• 6767 Bertner Ave, Mitchell Basic Science Research Building

    77030 Houston

    United States

  • 1153 Citations
  • 15 h-Index
19962019
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Research Output 1996 2019

  • 1153 Citations
  • 15 h-Index
  • 21 Article
  • 1 Review article
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Article
2019
1 Citation (Scopus)

Creating novel translation inhibitors to target pro-survival proteins in chronic lymphocytic leukemia

Chen, R., Zhu, M., Chaudhari, R. R., Robles, O., Chen, Y., Skillern, W., Qin, Q., Wierda, W. G., Zhang, S., Hull, K. G., Romo, D. & Plunkett, W., Jul 1 2019, In : Leukemia. 33, 7, p. 1663-1674 12 p.

Research output: Contribution to journalArticle

B-Cell Chronic Lymphocytic Leukemia
Survival
Proteins
Blood Proteins
Apoptosis
2016
12 Citations (Scopus)

Derivatization of agelastatin A leading to bioactive analogs and a trifunctional probe

Jouanneau, M., McClary, B., Reyes, J. C. P., Chen, R., Chen, Y., Plunkett Jr, W. K., Cheng, X., Milinichik, A. Z., Albone, E. F., Liu, J. O. & Romo, D., Apr 15 2016, In : Bioorganic and Medicinal Chemistry Letters. 26, 8, p. 2092-2097 6 p.

Research output: Contribution to journalArticle

Squamous Cell Carcinoma
T-cells
Diazomethane
Derivatives
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
2015
20 Citations (Scopus)

Up-regulation of CDK9 kinase activity and Mcl-1 stability contributes to the acquired resistance to cyclin-dependent kinase inhibitors in leukemia

Yeh, Y. Y., Chen, R., Hessler, J., Mahoney, E., Lehman, A. M., Heerema, N. A., Grever, M. R., Plunkett, W., Byrd, J. C. & Johnson, A. J., Jan 1 2015, In : Oncotarget. 6, 5, p. 2667-2679 13 p.

Research output: Contribution to journalArticle

alvocidib
Cyclin-Dependent Kinase 9
Cyclin-Dependent Kinases
Leukemia
Up-Regulation
2014
17 Citations (Scopus)

Intra-tumoral heterogeneity of gemcitabine delivery and mass transport in human pancreatic cancer

Koay, E. J., Baio, F. E., Ondari, A., Truty, M. J., Cristini, V., Thomas, R. M., Chen, R., Chatterjee, D., Kang, Y., Zhang, J., Court, L. E., Bhosale, P. R., Tamm, E. P., Qayyum, A., Crane, C. H., Javle, M., Katz, M. H., Gottumukkala, V., Rozner, M. A., Shen, H. & 10 others, Lee, J. E., Wang, H., Chen, Y., Plunkett Jr, W. K., Abbruzzese, J. L., Wolff, R. A., Maitra, A., Ferrari, M., Varadhachary, G. R. & Fleming, J. B., Dec 1 2014, In : Physical Biology. 11, 6, 065002.

Research output: Contribution to journalArticle

gemcitabine
Pancreatic Neoplasms
Neoplasms
Tomography
DNA
91 Citations (Scopus)

Transport properties of pancreatic cancer describe gemcitabine delivery and response

Koay, E. J., Truty, M. J., Cristini, V., Thomas, R. M., Chen, R., Chatterjee, D., Kang, YAA., Bhosale, P. R., Tamm, E. P., Crane, C. H., Javle, M., Katz, M. H., Gottumukkala, V. N., Rozner, M. A., Shen, H., Lee, J. E., Wang, H., Chen, Y., Plunkett, W., Abbruzzese, J. L. & 4 others, Wolff, R. A., Varadhachary, G. R., Ferrari, M. & Fleming, J. B., Apr 1 2014, In : Journal of Clinical Investigation. 124, 4, p. 1525-1536 12 p.

