Salah Eddine Bentebibel

2022

Distinct tumor-infiltrating lymphocyte landscapes are associated with clinical outcomes in localized non-small-cell lung cancer

Federico, L., McGrail, D. J., Bentebibel, S. E., Haymaker, C., Ravelli, A., Forget, M. A., Karpinets, T., Jiang, P., Reuben, A., Negrao, M. V., Li, J., Khairullah, R., Zhang, J., Weissferdt, A., Vaporciyan, A. A., Antonoff, M. B., Walsh, G., Lin, S. Y., Futreal, A., Wistuba, I., & 16 othersRoth, J., Byers, L. A., Gaudreau, P. O., Uraoka, N., Cruz, A. F., Dejima, H., Lazcano, R. N., Solis, L. M., Parra, E. R., Lee, J. J., Swisher, S., Cascone, T., Heymach, J. V., Sepesi, B., Gibbons, D. L. & Bernatchez, C., Jan 2022, In: Annals of Oncology. 33, 1, p. 42-56 15 p.

Research output: Contribution to journal › Article › peer-review

Open Access

49 Scopus citations

Interleukin-6 blockade abrogates immunotherapy toxicity and promotes tumor immunity

Hailemichael, Y., Johnson, D. H., Abdel-Wahab, N., Foo, W. C., Bentebibel, S. E., Daher, M., Haymaker, C., Wani, K., Saberian, C., Ogata, D., Kim, S. T., Nurieva, R., Lazar, A. J., Abu-Sbeih, H., Fa'ak, F., Mathew, A., Wang, Y., Falohun, A., Trinh, V., Zobniw, C., & 17 othersSpillson, C., Burks, J. K., Awiwi, M., Elsayes, K., Soto, L. S., Melendez, B. D., Davies, M. A., Wargo, J., Curry, J., Yee, C., Lizee, G., Singh, S., Sharma, P., Allison, J. P., Hwu, P., Ekmekcioglu, S. & Diab, A., May 9 2022, In: Cancer cell. 40, 5, p. 509-523.e6

Research output: Contribution to journal › Article › peer-review

Open Access

106 Scopus citations

LFA-1 activation enriches tumor-specific T cells in a cold tumor model and synergizes with CTLA-4 blockade

Hickman, A., Koetsier, J., Kurtanich, T., Nielsen, M. C., Winn, G., Wang, Y., Bentebibel, S. E., Shi, L., Punt, S., Williams, L., Haymaker, C., Chesson, C. B., Fa’ak, F., Dominguez, A. L., Jones, R., Kuiatse, I., Caivano, A. R., Khounlo, S., Warier, N. D., Marathi, U., & 10 othersMarket, R. V., Biediger, R. J., Craft, J. W., Hwu, P., Davies, M. A., Woodside, D. G., Vanderslice, P., Diab, A., Overwijk, W. W. & Hailemichael, Y., Jul 1 2022, In: Journal of Clinical Investigation. 132, 13, e154152.

Research output: Contribution to journal › Article › peer-review

Open Access

14 Scopus citations

2021

Cytokines in the Treatment of Melanoma

Bentebibel, S. E. & Diab, A., Jul 2021, In: Current oncology reports. 23, 7, 83.

Research output: Contribution to journal › Review article › peer-review

18 Scopus citations

Immune profiling mass cytometry assay harmonization: Multicenter experience from CIMAC-CIDC

Sahaf, B., Pichavant, M., Lee, B. H., Duault, C., Thrash, E. M., Davila, M., Fernandez, N., Millerchip, K., Bentebibel, S. E., Haymaker, C., Sigal, N., Del Valle, D. M., Ranasinghe, S., Fayle, S., Sanchez-Espiridion, B., Zhang, J., Bernatchez, C., Wu, C. J., Wistuba, I. I., Kim-Schulze, S., & 7 othersGnjatic, S., Bendall, S. C., Song, M., Thurin, M., Jack Lee, J., Maecker, H. T. & Rahman, A., Sep 15 2021, In: Clinical Cancer Research. 27, 18, p. 5062-5072 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

7 Scopus citations

Tilsotolimod with ipilimumab drives tumor responses in anti–pd-1 refractory melanoma

Haymaker, C., Johnson, D. H., Murthy, R., Bentebibel, S. E., Uemura, M. I., Hudgens, C. W., Safa, H., James, M., Andtbacka, R. H. I., Johnson, D. B., Shaheen, M., Davies, M. A., Rahimian, S., Chunduru, S. K., Milton, D. R., Tetzlaff, M. T., Overwijk, W. W., Hwu, P., Gabrail, N., Agrawal, S., & 5 othersDoolittle, G., Puzanov, I., Markowitz, J., Bernatchez, C. & Diab, A., Aug 2021, In: Cancer discovery. 11, 8, p. 1996-2013 18 p.

