Roza Nurieva

Associate Professor

  • 13279 Citations
  • 36 h-Index
19952019
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Research Output 1995 2019

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Article
2019
Open Access
Chondrocalcinosis
Synovial Fluid
Th17 Cells
Neutrophils
Interleukin-17
2018
8 Citations (Scopus)

Concomitant suppression of TH2 and TH17 cell responses in allergic asthma by targeting retinoic acid receptor–related orphan receptor γt

Na, H., Lim, H., Choi, G., Kim, B. K., Kim, S. H., Chang, Y. S., Nurieva, R., Dong, C., Chang, S. H. & Chung, Y., Jun 2018, In : Journal of Allergy and Clinical Immunology. 141, 6, p. 2061-2073.e5

Research output: Contribution to journalArticle

Th17 Cells
Tretinoin
Asthma
T-Lymphocytes
B-Cell Lymphoma
7 Citations (Scopus)

IL22 promotes kras-mutant lung cancer by induction of a protumor immune response and protection of stemness properties

Khosravi, N., Caetano, M. D. S., Cumpian, A. M., Unver, N., De la Garza Ramos, C., Noble, O., Daliri, S., Hernandez, B. J., Gutierrez, B. A., Evans, S., Hanash, S., Alekseev, A. M., Yang, Y., Chang, S. H., Nurieva, R., Kadara, H. N., Chen, J., Ostrin, E. J. & Moghaddam, S. J. M., Jul 1 2018, In : Cancer Immunology Research. 6, 7, p. 788-797 10 p.

Research output: Contribution to journalArticle

Lung Neoplasms
Carcinogenesis
Epithelial Cells
T-Lymphocytes
Neoplasms
2017
3 Citations (Scopus)

Absence of Grail promotes CD8 + T cell anti-tumour activity

Haymaker, C., Yang, Y., Wang, J., Zou, Q., Sahoo, A., Alekseev, A., Singh, D., Ritthipichai, K., Hailemichael, Y., Hoang, O. N., Qin, H., Schluns, K. S., Wang, T., Overwijk, W. W., Sun, S. C., Bernatchez, C., Kwak, L. W., Neelapu, S. S. & Nurieva, R., Dec 1 2017, In : Nature communications. 8, 1, 239.

Research output: Contribution to journalArticle

T-cells
Tumors
tumors
T-Lymphocytes
Interleukin-21 Receptors
27 Citations (Scopus)

Generation of RORγt + Antigen-Specific T Regulatory 17 Cells from Foxp3 + Precursors in Autoimmunity

Kim, B. S., Lu, H., Ichiyama, K., Chen, X., Zhang, Y. B., Mistry, N. A., Tanaka, K., Lee, Y., Nurieva, R., Zhang, L., Yang, X., Chung, Y., Jin, W., Chang, S. H. & Dong, C., Oct 3 2017, In : Cell Reports. 21, 1, p. 195-207 13 p.

Research output: Contribution to journalArticle

Regulatory T-Lymphocytes
Autoimmunity
Immunization
Antigens
T-cells
27 Citations (Scopus)

IL-21-dependent expansion of memory-like NK cells enhances protective immune responses against Mycobacterium tuberculosis

Venkatasubramanian, S., Cheekatla, S., Paidipally, P., Tripathi, D., Welch, E., Tvinnereim, A. R., Nurieva, R. & Vankayalapati, R., Jul 1 2017, In : Mucosal Immunology. 10, 4, p. 1031-1042 12 p.

Research output: Contribution to journalArticle

Mycobacterium tuberculosis
Natural Killer Cells
Bacterial Vaccines
Latent Tuberculosis
interleukin-21
4 Citations (Scopus)

IL-21 receptor signaling is essential for optimal CD4+ T cell function and control of mycobacterium tuberculosis infection in mice

Cheekatla, S. S., Tripathi, D., Venkatasubramanian, S., Paidipally, P., Welch, E., Tvinnereim, A. R., Nurieva, R. & Vankayalapati, R., Oct 15 2017, In : Journal of Immunology. 199, 8, p. 2815-2822 8 p.

