Shuxing Zhang

Associate Professor

  • 3280 Citations
  • 31 h-Index
1993 …2019
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Research Output 1993 2019

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Article
2019
1 Citation (Scopus)

Creating novel translation inhibitors to target pro-survival proteins in chronic lymphocytic leukemia

Chen, R., Zhu, M., Chaudhari, R. R., Robles, O., Chen, Y., Skillern, W., Qin, Q., Wierda, W. G., Zhang, S., Hull, K. G., Romo, D. & Plunkett, W., Jul 1 2019, In : Leukemia. 33, 7, p. 1663-1674 12 p.

Research output: Contribution to journalArticle

B-Cell Chronic Lymphocytic Leukemia
Survival
Proteins
Blood Proteins
Apoptosis

Tankyrase disrupts metabolic homeostasis and promotes tumorigenesis by inhibiting LKB1-AMPK signalling

Li, N., Wang, Y., Neri, S., Zhen, Y., Fong, L. W. R., Qiao, Y., Li, X., Chen, Z., Stephan, C., Deng, W., Ye, R., Jiang, W., Zhang, S., Yu, Y., Hung, M. C., Chen, J. & Lin, S. H., Dec 1 2019, In : Nature communications. 10, 1, 4363.

Research output: Contribution to journalArticle

Open Access
Tankyrases
homeostasis
AMP-Activated Protein Kinases
metabolic diseases
Carcinogenesis
2018
3 Citations (Scopus)

Caspase-3 Substrates for Noninvasive Pharmacodynamic Imaging of Apoptosis by PET/CT

Engel, B. J., Gammon, S. T., Chaudhari, R., Lu, Z., Pisaneschi, F., Yang, H., Ornelas, A., Yan, V., Kelderhouse, L., Najjar, A. M., Tong, W. P., Zhang, S., Piwnica-Worms, D., Bast, R. C. & Millward, S. W., Sep 19 2018, In : Bioconjugate Chemistry. 29, 9, p. 3180-3195 16 p.

Research output: Contribution to journalArticle

Pharmacodynamics
Cell death
Caspase 3
Apoptosis
Imaging techniques
1 Citation (Scopus)

Interaction between nanoparticles and charged phospholipid membranes

Huang, B., Tan, Z., Bohinc, K. & Zhang, S., Jan 1 2018, In : Physical Chemistry Chemical Physics. 20, 46, p. 29249-29263 15 p.

Research output: Contribution to journalArticle

lipids
Phospholipids
Nanoparticles
membranes
Membranes
58 Citations (Scopus)

Mechanisms and clinical activity of an EGFR and HER2 exon 20-selective kinase inhibitor in non-small cell lung cancer

Robichaux, J. P., Elamin, Y. Y., Tan, Z., Carter, B., Zhang, S., Liu, S., Li, S., Chen, T., Poteete, A., Estrada-Bernal, A., Le, A. T., Truini, A., Nilsson, M. B., Sun, H., Roarty, E., Goldberg, S. B., Brahmer, J. R., Altan, M., Lu, C., Papadimitrakopoulou, V. A. & 4 others, Politi, K., Doebele, R. C., Wong, K. K. & Heymach, J. V., May 1 2018, In : Nature medicine. 24, 5, p. 638-646 9 p.

Research output: Contribution to journalArticle

Epidermal Growth Factor Receptor
Non-Small Cell Lung Carcinoma
Exons
Phosphotransferases
Cells
3 Citations (Scopus)

OncomiR-10b hijacks the small molecule inhibitor linifanib in human cancers

Monroig-Bosque, P. D. C., Shah, M. Y., Fu, X., Fuentes-Mattei, E., Ling, H., Ivan, C., Nouraee, N., Huang, B., Chen, L., Pileczki, V., Redis, R. S., Jung, E. J., Zhang, X., Lehrer, M., Nagvekar, R., Mafra, A. C. P., Monroig-Bosque, M. D. M., Irimie, A., Rivera, C., Dan Dumitru, C. & 4 others, Berindan-Neagoe, I., Nikonowicz, E. P., Zhang, S. & Calin, G. A., Dec 1 2018, In : Scientific reports. 8, 1, 13106.

