Sivareddy Kotla

Research output

Research output per year 2010 2015 2019 2021 2022 2023 2023

• 31 Article
• 6 Comment/debate
• 4 Review article

Research output per year

Research output per year

Search results

• 12/15-Lipoxygenase-dependent ROS production is required for diet-induced endothelial barrier dysfunction

  Chattopadhyay, R., Tinnikov, A., Dyukova, E., Singh, N. K., Kotla, S., Mobley, J. A. & Rao, G. N., Mar 1 2015, In: Journal of lipid research. 56, 3, p. 562-577 16 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • 12-15-lipoxygenase 100%
  • Junctional Adhesion Molecules 74%
  • Xanthine Oxidase 73%
  • Tight Junctions 67%
  • Xanthine 67%
  19 Scopus citations

• Aerobic Exercise Alters the Melanoma Microenvironment and Modulates ERK5 S496 Phosphorylation

  Savage, H., Pareek, S., Lee, J., Ballarò, R., Minussi, D. C., Hayek, K., Sadullozoda, M., Lochmann, B. S., McQuade, J. L., LaVoy, E. C., Marmonti, E., Patel, H., Wang, G., Imanishi, M., Kotla, S., Abe, J. I. & Schadler, K., Sep 1 2023, In: Cancer Immunology Research. 11, 9, p. 1168-1183 16 p.

  Research output: Contribution to journal › Article › peer-review

  • Melanoma 100%
  • Phosphorylation 83%
  • Exercise 78%
  • Neoplasms 38%
  • Tumor Microenvironment 35%
  4 Scopus citations

• An ERK5-NRF2 Axis Mediates Senescence-Associated Stemness and Atherosclerosis

  Abe, J. I., Imanishi, M., Li, S., Zhang, A., Ko, K. A., Samanthapudi, V. S. K., Lee, L. L., Bojorges, A. P., Gi, Y. J., Hobbs, B. P., Deswal, A., Herrmann, J., Lin, S. H., Chini, E. N., Shen, Y. H., Schadler, K. L., Nguyen, T. H. M., Gupte, A. A., Reyes-Gibby, C., Yeung, S. C. J., & 14 othersAbe, R. J., Olmsted-Davis, E. A., Krishnan, S., Dantzer, R., Palaskas, N. L., Cooke, J. P., Pownall, H. J., Yoshimoto, M., Fujiwara, K., Hamilton, D. J., Burks, J. K., Wang, G., Le, N. T. & Kotla, S., Jun 23 2023, In: Circulation research. 133, 1, p. 25-44 20 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Mitogen-Activated Protein Kinase 7 100%
  • Atherosclerosis 47%
  • Phosphotransferases 15%
  • Clustered Regularly Interspaced Short Palindromic Repeats 13%
  • Cellular Senescence 13%
  4 Scopus citations

• Cationic microparticle [poly(d,l-lactide-co-glycolide)]-coated DNA vaccination induces a long-term immune response against foot and mouth disease in guinea pigs

  Reddy, K. S., Rashmi, B. R., Dechamma, H. J., Gopalakrishna, S., Banumathi, N., Suryanarayana, V. V. S. & Reddy, G. R., May 2012, In: Journal of Gene Medicine. 14, 5, p. 348-352 5 p.

  Research output: Contribution to journal › Article › peer-review

  • dilactide 100%
  • Foot-and-Mouth Disease 98%
  • Guinea Pigs 58%
  • DNA Vaccines 54%
  • Plasmids 54%
  13 Scopus citations

• Cyclic AMP Response Element Binding Protein Mediates Pathological Retinal Neovascularization via Modulating DLL4-NOTCH1 Signaling

  Singh, N. K., Kotla, S., Kumar, R. & Rao, G. N., Nov 1 2015, In: EBioMedicine. 2, 11, p. 1767-1784 18 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Retinal Neovascularization 100%
  • Pathologic Neovascularization 99%
  • Cyclic AMP Response Element-Binding Protein 89%
  • Retinal 81%
  • Protein 29%
  20 Scopus citations

• Developing a Reliable Mouse Model for Cancer Therapy-Induced Cardiovascular Toxicity in Cancer Patients and Survivors

  Ko, K. A., Wang, Y., Kotla, S., Fujii, Y., Vu, H. T., Venkatesulu, B. P., Thomas, T. N., Medina, J. L., Gi, Y. J., Hada, M., Grande-Allen, J., Patel, Z. S., Milgrom, S. A., Krishnan, S., Fujiwara, K. & Abe, J. I., Apr 5 2018, In: Frontiers in Cardiovascular Medicine. 5, 26.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Cancer Survivors 100%
  • Ionizing Radiation 94%
  • Atherosclerotic Plaques 40%
  • Neoplasms 29%
  • Carotid Arteries 25%
  7 Scopus citations