Research output: Contribution to journalArticle

Interleukin-21 Receptors
Mycobacterium Infections
Mycobacterium tuberculosis
T-Lymphocytes
Knockout Mice
T-cells
Antigens
Assays
Vaccination
T-Lymphocytes
6 Citations (Scopus)

Multifaceted role of BTLA in the control of CD8+ T-cell fate after antigen encounter

Ritthipichai, K., Haymaker, C. L., Martinez, M., Aschenbrenner, A., Yi, X., Zhang, M., Kale, C., Vence, L. M., Roszik, J., Hailemichael, Y., Overwijk, W. W., Varadarajan, N., Nurieva, R., Radvanyi, L. G., Hwu, P. & Bernatchez, C., Oct 15 2017, In : Clinical Cancer Research. 23, 20, p. 6151-6165 15 p.

Research output: Contribution to journalArticle

T-Lymphocytes
Antigens
Tumor-Infiltrating Lymphocytes
Neoplasms
Single-Cell Analysis
2 Citations (Scopus)

STAT4 regulates the CD8+ regulatory T Cell/T follicular helper cell axis and promotes atherogenesis in insulin-resistant Ldlr-/- Mice

Taghavie-Moghadam, P. L., Waseem, T. C., Hattler, J., Glenn, L. M., Dobrian, A. D., Kaplan, M. H., Yang, Y., Nurieva, R., Nadler, J. L. & Galkina, E. V., Nov 15 2017, In : Journal of Immunology. 199, 10, p. 3453-3465 13 p.

Research output: Contribution to journalArticle

Regulatory T-Lymphocytes
Helper-Inducer T-Lymphocytes
Atherosclerosis
Insulin
Insulin Resistance
2016
7 Citations (Scopus)

Insights into the development and regulation of T follicular helper cells

Wali, S., Sahoo, A., Puri, S., Alekseev, A. & Nurieva, R., Nov 1 2016, In : Cytokine. 87, p. 9-19 11 p.

Research output: Contribution to journalArticle

Helper-Inducer T-Lymphocytes
Cells
B-Lymphocytes
Germinal Center
Cell Differentiation
2015
33 Citations (Scopus)

Batf is important for IL-4 expression in T follicular helper cells

Sahoo, A., Alekseev, A., Tanaka, K., Obertas, L., Lerman, B., Haymaker, C., Clise-Dwyer, K., McMurray, J. S. & Nurieva, R., Aug 17 2015, In : Nature communications. 6, 7997.

Research output: Contribution to journalArticle

Helper-Inducer T-Lymphocytes
Interleukin-4
cells
Th2 Cells
Basic-Leucine Zipper Transcription Factors
47 Citations (Scopus)

Interleukin (IL)-21 promotes intestinal IgA response to microbiota

Cao, A. T., Yao, S., Gong, B., Nurieva, R., Elson, C. O. & Cong, Y., Sep 19 2015, In : Mucosal Immunology. 8, 5, p. 1072-1082 11 p.

Research output: Contribution to journalArticle

Microbiota
Immunoglobulin A
B-Lymphocytes
Immunoglobulin Isotypes
Genetic Recombination
13 Citations (Scopus)

Targeting the Src Homology 2 (SH2) Domain of Signal Transducer and Activator of Transcription 6 (STAT6) with Cell-Permeable, Phosphatase-Stable Phosphopeptide Mimics Potently Inhibits Tyr641 Phosphorylation and Transcriptional Activity

Mandal, P. K., Morlacchi, P., Knight, J. M., Link, T. M., Lee, G. R., Nurieva, R., Singh, D., Dhanik, A., Kavraki, L., Corry, D. B., Ladbury, J. E. & McMurray, J. S., Nov 25 2015, In : Journal of Medicinal Chemistry. 58, 22, p. 8970-8984 15 p.

Research output: Contribution to journalArticle

STAT6 Transcription Factor
Phosphopeptides
src Homology Domains
Phosphoric Monoester Hydrolases
Phosphorylation
2014
4 Citations (Scopus)

CCAAT/enhancer-binding protein α negatively regulates IFN-γ expression in T cells

Tanaka, S., Tanaka, K., Magnusson, F., Chung, Y., Martinez, G. J., Wang, Y. H., Nurieva, R., Kurosaki, T. & Dong, C., Dec 15 2014, In : Journal of Immunology. 193, 12, p. 6152-6160 9 p.