Research output: Contribution to journalArticle

N-(4-(3-amino-1H-indazol-4-yl)phenyl)-N1-(2-fluoro-5-methylphenyl)urea
MicroRNAs
Neoplasms
Liver Neoplasms
Protein-Tyrosine Kinases
8 Citations (Scopus)

The critical role of AMPK in driving Akt activation under stress, tumorigenesis and drug resistance

Han, F., Li, C. F., Cai, Z., Zhang, X., Jin, G., Zhang, W. N., Xu, C., Wang, C. Y., Morrow, J., Zhang, S., Xu, D., Wang, G. & Lin, H. K., Dec 1 2018, In : Nature communications. 9, 1, 4728.

Research output: Contribution to journalArticle

AMP-Activated Protein Kinases
Drug Resistance
Carcinogenesis
drugs
Chemical activation
2017
78 Citations (Scopus)

A ROR1-HER3-lncRNA signalling axis modulates the Hippo-YAP pathway to regulate bone metastasis

Li, C., Wang, S., Xing, Z., Lin, A., Liang, K., Song, J., Hu, Q., Yao, J., Chen, Z., Park, P. K., Hawke, D. H., Zhou, J., Zhou, Y., Zhang, S., Liang, H., Hung, M. C., Gallick, G. E., Han, L., Lin, C. & Yang, L., Jan 31 2017, In : Nature cell biology. 19, 2, p. 106-119 14 p.

Research output: Contribution to journalArticle

Long Noncoding RNA
Neoplasm Metastasis
Bone and Bones
Receptor Tyrosine Kinase-like Orphan Receptors
Neoplasms
9 Citations (Scopus)

Transcribed ultraconserved region 339 promotes carcinogenesis by modulating tumor suppressor microRNAs

Vannini, I., Wise, P. M., Challagundla, K. B., Plousiou, M., Raffini, M., Bandini, E., Fanini, F., Paliaga, G., Crawford, M., Ferracin, M., Ivan, C., Fabris, L., Davuluri, R. V., Guo, Z., Cortez, M. A., Zhang, X., Chen, L., Zhang, S., Fernandez-Cymering, C., Han, L. & 14 others, Carloni, S., Salvi, S., Ling, H., Murtadha, M., Neviani, P., Gitlitz, B. J., Laird-Offringa, I. A., Nana-Sinkam, P., Negrini, M., Liang, H., Amadori, D., Cimmino, A., Fabbri, M. & Calin, G. A., Dec 1 2017, In : Nature communications. 8, 1, 1801.

Research output: Contribution to journalArticle

suppressors
MicroRNAs
Tumors
Carcinogenesis
tumors
2016
8 Citations (Scopus)

Comprehensive modeling and discovery of mebendazole as a novel TRAF2- and NCK-interacting kinase inhibitor

Tan, Z., Chen, L. & Zhang, S., Sep 21 2016, In : Scientific reports. 6, 33534.

Research output: Contribution to journalArticle

TNF Receptor-Associated Factor 2
Mebendazole
Phosphotransferases
Anthelmintics
Pharmaceutical Preparations
7 Citations (Scopus)

Past, present, and future of targeting ras for cancer therapies

Tan, Z. & Zhang, S., Mar 1 2016, In : Mini-Reviews in Medicinal Chemistry. 16, 5, p. 345-357 13 p.

Research output: Contribution to journalArticle

ras Proteins
Therapeutic Uses
Mutant Proteins
Drug Delivery Systems
Pancreatic Neoplasms
2015
9 Citations (Scopus)

Novel Inhibitors Induce Large Conformational Changes of GAB1 Pleckstrin Homology Domain and Kill Breast Cancer Cells

Chen, L., Du-Cuny, L., Moses, S., Dumas, S., Song, Z., Rezaeian, A. H., Lin, H. K., Meuillet, E. J. & Zhang, S., Jan 1 2015, In : PLoS computational biology. 11, 1

Research output: Contribution to journalArticle

pleckstrin
sequence homology
Breast Cancer
homology
breast neoplasms
2014
11 Citations (Scopus)

Curation and analysis of multitargeting agents for polypharmacological modeling

Reddy, A. S., Tan, Z. & Zhang, S., Sep 22 2014, In : Journal of Chemical Information and Modeling. 54, 9, p. 2536-2543 8 p.

