Weiya Xia

Assistant Professor

  • 15510 Citations
  • 58 h-Index
1980 …2019
If you made any changes in Pure, your changes will be visible here soon.

Research Output 1980 2019

  • 15510 Citations
  • 58 h-Index
  • 133 Article
  • 7 Comment/debate
  • 2 Letter
2019
1 Citation (Scopus)

Blocking autophagy flux promotes interferon-alpha-mediated apoptosis in head and neck squamous cell carcinoma

Yang, W., Jiang, C., Xia, W., Ju, H., Jin, S., Liu, S., Zhang, L., Ren, G., Ma, H., Ruan, M. & Hu, J., Jun 1 2019, In : Cancer Letters. 451, p. 34-47 14 p.

Research output: Contribution to journalArticle

Autophagy
Interferon-alpha
Apoptosis
STAT1 Transcription Factor
Hydroxychloroquine

CDK2-mediated site-specific phosphorylation of EZH2 drives and maintains triple-negative breast cancer

Nie, L., Wei, Y., Zhang, F., Hsu, Y. H., Chan, L. C., Xia, W., Ke, B., Zhu, C., Deng, R., Tang, J., Yao, J., Chu, Y. Y., Zhao, X., Han, Y., Hou, J., Huo, L., Ko, H. W., Lin, W. C., Yamaguchi, H., Hsu, J. M. & 7 others, Yang, Y., Pan, D. N., Hsu, J. L., Kleer, C. G., Davidson, N. E., Hortobagyi, G. N. & Hung, M. C., Dec 1 2019, In : Nature communications. 10, 1, 5114.

Research output: Contribution to journalArticle

Open Access
Cyclin-Dependent Kinase 2
Triple Negative Breast Neoplasms
phosphorylation
Phosphorylation
breast
2 Citations (Scopus)

IL-6/JAK1 pathway drives PD-L1 Y112 phosphorylation to promote cancer immune evasion

Chan, L. C., Li, C. W., Xia, W., Hsu, J. M., Lee, H. H., Cha, J. H., Wang, H. L., Yang, W. H., Yen, E. Y., Chang, W. C., Zha, Z., Lim, S. O., Lai, Y. J., Liu, C., Liu, J., Dong, Q., Yang, Y., Sun, L., Wei, Y., Nie, L. & 9 others, Hsu, J. L., Li, H., Ye, Q., Hassan, M. M., Amin, H. M., Kaseb, A. O., Lin, X., Wang, S. C. & Hung, M. C., Aug 1 2019, In : Journal of Clinical Investigation. 129, 8, p. 3324-3338 15 p.

Research output: Contribution to journalArticle

Open Access
Immune Evasion
Interleukin-6
Phosphorylation
Ligands
Glycosylation
6 Citations (Scopus)

MET Inhibitors Promote Liver Tumor Evasion of the Immune Response by Stabilizing PDL1

Li, H., Li, C. W., Li, X., Ding, Q., Guo, L., Liu, S., Liu, C., Lai, C. C., Hsu, J. M., Dong, Q., Xia, W., Hsu, J. L., Yamaguchi, H., Du, Y., Lai, Y. J., Sun, X., Koller, P. B., Ye, Q. & Hung, M. C., May 2019, In : Gastroenterology. 156, 6, p. 1849-1861.e13

Research output: Contribution to journalArticle

Tumor Escape
Liver Neoplasms
Ligands
Liver
Neoplasms
8 Citations (Scopus)

Oncogenic lncRNA downregulates cancer cell antigen presentation and intrinsic tumor suppression

Hu, Q., Ye, Y., Chan, L. C., Li, Y., Liang, K., Lin, A., Egranov, S. D., Zhang, Y., Xia, W., Gong, J., Pan, Y., Chatterjee, S. S., Yao, J., Evans, K. W., Nguyen, T. K., Park, P. K., Liu, J., Coarfa, C., Donepudi, S. R., Putluri, V. & 17 others, Putluri, N., Sreekumar, A., Ambati, C. R., Hawke, D. H., Marks, J. R., Gunaratne, P. H., Caudle, A. S., Sahin, A. A., Hortobagyi, G. N., Meric-Bernstam, F., Chen, L., Yu, D., Hung, M. C., Curran, M. A., Han, L., Lin, C. & Yang, L., Jul 1 2019, In : Nature Immunology. 20, 7, p. 835-851 17 p.

