• 596 Citations
  • 12 h-Index
19982019
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Research Output 1998 2019

  • 596 Citations
  • 12 h-Index
  • 18 Article
  • 1 Chapter
  • 1 Review article
2019

A Three-dimensional Ex Vivo Viability Assay Reveals a Strong Correlation Between Response to Targeted Inhibitors and Mutation Status in Melanoma Lymph Node Metastases

Flørenes, V. A., Flem-Karlsen, K., McFadden, E., Bergheim, I. R., Nygaard, V., Nygård, V., Farstad, I. N., Øy, G. F., Emilsen, E., Giller-Fleten, K., Ree, A. H., Flatmark, K., Gullestad, H. P., Hermann, R., Ryder, T., Wernhoff, P. & Mælandsmo, G. M., Jul 2019, In : Translational Oncology. 12, 7, p. 951-958 8 p.

Research output: Contribution to journalArticle

Open Access
Melanoma
Lymph Nodes
Neoplasm Metastasis
Mutation
Neoplasms

Responsiveness to PD-1 Blockade in End-Stage Colon Cancer with Gene Locus 9p24.1 Copy-Number Gain

Ree, A. H., Nygaard, V., Russnes, H. G., Heinrich, D., Nygaard, V., Johansen, C., Bergheim, I. R., Hovig, E., Beiske, K., Negard, A., Borresen-Dale, A-L., Flatmark, K. & Mælandsmo, G. M., May 1 2019, In : Cancer Immunology Research. 7, 5, p. 701-706 6 p.

Research output: Contribution to journalArticle

Neoplasm Genes
Colonic Neoplasms
Genes
RNA Sequence Analysis
Neoplasms
2017
3 Citations (Scopus)

Implementing precision cancer medicine in the public health services of Norway: The diagnostic infrastructure and a cost estimate

Ree, A. H., Russnes, H. G., Heinrich, D., Dueland, S., Boye, K., Nygaard, V., Silwal-Pandit, L., Østrup, O., Hovig, E., Nygaard, V., Rødland, E. A., Nakken, S., Øien, J. T., Johansen, C., Bergheim, I. R., Skarpeteig, V., Sathermugathevan, M., Sauer, T., Lund-Iversen, M., Beiske, K. & 14 others, Nasser, S., Julsrud, L., Reisse, C. H., Ruud, E. A., Flørenes, V. A., Hagene, K. T., Aas, E., Lurås, H., Johnsen-Soriano, S., Geitvik, G. A., Lingjærde, O. C., Børresen-Dale, A. L., Mælandsmo, G. M. & Flatmark, K., Jun 2017, In : ESMO Open. 2, 2, e000158.

Research output: Contribution to journalArticle

Precision Medicine
United States Public Health Service
Norway
Costs and Cost Analysis
Biomarkers
4 Citations (Scopus)

Molecular signatures reflecting microenvironmental metabolism and chemotherapy-induced immunogenic cell death in colorectal liver metastases

Østrup, O., Dagenborg, V. J., Rødland, E. A., Skarpeteig, V., Silwal-Pandit, L., Grzyb, K., Berstad, A. E., Fretland, Å. A., Mælandsmo, G. M., Børresen-Dale, A. L., Ree, A. H., Edwin, B., Nygaard, V. & Flatmark, K., Jan 1 2017, In : Oncotarget. 8, 44, p. 76290-76304 15 p.

Research output: Contribution to journalArticle

Cell Death
Neoplasm Metastasis
Drug Therapy
Liver
Colorectal Neoplasms
2016
11 Citations (Scopus)

Fibroblast-induced switching to the mesenchymal-like phenotype and PI3K/mTOR signaling protects melanoma cells from BRAF inhibitors

Seip, K., Fleten, K. G., Barkovskaya, A., Nygaard, V., Haugen, M. H., Engesæter, B., Mælandsmo, G. M. & Prasmickaite, L., Apr 12 2016, In : Oncotarget. 7, 15, p. 19997-20015 19 p.

Research output: Contribution to journalArticle

Phosphatidylinositol 3-Kinases
Melanoma
Fibroblasts
Phenotype
Ribosomal Protein S6
2015
34 Citations (Scopus)

Metabolic reprogramming supports the invasive phenotype in malignant melanoma

Bettum, I. J., Gorad, S. S., Barkovskaya, A., Pettersen, S., Moestue, S. A., Vasiliauskaite, K., Tenstad, E., Øyjord, T., Risa, Ø., Nygaard, V., Mælandsmo, G. M. & Prasmickaite, L., Sep 28 2015, In : Cancer Letters. 366, 1, p. 71-83 13 p.

Research output: Contribution to journalArticle

Melanoma
Phenotype
Glycolysis
Neoplasms
Respiration
2014
21 Citations (Scopus)

Melanoma brain colonization involves the emergence of a brain-adaptive phenotype

Nygaard, V., Prasmickaite, L., Vasiliauskaite, K., Clancy, T. & Hovig, E., Jan 1 2014, In : Oncoscience. 1, 1, p. 82-94 13 p.

Research output: Contribution to journalArticle

Melanoma
Phenotype
Brain
Neoplasm Metastasis
Biological Phenomena
32 Citations (Scopus)

Metastasis-associated protein S100A4 induces a network of inflammatory cytokines that activate stromal cells to acquire pro-tumorigenic properties

Bettum, I. J., Vasiliauskaite, K., Nygaard, V., Clancy, T., Pettersen, S. J., Tenstad, E., Mælandsmo, G. M. & Prasmickaite, L., Mar 1 2014, In : Cancer Letters. 344, 1, p. 28-39 12 p.