Research output: Contribution to journalArticle

drug
Pharmaceutical Preparations
Ligands
Proteins
Drug Discovery
11 Citations (Scopus)

Genetic and pharmacological strategies to refunctionalize the von hippel lindau R167Q mutant protein

Ding, Z., German, P., Bai, S., Reddy, A. S., Liu, X. D., Sun, M., Zhou, L., Chen, X., Zhao, X., Wu, C., Zhang, S., Mills, G. B. & Jonasch, E., Jun 1 2014, In : Cancer research. 74, 11, p. 3127-3136 10 p.

Research output: Contribution to journalArticle

Mutant Proteins
von Hippel-Lindau Disease
Pharmacology
Missense Mutation
Down-Regulation
2013
175 Citations (Scopus)

Pharmacological inactivation of Skp2 SCF ubiquitin ligase restricts cancer stem cell traits and cancer progression

Chan, C. H., Morrow, J. K., Li, C. F., Gao, Y., Jin, G., Moten, A., Stagg, L. J., Ladbury, J. E., Cai, Z., Xu, D-Z., Logothetis, C. J., Hung, M-C., Zhang, S. & Lin, H. K., Aug 1 2013, In : Cell. 154, 3, p. 556-568 13 p.

Research output: Contribution to journalArticle

SKP Cullin F-Box Protein Ligases
Ubiquitin-Protein Ligases
Neoplastic Stem Cells
Stem cells
Cells
25 Citations (Scopus)

Quantitative prediction of glucuronidation in humans using the in vitro-in vivo extrapolation approach

Wu, B., Dong, D., Hu, M. & Zhang, S., Aug 15 2013, In : Current Topics in Medicinal Chemistry. 13, 11, p. 1343-1352 10 p.

Research output: Contribution to journalArticle

Hepatocytes
Glucuronides
Bovine Serum Albumin
Microsomes
Pharmaceutical Preparations
2 Citations (Scopus)

Synthesis of a 2(1 h)-pyridone library via rhodium-catalyzed formation of isomunchones

De, S., Chen, L., Zhang, S. & Gilbertson, S. R., Jul 8 2013, In : ACS Combinatorial Science. 15, 7, p. 340-343 4 p.

Research output: Contribution to journalArticle

Pyridones
Rhodium
Cycloaddition
Cyclization
Alkenes
2012
20 Citations (Scopus)
Cysteine
Tumors
Phosphotransferases
Down-Regulation
Genes
13 Citations (Scopus)

Accurate prediction of glucuronidation of structurally diverse phenolics by human UGT1A9 using combined experimental and in silico approaches

Wu, B., Wang, X., Zhang, S. & Hu, M., Jun 1 2012, In : Pharmaceutical Research. 29, 6, p. 1544-1561 18 p.

Research output: Contribution to journalArticle

Quantitative Structure-Activity Relationship
Computer Simulation
Substrates
Xenobiotics
Catalytic Domain
52 Citations (Scopus)

Computational prediction of protein hot spot residues

Morrow, J. K. & Zhang, S., Mar 1 2012, In : Current pharmaceutical design. 18, 9, p. 1255-1265 11 p.

Research output: Contribution to journalArticle

Proteins
Biological Phenomena
Computer Simulation
Therapeutics
232 Citations (Scopus)

Effect of KRAS oncogene substitutions on protein behavior: Implications for signaling and clinical outcome

Ihle, N. T., Byers, L. A., Kim, E. S., Saintigny, P., Lee, J. J., Blumenschein, G. R., Tsao, A., Liu, S., Larsen, J. E., Wang, J., Diao, L., Coombes, K. R., Chen, L., Zhang, S., Abdelmelek, M. F., Tang, X., Papadimitrakopoulou, V., Minna, J. D., Lippman, S. M., Hong, W. K. & 4 others, Herbst, R. S., Wistuba, I. I., Heymach, J. V. & Powis, G., Feb 8 2012, In : Journal of the National Cancer Institute. 104, 3, p. 228-239 12 p.

Research output: Contribution to journalArticle

Oncogenes
Mutant Proteins
Non-Small Cell Lung Carcinoma
Proteins
Neoplasms
19 Citations (Scopus)

Novel insights of structure-based modeling for RNA-targeted drug discovery

Chen, L., Calin, G. A. & Zhang, S., Oct 22 2012, In : Journal of Chemical Information and Modeling. 52, 10, p. 2741-2753 13 p.