Research output: Contribution to journalArticle

Long Noncoding RNA
Triple Negative Breast Neoplasms
Antigen Presentation
Human Mammary Glands
Down-Regulation
6 Citations (Scopus)

Palmitoylation stabilizes PD-L1 to promote breast tumor growth

Yang, Y., Hsu, J-M., Sun, L., Chan, L. C., Li, C-W., Hsu, J. L., Wei, Y., Xia, W., Hou, J., Qiu, Y. & Hung, M-C., Jan 1 2019, In : Cell research. 29, 1, p. 83-86 4 p.

Research output: Contribution to journalLetter

Lipoylation
Breast Neoplasms
Growth
6 Citations (Scopus)

PTEN self-regulates through USP11 via the PI3K-FOXO pathway to stabilize tumor suppression

Park, M. K., Yao, Y., Xia, W., Setijono, S. R., Kim, J. H., Vila, I. K., Chiu, H. H., Wu, Y., Billalabeitia, E. G., Lee, M. G., Kalb, R. G., Hung, M. C., Pandolfi, P. P., Song, S. J. & Song, M. S., Feb 7 2019, In : Nature communications. 10, 1, 1 p.

Research output: Contribution to journalArticle

Open Access
Phosphatidylinositol 3-Kinases
Tumors
tumors
retarding
Neoplasms
4 Citations (Scopus)

Removal of N-Linked Glycosylation Enhances PD-L1 Detection and Predicts Anti-PD-1/PD-L1 Therapeutic Efficacy

Lee, H. H., Wang, Y. N., Xia, W., Chen, C. H., Rau, K. M., Ye, L., Wei, Y., Chou, C. K., Wang, S. C., Yan, M., Tu, C. Y., Hsia, T. C., Chiang, S. F., Chao, K. S. C., Wistuba, I. I., Hsu, J. L., Hortobagyi, G. N. & Hung, M. C., Aug 12 2019, In : Cancer cell. 36, 2, p. 168-178.e4

Research output: Contribution to journalArticle

Glycosylation
Leukocyte L1 Antigen Complex
Antibody Affinity
Therapeutics
Surface Antigens
2018
3 Citations (Scopus)

A homozygous p53 R282W mutant human embryonic stem cell line generated using TALEN-mediated precise gene editing

Zhou, R., Xu, A., Wang, D., Zhu, D., Mata, H., Huo, Z., Tu, J., Liu, M., Mohamed, A. M. T., Jewell, B. E., Gingold, J., Xia, W., Rao, P. H., Hung, M. C., Zhao, R. & Lee, D. F., Mar 2018, In : Stem Cell Research. 27, p. 131-135 5 p.

Research output: Contribution to journalArticle

Cell Line
Germ Layers
Mutation
Teratoma
Tumor Suppressor Genes
8 Citations (Scopus)

Angiogenin/Ribonuclease 5 Is an EGFR Ligand and a Serum Biomarker for Erlotinib Sensitivity in Pancreatic Cancer

Wang, Y. N., Lee, H. H., Chou, C. K., Yang, W. H., Wei, Y., Chen, C. T., Yao, J., Hsu, J. L., Zhu, C., Ying, H., Ye, Y., Wang, W. J., Lim, S. O., Xia, W., Ko, H. W., Liu, X., Liu, C. G., Wu, X., Wang, H., Li, D. & 9 others, Prakash, L. R., Katz, M. H., Kang, Y., Kim, M., Fleming, J. B., Fogelman, D., Javle, M., Maitra, A. & Hung, M. C., Apr 9 2018, In : Cancer cell. 33, 4, p. 752-769.e8

Research output: Contribution to journalArticle

Pancreatic Neoplasms
Epidermal Growth Factor Receptor
Biomarkers
Ligands
Serum
56 Citations (Scopus)

Eradication of Triple-Negative Breast Cancer Cells by Targeting Glycosylated PD-L1