Research output: Contribution to journalArticle

CCAAT-Enhancer-Binding Proteins
Helper-Inducer T-Lymphocytes
T-Lymphocytes
Basic-Leucine Zipper Transcription Factors
Immunoglobulin Class Switching
88 Citations (Scopus)

Generation of a new therapeutic peptide that depletes myeloid-derived suppressor cells in tumor-bearing mice

Qin, H., Lerman, B., Sakamaki, I., Wei, G., Cha, S-C., Rao, S. S., Qian, J., Hailemichael, Y., Nurieva, R., Dwyer, K. C., Roth, J., Yi, Q., Overwijk, W. & Kwak, L. W., Jan 1 2014, In : Nature medicine. 20, 6, p. 676-681 6 p.

Research output: Contribution to journalArticle

Bearings (structural)
Tumors
Peptides
Neoplasms
Bacteriophages
26 Citations (Scopus)

Grail controls Th2 cell development by targeting STAT6 for degradation

Sahoo, A., Alekseev, A., Obertas, L. & Nurieva, R., Aug 22 2014, In : Nature communications. 5, 4732.

Research output: Contribution to journalArticle

STAT6 Transcription Factor
Th2 Cells
asthma
interleukins
effectors
165 Citations (Scopus)

Transcription factor achaete-scute homologue 2 initiates follicular T-helper-cell development

Liu, X., Chen, X., Zhong, B., Wang, A., Wang, X., Chu, F., Nurieva, R., Yan, X., Chen, P., Van Der Flier, L. G., Nakatsukasa, H., Neelapu, S. S., Chen, W., Clevers, H., Tian, Q., Qi, H., Wei, L. & Dong, C., Jan 1 2014, In : Nature. 507, 7493, p. 513-518 6 p.

Research output: Contribution to journalArticle

Helper-Inducer T-Lymphocytes
Transcription Factors
Chemokine Receptors
T-Lymphocytes
CXC Chemokines
2013
3 Citations (Scopus)

Activation of the transcription factor c-Maf in T cells is dependent on the CARMA1-IKKβ signaling cascade

Blonska, M., Joo, D., Nurieva, R. I., Zhao, X., Chiao, P., Sun, S. C., Dong, C. & Lin, X., Dec 17 2013, In : Science Signaling. 6, 306, ra110.

Research output: Contribution to journalArticle

MafF Transcription Factor
Germinal Center
T-cells
T-Cell Antigen Receptor
Transcription Factors
14 Citations (Scopus)

T-cell tolerance in cancer

Nurieva, R., Wang, J. & Sahoo, A., May 1 2013, In : Immunotherapy. 5, 5, p. 513-531 19 p.

Research output: Contribution to journalArticle

T-Lymphocytes
Neoplasms
Maintenance
Ubiquitin-Protein Ligases
Tumor Microenvironment
83 Citations (Scopus)

Transcriptional regulation of follicular T-helper (Tfh) cells

Liu, X., Nurieva, R. I. & Dong, C., Mar 1 2013, In : Immunological Reviews. 252, 1, p. 139-145 7 p.

Research output: Contribution to journalArticle

Helper-Inducer T-Lymphocytes
T-Lymphocytes
B-Lymphocytes
Germinal Center
Gene Regulatory Networks
2012
172 Citations (Scopus)

A genomic regulatory element that directs assembly and function of immune-specific AP-1 - IRF complexes

Glasmacher, E., Agrawal, S., Chang, A. B., Murphy, T. L., Zeng, W., Lugt, B. V., Khan, A. A., Ciofani, M., Spooner, C. J., Rutz, S., Hackney, J., Nurieva, R., Escalante, C. R., Ouyang, W., Littman, D. R., Murphy, K. M. & Singh, H., Nov 16 2012, In : Science. 338, 6109, p. 975-980 6 p.