• Disruption of p21-activated kinase 1 gene diminishes atherosclerosis in apolipoprotein E-deficient mice

  Singh, N. K., Kotla, S., Dyukova, E., Traylor, J. G., Orr, A. W., Chernoff, J., Marion, T. N. & Rao, G. N., Jun 24 2015, In: Nature communications. 6, 7450.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Oxidised LDL 100%
  • arteriosclerosis 86%
  • p21-Activated Kinases 86%
  • genes 70%
  • Apolipoproteins E 64%
  20 Scopus citations

• Disturbed flow-induced FAK K152 SUMOylation initiates the formation of pro-inflammation positive feedback loop by inducing reactive oxygen species production in endothelial cells

  Velatooru, L. R., Abe, R. J., Imanishi, M., Gi, Y. J., Ko, K. A., Heo, K. S., Fujiwara, K., Le, N. T. & Kotla, S., Dec 2021, In: Free Radical Biology and Medicine. 177, p. 404-418 15 p.

  Research output: Contribution to journal › Article › peer-review

  • Sumoylation 100%
  • Focal Adhesion Protein-Tyrosine Kinases 92%
  • Reactive Oxygen Metabolite 69%
  • Reactive Oxygen Species 59%
  • Endothelial Cells 55%
  9 Scopus citations

• DNA vaccine (P1-2A-3C-pCDNA) co-administered with Bovine IL-18 gives protective immune response against Foot and Mouth Disease in cattle

  Kotla, S., Sanghratna Vishanath, B., H.J., D., K., G., V.V.S., S. & Reddy, G. R., Sep 25 2016, In: Veterinary Microbiology. 193, p. 106-115 10 p.

  Research output: Contribution to journal › Article › peer-review

  • interleukin-18 100%
  • Foot-and-Mouth Disease 97%
  • recombinant vaccines 87%
  • foot-and-mouth disease 81%
  • DNA Vaccines 79%
  12 Scopus citations

• Endothelial activation and fibrotic changes are impeded by laminar flow-induced CHK1-SENP2 activity through mechanisms distinct from endothelial-to-mesenchymal cell transition

  Nguyen, M. T. H., Imanishi, M., Li, S., Chau, K., Banerjee, P., Velatooru, L. R., Ko, K. A., Samanthapudi, V. S. K., Gi, Y. J., Lee, L. L., Abe, R. J., McBeath, E., Deswal, A., Lin, S. H., Palaskas, N. L., Dantzer, R., Fujiwara, K., Borchrdt, M. K., Turcios, E. B., Olmsted-Davis, E. A., & 5 othersKotla, S., Cooke, J. P., Wang, G., Abe, J. I. & Le, N. T., 2023, In: Frontiers in Cardiovascular Medicine. 10, 1187490.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • isopeptidase 100%
  • SUMO-1 Protein 96%
  • Checkpoint Kinase 1 87%
  • Endothelial Cells 19%
  • Phosphorylation 13%

• Endothelial senescence-associated secretory phenotype (SASP) is regulated by Makorin-1 ubiquitin E3 ligase

  Kotla, S., Le, N. T., Vu, H. T., Ko, K. A., Gi, Y. J., Thomas, T. N., Giancursio, C., Lusis, A. J., Cooke, J. P., Fujiwara, K. & Abe, J. I., Nov 2019, In: Metabolism: clinical and experimental. 100, 153962.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Telomeric Repeat Binding Protein 2 100%
  • Ubiquitin-Protein Ligases 62%
  • Cellular Senescence 59%
  • Endothelial Cells 28%
  • Phosphorylation 18%
  16 Scopus citations

• Endothelial senescence is induced by phosphorylation and nuclear export of telomeric repeat binding factor 2-interacting protein

  Kotla, S., Vu, H. T., Ko, K. A., Wang, Y., Imanishi, M., Heo, K. S., Fujii, Y., Thomas, T. N., Gi, Y. J., Mazhar, H., Paez-Mayorga, J., Shin, J. H., Tao, Y., Giancursio, C. J., Medina, J. L. M., Taunton, J., Lusis, A. J., Cooke, J. P., Fujiwara, K., Le, N. T., & 1 othersAbe, J. I., 2019, In: JCI Insight. 4, 9, e124867.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Cell Nucleus Active Transport 100%
  • Phosphorylation 58%
  • Cellular Senescence 51%
  • Endothelial Cells 48%
  • Apoptosis 34%
  26 Scopus citations