Li, C-W., Lim, S-O., Chung, E. M., Kim, Y. S., Park, A. H., Yao, J., Cha, J-H., Xia, W., Chan, L. C., Kim, T., Chang, S-S., Lee, H-H., Chou, C-K., Liu, Y. L., Yeh, H. C., Perillo, E. P., Dunn, A. K., Kuo, C. W., Khoo, K. H., Hsu, J. L. & 8 others, Wu, Y., Hsu, J-M., Yamaguchi, H., Huang, T. H., Sahin, A. A., Hortobagyi, G. N., Yoo, S. S. & Hung, M-C., Feb 12 2018, In : Cancer cell. 33, 2, p. 187-201.e10

Research output: Contribution to journalArticle

Triple Negative Breast Neoplasms
Ligands
Glycosylation
CD274 Antigen
Immunosuppression
3 Citations (Scopus)

Establishment of a human embryonic stem cell line with homozygous TP53 R248W mutant by TALEN mediated gene editing

Xu, A., Zhou, R., Tu, J., Huo, Z., Zhu, D., Wang, D., Gingold, J. A., Mata, H., Rao, P. H., Liu, M., Mohamed, A. M. T., Kong, C. S. L., Jewell, B. E., Xia, W., Zhao, R., Hung, M. C. & Lee, D. F., May 2018, In : Stem Cell Research. 29, p. 215-219 5 p.

Research output: Contribution to journalArticle

Cell Line
Germ Layers
Mutation
Karyotype
Gene Expression
22 Citations (Scopus)

Exosomal PD-L1 harbors active defense function to suppress t cell killing of breast cancer cells and promote tumor growth

Yang, Y., Li, C. W., Chan, L. C., Wei, Y., Hsu, J. M., Xia, W., Cha, J. H., Hou, J., Hsu, J. L., Sun, L. & Hung, M. C., Aug 1 2018, In : Cell research. 28, 8, p. 862-864 3 p.

Research output: Contribution to journalLetter

Breast Neoplasms
Growth
Neoplasms

Generation of an induced pluripotent stem cell line from an individual with a heterozygous RECQL4 mutation

Jewell, B. E., Liu, M., Lu, L., Zhou, R., Tu, J., Zhu, D., Huo, Z., Xu, A., Wang, D., Mata, H., Jin, W., Xia, W., Rao, P. H., Zhao, R., Hung, M. C., Wang, L. L. & Lee, D. F., Dec 2018, In : Stem Cell Research. 33, p. 36-40 5 p.

Research output: Contribution to journalArticle

DNA Helicases
Induced Pluripotent Stem Cells
Rothmund-Thomson Syndrome
Cell Line
Germ Layers
2 Citations (Scopus)

Juxtacrine signaling inhibits antitumor immunity by upregulating PD-L1 expression

Yang, W. H., Cha, J. H., Xia, W., Lee, H. H., Chan, L. C., Wang, Y. N., Hsu, J. L., Ren, G. & Hung, M. C., Jul 15 2018, In : Cancer research. 78, 14, p. 3761-3768 8 p.

Research output: Contribution to journalArticle

Immunity
Ligands
Eph Family Receptors
antineoplaston A10
Neoplasms
44 Citations (Scopus)

Metformin Promotes Antitumor Immunity via Endoplasmic-Reticulum-Associated Degradation of PD-L1

Cha, J. H., Yang, W. H., Xia, W., Wei, Y., Chan, L. C., Lim, S. O., Li, C. W., Kim, T., Chang, S. S., Lee, H. H., Hsu, J. L., Wang, H. L., Kuo, C. W., Chang, W. C., Hadad, S., Purdie, C. A., McCoy, A. M., Cai, S., Tu, Y., Litton, J. K. & 8 others, Mittendorf, E. A., Moulder, S. L., Symmans, W. F., Thompson, A. M., Piwnica-Worms, H., Chen, C. H., Khoo, K. H. & Hung, M. C., Aug 16 2018, In : Molecular cell. 71, 4, p. 606-620.e7

Research output: Contribution to journalArticle

Endoplasmic Reticulum-Associated Degradation
Metformin
Immunity
Ligands
AMP-Activated Protein Kinases
17 Citations (Scopus)

Phosphorylation of EZH2 by AMPK Suppresses PRC2 Methyltransferase Activity and Oncogenic Function