Research output: Contribution to journalArticle

Interferon Regulatory Factor-1
Dendritic Cells
Th17 Cells
Transcription Factor AP-1
Cell Differentiation
130 Citations (Scopus)

Bcl6 expression specifies the T follicular helper cell program in vivo

Liu, X., Yan, X., Zhong, B., Nurieva, R., Wang, A., Wang, X., Martin-Orozco, N., Wang, Y., Chang, S. H., Esplugues, E., Flavell, R. A., Tian, Q. & Dong, C., Sep 1 2012, In : Journal of Experimental Medicine. 209, 10, p. 1841-1852 12 p.

Research output: Contribution to journalArticle

B-Cell Lymphoma
Helper-Inducer T-Lymphocytes
T-Lymphocytes
Germinal Center
Gene Expression Profiling
13 Citations (Scopus)

Reduced Graft-versus-Host Disease in C3-Deficient Mice Is Associated with Decreased Donor Th1/Th17 Differentiation

Ma, Q., Li, D., Nurieva, R., Patenia, R., Bassett, R., Cao, W., Alekseev, A. M., He, H., Molldrem, J. J., Kroll, M., Champlin, R. E., Sale, G. E. & Afshar-Kharghan, V., Aug 1 2012, In : Biology of Blood and Marrow Transplantation. 18, 8, p. 1174-1181 8 p.

Research output: Contribution to journalArticle

Graft vs Host Disease
T-Lymphocytes
Interleukin-17
Bone Marrow Transplantation
Dendritic Cells
130 Citations (Scopus)

STAT5 protein negatively regulates T follicular helper (Tfh) cell generation and function

Nurieva, R., Podd, A., Chen, Y., Alekseev, A. M., Yu, M., Qi, X., Huang, H., Wen, R., Wang, J., Li, H., Watowich, S. S., Qi, H., Dong, C. & Wang, D., Mar 30 2012, In : Journal of Biological Chemistry. 287, 14, p. 11234-11239 6 p.

Research output: Contribution to journalArticle

STAT5 Transcription Factor
Lymphocytes
Helper-Inducer T-Lymphocytes
B-Lymphocytes
T-cells
107 Citations (Scopus)

Transcription factor IRF4 determines germinal center formation through follicular T-helper cell differentiation

Bollig, N., Brus̈tle, A., Kellner, K., Ackermann, W., Abass, E., Raifer, H., Camara, B., Brendel, C., Giel, G., Bothur, E., Huber, M., Paul, C., Elli, A., Kroczek, R. A., Nurieva, R., Dong, C., Jacob, R., Mak, T. W. & Lohoff, M., May 29 2012, In : Proceedings of the National Academy of Sciences of the United States of America. 109, 22, p. 8664-8669 6 p.

Research output: Contribution to journalArticle

Germinal Center
Cell Differentiation
Transcription Factors
T-Lymphocytes
Lymph Nodes
66 Citations (Scopus)

Transcription of Il17 and Il17f Is Controlled by Conserved Noncoding Sequence 2

Wang, X., Zhang, Y., Yang, X. O., Nurieva, R. I., Chang, S. H., Ojeda, S. S., Kang, H. S., Schluns, K. S., Gui, J., Jetten, A. M. & Dong, C., Jan 27 2012, In : Immunity. 36, 1, p. 23-31 9 p.

Research output: Contribution to journalArticle

Conserved Sequence
Th17 Cells
Interleukin-17
Genes
Chromatin Assembly and Disassembly
2011
541 Citations (Scopus)

Follicular regulatory T cells expressing Foxp3 and Bcl-6 suppress germinal center reactions

Chung, Y., Tanaka, S., Chu, F., Nurieva, R. I., Martinez, G. J., Rawal, S., Wang, Y. H., Lim, H., Reynolds, J. M., Zhou, X. H., Fan, H. M., Liu, Z. M., Neelapu, S. S. & Dong, C., Aug 1 2011, In : Nature medicine. 17, 8, p. 983-988 6 p.

Research output: Contribution to journalArticle

Germinal Center
T-cells
Regulatory T-Lymphocytes
Cells
Thymus
110 Citations (Scopus)

Ursolic acid suppresses interleukin-17 (IL-17) production by selectively antagonizing the function of RORγt protein

Xu, T., Wang, X., Zhong, B., Nurieva, R. I., Ding, S. & Dong, C., Jul 1 2011, In : Journal of Biological Chemistry. 286, 26, p. 22707-22710 4 p.