Research output: Contribution to journal › Article › peer-review

Open Access

29 Scopus citations

Tox2 is required for the maintenance of GC TFH cells and the generation of memory TFH cells

Horiuchi, S., Wu, H., Liu, W. C., Schmitt, N., Provot, J., Liu, Y., Bentebibel, S. E., Albrecht, R. A., Schotsaert, M., Forst, C. V., Zhang, B. & Ueno, H., Oct 2021, In: Science Advances. 7, 41, abj1249.

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

2020

Bempegaldesleukin (NKTR-214) plus nivolumab in patients with advanced solid tumors: Phase I dose-escalation study of safety, effi cacy, and immune activation (PIVOT-02)

Diab, A., Tannir, N. M., Bentebibel, S. E., Hwu, P., Papadimitrakopoulou, V., Haymaker, C., Kluger, H. M., Gettinger, S. N., Sznol, M., Tykodi, S. S., Curti, B. D., Tagliaferri, M. A., Zalevsky, J., Hannah, A. L., Hoch, U., Aung, S., Fanton, C., Rizwan, A., Iacucci, E., Liao, Y., & 3 othersBernatchez, C., Hurwitz, M. E. & Cho, D. C., Aug 2020, In: Cancer discovery. 10, 8, p. 1158-1173 16 p.

Research output: Contribution to journal › Article › peer-review

Open Access

150 Scopus citations

Bempegaldesleukin selectively depletes intratumoral Tregs and potentiates T cell-mediated cancer therapy

Sharma, M., Khong, H., Fa’ak, F., Bentebibel, S. E., Janssen, L. M. E., Chesson, B. C., Creasy, C. A., Forget, M. A., Kahn, L. M. S., Pazdrak, B., Karki, B., Hailemichael, Y., Singh, M., Vianden, C., Vennam, S., Bharadwaj, U., Tweardy, D. J., Haymaker, C., Bernatchez, C., Huang, S., & 11 othersRajapakshe, K., Coarfa, C., Hurwitz, M. E., Sznol, M., Hwu, P., Hoch, U., Addepalli, M., Charych, D. H., Zalevsky, J., Diab, A. & Overwijk, W. W., Dec 1 2020, In: Nature communications. 11, 1, 661.

Research output: Contribution to journal › Article › peer-review

Open Access

114 Scopus citations

Novel Immunotherapies and Novel Combinations of Immunotherapy for Metastatic Melanoma

Olson, D. J., Gutierrez, R., Bentebibel, S. E., Sweis, R. F., Hamid, O., Diab, A., Johnson, D. B. & Luke, J. J., Jan 1 2020, Cutaneous Melanoma, Sixth Edition. Springer International Publishing, Vol. 2. p. 1165-1156 10 p.

Research output: Chapter in Book/Report/Conference proceeding › Chapter

2019

A first-in-human study and biomarker analysis of NKTR-214, a novel IL2Rβγ-biased cytokine, in patients with advanced or metastatic solid tumors

Bentebibel, S. E., Hurwitz, M. E., Bernatchez, C., Haymaker, C., Hudgens, C. W., Kluger, H. M., Tetzlaff, M. T., Tagliaferri, M. A., Zalevsky, J., Hoch, U., Fanton, C., Aung, S., Hwu, P., Curti, B. D., Tannir, N. M., Sznol, M. & Diab, A., Jun 2019, In: Cancer discovery. 9, 6, p. 711-721 11 p.

Research output: Contribution to journal › Article › peer-review

162 Scopus citations

2016

ICOS + PD-1 + CXCR3 + T follicular helper cells contribute to the generation of high-avidity antibodies following influenza vaccination

Bentebibel, S. E., Khurana, S., Schmitt, N., Kurup, P., Mueller, C., Obermoser, G., Palucka, A. K., Albrecht, R. A., Garcia-Sastre, A., Golding, H. & Ueno, H., May 27 2016, In: Scientific reports. 6, 26494.

Research output: Contribution to journal › Article › peer-review

Open Access

117 Scopus citations

Molecular Mechanisms Regulating T Helper 1 versus T Follicular Helper Cell Differentiation in Humans

Schmitt, N., Liu, Y., Bentebibel, S. E. & Ueno, H., Jul 26 2016, In: Cell Reports. 16, 4, p. 1082-1095 14 p.