Wan, L., Xu, K., Wei, Y., Zhang, J., Han, T., Fry, C., Zhang, Z., Wang, Y. V., Huang, L., Yuan, M., Xia, W., Chang, W-C., Huang, W. C., Liu, C. L., Chang, Y. C., Liu, J., Wu, Y., Jin, V. X., Dai, X., Guo, J. & 7 others, Liu, J., Jiang, S., Li, J., Asara, J. M., Brown, M., Hung, M-C. & Wei, W., Jan 18 2018, In : Molecular cell. 69, 2, p. 279-291.e5

Research output: Contribution to journalArticle

Polycomb Repressive Complex 2
AMP-Activated Protein Kinases
Methyltransferases
Phosphorylation
Histone Code
32 Citations (Scopus)

STT3-dependent PD-L1 accumulation on cancer stem cells promotes immune evasion

Hsu, J. M., Xia, W., Hsu, Y. H., Chan, L. C., Yu, W. H., Cha, J. H., Chen, C. T., Liao, H. W., Kuo, C. W., Khoo, K. H., Hsu, J. L., Li, C. W., Lim, S. O., Chang, S. S., Chen, Y. C., Ren, G. X. & Hung, M. C., Dec 1 2018, In : Nature communications. 9, 1, 1908.

Research output: Contribution to journalArticle

Immune Evasion
Catenins
Epithelial-Mesenchymal Transition
Neoplastic Stem Cells
stem cells
4 Citations (Scopus)

Targeting PKCδ as a Therapeutic Strategy against Heterogeneous Mechanisms of EGFR Inhibitor Resistance in EGFR-Mutant Lung Cancer

Lee, P. C., Fang, Y. F., Yamaguchi, H., Wang, W. J., Chen, T. C., Hong, X., Ke, B., Xia, W., Wei, Y., Zha, Z., Wang, Y., Kuo, H. P., Wang, C. W., Tu, C. Y., Chen, C. H., Huang, W. C., Chiang, S. F., Nie, L., Hou, J., Chen, C. T. & 15 others, Huo, L., Yang, W. H., Deng, R., Nakai, K., Hsu, Y. H., Chang, S. S., Chiu, T. J., Tang, J., Zhang, R., Wang, L., Fang, B., Chen, T., Wong, K. K., Hsu, J. L. & Hung, M. C., Dec 10 2018, In : Cancer cell. 34, 6, p. 954-969.e4

Research output: Contribution to journalArticle

Epidermal Growth Factor Receptor
Protein-Tyrosine Kinases
Protein Kinase C
Lung Neoplasms
Nuclear Proteins
6 Citations (Scopus)

The role of PRMT1 in EGFR methylation and signaling in MDA-MB-468 triple-negative breast cancer cells

Nakai, K., Xia, W., Liao, H. W., Saito, M., Hung, M-C. & Yamaguchi, H., Jan 1 2018, In : Breast Cancer. 25, 1, p. 74-80 7 p.

Research output: Contribution to journalArticle

Triple Negative Breast Neoplasms
Epidermal Growth Factor Receptor
Methylation
Cell Proliferation
Small Interfering RNA
2017
1 Citation (Scopus)

Arginine methylation of EGFR: A new biomarker for predicting resistance to anti-EGFR treatment

Korphaisarn, K., Chou, C-K., Xia, W., Clarke, C. N., Katkhuda, R., Davis, J. S., Raghav, K. P. S., Liao, H. W., Wu, J. Y., Menter, D. G., Maru, D. M., Hung, M-C. & Kopetz, E. S., Jan 1 2017, In : American Journal of Cancer Research. 7, 12, p. 2587-2599 13 p.

Research output: Contribution to journalArticle

Circulating Neoplastic Cells
Epidermal Growth Factor Receptor
Methylation
Arginine
Biomarkers
30 Citations (Scopus)

A UBE2O-AMPKα2 Axis that Promotes Tumor Initiation and Progression Offers Opportunities for Therapy

Vila, I., Yao, Y., Kim, G., Xia, W., Kim, H., Kim, S. J., Park, M., Hwang, J. P., González-Billalabeitia, E., Hung, M-C., Song, S. J. & Song, M. S., Feb 13 2017, In : Cancer cell. 31, 2, p. 208-224 17 p.

Research output: Contribution to journalArticle

Neoplasms
Carcinogenesis
Therapeutics
Ubiquitination
Sirolimus
14 Citations (Scopus)

Aurora A kinase activates YAP signaling in triple-negative breast cancer

Chang, S. S., Yamaguchi, H., Xia, W., Lim, S. O., Khotskaya, Y., Wu, Y., Chang, W. C., Liu, Q. & Hung, M. C., Mar 2 2017, In : Oncogene. 36, 9, p. 1265-1275 11 p.

