. E. G., Bristow, C. A., Wang, Q., Multani, A. S., Chen, P., Nezi, L., Jiang, S., Gorman, C. E., Monasterio, M. M., Koul, D., Marchesini, M., Colla, S., Jin, E. J., Sulman, E. P., Spring, D. J., Yung, W. K. A., Verhaak, R. G. W. & 3 others, Chin, L., Wang, Y. A. & DePinho, R. A., Oct 24 2017, In : Proceedings of the National Academy of Sciences of the United States of America. 114, 43, p. E9085-E9095

Research output: Contribution to journalArticle

Proliferating Cell Nuclear Antigen
Glioma
Stem Cells
Glioblastoma
DNA Replication
15 Citations (Scopus)

PRKCI promotes immune suppression in ovarian cancer

Sarkar, S., Bristow, C. A., Dey, P., Rai, K., Perets, R., Ramirez-Cardenas, A., Malasi, S., Huang-Hobbs, E., Haemmerle, M., Wu, S. Y., McGuire, M., Protopopov, A., Jiang, S., Liu, J. F., Hirsch, M. S., Chang, Q., Lazar, A. J., Sood, A. K., Drapkin, R., DePinho, R. & 2 others, Draetta, G. & Chin, L., Jan 1 2017, In : Genes and Development. 31, 11, p. 1109-1121 13 p.

Research output: Contribution to journalArticle

Ovarian Neoplasms
T-Lymphocytes
Tumor Microenvironment
Fallopian Tubes
Carcinoma in Situ
62 Citations (Scopus)

Synthetic essentiality of chromatin remodelling factor CHD1 in PTEN-deficient cancer

Zhao, D., Lu, X., Wang, G., Lan, Z., Liao, W., Li, J., Liang, X., Chen, J. R., Shah, S., Shang, X., Tang, M., Deng, P., Dey, P., Chakravarti, D., Chen, P., Spring, D. J., Navone, N. M., Troncoso, P., Zhang, J., Wang, Y. A. & 1 others, DePinho, R. A., Feb 23 2017, In : Nature. 542, 7642, p. 484-488 5 p.

Research output: Contribution to journalArticle

Chromatin Assembly and Disassembly
Neoplasms
Synthetic Genes
Essential Genes
Histone Code
30 Citations (Scopus)

Synthetic vulnerabilities of mesenchymal subpopulations in pancreatic cancer

Genovese, G., Carugo, A., Tepper, J., Robinson, F. S., Li, L-R., Svelto, M., Nezi, L., Corti, D., Minelli, R., Pettazzoni, P., Gutschner, T., Wu, C. C., Seth, S., Akdemir, K. C., Leo, E., Amin, S., Molin, M. D., Ying, H., Kwong, L., Colla, S. & 23 others, Takahashi, K., Ghosh, P., Giuliani, V., Muller, F., Dey, P., Jiang, S., Garvey, J., Liu, C-G., Zhang, J., Heffernan, T. P., Toniatti, C., Fleming, J. B., Goggins, M. G., Wood, L. D., Sgambato, A., Agaimy, A., Maitra, A., Roberts, C. W. M., Wang, H., Viale, A., DePinho, R. A., Draetta, G. & Chin, L., Feb 16 2017, In : Nature. 542, 7641, p. 362-366 5 p.

Research output: Contribution to journalArticle

Pancreatic Neoplasms
Adenocarcinoma
Endoplasmic Reticulum Stress
Neoplasms
Unfolded Protein Response
182 Citations (Scopus)

Tumor Evolution of Glioma-Intrinsic Gene Expression Subtypes Associates with Immunological Changes in the Microenvironment

Wang, Q., Hu, B., Hu, X., Kim, H., Squatrito, M., Scarpace, L., deCarvalho, A. C., Lyu, S., Li, P., Li, Y., Barthel, F., Cho, H. J., Lin, Y. H., Satani, N., Martinez-Ledesma, E., Zheng, S., Chang, E., Sauvé, C. E. G., Olar, A., Lan, Z. D. & 14 others, Finocchiaro, G., Phillips, J. J., Berger, M. S., Gabrusiewicz, K. R., Wang, G., Eskilsson, E., Hu, J., Mikkelsen, T., DePinho, R. A., Muller, F., Heimberger, A. B., Sulman, E. P., Nam, D. H. & Verhaak, R. G. W., Jul 10 2017, In : Cancer cell. 32, 1, p. 42-56.e6

Research output: Contribution to journalArticle

Glioma
Microglia
Macrophages
Gene Expression
Tumor Microenvironment
2016
4 Citations (Scopus)

Cancer moonshot countdown

Lowy, D., Singer, D., Depinho, R., Simon, G. C. & Soon-Shiong, P., Jun 9 2016, In : Nature biotechnology. 34, 6, p. 596-599 4 p.