Research output: Contribution to journal › Article › peer-review

Open Access

40 Scopus citations

2015

Analysis of human blood memory T follicular helper subsets

Bentebibel, S. E., Jacquemin, C., Schmitt, N. & Ueno, H., 2015, In: Methods in Molecular Biology. 1291, p. 187-197 11 p.

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Analysis of human blood memory T follicular helper subsets

Bentebibel, S. E., Jacquemin, C., Schmitt, N. & Ueno, H., Apr 2 2015, T Follicular Helper Cells: Methods and Protocols. Springer New York, p. 187-197 11 p.

Research output: Chapter in Book/Report/Conference proceeding › Chapter

2 Scopus citations

2014

Phenotype and functions of memory Tfh cells in human blood

Schmitt, N., Bentebibel, S. E. & Ueno, H., 2014, In: Trends in Immunology. 35, 9, p. 436-442 7 p.

Research output: Contribution to journal › Review article › peer-review

314 Scopus citations

The cytokine TGF-β 2 co-opts signaling via STAT3-STAT4 to promote the differentiation of human T _FH cells

Schmitt, N., Liu, Y., Bentebibel, S. E., Munagala, I., Bourdery, L., Venuprasad, K., Banchereau, J. & Ueno, H., Sep 2014, In: Nature Immunology. 15, 9, p. 856-865 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

256 Scopus citations

2013

IL-12 receptor b1 deficiency alters in vivo T follicular helper cell response in humans

Schmitt, N., Bustamante, J., Bourdery, L., Bentebibel, S. E., Boisson-Dupuis, S., Hamlin, F., Tran, M. V., Blankenship, D., Pascual, V., Savino, D. A., Banchereau, J., Casanova, J. L. & Ueno, H., Apr 25 2013, In: Blood. 121, 17, p. 3375-3385 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

134 Scopus citations

Induction of ICOS⁺CXCR3⁺CXCR5⁺ T _H cells correlates with antibody responses to influenza vaccination

Bentebibel, S. E., Lopez, S., Obermoser, G., Schmitt, N., Mueller, C., Harrod, C., Flano, E., Mejias, A., Albrecht, R. A., Blankenship, D., Xu, H., Pascual, V., Banchereau, J., Garcia-Sastre, A., Palucka, A. K., Ramilo, O. & Ueno, H., Mar 13 2013, In: Science translational medicine. 5, 176, 176ra32.

Research output: Contribution to journal › Article › peer-review

Open Access

468 Scopus citations

2011

Human Blood CXCR5⁺CD4⁺ T Cells Are Counterparts of T Follicular Cells and Contain Specific Subsets that Differentially Support Antibody Secretion

Morita, R., Schmitt, N., Bentebibel, S. E., Ranganathan, R., Bourdery, L., Zurawski, G., Foucat, E., Dullaers, M., Oh, S. K., Sabzghabaei, N., Lavecchio, E. M., Punaro, M., Pascual, V., Banchereau, J. & Ueno, H., Jan 28 2011, In: Immunity. 34, 1, p. 108-121 14 p.

Research output: Contribution to journal › Article › peer-review

Open Access

994 Scopus citations

Human Blood CXCR5 CD4 T Cells Are Counterparts of T Follicular Cells and Contain Specific Subsets that Differentially Support Antibody Secretion

Morita, R., Schmitt, N., Bentebibel, S. E., Ranganathan, R., Bourdery, L., Zurawski, G., Foucat, E., Dullaers, M., Oh, S. K., Sabzghabaei, N., Lavecchio, E. M., Punaro, M., Pascual, V., Banchereau, J. & Ueno, H., Jan 28 2011, In: Immunity. 34, 1, p. 135 1 p.

Research output: Contribution to journal › Comment/debate › peer-review

Open Access

249 Scopus citations

Human tonsil B-cell lymphoma 6 (BCL6)-expressing CD4 ⁺ T-cell subset specialized for B-cell help outside germinal centers

Bentebibel, S. E., Schmitt, N., Banchereau, J. & Ueno, H., Aug 16 2011, In: Proceedings of the National Academy of Sciences of the United States of America. 108, 33, p. E488-E497

Research output: Contribution to journal › Article › peer-review

Open Access

126 Scopus citations

2009

Human Dendritic Cells Induce the Differentiation of Interleukin-21-Producing T Follicular Helper-like Cells through Interleukin-12

Schmitt, N., Morita, R., Bourdery, L., Bentebibel, S. E., Zurawski, S. M., Banchereau, J. & Ueno, H., Jul 17 2009, In: Immunity. 31, 1, p. 158-169 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

302 Scopus citations

Salah Eddine Bentebibel

Research output

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