• Expression of bovine (Bos indicus) interleukin-18 in Escherichia coli and its biological activity

  Reddy, K. S., Rao, M., Dechamma, H. J., Suryanarayana, V. V. S. & Reddy, G. R., Sep 2010, In: Microbiology and Immunology. 54, 9, p. 564-567 4 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Interleukin-18 100%
  • Cattle 68%
  • Escherichia coli 59%
  • Proteins 31%
  • Ruminants 26%

• Heterodimers of the transcriptional factors NFATc3 and FosB mediate tissue factor expression for 15(S)-hydroxyeicosatetraenoic acid-induced monocyte trafficking

  Kotla, S., Singh, N. K., Kirchhofer, D. & Rao, G. N., Sep 8 2017, In: Journal of Biological Chemistry. 292, 36, p. 14885-14901 17 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Hydroxyeicosatetraenoic Acids 100%
  • TCF Transcription Factors 91%
  • NFATC Transcription Factors 90%
  • Heterodimer 76%
  • Thromboplastin 75%
  5 Scopus citations

• Improved immune response by ID-pVAC: A secretory DNA vaccine construct delivered by PLG micro particles against foot and mouth disease in guinea pigs

  Jadav, S. K., Reddy, K. S., Rashmi, B. R., Dechamma, H. J., Ganesh, K., Suryanarayana, V. V. S. & Reddy, G. R., Aug 2011, In: Research in Veterinary Science. 91, 1, p. 86-89 4 p.

  Research output: Contribution to journal › Article › peer-review

  • Foot-and-Mouth Disease 100%
  • recombinant vaccines 89%
  • foot-and-mouth disease 83%
  • DNA Vaccines 82%
  • Guinea Pigs 59%
  4 Scopus citations

• Ionizing Radiation Induces Endothelial Inflammation and Apoptosis via p90RSK-Mediated ERK5 S496 Phosphorylation

  Vu, H. T., Kotla, S., Ko, K. A., Fujii, Y., Tao, Y., Medina, J., Thomas, T., Hada, M., Sood, A. K., Singh, P. K., Milgrom, S. A., Krishnan, S., Fujiwara, K., Le, N. T. & Abe, J. I., Mar 14 2018, In: Frontiers in Cardiovascular Medicine. 5, 23.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Ionizing Radiation 100%
  • Phosphorylation 66%
  • Apoptosis 59%
  • Inflammation 57%
  • Endothelial Cells 47%
  15 Scopus citations

• MAGI1 as a link between endothelial activation and ER stress drives atherosclerosis

  Abe, J-I., Ko, K. A., Kotla, S., Wang, Y., Paez-Mayorga, J., Shin, I. J., Imanishi, M., Vu, H. T., Tao, Y., Leiva-Juarez, M. M., Thomas, T. N., Medina, J. L., Won, J. H., Fujii, Y., Giancursio, C. J., McBeath, E., Shin, J-H., Guzman, L., Abe, R. J., Taunton, J., & 6 othersMochizuki, N., Faubion, W., Cooke, J. P., Fujiwara, K., Evans, S. E. & Le, N-T., Apr 4 2019, In: JCI Insight. 4, 7

  Research output: Contribution to journal › Article › peer-review

  • Endoplasmic Reticulum Stress 100%
  • Atherosclerosis 72%
  • Endothelial Cells 66%
  • 90-kDa Ribosomal Protein S6 Kinases 49%
  • Activating Transcription Factor 6 48%
  31 Scopus citations

• MAGI1 inhibits interferon signaling to promote influenza A infection

  Wang, Y., Abe, J. I., Chau, K. M., Wang, Y., Vu, H. T., Reddy Velatooru, L., Gulraiz, F., Imanishi, M., Samanthapudi, V. S. K., Nguyen, M. T. H., Ko, K. A., Lee, L. L., Thomas, T. N., Olmsted-Davis, E. A., Kotla, S., Fujiwara, K., Cooke, J. P., Zhao, D., Evans, S. E. & Le, N. T., Aug 23 2022, In: Frontiers in Cardiovascular Medicine. 9, 791143.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Influenza A virus 100%
  • Human Influenza 83%
  • Interferons 83%
  • Interferon Regulatory Factor-3 73%
  • Infections 43%
  1 Scopus citations