Research output: Contribution to journalArticle

78 Citations (Scopus)

Epigenetic Activation of WNT5A Drives Glioblastoma Stem Cell Differentiation and Invasive Growth

Hu, B., Wang, Q., Wang, Y. A., Hua, S., Sauvé, C. E. G., Ong, D., Lan, Z. D., Chang, Q., Ho, Y. W., Monasterio, M. M., Lu, X., Zhong, Y., Zhang, J., Deng, P., Tan, Z., Wang, G., Liao, W. T., Corley, L. J., Yan, H., Zhang, J. & 13 others, You, Y., Liu, N., Cai, L., Finocchiaro, G., Phillips, J. J., Berger, M. S., Spring, D. J., Hu, J., Sulman, E. P., Fuller, G. N., Chin, L., Verhaak, R. G. W. & DePinho, R. A., Nov 17 2016, In : Cell. 167, 5, p. 1281-1295.e18

Research output: Contribution to journalArticle

Glioblastoma
Stem cells
Epigenomics
Cell Differentiation
Stem Cells
14 Citations (Scopus)

FoxO1 in dopaminergic neurons regulates energy homeostasis and targets tyrosine hydroxylase

Doan, K. V., Kinyua, A. W., Yang, D. J., Ko, C. M., Moh, S. H., Shong, K. E., Kim, H., Park, S. K., Kim, D. H., Kim, I., Paik, J. H., Depinho, R. A., Yoon, S. G., Kim, I. Y., Seong, J. K., Choi, Y. H. & Kim, K. W., Sep 29 2016, In : Nature communications. 7, 12733.

Research output: Contribution to journalArticle

homeostasis
tyrosine
Dopaminergic Neurons
Tyrosine 3-Monooxygenase
neurons
34 Citations (Scopus)

In Vivo Functional Platform Targeting Patient-Derived Xenografts Identifies WDR5-Myc Association as a Critical Determinant of Pancreatic Cancer

Carugo, A., Genovese, G., Seth, S., Nezi, L., Rose, J. L., Bossi, D., Cicalese, A., Shah, P. K., Viale, A., Pettazzoni, P. F., Akdemir, K. C., Bristow, C. A., Robinson, F. S., Tepper, J., Sanchez, N., Gupta, S., Estecio, M. R., Giuliani, V., Dellino, G. I., Riva, L. & 16 others, Yao, W., Di Francesco, M. E., Green, T., D'Alesio, C., Corti, D., Kang, Y., Jones, P., Wang, H., Fleming, J. B., Maitra, A., Pelicci, P. G., Chin, L., DePinho, R. A., Lanfrancone, L., Heffernan, T. P. & Draetta, G. F., Jun 1 2016, In : Cell Reports. 16, 1, p. 133-147 15 p.

Research output: Contribution to journalArticle

Pancreatic Neoplasms
Heterografts
Tumors
Adenocarcinoma
Methyltransferases

Pillars Article: A Functional T3 Molecule Associated with a Novel Heterodimer on the Surface of Immature Human Thymocytes. Nature. 1986. 322: 179-181

Bank, I., DePinho, R. A., Brenner, M. B., Cassimeris, J., Alt, F. W. & Chess, L., May 1 2016, In : Journal of immunology (Baltimore, Md. : 1950). 196, 9, p. 3514-3516 3 p.

Research output: Contribution to journalArticle

Thymocytes
22 Citations (Scopus)

SF2312 is a natural phosphonate inhibitor of enolase

Leonard, P. G., Satani, N., Maxwell, D., Lin, Y. H., Hammoudi, N., Peng, Z., Pisaneschi, F., Link, T. M., Lee, G. R., Sun, D., Prasad, B. A. B., Di Francesco, M. E., Czako, B., Asara, J. M., Wang, Y. A., Bornmann, W., Depinho, R. A. & Muller, F. L., Dec 1 2016, In : Nature Chemical Biology. 12, 12, p. 1053-1058 6 p.

