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2019

ATG5 cancer mutations and alternative mRNA splicing reveal a conjugation switch that regulates ATG12–ATG5-ATG16L1 complex assembly and autophagy

Wible, D., Chao, H. P., Tang, D. G. & Bratton, S. B., Dec 1 2019, In : Cell Discovery. 5, 1, 42.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations
2017

Caspase-9 swings both ways in the apoptosome

Wu, C. C. & Bratton, S. B., Mar 4 2017, In : Molecular and Cellular Oncology. 4, 2, e1281865.

Research output: Contribution to journalArticle

5 Scopus citations
2016

The Apaf-1 apoptosome induces formation of caspase-9 homo- and heterodimers with distinct activities

Wu, C. C., Lee, S., Malladi, S., Chen, M. D., Mastrandrea, N. J., Zhang, Z. & Bratton, S. B., Nov 24 2016, In : Nature communications. 7, 13565.

Research output: Contribution to journalArticle

31 Scopus citations
2015

Mitochondrial uncoupling links lipid catabolism to Akt inhibition and resistance to tumorigenesis

Nowinski, S. M., Solmonson, A., Rundhaug, J. E., Rho, O., Cho, J., Lago, C. U., Riley, C. L., Lee, S., Kohno, S., Dao, C. K., Nikawa, T., Bratton, S. B., Wright, C. W., Fischer, S. M., DiGiovanni, J. & Mills, E. M., Aug 27 2015, In : Nature communications. 6, 8137.

Research output: Contribution to journalArticle

17 Scopus citations
2014

BH3-only protein BIM mediates heat shock-induced apoptosis

Mahajan, I. M., Chen, M. D., Muro, I., Robertson, J. D., Wright, C. W. & Bratton, S. B., Jan 10 2014, In : PloS one. 9, 1, e84388.

Research output: Contribution to journalArticle

12 Scopus citations
16 Scopus citations
2013
9 Scopus citations
2012

Mitochondrial respiratory uncoupling promotes keratinocyte differentiation and blocks skin carcinogenesis

Lago, C. U., Nowinski, S. M., Rundhaug, J. E., Pfeiffer, M. E., Kiguchi, K., Hirasaka, K., Yang, X., Abramson, E. M., Bratton, S. B., Rho, O., Colavitti, R., Kenaston, M. A., Nikawa, T., Trempus, C., Digiovanni, J., Fischer, S. M. & Mills, E. M., Nov 1 2012, In : Oncogene. 31, 44, p. 4725-4731 7 p.

Research output: Contribution to journalArticle

13 Scopus citations
2011

The frequency of 1,4-Benzoquinone-lysine adducts in cytochrome c correlate with defects in apoptosome activation

Fisher, A. A., Labenski, M. T., Malladi, S., Chapman, J. D., Bratton, S. B., Monks, T. J. & Lau, S. S., 2011, In : Toxicological Sciences. 122, 1, p. 64-72 9 p.

Research output: Contribution to journalArticle

9 Scopus citations
2010

Role of hydroquinone-thiol conjugates in benzene-mediated toxicity

Lau, S. S., Kuhlman, C. L., Bratton, S. B. & Monks, T. J., Mar 1 2010, In : Chemico-Biological Interactions. 184, 1-2, p. 212-217 6 p.

Research output: Contribution to journalArticle

12 Scopus citations

TRAIL-activated stress kinases suppress apoptosis through transcriptional upregulation of MCL-1

Son, J. K., Varadarajan, S. & Bratton, S. B., Aug 1 2010, In : Cell death and differentiation. 17, 8, p. 1288-1301 14 p.

Research output: Contribution to journalArticle

30 Scopus citations
2009

The Apaf-1procaspase-9 apoptosome complex functions as a proteolytic-based molecular timer

Malladi, S., Challa-Malladi, M., Fearnhead, H. O. & Bratton, S. B., Jul 8 2009, In : EMBO Journal. 28, 13, p. 1916-1925 10 p.

Research output: Contribution to journalArticle

91 Scopus citations

The E3 ubiquitin ligase cIAP1 binds and ubiquitinates caspase-3 and -7 via unique mechanisms at distinct steps in their processing

Choi, Y. E., Butterworth, M., Malladi, S., Duckett, C. S., Cohen, G. M. & Bratton, S. B., May 8 2009, In : Journal of Biological Chemistry. 284, 19, p. 12772-12782 11 p.

Research output: Contribution to journalArticle

106 Scopus citations
2007

Drosophila Omi, a mitochondrial-localized IAP antagonist and proapoptotic serine protease

Challa, M., Malladi, S., Pellock, B. J., Dresnek, D., Varadarajan, S., Yin, Y. W., White, K. & Bratton, S. B., Jul 11 2007, In : EMBO Journal. 26, 13, p. 3144-3156 13 p.

Research output: Contribution to journalArticle

40 Scopus citations

Novel localization of NMDA receptors within neuroendocrine gonadotropin-releasing hormone terminals

Weiling, Y. I. N., Mendenhall, J. M., Bratton, S. B., Oung, T., Janssen, W. G. M., Morrison, J. H. & Gore, A. C., May 1 2007, In : Experimental Biology and Medicine. 232, 5, p. 662-673 12 p.

Research output: Contribution to journalArticle

30 Scopus citations

Quinone electrophiles selectively adduct "electrophile binding motifs" within cytochrome c

Fisher, A. A., Labenski, M. T., Malladi, S., Gokhale, V., Bowen, M. E., Milleron, R. S., Bratton, S. B., Monks, T. J. & Lau, S. S., Oct 2 2007, In : Biochemistry. 46, 39, p. 11090-11100 11 p.