Research output: Contribution to journalArticle

gemcitabine
Pancreatic Neoplasms
Adenocarcinoma
Neoplasms
DNA
2012
22 Citations (Scopus)

MRx102, a triptolide derivative, has potent antileukemic activity in vitro and in a murine model of AML

Carter, B. Z., Mak, D. H., Shi, Y., Fidler, J. M., Chen, R., Ling, X., Plunkett Jr, W. K. & Andreeff, M., Mar 1 2012, In : Leukemia. 26, 3, p. 443-450 8 p.

Research output: Contribution to journalArticle

Acute Myeloid Leukemia
Stem Cells
Apoptosis
Myeloid Cells
Tripterygium
3 Citations (Scopus)

Multiple kinase pathways involved in the different de novo sensitivity of pancreatic cancer cell lines to 17-AAG

Liu, H., Zhang, T., Chen, R., McConkey, D. J., Ward, J. F. & Curley, S. A., Jul 1 2012, In : Journal of Surgical Research. 176, 1, p. 147-153 7 p.

Research output: Contribution to journalArticle

tanespimycin
Pancreatic Neoplasms
Phosphotransferases
Cell Line
P-Glycoprotein
2011
54 Citations (Scopus)

Homoharringtonine reduced Mcl-1 expression and induced apoptosis in chronic lymphocytic leukemia

Chen, R., Guo, L., Chen, Y., Jiang, Y., Wierda, W. G. & Plunkett, W., Jan 6 2011, In : Blood. 117, 1, p. 156-164 9 p.

Research output: Contribution to journalArticle

Myeloid Leukemia
Myeloid Cells
B-Cell Chronic Lymphocytic Leukemia
Apoptosis
Transcription
7 Citations (Scopus)

Killing of chronic lymphocytic leukemia by the combination of fludarabine and oxaliplatin is dependent on the activity of XPF endonuclease

Zecevic, A., Sampath, D., Ewald, B., Chen, R., Wierda, W. G. & Plunkett Jr, W. K., Jul 15 2011, In : Clinical Cancer Research. 17, 14, p. 4731-4741 11 p.

Research output: Contribution to journalArticle

oxaliplatin
Endonucleases
B-Cell Chronic Lymphocytic Leukemia
DNA Repair
Single-Stranded DNA Breaks
2010
125 Citations (Scopus)

Phase I and pharmacologic study of SNS-032, a potent and selective Cdk2, 7, and 9 inhibitor, in patients with advanced chronic lymphocytic leukemia and multiple myeloma

Tong, W. G., Chen, R., Plunkett Jr, W. K., Siegel, D., Sinha, R., Harvey, R. D., Badros, A. Z., Popplewell, L., Coutre, S., Fox, J. A., Mahadocon, K., Chen, T., Kegley, P., Hoch, U. & Wierda, W. G., Jun 20 2010, In : Journal of Clinical Oncology. 28, 18, p. 3015-3022 8 p.

Research output: Contribution to journalArticle

B-Cell Chronic Lymphocytic Leukemia
Multiple Myeloma
Maximum Tolerated Dose
Cyclin-Dependent Kinase 9
Biomarkers
21 Citations (Scopus)

Responses in mantle cell lymphoma cells to SNS-032 depend on the biological context of each cell line

Chen, R., Chubb, S., Cheng, T., Hawtin, R. E., Gandhi, V. V. & Plunkett Jr, W. K., Aug 15 2010, In : Cancer research. 70, 16, p. 6587-6597 11 p.

Research output: Contribution to journalArticle

Mantle-Cell Lymphoma
Cell Line
Cyclin D1
Apoptosis
Cyclin-Dependent Kinase 9
2009
208 Citations (Scopus)

Diverse marrow stromal cells protect CLL cells from spontaneous and drug-induced apoptosis: Development of a reliable and reproducible system to assess stromal cell adhesion-mediated drug resistance

Kurtova, A. V., Balakrishnan, K., Chen, R., Ding, W., Schnabl, S., Quiroga, M. P., Sivina, M., Wierda, W. G., Estrov, Z., Keating, M. J., Shehata, M., Jäger, U., Gandhi, V., Kay, N. E., Plunkett, W. & Burger, J. A., Nov 12 2009, In : Blood. 114, 20, p. 4441-4450 10 p.