Research output: Contribution to journalArticle

Aurora Kinase A
Triple Negative Breast Neoplasms
Proteins
Neoplasms
Phosphorylation
26 Citations (Scopus)

JAK2-binding long noncoding RNA promotes breast cancer brain metastasis

Wang, S., Liang, K., Hu, Q., Li, P., Song, J., Yang, Y., Yao, J., Mangala, L. S., Li, C., Yang, W., Park, P. K., Hawke, D. H., Zhou, J., Zhou, Y., Xia, W., Hung, M. C., Marks, J. R., Gallick, G. E., Lopez-Berestein, G., Flores, E. R. & 5 others, Sood, A. K., Huang, S., Yu, D., Yang, L. & Lin, C., Dec 1 2017, In : Journal of Clinical Investigation. 127, 12, p. 4498-4515 18 p.

Research output: Contribution to journalArticle

Long Noncoding RNA
Brain Neoplasms
Breast Neoplasms
Neoplasm Metastasis
Oncostatin M
156 Citations (Scopus)

PARP inhibitor upregulates PD-L1 expression and enhances cancer-associated immunosuppression

Jiao, S., Xia, W., Yamaguchi, H., Wei, Y., Chen, M. K., Hsu, J. M., Hsu, J. L., Yu, W. H., Du, Y., Lee, H. H., Li, C. W., Chou, C. K., Lim, S. O., Chang, S. S., Litton, J., Arun, B., Hortobagyi, G. N. & Hung, M. C., Jul 15 2017, In : Clinical Cancer Research. 23, 14, p. 3711-3720 10 p.

Research output: Contribution to journalArticle

Immunosuppression
Up-Regulation
Neoplasms
Breast Neoplasms
Poly(ADP-ribose) Polymerase Inhibitors
2016
39 Citations (Scopus)

AKT1 inhibits epithelial-to-mesenchymal transition in breast cancer through phosphorylation-dependent twist1 degradation

Li, C. W., Xia, W., Lim, S. O., Hsu, J. L., Huo, L., Wu, Y., Li, L. Y., Lai, C. C., Chang, S. S., Hsu, Y. H., Sun, H. L., Kim, J., Yamaguchi, H., Lee, D. F., Wang, H., Wang, Y., Chou, C. K., Hsu, J. M., Lai, Y. J., LaBaff, A. M. & 6 others, Ding, Q., Ko, H. W., Tsai, F. J., Tsai, C. H., Hortobagyi, G. N. & Hung, M. C., Mar 15 2016, In : Cancer research. 76, 6, p. 1451-1462 12 p.

Research output: Contribution to journalArticle

Epithelial-Mesenchymal Transition
Phosphorylation
Breast Neoplasms
Neoplasm Metastasis
Ubiquitination
114 Citations (Scopus)

Deubiquitination and Stabilization of PD-L1 by CSN5

Lim, S. O., Li, C. W., Xia, W., Cha, J. H., Chan, L. C., Wu, Y., Chang, S. S., Lin, W. C., Hsu, J. M., Hsu, Y. H., Kim, T., Chang, W. C., Hsu, J. L., Yamaguchi, H., Ding, Q., Wang, Y., Yang, Y., Chen, C. H., Sahin, A. A., Yu, D. & 2 others, Hortobagyi, G. N. & Hung, M. C., Dec 12 2016, In : Cancer cell. 30, 6, p. 925-939 15 p.

Research output: Contribution to journalArticle

Cell Death
Ligands
Neoplasms
Tumor Necrosis Factor-alpha
Curcumin
72 Citations (Scopus)

EGFR signaling enhances aerobic glycolysis in triple-negative breast cancer cells to promote tumor growth and immune escape

Lim, S. O., Li, C. W., Xia, W., Lee, H. H., Chang, S. S., Shen, J., Hsu, J. L., Raftery, D., Djukovic, D., Gu, H., Chang, W. C., Wang, H. L., Chen, M. L., Huo, L., Chen, C. H., Wu, Y., Sahin, A., Hanash, S. M., Hortobagyi, G. N. & Hung, M. C., Mar 1 2016, In : Cancer research. 76, 5, p. 1284-1296 13 p.