Research output: Contribution to journalArticle

Stromal Cells
Cytokines
Neoplasm Metastasis
Neoplasms
Interleukin-8
2009
17 Citations (Scopus)

Methods for quantitation of gene expression

Nygaard, V. & Hovig, E., Jan 1 2009, In : Frontiers in Bioscience. 14, 2, p. 552-569 18 p.

Research output: Contribution to journalArticle

Gene expression
Gene Expression
Technology
Messenger RNA
Gene encoding
2008

Cell sampling and global nucleic acid amplification

Nygaard, V. & Hovig, E., Jan 1 2008, Practical Systems Biology. CRC Press, p. 17-36 20 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Nucleic Acid Amplification Techniques
Genetic Techniques
Systems Biology
Gene Expression Profiling
Oligonucleotide Array Sequence Analysis
4 Citations (Scopus)

Validation of oligoarrays for quantitative exploration of the transcriptome

Nygaard, V., Liu, F., Holden, M., Kuo, W. P., Trimarchi, J., Ohno-Machado, L., Cepko, C. L., Frigessi, A., Glad, I. K., van de Wiel, M., Hovig, E. & Lyng, H., May 30 2008, In : BMC genomics. 9, 258.

Research output: Contribution to journalArticle

High-Throughput Nucleotide Sequencing
Transcriptome
Gene Expression
Technology
Overlapping Genes
2006
99 Citations (Scopus)
Microarray Analysis
Technology
Sample Size
Publications
RNA
2005
34 Citations (Scopus)

Limitations of mRNA amplification from small-size cell samples

Nygaard, V., Holden, M., Loland, A., Langaas, M., Myklebost, O. & Hovig, E., Oct 27 2005, In : BMC genomics. 6, 147.

Research output: Contribution to journalArticle

Cell Size
Sample Size
Messenger RNA
RNA
Single-Cell Analysis
2004
36 Citations (Scopus)

Constitutive expression of the AP-1 transcription factors c-jun, junD, junB, and c-fos and the marginal zone B-cell transcription factor notch2 in splenic marginal zone lymphoma

Trøen, G., Nygaard, V., Jenssen, T. K., Ikonomou, I. M., Tierens, A., Matutes, E., Gruszka-Westwood, A., Catovsky, D., Myklebost, O., Lauritzsen, G., Hovig, E. & Delabie, J., Jan 1 2004, In : Journal of Molecular Diagnostics. 6, 4, p. 297-307 11 p.

Research output: Contribution to journalArticle

Transcription Factor AP-1
Lymphoma
B-Lymphocytes
Transcription Factors
DNA Helicases
2003
39 Citations (Scopus)

ABI3 mediates expression of the peroxiredoxin antioxidant AtPER1 gene and induction by oxidative stress

Haslekås, C., Grini, P. E., Nordgard, S., Thorstensen, T., Viken, M. K., Nygaard, V. & Aalen, R. B., Oct 1 2003, In : Plant Molecular Biology. 53, 3, p. 313-326 14 p.

Research output: Contribution to journalArticle

peroxiredoxin
Peroxiredoxins
Oxidative Stress
oxidative stress
Embryonic Structures
58 Citations (Scopus)

Effects of mRNA amplification on gene expression ratios in cDNA experiments estimated by analysis of variance

Nygaard, V., Løland, A., Holden, M., Langaas, M., Rue, H., Liu, F., Myklebost, O., Fodstad, O., Hovig, E. & Smith-Sørensen, B., Mar 23 2003, In : BMC genomics. 4, 11.

Research output: Contribution to journalArticle

Analysis of Variance
Complementary DNA
Gene Expression
Messenger RNA
RNA

Effects of mRNA amplification on gene expression ratios in cDNA experiments estimated by analysis of variance.

Nygaard, V., Løland, A., Holden, M., Langaas, M., Rue, H., Liu, F., Myklebost, O., Fodstad, Ø., Hovig, E. & Smith-Sørensen, B., Mar 23 2003, In : BMC genomics [electronic resource]. 4, 1, 1 p.

Research output: Contribution to journalArticle

Analysis of Variance
Complementary DNA
Gene Expression
Messenger RNA
RNA
94 Citations (Scopus)

Seed 1-Cysteine Peroxiredoxin Antioxidants Are Not Involved in Dormancy, But Contribute to Inhibition of Germination during Stress

Haslekås, C., Viken, M. K., Grini, P. E., Nygaard, V., Nordgard, S. H., Meza, T. J. & Aalen, R. B., Nov 1 2003, In : Plant Physiology. 133, 3, p. 1148-1157 10 p.

Research output: Contribution to journalArticle

peroxiredoxin
Peroxiredoxins
Germination
dormancy
Cysteine
2002
25 Citations (Scopus)

MArray: Analysing single, replicated or reversed microarray experiments

Wang, J., Nygaard, V., Smith-Sørensen, B., Hovig, E. & Myklebost, O., Aug 2002, In : Bioinformatics. 18, 8, p. 1139-1140 2 p.

Research output: Contribution to journalArticle

Microarrays
Microarray
Normalization
MATLAB
Function evaluation
1998
85 Citations (Scopus)

The expression of peroxiredoxin antioxidant gene, AtPer1, in Arabiodopsis thaliana is seed-specific and related to dormancy

Haslekås, C., Stacy, R. A. P., Nygaard, V., Culiáñez-Macià, F. A. & Aalen, R. B., Apr 1 1998, In : Plant Molecular Biology. 36, 6, p. 833-845 13 p.

Research output: Contribution to journalArticle

peroxiredoxin
Peroxiredoxins
dormancy
Seeds
Antioxidants