Research output: Contribution to journalArticle

Th17 Cells
Interleukin-17
Cytokines
Proteins
Autoimmune Experimental Encephalomyelitis
2010
78 Citations (Scopus)

The E3 ubiquitin ligase GRAIL regulates T cell tolerance and regulatory T cell function by mediating T cell receptor-CD3 degradation

Nurieva, R., Zheng, S., Jin, W., Chung, Y., Zhang, Y., Martinez, G. J., Reynolds, J. M., Wang, S. L., Lin, X., Sun, S-C., Lozano, G. & Dong, C., May 1 2010, In : Immunity. 32, 5, p. 670-680 11 p.

Research output: Contribution to journalArticle

Ubiquitin-Protein Ligases
Regulatory T-Lymphocytes
T-Cell Antigen Receptor
T-Lymphocytes
Th17 Cells
185 Citations (Scopus)

Toll-like receptor 2 signaling in CD4+ T lymphocytes promotes T helper 17 responses and regulates the pathogenesis of autoimmune disease

Reynolds, J. M., Pappu, B. P., Peng, J., Martinez, G. J., Zhang, Y., Chung, Y., Ma, L., Yang, X. O., Nurieva, R. I., Tian, Q. & Dong, C., May 1 2010, In : Immunity. 32, 5, p. 692-702 11 p.

Research output: Contribution to journalArticle

Th17 Cells
Toll-Like Receptor 2
Autoimmune Experimental Encephalomyelitis
Toll-Like Receptors
Autoimmune Diseases
2009
808 Citations (Scopus)

Bcl6 mediates the development of T follicular helper cells

Nurieva, R., Chung, Y., Martinez, G. J., Yang, X. O., Tanaka, S., Matskevitch, T. D., Wang, Y. H. & Dong, C., Aug 31 2009, In : Science. 325, 5943, p. 1001-1005 5 p.

Research output: Contribution to journalArticle

Helper-Inducer T-Lymphocytes
Interleukin-6
B-Lymphocytes
Th17 Cells
Germinal Center
698 Citations (Scopus)

Critical Regulation of Early Th17 Cell Differentiation by Interleukin-1 Signaling

Chung, Y., Chang, S. H., Martinez, G. J., Yang, X. O., Nurieva, R., Kang, H. S., Ma, L., Watowich, S. S., Jetten, A. M., Tian, Q. & Dong, C., Apr 17 2009, In : Immunity. 30, 4, p. 576-587 12 p.

Research output: Contribution to journalArticle

Th17 Cells
Interleukin-1
Cell Differentiation
Interleukin-6
Interleukin-23
73 Citations (Scopus)

Cutting edge: In vitro generated Th17 cells maintain their cytokine expression program in normal but not lymphopenic hosts

Nurieva, R., Yang, X. O., Chung, Y. & Dong, C., Mar 1 2009, In : Journal of Immunology. 182, 5, p. 2565-2568 4 p.

Research output: Contribution to journalArticle

Th17 Cells
Cytokines
Interleukin-17
T-Lymphocytes
Interleukin-7
33 Citations (Scopus)

Cutting edge: A critical role of B and T lymphocyte attenuator in peripheral T cell tolerance induction

Liu, X., Alexiou, M., Martin-Orozco, N., Chung, Y., Nurieva, R., Ma, L., Tian, Q., Kollias, G., Lu, S., Graf, D. & Dong, C., Apr 15 2009, In : Journal of Immunology. 182, 8, p. 4516-4520 5 p.

Research output: Contribution to journalArticle

B-Lymphocytes
T-Lymphocytes
Peripheral Tolerance
Type 1 Diabetes Mellitus
Peptides
27 Citations (Scopus)

LFA-1 affinity regulation is necessary for the activation and proliferation of naive T cells

Wang, Y., Li, D., Nurieva, R., Yang, J., Sen, M., Carreño, R., Lu, S., McIntyre, B. W., Molldrem, J. J., Legge, G. B. & Ma, Q., May 8 2009, In : Journal of Biological Chemistry. 284, 19, p. 12645-12653 9 p.