Research output: Contribution to journalArticle

Organophosphonates
Phosphopyruvate Hydratase
Micromonospora
Anti-Bacterial Agents
Actinobacteria
123 Citations (Scopus)

Targeting YAP-dependent MDSC infiltration impairs tumor progression

Wang, G., Lu, X., Dey, P., Deng, P., Wu, C. C., Jiang, S., Fang, Z., Zhao, K., Konaparthi, R., Hua, S., Zhang, J., Li-Ni-Ngtapia, E. M., Kapoor, A., Wu, C. J., Patel, N. B., Guo, Z., Ramamoorthy, V., Tieu, T. N., Heffernan, T., Zhao, D. & 17 others, Shang, X., Khadka, S., Hou, P., Hu, B., Jin, E. J., Yao, W., Pan, X., Ding, Z., Shi, Y., Li, L., Chang, Q., Troncoso, P., Logothetis, C. J., McArthur, M. J., Chin, L., Alan Wang, Y. & Depinho, R. A., Jan 2016, In : Cancer discovery. 6, 1, p. 80-95 16 p.

Research output: Contribution to journalArticle

Neoplasms
Prostate
Prostatic Neoplasms
Up-Regulation
Myeloid-Derived Suppressor Cells
2015
80 Citations (Scopus)

FoxO1 integrates direct and indirect effects of insulin on hepatic glucose production and glucose utilization

O-Sullivan, I., Zhang, W., Wasserman, D. H., Liew, C. W., Liu, J., Paik, J., Depinho, R. A., Stolz, D. B., Kahn, C. R., Schwartz, M. W. & Unterman, T. G., May 12 2015, In : Nature communications. 6, 7079.

Research output: Contribution to journalArticle

insulin
glucose
Insulin
Glucose
Liver
37 Citations (Scopus)

Genetic events that limit the efficacy of MEK and RTK inhibitor therapies in a mouse model of KRAS-driven pancreatic cancer

Pettazzoni, P., Viale, A., Shah, P., Carugo, A., Ying, H., Wang, H., Genovese, G., Seth, S., Minelli, R., Green, T., Huang-Hobbs, E., Corti, D., Sanchez, N., Nezi, L., Marchesini, M., Kapoor, A., Yao, W., Di Francesco, M. E., Petrocchi, A., Deem, A. K. & 9 others, Scott, K., Colla, S., Mills, G. B., Fleming, J. B., Heffernan, T. P., Jones, P., Toniatti, C., Depinho, R. A. & Draetta, G. F., Mar 15 2015, In : Cancer research. 75, 6, p. 1091-1101 11 p.

Research output: Contribution to journalArticle

Mitogen-Activated Protein Kinase Kinases
Receptor Protein-Tyrosine Kinases
Pancreatic Neoplasms
Adenocarcinoma
Apoptosis
12 Citations (Scopus)

MAPRE1 as a plasma biomarker for early-stage colorectal cancer and adenomas

Taguchi, A., Rho, J. H., Yan, Q., Zhang, Y., Zhao, Y., Xu, H., Tripathi, S. C., Wang, H., Brenner, D. E., Kucherlapati, M., Kucherlapati, R., Boutin, A. T., Wang, Y. A., DePinho, R. A., Feng, Z., Lampe, P. D. & Hanash, S. M., Nov 2015, In : Cancer Prevention Research. 8, 11, p. 1112-1119 8 p.

Research output: Contribution to journalArticle

Adenoma
Colorectal Neoplasms
Biomarkers
Carcinoembryonic Antigen
Early Detection of Cancer
92 Citations (Scopus)

Metabolite profiling stratifies pancreatic ductal adenocarcinomas into subtypes with distinct sensitivities to metabolic inhibitors

Daemen, A., Peterson, D., Sahu, N., McCord, R., Du, X., Liu, B., Kowanetz, K., Hong, R., Moffat, J., Gao, M., Boudreau, A., Mroue, R., Corson, L., O'Brien, T., Qing, J., Sampath, D., Merchant, M., Yauch, R., Manning, G., Settleman, J. & 3 others, Hatzivassiliou, G., Evangelista, M. & DePinho, R. A., Aug 11 2015, In : Proceedings of the National Academy of Sciences of the United States of America. 112, 32, p. E4410-E4417

Research output: Contribution to journalArticle

Adenocarcinoma
Glycolysis
Glutamine
Oxidation-Reduction
Neoplasms
193 Citations (Scopus)

Regulation of autophagy and the ubiquitin-proteasome system by the FoxO transcriptional network during muscle atrophy

Milan, G., Romanello, V., Pescatore, F., Armani, A., Paik, J. H., Frasson, L., Seydel, A., Zhao, J., Abraham, R., Goldberg, A. L., Blaauw, B., DePinho, R. A. & Sandri, M., Apr 10 2015, In : Nature communications. 6, 7670.