Research output: Contribution to journalArticle

RNA
drug
fitness
statistical analysis
biology
22 Citations (Scopus)

SULT1A3-mediated regiospecific 7-O-sulfation of flavonoids in caco-2 cells can be explained by the relevant molecular docking studies

Meng, S., Wu, B., Singh, R., Yin, T., Morrow, J. K., Zhang, S. & Hu, M., Apr 2 2012, In : Molecular Pharmaceutics. 9, 4, p. 862-873 12 p.

Research output: Contribution to journalArticle

Caco-2 Cells
Flavonoids
Flavones
Flavonols
flavone
115 Citations (Scopus)

Transcription factors ETS2 and MESP1 transdifferentiate human dermal fibroblasts into cardiac progenitors

Islas, J. F., Liu, Y., Weng, K. C., Robertson, M. J., Zhang, S., Prejusa, A., Harger, J., Tikhomirova, D., Chopra, M., Iyer, D., Mercola, M., Oshima, R. G., Willerson, J. T., Potaman, V. N. & Schwartz, R. J., Aug 7 2012, In : Proceedings of the National Academy of Sciences of the United States of America. 109, 32, p. 13016-13021 6 p.

Research output: Contribution to journalArticle

Transcription Factors
Fibroblasts
Skin
Mesoderm
Urochordata
2011
5 Citations (Scopus)
flexibility
Ligands
Crystal structure
X rays
platelet protein P47
38 Citations (Scopus)

A critical assessment of combined ligand- and structure-based approaches to hERG channel blocker modeling

Du-Cuny, L., Chen, L. & Zhang, S., Nov 28 2011, In : Journal of Chemical Information and Modeling. 51, 11, p. 2948-2960 13 p.

Research output: Contribution to journalArticle

Ether
Ethers
Genes
Ligands
drug
7 Citations (Scopus)

Design, synthesis, and diversification of 3,5-substituted enone library

Khalaf, J., Estrella-Jimenez, M. E., Shashack, M. J., Phatak, S. S., Zhang, S. & Gilbertson, S. R., Jul 11 2011, In : ACS Combinatorial Science. 13, 4, p. 351-356 6 p.

Research output: Contribution to journalArticle

Boronic Acids
Triazoles
Cycloaddition
Bromides
Principal component analysis
23 Citations (Scopus)

Development of sulfonamide AKT PH domain inhibitors

Ahad, A. M., Zuohe, S., Du-Cuny, L., Moses, S. A., Zhou, L. L., Zhang, S., Powis, G., Meuillet, E. J. & Mash, E. A., Mar 15 2011, In : Bioorganic and Medicinal Chemistry. 19, 6, p. 2046-2054 9 p.

Research output: Contribution to journalArticle

Sulfonamides
Assays
Cells
Phosphatidylinositol 3-Kinase
Apoptosis
18 Citations (Scopus)
irinotecan
Flavonoids
Glucuronosyltransferase
Liver
Protein Isoforms
23 Citations (Scopus)

Recent development of anticancer therapeutics targeting AKT

Morrow, J. K., Du-Cuny, L., Chen, L., Meuillet, E. J., Mash, E. A., Powis, G. & Zhang, S., Jan 11 2011, In : Recent Patents on Anti-Cancer Drug Discovery. 6, 1, p. 146-159 14 p.

Research output: Contribution to journalArticle

Patents
Phosphotransferases
Computer-Aided Design
Drug Design
Protein-Serine-Threonine Kinases
32 Citations (Scopus)
Flavonols
Quantitative Structure-Activity Relationship
Biological Availability
2010
14 Citations (Scopus)

Chain termination and inhibition of mammalian poly(A) polymerase by modified ATP analogues

Chen, L. S., Du-Cuny, L., Vethantham, V., Hawke, D. H., Manley, J. L., Zhang, S. & Gandhi, V. V., Mar 1 2010, In : Biochemical Pharmacology. 79, 5, p. 669-677 9 p.