Research output: Contribution to journalArticle

Lymphocyte Function-Associated Antigen-1
T-cells
Chemical activation
T-Lymphocytes
Conformations
37 Citations (Scopus)

MKP-1 is necessary for T cell activation and function

Zhang, Y., Reynolds, J. M., Chang, S. H., Martin-Orozco, N., Chung, Y., Nurieva, R. I. & Dong, C., Nov 6 2009, In : Journal of Biological Chemistry. 284, 45, p. 30815-30824 10 p.

Research output: Contribution to journalArticle

Mitogen-Activated Protein Kinase Phosphatases
T-cells
Chemical activation
T-Lymphocytes
Innate Immunity
63 Citations (Scopus)

Requirement for the basic helix-loop-helix transcription factor Dec2 in initial T H 2 lineage commitment

Yang, X. O., Angkasekwinai, P., Zhu, J., Peng, J., Liu, Z., Nurieva, R., Liu, X., Chung, Y., Chang, S. H., Sun, B. & Dong, C., Nov 2 2009, In : Nature Immunology. 10, 12, p. 1260-1266 7 p.

Research output: Contribution to journalArticle

Basic Helix-Loop-Helix Transcription Factors
GATA3 Transcription Factor
GATA Transcription Factors
T-Lymphocytes
Th2 Cells
2008
29 Citations (Scopus)

A critical role of costimulation during intrathymic development of invariant NK T cells

Chung, Y., Nurieva, R., Esashi, E., Wang, Y. H., Zhou, D., Gapin, L. & Dong, C., Feb 15 2008, In : Journal of Immunology. 180, 4, p. 2276-2283 8 p.

Research output: Contribution to journalArticle

Natural Killer Cells
T-Lymphocytes
Thymus Gland
T-Lymphocyte Subsets
Adaptive Immunity
286 Citations (Scopus)

CCR6 regulates the migration of inflammatory and regulatory T cells

Yamazaki, T., Yang, X. O., Chung, Y., Fukunaga, A., Nurieva, R., Pappu, B., Martin-Orozco, N., Kang, H. S., Ma, L., Panopoulos, A. D., Craig, S., Watowich, S. S., Jetten, A. M., Tian, Q. & Dong, C., Dec 15 2008, In : Journal of Immunology. 181, 12, p. 8391-8401 11 p.

Research output: Contribution to journalArticle

Th17 Cells
Regulatory T-Lymphocytes
Autoimmune Experimental Encephalomyelitis
T-Lymphocyte Subsets
Cytoplasmic and Nuclear Receptors
755 Citations (Scopus)

Generation of T Follicular Helper Cells Is Mediated by Interleukin-21 but Independent of T Helper 1, 2, or 17 Cell Lineages

Nurieva, R., Chung, Y., Hwang, D., Yang, X. O., Kang, H. S., Ma, L., Wang, Y. H., Watowich, S. S., Jetten, A. M., Tian, Q. & Dong, C., Jul 18 2008, In : Immunity. 29, 1, p. 138-149 12 p.

Research output: Contribution to journalArticle

Th17 Cells
Th2 Cells
Th1 Cells
Cell Lineage
Helper-Inducer T-Lymphocytes
765 Citations (Scopus)

Molecular Antagonism and Plasticity of Regulatory and Inflammatory T Cell Programs

Yang, X. O., Nurieva, R., Martinez, G. J., Kang, H. S., Chung, Y., Pappu, B. P., Shah, B., Chang, S. H., Schluns, K., Watowich, S. S., Feng, X. H., Jetten, A. M. & Dong, C., Jul 18 2008, In : Immunity. 29, 1, p. 44-56 13 p.

Research output: Contribution to journalArticle

Interleukin-17
Regulatory T-Lymphocytes
Th17 Cells
Interleukin-1
Interleukin-6
497 Citations (Scopus)

Regulation of inflammatory responses by IL-17F

Yang, X. O., Seon, H. C., Park, H., Nurieva, R., Shah, B., Acero, L., Wang, Y. H., Schluns, K. S., Broaddus, R. R., Zhu, Z. & Dong, C., May 12 2008, In : Journal of Experimental Medicine. 205, 5, p. 1063-1075 13 p.