Research output: Contribution to journalArticle

atrophy
Muscular Atrophy
Gene Regulatory Networks
Autophagy
Proteasome Endopeptidase Complex
52 Citations (Scopus)

Telomere Dysfunction Drives Aberrant Hematopoietic Differentiation and Myelodysplastic Syndrome

Colla, S., Ong, D. S. T., Ogoti, Y., Marchesini, M., Mistry, N. A., Clise-Dwyer, K., Ang, S. A., Storti, P., Viale, A., Giuliani, N., Ruisaard, K., Ganan Gomez, I., Bristow, C. A., Estecio, M., Weksberg, D. C., Ho, Y. W., Hu, B., Genovese, G., Pettazzoni, P., Multani, A. S. & 22 others, Jiang, S., Hua, S., Ryan, M. C., Carugo, A., Nezi, L., Wei, Y., Yang, H., D'Anca, M., Zhang, L., Gaddis, S., Gong, T., Horner, J. W., Heffernan, T. P., Jones, P., Cooper, L. J. N., Liang, H., Kantarjian, H., Wang, Y. A., Chin, L., Bueso-Ramos, C., Garcia-Manero, G. & DePinho, R. A., May 11 2015, In : Cancer cell. 27, 5, p. 644-657 14 p.

Research output: Contribution to journalArticle

Myelodysplastic Syndromes
Telomere
Myeloid Progenitor Cells
DNA Damage
Histone Code
2014
4 Citations (Scopus)

Cancer signaling: When phosphorylation meets methylation

Ying, H. & DePinho, R. A., Nov 5 2014, In : Cell research. 24, 11, p. 1282-1283 2 p.

Research output: Contribution to journalArticle

Methylation
Phosphorylation
Lysine
Neoplasms
Phosphotransferases
43 Citations (Scopus)

MTORC1 promotes denervation-induced muscle atrophy through a mechanism involving the activation of FoxO and E3 ubiquitin ligases

Tang, H., Inoki, K., Lee, M., Wright, E., Khuong, A., Khuong, A., Sugiarto, S., Garner, M., Paik, J., DePinho, R. A., Goldman, D., Guan, K. L. & Shrager, J. B., Feb 25 2014, In : Science Signaling. 7, 314

Research output: Contribution to journalArticle

Ubiquitin-Protein Ligases
Muscular Atrophy
Denervation
Muscle
Chemical activation
55 Citations (Scopus)

Neuroplastic changes occur early in the development of pancreatic ductal adenocarcinoma

Stopczynski, R. E., Normolle, D. P., Hartman, D. J., Ying, H., DeBerry, J. J., Bielefeldt, K., Rhim, A. D., DePinho, R. A., Albers, K. M. & Davis, B. M., Mar 15 2014, In : Cancer research. 74, 6, p. 1718-1727 10 p.

Research output: Contribution to journalArticle

Adenocarcinoma
Neoplasms
Neurogenic Inflammation
Sensory Ganglia
Inflammation
441 Citations (Scopus)

Oncogene ablation-resistant pancreatic cancer cells depend on mitochondrial function

Viale, A., Pettazzoni, P., Lyssiotis, C. A., Ying, H., Sánchez, N., Marchesini, M., Carugo, A., Green, T., Seth, S., Giuliani, V., Kost-Alimova, M., Muller, F., Colla, S., Nezi, L., Genovese, G., Deem, A. K., Kapoor, A., Yao, W., Brunetto, E., Kang, Y. & 10 others, Yuan, M., Asara, J. M., Wang, Y. A., Heffernan, T. P., Kimmelman, A. C., Wang, H., Fleming, J. B., Cantley, L. C., DePinho, R. A. & Draetta, G. F., Oct 30 2014, In : Nature. 514, 7524, p. 628-632 5 p.

Research output: Contribution to journalArticle

Pancreatic Neoplasms
Oncogenes
Neoplasms
Adenocarcinoma
Oxidative Phosphorylation
57 Citations (Scopus)

Prolyl hydroxylation by EglN2 destabilizes FOXO3a by blocking its interaction with the USP9x deubiquitinase

Zheng, X., Zhai, B., Koivunen, P., Shin, S. J., Lu, G., Liu, J., Geisen, C., Chakraborty, A. A., Moslehi, J. J., Smalley, D. M., Wei, X., Chen, X., Chen, Z., Beres, J. M., Zhang, J., Tsao, J. L., Brenner, M. C., Zhang, Y., Fan, C., DePinho, R. A. & 4 others, Paik, J., Gygi, S. P., Kaelin, W. G. & Zhang, Q., Jul 1 2014, In : Genes and Development. 28, 13, p. 1429-1444 16 p.