Research output: Contribution to journalArticle

Polynucleotide Adenylyltransferase
Adenosine Triphosphate
RNA
Polyadenylation
Messenger RNA
45 Citations (Scopus)

Molecular pharmacology and antitumor activity of PHT-427, a novel akt/phosphatidylinositide-dependent protein kinase 1 pleckstrin homology domain inhibitor

Meuillet, E. J., Zuohe, S., Lemos, R., Ihle, N., Kingston, J., Watkins, R., Moses, S. A., Zhang, S., Du-Cuny, L., Herbst, R., Jacoby, J. J., Zhou, L. L., Ahad, A. M., Mash, E. A., Kirkpatrick, D. L. & Powis, G., Mar 1 2010, In : Molecular cancer therapeutics. 9, 3, p. 706-717 12 p.

Research output: Contribution to journalArticle

Protein Kinases
Pharmacology
Phosphotransferases
Neoplasms
Heterografts
2009
24 Citations (Scopus)

Computational modeling of novel inhibitors targeting the Akt pleckstrin homology domain

Du-Cuny, L., Song, Z., Moses, S., Powis, G., Mash, E. A., Meuillet, E. J. & Zhang, S., Oct 1 2009, In : Bioorganic and Medicinal Chemistry. 17, 19, p. 6983-6992 10 p.

Research output: Contribution to journalArticle

Proto-Oncogene Proteins c-akt
Computer Simulation
Assays
Quantitative Structure-Activity Relationship
Testing
9 Citations (Scopus)
Statistical Models
Drug Discovery
Screening
Computing Methodologies
Throughput
17 Citations (Scopus)

Inhibition of ATP synthase by chlorinated adenosine analogue

Chen, L. S., Nowak, B. J., Ayres, M. L., Krett, N. L., Rosen, S. T., Zhang, S. & Gandhi, V., Sep 15 2009, In : Biochemical Pharmacology. 78, 6, p. 583-591 9 p.

Research output: Contribution to journalArticle

Adenosine
Adenosine Triphosphate
Adenosine Diphosphate
Substrates
Mitochondrial Proton-Translocating ATPases
38 Citations (Scopus)

In vitro and in vivo activity of novel small-molecule inhibitors targeting the pleckstrin homology domain of protein kinase B/AKT

Moses, S. A., Ali, M. A., Zuohe, S., Du-Cuny, L., Li, L. Z., Lemos, R., Ihle, N., Skillman, A. G., Zhang, S., Mash, E. A., Powis, G. & Meuillet, E. J., Jun 15 2009, In : Cancer research. 69, 12, p. 5073-5081 9 p.

Research output: Contribution to journalArticle

Proto-Oncogene Proteins c-akt
Pancreatic Neoplasms
Phosphatidylinositol 3-Kinase
Surface Plasmon Resonance
Heterografts
2008
51 Citations (Scopus)

Discovery of a novel class of AKT pleckstrin homology domain inhibitors

Mahadevan, D., Powis, G., Mash, E. A., George, B., Gokhale, V. M., Zhang, S., Shakalya, K., Du-Cuny, L., Berggren, M., Ali, M. A., Jana, U., Ihle, N., Moses, S., Franklin, C., Narayan, S., Shirahatti, N. & Meuillet, E. J., Oct 22 2008, In : Molecular cancer therapeutics. 7, 9, p. 2621-2632 12 p.

Research output: Contribution to journalArticle

Insulin Receptor Substrate Proteins
3-Phosphoinositide-Dependent Protein Kinases
Computer Simulation
1-Phosphatidylinositol 4-Kinase
Surface Plasmon Resonance
68 Citations (Scopus)

DOVIS: An implementation for high-throughput virtual screening using AutoDock

Zhang, S., Kumar, K., Jiang, X., Wallqvist, A. & Reifman, J., Feb 27 2008, In : BMC bioinformatics. 9, 126.

Research output: Contribution to journalArticle

Computing Methodologies
High-throughput Screening
Virtual Screening
Docking
Linux
4 Citations (Scopus)

HIV-1 protease function and structure studies with the simplicial neighborhood analysis of protein packing method

Zhang, S., Kaplan, A. H. & Tropsha, A., Nov 15 2008, In : Proteins: Structure, Function and Genetics. 73, 3, p. 742-753 12 p.