• Novel role for p21-activated kinase 2 in thrombin-induced monocyte migration

  Gadepalli, R., Kotla, S., Heckle, M. R., Verma, S. K., Singh, N. K. & Rao, G. N., Oct 25 2013, In: Journal of Biological Chemistry. 288, 43, p. 30815-30831 17 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • p21-Activated Kinases 100%
  • Thrombin 74%
  • Monocytes 57%
  • Anti-Inflammatory Drug 44%
  • Actins 19%
  30 Scopus citations

• Nucleus-mitochondria positive feedback loop formed by ERK5 S496 phosphorylation-mediated poly (ADP-ribose) polymerase activation provokes persistent pro-inflammatory senescent phenotype and accelerates coronary atherosclerosis after chemo-radiation

  Kotla, S., Zhang, A., Imanishi, M., Ko, K. A., Lin, S. H., Gi, Y. J., Moczygemba, M., Isgandarova, S., Schadler, K. L., Chung, C., Milgrom, S. A., Banchs, J., Yusuf, S. W., Amaya, D. N., Guo, H., Thomas, T. N., Shen, Y. H., Deswal, A., Herrmann, J., Kleinerman, E. S., & 15 othersEntman, M. L., Cooke, J. P., Schifitto, G., Maggirwar, S. B., McBeath, E., Gupte, A. A., Krishnan, S., Patel, Z. S., Yoon, Y., Burks, J. K., Fujiwara, K., Brookes, P. S., Le, N. T., Hamilton, D. J. & Abe, J. I., Nov 2021, In: Redox Biology. 47, 102132.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Poly(ADPribose) 100%
  • Poly(ADP-ribose) Polymerases 87%
  • Cellular Senescence 80%
  • Ionizing Radiation 71%
  • Coronary Artery Disease 60%
  17 Scopus citations

• p90RSK-MAGI1 Module Controls Endothelial Permeability by Post-translational Modifications of MAGI1 and Hippo Pathway

  Abe, R. J., Savage, H., Imanishi, M., Banerjee, P., Kotla, S., Paez-Mayorga, J., Taunton, J., Fujiwara, K., Won, J. H., Yusuf, S. W., Palaskas, N. L., Banchs, J., Lin, S. H., Schadler, K. L., Abe, J. I. & Le, N. T., Nov 13 2020, In: Frontiers in Cardiovascular Medicine. 7, 542485.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Post Translational Protein Processing 100%
  • Permeability 83%
  • Endothelial Cells 71%
  • Sumoylation 52%
  • Neoplasms 31%
  7 Scopus citations

• PLCβ3 mediates cortactin interaction with WAVE2 in MCP1-induced actin polymerization and cell migration

  Janjanam, J., Kumar Chandaka, G., Kotla, S. & Rao, G. N., Dec 15 2015, In: Molecular Biology of the Cell. 26, 25, p. 4589-4606 18 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Cortactin 100%
  • Chemokine CCL2 72%
  • Actins 55%
  • Cell Movement 53%
  • Smooth Muscle Myocytes 44%
  21 Scopus citations

• Ponatinib Activates an Inflammatory Response in Endothelial Cells via ERK5 SUMOylation

  Paez-Mayorga, J., Chen, A. L., Kotla, S., Tao, Y., Abe, R. J., He, E. D., Danysh, B. P., Hofmann, M. C. C. & Le, N. T., Sep 6 2018, In: Frontiers in Cardiovascular Medicine. 5, 125.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Mitogen-Activated Protein Kinase 7 100%
  • ponatinib 98%
  • Sumoylation 79%
  • Endothelial Cells 43%
  • Blood Vessels 11%
  24 Scopus citations

• Protein kinase N1 is a novel substrate of NFATc1-mediated cyclin D1-CDK6 activity and modulates vascular smooth muscle cell division and migration leading to inward blood vessel wall remodeling

  Singh, N. K., Kundumani-Sridharan, V., Kumar, S., Verma, S. K., Kotla, S., Mukai, H., Heckle, M. R. & Rao, G. N., Oct 19 2012, In: Journal of Biological Chemistry. 287, 43, p. 36291-36304 14 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • protein kinase N 100%
  • Chemoattractant 93%
  • Cyclin D1 69%
  • Vascular Smooth Muscle 62%
  • Cell Division 60%
  34 Scopus citations