Research output: Contribution to journalArticle

Cyclin D1
Hydroxylation
Transcription Factors
Prolyl Hydroxylases
Down-Regulation
1 Citation (Scopus)

Telomere dysfunction suppresses multiple endocrine Neoplasia in mice

Lee, J. H., Anver, M., Kost-Alimova, M., Protopopov, A., Depinho, R. A. & Rane, S. G., Jan 1 2014, In : Genes and Cancer. 5, 9-10, p. 306-319 14 p.

Research output: Contribution to journalArticle

Multiple Endocrine Neoplasia
Telomere
Telomerase
Pituitary Neoplasms
Fibroblasts
289 Citations (Scopus)

Yap1 activation enables bypass of oncogenic KRAS addiction in pancreatic cancer

Kapoor, A., Yao, W., Ying, H., Hua, S., Liewen, A., Wang, Q., Zhong, Y., Wu, C. J., Sadanandam, A., Hu, B., Chang, Q., Chu, G. C., Al-Khalil, R., Jiang, S., Xia, H., Fletcher-Sananikone, E., Lim, C., Horwitz, G. I., Viale, A., Pettazzoni, P. & 10 others, Sanchez, N., Wang, H., Protopopov, A., Zhang, J., Heffernan, T., Johnson, R. L., Chin, L., Wang, Y. A., Draetta, G. & Depinho, R. A., Jul 3 2014, In : Cell. 158, 1, p. 185-197 13 p.

Research output: Contribution to journalArticle

Pancreatic Neoplasms
Tumors
Adenocarcinoma
Chemical activation
E2F Transcription Factors
2013
14 Citations (Scopus)

Activation of FoxO3a/Bim axis in patients with Primary Biliary Cirrhosis

Kopycinska, J., Kempińska-Podhorodecka, A., Haas, T., Elias, E., Depinho, R. A., Paik, J., Milkiewicz, P. & Milkiewicz, M., Feb 1 2013, In : Liver International. 33, 2, p. 231-238 8 p.

Research output: Contribution to journalArticle

Biliary Liver Cirrhosis
Liver
Sclerosing Cholangitis
Alcoholic Liver Diseases
Caspase 3
122 Citations (Scopus)

Adiponectin regulates bone mass via opposite central and peripheral mechanisms through foxo1

Kajimura, D., Lee, H. W., Riley, K. J., Arteaga-Solis, E., Ferron, M., Zhou, B., Clarke, C. J., Hannun, Y. A., DePinho, R. A., Guo, E. X., Mann, J. J. & Karsenty, G., Jun 4 2013, In : Cell Metabolism. 17, 6, p. 901-915 15 p.

Research output: Contribution to journalArticle

Adiponectin
Bone and Bones
Osteocalcin
Osteoblasts
Phosphatidylinositol 3-Kinases
48 Citations (Scopus)
Gluconeogenesis
gluconeogenesis
glycolysis
Glycolysis
Metabolism
18 Citations (Scopus)

Distinct requirements for Sin3a in perinatal male gonocytes and differentiating spermatogonia

Gallagher, S. J., Kofman, A. E., Huszar, J. M., Dannenberg, J. H., DePinho, R. A., Braun, R. E. & Payne, C. J., Jan 1 2013, In : Developmental Biology. 373, 1, p. 83-94 12 p.

Research output: Contribution to journalArticle

Spermatogonia
Tretinoin
Germ Cells
Testis
Maintenance
29 Citations (Scopus)

Endothelial FoxO1 is an intrinsic regulator of thrombospondin 1 expression that restrains angiogenesis in ischemic muscle

Roudier, E., Milkiewicz, M., Birot, O., Slopack, D., Montelius, A., Gustafsson, T., Paik, J. H., DePinho, R. A., Casale, G. P., Pipinos, I. I. & Haas, T. L., Oct 1 2013, In : Angiogenesis. 16, 4, p. 759-772 14 p.

Research output: Contribution to journalArticle

Thrombospondin 1
Muscle
Forkhead Transcription Factors
Endothelial cells
Muscles