Research output: Contribution to journalArticle

Proteins
Peptide Hydrolases
Mutagenesis
Protein Engineering
Mutant Proteins
2007
76 Citations (Scopus)

Antitumor agents 252. Application of validated QSAR models to database mining: Discovery of novel tylophorine derivatives as potential anticancer agents

Zhang, S., Wei, L., Bastow, K., Zheng, W., Brossi, A., Lee, K. H. & Tropsha, A., Jan 1 2007, In : Journal of Computer-Aided Molecular Design. 21, 1-3, p. 97-112 16 p.

Research output: Contribution to journalArticle

Quantitative Structure-Activity Relationship
Antineoplastic Agents
Databases
Derivatives
correlation coefficients
2006
170 Citations (Scopus)
Anticonvulsants
Screening
Bioactivity
learning
Linear regression
46 Citations (Scopus)

Chemometric analysis of ligand receptor Complementarity: Identifying Complementary Ligands Based on Receptor Information (CoLiBRI)

Oloff, S., Zhang, S., Sukumar, N., Breneman, C. & Tropsha, A., Mar 1 2006, In : Journal of Chemical Information and Modeling. 46, 2, p. 844-851 8 p.

Research output: Contribution to journalArticle

Ligands
pattern recognition
Binding sites
mathematics
present
61 Citations (Scopus)
Electronegativity
Ligands
Proteins
Computational geometry
X-Rays
2005
16 Citations (Scopus)

An alternative domain near the nucleotide-binding site of Drosophila muscle myosin affects ATPase kinetics

Miller, B. M., Zhang, S., Suggs, J. A., Swank, D. M., Littlefield, K. P., Knowles, A. F. & Bernstein, S. I., Oct 14 2005, In : Journal of Molecular Biology. 353, 1, p. 14-25 12 p.

Research output: Contribution to journalArticle

Myosins
Drosophila
Exons
Nucleotides
Binding Sites
26 Citations (Scopus)

Complex cardiac Nkx2-5 gene expression activated by noggin-sensitive enhancers followed by chamber-specific modules

Chi, X., Chatterjee, P. K., Wilson, W., Zhang, S. X., DeMayo, F. J. & Schwartz, R. J., Sep 20 2005, In : Proceedings of the National Academy of Sciences of the United States of America. 102, 38, p. 13490-13495 6 p.

Research output: Contribution to journalArticle

Transgenes
Chromatin
Gene Expression
Tongue
Atrial Septum
90 Citations (Scopus)

Conditional mutagenesis of the murine serum response factor gene blocks cardiogenesis and the transcription of downstream gene targets

Niu, Z., Yu, W., Zhang, S. X., Barron, M., Belaguli, N. S., Schneider, M. D., Parmacek, M., Nordheim, A. & Schwartz, R. J., Sep 16 2005, In : Journal of Biological Chemistry. 280, 37, p. 32531-32538 8 p.

Research output: Contribution to journalArticle

Serum Response Factor
Mutagenesis
Transcription
Genes
Ablation
68 Citations (Scopus)

Identification of direct serum-response factor gene targets during Me 2SO-induced P19 cardiac cell differentiation

Zhang, S. X., Garcia-Gras, E., Wycuff, D. R., Marriot, S. J., Kadeer, N., Yu, W., Olson, E. N., Garry, D. J., Parmacek, M. S. & Schwartz, R. J., May 13 2005, In : Journal of Biological Chemistry. 280, 19, p. 19115-19126 12 p.

Research output: Contribution to journalArticle

Serum Response Factor
Cell Differentiation
Genes
Mesoderm
Semaphorin-3A
2004
8 Citations (Scopus)
Protein Conformation
Conformations
Ligands
Periplasmic Binding Proteins
Proteins
2003
17 Citations (Scopus)

Expression of Nkx2-5-GFP bacterial artificial chromosome transgenic mice closely resembles endogenous Nkx2-5 gene activity

Chi, X., Zhang, S. X., Yu, W., DeMayo, F. J., Rosenberg, S. M. & Schwartz, R. J., Apr 1 2003, In : Genesis. 35, 4, p. 220-226 7 p.

Research output: Contribution to journalArticle

Bacterial Artificial Chromosomes
Transgenic Mice
Genetic Recombination
Genes
Clone Cells