Research output: Contribution to journalArticle

Cell adhesion
B-Cell Chronic Lymphocytic Leukemia
Stromal Cells
Drug Resistance
Cell Adhesion
104 Citations (Scopus)

Mechanism of action of SNS-032, a novel cyclin-dependent kinase inhibitor, in chronic lymphocytic leukemia

Chen, R., Wierda, W. G., Chubb, S., Hawtin, R. E., Fox, J. A., Keating, M. J., Gandhi, V. V. & Plunkett Jr, W. K., Nov 17 2009, In : Blood. 113, 19, p. 4637-4645 9 p.

Research output: Contribution to journalArticle

Cyclin-Dependent Kinases
B-Cell Chronic Lymphocytic Leukemia
RNA Polymerase II
alvocidib
Transcription
2007
83 Citations (Scopus)

Effect of cytarabine and decitabine in combination in human leukemic cell lines

Qin, T., Youssef, E. M., Jelinek, J., Chen, R., Yang, A. S., Garcia-Manero, G. & Issa, J. P. J., Jul 15 2007, In : Clinical Cancer Research. 13, 14, p. 4225-4232 8 p.

Research output: Contribution to journalArticle

decitabine
Cytarabine
Cell Line
Annexin A5
DNA Methylation
2006
76 Citations (Scopus)
alvocidib
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Oncogenes
Phosphotransferases
RNA Polymerase II
2005
185 Citations (Scopus)

Transcription inhibition by flavopiridol: Mechanism of chronic lymphocytic leukemia cell death

Chen, R., Keating, M. J., Gandhi, V. & Plunkett, W., Oct 1 2005, In : Blood. 106, 7, p. 2513-2519 7 p.

Research output: Contribution to journalArticle

alvocidib
Cell death
B-Cell Chronic Lymphocytic Leukemia
Transcription
Cell Death
2002
14 Citations (Scopus)

Renal organic cation and nucleoside transport

Chen, R., Jonker, J. W. & Nelson, J. A., Jul 15 2002, In : Biochemical Pharmacology. 64, 2, p. 185-190 6 p.

Research output: Contribution to journalArticle

Nucleosides
Cations
Tissue Distribution
Kidney
Knockout Mice
2000
47 Citations (Scopus)

Role of organic cation transporters in the renal secretion of nucleosides

Chen, R. & Nelson, J. A., Jul 15 2000, In : Biochemical Pharmacology. 60, 2, p. 215-219 5 p.

Research output: Contribution to journalArticle

Tetraethylammonium
Nucleosides
Cations
Kidney
Protons
1999
12 Citations (Scopus)

A nucleoside-sensitive organic cation transporter in opossum kidney cells

Chen, R., Pan, B. F., Sakurai, M. & Nelson, J. A., Feb 1 1999, In : American Journal of Physiology - Renal Physiology. 276, 2 45-2

Research output: Contribution to journalArticle

Opossums
Nucleosides
Cations
Kidney
Nucleoside Transport Proteins
35 Citations (Scopus)

A transfected cell model for the renal toxin transporter, rOCT2

Pan, B. F., Sweet, D. H., Pritchard, J. B., Chen, R. & Nelson, J. A., May 18 1999, In : Toxicological Sciences. 47, 2, p. 181-186 6 p.

Research output: Contribution to journalArticle

Tetraethylammonium
Kidney
Cations
Plasmids
Cladribine
1996
1 Citation (Scopus)

High level expression of oryzacystatin in Escherichia coli.

Zhou, Z., Zhu, Z., Chen, R., Liu, C. & Li, X., Jan 1 1996, In : Chinese Journal of Biotechnology. 12, 1, p. 17-24 8 p.

Research output: Contribution to journalArticle

Escherichia coli
Papain
Escherichia coli Proteins
Gene Library
Sulfhydryl Compounds