Research output: Contribution to journalArticle

Triple Negative Breast Neoplasms
Tumor Escape
Glycolysis
Growth
Epidermal Growth Factor
136 Citations (Scopus)

Glycosylation and stabilization of programmed death ligand-1 suppresses T-cell activity

Li, C. W., Lim, S. O., Xia, W., Lee, H. H., Chan, L. C., Kuo, C. W., Khoo, K. H., Chang, S. S., Cha, J. H., Kim, T., Hsu, J. L., Wu, Y., Hsu, J. M., Yamaguchi, H., Ding, Q., Wang, Y., Yao, J., Lee, C. C., Wu, H. J., Sahin, A. A. & 4 others, Allison, J. P., Yu, D., Hortobagyi, G. N. & Hung, M. C., Aug 30 2016, In : Nature communications. 7, 12632.

Research output: Contribution to journalArticle

Glycosylation
T-cells
death
Stabilization
stabilization
12 Citations (Scopus)

GSK3β inactivation promotes the oncogenic functions of EZH2 and enhances methylation of H3K27 in human breast cancers

Ko, H. W., Lee, H. H., Huo, L., Xia, W., Yang, C. C., Hsu, J. L., Li, L. Y., Lai, C. C., Chan, L. C., Cheng, C. C., Labaff, A. M., Liao, H. W., Lim, S. O., Li, C. W., Wei, Y., Nie, L., Yamaguchi, H. & Hung, M. C., Jan 1 2016, In : Oncotarget. 7, 35, p. 57131-57144 14 p.

Research output: Contribution to journalArticle

Methylation
Breast Neoplasms
Cell Movement
Carcinogenesis
Phosphorylation
13 Citations (Scopus)

Oncogenic functions of Gli1 in pancreatic adenocarcinoma are supported by its PRMT1-mediated methylation

Wang, Y., Hsu, J. M., Kang, Y., Wei, Y., Lee, P. C., Chang, S. J., Hsu, Y. H., Hsu, J. L., Wang, H. L., Chang, W. C., Li, C. W., Liao, H. W., Chang, S. S., Xia, W., Ko, H. W., Chou, C. K., Fleming, J. B., Wang, H., Hwang, R. F., Chen, Y. & 2 others, Qin, J. & Hung, M. C., Dec 1 2016, In : Cancer research. 76, 23, p. 7049-7058 10 p.

Research output: Contribution to journalArticle

Methylation
Adenocarcinoma
gemcitabine
Protein-Arginine N-Methyltransferases
Post Translational Protein Processing
6 Citations (Scopus)

PFKFB3 potentially contributes to paclitaxel resistance in breast cancer cells through TLR4 activation by stimulating lactate production

Ge, X., Cao, Z., Gu, Y., Wang, F., Li, J., Han, M., Xia, W., Yu, Z. & Lyu, P., Jan 1 2016, In : Cellular and Molecular Biology. 62, 6, p. 119-125 7 p.

Research output: Contribution to journalArticle

Toll-Like Receptor 4
Paclitaxel
Lactic Acid
Chemical activation
Cells
2015
8 Citations (Scopus)

Interferon-α-2b as an adjuvant therapy prolongs survival of patients with previously resected oral muscosal melanoma

Wang, R., Jing, G., Lv, J., Song, H., Li, C., Wang, X., Xia, W., Wu, Y., Ren, G. & Guo, W., Oct 5 2015, In : Genetics and Molecular Research. 14, 4, p. 11944-11954 11 p.

Research output: Contribution to journalArticle

Interferons
Melanoma
Survival
temozolomide
Therapeutics
73 Citations (Scopus)

Modeling familial cancer with induced pluripotent stem cells

Lee, D. F., Su, J., Kim, H. S., Chang, B., Papatsenko, D., Zhao, R., Yuan, Y., Gingold, J., Xia, W., Darr, H., Mirzayans, R., Hung, M-C., Schaniel, C. & Lemischka, I. R., Apr 9 2015, In : Cell. 161, 2, p. 240-254 15 p.