• Radiation therapy induces immunosenescence mediated by p90RSK

  Imanishi, M., Cheng, H., Kotla, S., Deswal, A., Le, N. T., Chini, E., Ko, K. A., Samanthapudi, V. S. K., Lee, L. L., Herrmann, J., Xu, X., Reyes-Gibby, C., Yeung, S. C. J., Schadler, K. L., Yusuf, S. W., Liao, Z., Nurieva, R., Amir, E. A. D., Burks, J. K., Palaskas, N. L., & 5 othersCooke, J. P., Lin, S. H., Kobayashi, M., Yoshimoto, M. & Abe, J. I., Nov 7 2022, In: Frontiers in Cardiovascular Medicine. 9, 988713.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Immunosenescence 100%
  • Radiotherapy 47%
  • Cardiovascular Diseases 35%
  • B-Lymphocytes 30%
  • Cellular Senescence 21%
  3 Scopus citations

• ROS-dependent Syk and Pyk2-mediated STAT1 activation is required for 15(S)-hydroxyeicosatetraenoic acid-induced CD36 expression and foam cell formation

  Kotla, S., Singh, N. K., Traylor, J. G., Wayne Orr, A. & Rao, G. N., Nov 2014, In: Free Radical Biology and Medicine. 76, p. 147-162 16 p.

  Research output: Contribution to journal › Article › peer-review

  • Hydroxyeicosatetraenoic Acids 100%
  • Foam Cells 84%
  • Xanthine Oxidase 82%
  • NADPH Oxidases 77%
  • Apolipoproteins E 71%
  26 Scopus citations

• ROS via BTK-p300-STAT1-PPARγ signaling activation mediates cholesterol crystals-induced CD36 expression and foam cell formation

  Kotla, S., Singh, N. K. & Rao, G. N., Apr 1 2017, In: Redox Biology. 11, p. 350-364 15 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Foam Cells 100%
  • Peroxisome Proliferator-Activated Receptors 96%
  • Foam 72%
  • Cholesterol 71%
  • Acetylation 23%
  57 Scopus citations

• Senescent Phenotype Induced by p90RSK-NRF2 Signaling Sensitizes Monocytes and Macrophages to Oxidative Stress in HIV-Positive Individuals: Implications for Atherogenesis

  Singh, M. V., Kotla, S., Le, N. T., Ko, K. A., Heo, K. S., Wang, Y., Fujii, Y., Thi Vu, H., McBeath, E., Thomas, T. N., Gi, Y. J., Tao, Y., Medina, J. L., Taunton, J., Carson, N., Dogra, V., Doyley, M. M., Tyrell, A., Lu, W., Qiu, X., & 7 othersStirpe, N. E., Gates, K. J., Hurley, C., Fujiwara, K., Maggirwar, S. B., Schifitto, G. & Abe, J. I., Feb 26 2019, In: Circulation. 139, 9, p. 1199-1216 18 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Monocytes 100%
  • Atherosclerosis 97%
  • Oxidative Stress 88%
  • Macrophages 84%
  • HIV 83%
  35 Scopus citations

• Single-cell RNA sequencing analysis of SARS-CoV-2 entry receptors in human organoids

  Mahalingam, R., Dharmalingam, P., Santhanam, A., Kotla, S., Davuluri, G., Karmouty-Quintana, H., Ashrith, G. & Thandavarayan, R. A., Apr 2021, In: Journal of Cellular Physiology. 236, 4, p. 2950-2958 9 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • RNA Sequencing 100%
  • Organoids 79%
  • Severe Acute Respiratory Syndrome 77%
  • Coronavirus 75%
  • angiotensin converting enzyme 2 74%
  16 Scopus citations

• The transcription factor CREB enhances interleukin-17A production and inflammation in a mouse model of atherosclerosis

  Kotla, S., Singh, N. K., Heckle, M. R., Tigyi, G. J. & Rao, G. N., Sep 17 2013, In: Science signaling. 6, 293, ra83.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Hydroxyeicosatetraenoic Acids 100%
  • Interleukin-17 95%
  • Reactive Oxygen Metabolite 84%
  • Atherosclerosis 72%
  • Apolipoproteins E 71%
  56 Scopus citations

• TNIK regulation of interferon signaling and endothelial cell response to virus infection

  Chau, K. M., Dominic, A., Davis, E. L., Kotla, S., Berrios, E. T., Fahim, A., Arunesh, A., Li, S., Zhao, D., Chen, K., Davis, A. R., Nguyen, M. T. H., Wang, Y., Evans, S. E., Wang, G., Cooke, J. P., Abe, J. I., Huston, D. P. & Le, N. T., 2023, In: Frontiers in Cardiovascular Medicine. 10, 1213428.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Interferons 100%
  • Phosphotransferases 84%
  • Endothelial Cells 80%
  • Virus Diseases 80%
  • RNA-Seq 31%