Research output: Contribution to journalArticle

42 Scopus citations
2006

Heat shock induces apoptosis independently of any known initiator caspase-activating complex

Milleron, R. S. & Bratton, S. B., Jun 23 2006, In : Journal of Biological Chemistry. 281, 25, p. 16991-17000 10 p.

Research output: Contribution to journalArticle

44 Scopus citations

Intracellular Nucleotides Act as Critical Prosurvival Factors by Binding to Cytochrome C and Inhibiting Apoptosome

Chandra, D., Bratton, S. B., Person, M. D., Tian, Y., Martin, A. G., Ayres, M., Fearnhead, H. O., Gandhi, V. & Tang, D. G., Jun 30 2006, In : Cell. 125, 7, p. 1333-1346 14 p.

Research output: Contribution to journalArticle

100 Scopus citations

XIAP is a copper binding protein deregulated in Wilson's disease and other copper toxicosis disorders

Mufti, A. R., Burstein, E., Csomos, R. A., Graf, P. C. F., Wilkinson, J. C., Dick, R. D., Challa, M., Son, J. K., Bratton, S. B., Su, G. L., Brewer, G. J., Jakob, U. & Duckett, C. S., Mar 17 2006, In : Molecular cell. 21, 6, p. 775-785 11 p.

Research output: Contribution to journalArticle

129 Scopus citations
2004

Uncoupling of the Signaling and Caspase-inhibitory Properties of X-linked Inhibitor of Apoptosis

Lewis, J., Burstein, E., Reffey, S. B., Bratton, S. B., Roberts, A. B. & Duckett, C. S., Mar 5 2004, In : Journal of Biological Chemistry. 279, 10, p. 9023-9029 7 p.

Research output: Contribution to journalArticle

83 Scopus citations
2002

Bcl-2 and Bcl-xL inhibit CD95-mediated apoptosis by preventing mitochondrial release of Smac/DIABLO and subsequent inactivation of X-linked inhibitor-of-apoptosis protein

Sun, X. M., Bratton, S. B., Butterworth, M., MacFarlane, M. & Cohen, G. M., Mar 29 2002, In : Journal of Biological Chemistry. 277, 13, p. 11345-11351 7 p.

Research output: Contribution to journalArticle

198 Scopus citations

Proteasome-mediated degradation of Smac during apoptosis: XIAP promotes Smac ubiquitination in vitro

MacFarlane, M., Merrison, W., Bratton, S. B. & Cohen, G. M., Sep 27 2002, In : Journal of Biological Chemistry. 277, 39, p. 36611-36616 6 p.

Research output: Contribution to journalArticle

240 Scopus citations

The Apaf-1 apoptosome: A large caspase-activating complex

Cain, K., Bratton, S. B. & Cohen, G. M., Jan 1 2002, In : Biochimie. 84, 2-3, p. 203-214 12 p.

Research output: Contribution to journalArticle

320 Scopus citations

XIAP inhibition of caspase-3 preserves its association with the Apaf-1 apoptosome and prevents CD95- and Bax-induced apoptosis

Bratton, S. B., Lewis, J., Butterworth, M., Duckett, C. S. & Cohen, G. M., Jan 1 2002, In : Cell death and differentiation. 9, 9, p. 881-892 12 p.

Research output: Contribution to journalArticle

108 Scopus citations
2001

Caspase-3 cleaves Apaf-1 into an ∼ 30 kDa fragment that associates with an inappropriately oligomerized and biologically inactive ∼ 1.4 MDa apoptosome complex

Bratton, S. B., Walker, G., Roberts, D. L., Cain, K. & Cohen, G. M., May 17 2001, In : Cell death and differentiation. 8, 4, p. 425-433 9 p.

Research output: Contribution to journalArticle

41 Scopus citations

Caspase cascades in chemically-induced apoptosis

Bratton, S. B. & Cohen, G. M., Jan 1 2001, In : Advances in experimental medicine and biology. 500, p. 407-420 14 p.

Research output: Contribution to journalArticle

18 Scopus citations

Recruitment, activation and retention of caspases-9 and-3 by Apaf-1 apoptosome and associated XIAP complexes

Bratton, S. B., Walker, G., Srinivasula, S. M., Sun, X. M., Butterworth, M., Alnemri, E. S. & Cohen, G. M., Mar 1 2001, In : EMBO Journal. 20, 5, p. 998-1009 12 p.

Research output: Contribution to journalArticle

306 Scopus citations
2000

Apaf-1 oligomerizes into biologically active ~700-kDa and inactive ~1.4-MDa apoptosome complexes

Cain, K., Bratton, S. B., Langlais, C., Walker, G., Brown, D. G., Sun, X. M. & Cohen, G. M., Mar 3 2000, In : Journal of Biological Chemistry. 275, 9, p. 6067-6070 4 p.

Research output: Contribution to journalArticle

271 Scopus citations

Protein complexes activate distinct caspase cascades in death receptor and stress-induced apoptosis

Bratton, S. B., MacFarlane, M., Cain, K. & Cohen, G. M., Apr 10 2000, In : Experimental Cell Research. 256, 1, p. 27-33 7 p.

Research output: Contribution to journalArticle

275 Scopus citations
32 Scopus citations
1997
31 Scopus citations