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Dive into the research topics where Roopa Thapar is active. These topic labels come from the works of this person. Together they form a unique fingerprint.
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Structure-Guided Development of NRAS G12D Inhibitors Based on a 5-Azaindole Core
Cox, J. B., Nair, V., Mandal, P., Reyna, N., Tran, T., Mustachio, L. M., Bardenhagen, J., Fawver, J., Shepard, H., Hickey, A. M., Wu, Q., Rodriguez, C., Yu, F., Phan, P., Mendiola, A. J., Johnson, R., Thapar, R., Johnson, T., Jiang, Y. & Cross, J. B. & 6 others, , Feb 12 2026, In: ACS Medicinal Chemistry Letters. 17, 2, p. 425-432 8 p.Research output: Contribution to journal › Article › peer-review
Open Access -
A Hit Prioritization Strategy for Compound Library Screening Using LiP-MS and Molecular Dynamics Simulations Applied to KRas G12D Inhibitors
Absar, F., Novy, B., Nagy, E., Petrotchenko, E. V., Popov, K. I., Cross, J. B., Thapar, R. & Borchers, C. H., Sep 23 2025, In: Analytical Chemistry. 97, 37, p. 20228-20236 9 p.Research output: Contribution to journal › Article › peer-review
Open Access1 Link opens in a new tab Scopus citations -
Characterization of the KRas G12D-inhibitor interactions by differential HDX-MS and molecular dynamics simulations
Petrotchenko, E. V., Novy, B., Nagy, E., Popov, K. I., Cross, J. B., Thapar, R. & Borchers, C. H., Jan 2025, In: Computational and Structural Biotechnology Journal. 27, p. 3618-3624 7 p.Research output: Contribution to journal › Article › peer-review
Open Access2 Link opens in a new tab Scopus citations -
ASCC1 structures and bioinformatics reveal a novel helix-clasp-helix RNA-binding motif linked to a two-histidine phosphodiesterase
Chinnam, N. B., Thapar, R., Arvai, A. S., Sarker, A. H., Soll, J. M., Paul, T., Syed, A., Rosenberg, D. J., Hammel, M., Bacolla, A., Katsonis, P., Asthana, A., Tsai, M. S., Ivanov, I., Lichtarge, O., Silverman, R. H., Mosammaparast, N., Tsutakawa, S. E. & Tainer, J. A., Jun 2024, In: Journal of Biological Chemistry. 300, 6, 107368.Research output: Contribution to journal › Article › peer-review
Open Access5 Link opens in a new tab Scopus citations -
Erratum: Mechanism of efficient double-strand break repair by a long non-coding RNA (Nucleic Acids Research (2020) 48:19 (10953-10972) DOI: 10.1093/nar/gkaa784)
Thapar, R., Wang, J. L., Hammel, M., Ye, R., Liang, K., Sun, C., Hnizda, A., Liang, S., Maw, S. S., Lee, L., Villarreal, H., Forrester, I., Fang, S., Tsai, M. S., Blundell, T. L., Davis, A. J., Lin, C., Lees-Miller, S. P., Strick, T. R. & Tainer, J. A., Jan 25 2021, In: Nucleic acids research. 49, 2, p. 1199-1200 2 p.Research output: Contribution to journal › Comment/debate › peer-review
Open Access8 Link opens in a new tab Scopus citations