Research output: Contribution to journalArticle

Interleukin-17
Interleukin-17 Receptors
Tumor Necrosis Factor Receptor-Associated Peptides and Proteins
Dextran Sulfate
Autoimmune Experimental Encephalomyelitis
1041 Citations (Scopus)

T Helper 17 Lineage Differentiation Is Programmed by Orphan Nuclear Receptors RORα and RORγ

Yang, X. O., Pappu, B. P., Nurieva, R., Akimzhanov, A., Kang, H. S., Chung, Y., Ma, L., Shah, B., Panopoulos, A. D., Schluns, K. S., Watowich, S. S., Tian, Q., Jetten, A. M. & Dong, C., Jan 18 2008, In : Immunity. 28, 1, p. 29-39 11 p.

Research output: Contribution to journalArticle

Orphan Nuclear Receptors
Th17 Cells
STAT3 Transcription Factor
Retinoic Acid Receptors
Autoimmune Experimental Encephalomyelitis
2007
24 Citations (Scopus)

A costimulation-initiated signaling pathway regulates NFATc1 transcription in T lymphocytes

Nurieva, R., Chuvpilo, S., Wieder, E. D., Elkon, K. B., Locksley, R., Serfling, E. & Dong, C., Jul 15 2007, In : Journal of Immunology. 179, 2, p. 1096-1103 8 p.

Research output: Contribution to journalArticle

T-Lymphocytes
Phosphatidylinositol 3-Kinases
Genes
Immune Tolerance
Cell Differentiation
1103 Citations (Scopus)

Essential autocrine regulation by IL-21 in the generation of inflammatory T cells

Nurieva, R., Yang, X. O., Martinez, G., Zhang, Y., Panopoulos, A. D., Ma, L., Schluns, K., Tian, Q., Watowich, S. S., Jetten, A. M. & Dong, C., Jul 26 2007, In : Nature. 448, 7152, p. 480-483 4 p.

Research output: Contribution to journalArticle

Th17 Cells
T-Lymphocytes
Interleukin-17
Cytokines
Interleukin-6
916 Citations (Scopus)

STAT3 regulates cytokine-mediated generation of inflammatory helper T cells

Yang, X. O., Panopoulos, A. D., Nurieva, R., Chang, S. H., Wang, D., Watowich, S. S. & Dong, C., Mar 30 2007, In : Journal of Biological Chemistry. 282, 13, p. 9358-9363 6 p.

Research output: Contribution to journalArticle

T-cells
Helper-Inducer T-Lymphocytes
Interleukin-23
Interleukin-6
Interleukin-17
2006
35 Citations (Scopus)

Opposing effects of ICOS on graft-versus-host disease mediated by CD4 and CD8 T cells

Yu, X. Z., Liang, Y., Nurieva, R., Guo, F., Anasetti, C. & Dong, C., Jun 15 2006, In : Journal of Immunology. 176, 12, p. 7394-7401 8 p.

Research output: Contribution to journalArticle

Graft vs Host Disease
T-Lymphocytes
Morbidity
Aptitude
Fas Ligand Protein
146 Citations (Scopus)

T-cell tolerance or function is determined by combinatorial costimulatory signals

Nurieva, R., Thomas, S., Nguyen, T., Martin-Orozco, N., Wang, Y., Kaja, M. K., Yu, X. Z. & Dong, C., Jul 7 2006, In : EMBO Journal. 25, 11, p. 2623-2633 11 p.

Research output: Contribution to journalArticle

T-cells
T-Lymphocytes
Molecules
Costimulatory and Inhibitory T-Cell Receptors
Chemical activation
2005
2995 Citations (Scopus)

A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17

Park, H., Li, Z., Yang, X. O., Chang, S. H., Nurieva, R., Wang, Y. H., Wang, Y., Hood, L., Zhu, Z., Tian, Q. & Dong, C., Nov 1 2005, In : Nature Immunology. 6, 11, p. 1133-1141 9 p.

Research output: Contribution to journalArticle

Interleukin-17
Inflammation
T-Lymphocytes
Helper-Inducer T-Lymphocytes
Chemokines