Research output: Contribution to journalArticle

Li-Fraumeni Syndrome
Induced Pluripotent Stem Cells
Osteoblasts
Stem cells
Genes
17 Citations (Scopus)

Phosphorylation of ezh2 at t416 by cdk2 contributes to the malignancy of triple negative breast cancers

Yang, C. C., Labaff, A., Wei, Y., Nie, L., Xia, W., Huo, L., Yamaguchi, H., Hsu, Y-H., Hsu, J. L., Liu, D., Lang, J., Du, Y., Lien, H. C., Li, L-Y., Deng, R., Chan, L. C., Yao, J., Kleer, C. G., Hortobagyi, G. N. & Hung, M-C., Feb 25 2015, In : American Journal of Translational Research. 7, 6, p. 1009-1020 12 p.

Research output: Contribution to journalArticle

Triple Negative Breast Neoplasms
Cyclin E
Phosphorylation
Chemotherapy
Biomarkers
45 Citations (Scopus)

PRMT1-mediated methylation of the EGF receptor regulates signaling and cetuximab response

Liao, H. W., Hsu, J. M., Xia, W., Wang, H. L., Wang, Y. N., Chang, W. C., Arold, S. T., Chou, C. K., Tsou, P. H., Yamaguchi, H., Fang, Y. F., Lee, H. J., Lee, H. H., Tai, S. K., Yang, M. H., Morelli, M. P., Sen, M., Ladbury, J. E., Chen, C. H., Grandis, J. R. & 2 others, Kopetz, S. & Hung, M. C., Dec 2015, In : Journal of Clinical Investigation. 125, 12, p. 4529-4543 15 p.

Research output: Contribution to journalArticle

Protein-Arginine N-Methyltransferases
Epidermal Growth Factor Receptor
Methylation
Colorectal Neoplasms
Dimerization
2014
14 Citations (Scopus)

Activation of keap1/nrf2 signaling pathway by nuclear epidermal growth factor receptor in cancer cells

Huo, L., Li, C. W., Huang, T. H., Lam, Y. C., Xia, W., Tu, C., Chang, W. C., Hsu, J. L., Lee, D. F., Nie, L., Yamaguchi, H., Wang, Y., Lang, J., Li, L. Y., Chen, C. H., Mishra, L. & Hung, M. C., Jan 1 2014, In : American Journal of Translational Research. 6, 6, p. 649-663 15 p.

Research output: Contribution to journalArticle

Epidermal Growth Factor Receptor
Tumors
Chemical activation
Cells
Oxidative stress
44 Citations (Scopus)

EGFR Modulates DNA Synthesis and Repair through Tyr Phosphorylation of Histone H4

Chou, R-H., Wang, Y-N., Hsieh, Y. H., Li, L-Y., Xia, W., Chang, W-C., Chang, L. C., Cheng, C-C., Lai, C. C., Hsu, J. L., Chang, W. J., Chiang, S. Y., Lee, H. J., Liao, H. W., Chuang, P. H., Chen, H. Y., Wang, H. L., Kuo, S. C., Chen, C. H., Yu, Y. & 1 others, Hung, M-C., Jul 28 2014, In : Developmental cell. 30, 2, p. 224-237 14 p.

Research output: Contribution to journalArticle

Phosphorylation
Epidermal Growth Factor Receptor
DNA Repair
Histones
Repair
10 Citations (Scopus)

Expression of metastasis suppressor BRMS1 in breast cancer cells results in a marked delay in cellular adhesion to matrix

Khotskaya, Y. B., Beck, B. H., Hurst, D. R., Han, Z., Xia, W., Hung, M. C. & Welch, D. R., Dec 1 2014, In : Molecular Carcinogenesis. 53, 12, p. 1011-1026 16 p.

Research output: Contribution to journalArticle

Breast Neoplasms
Neoplasm Metastasis
Aptitude
Integrins
Focal Adhesion Kinase 1
33 Citations (Scopus)

MDM2-mediated degradation of SIRT6 phosphorylated by AKT1 promotes tumorigenesis and trastuzumab resistance in breast cancer

Thirumurthi, U., Shen, J., Xia, W., LaBaff, A. M., Wei, Y., Li, C. W., Chang, W. C., Chen, C. H., Lin, H. K., Yu, D. & Hung, M. C., Jul 29 2014, In : Science Signaling. 7, 336, ra71.

Research output: Contribution to journalArticle

Carcinogenesis
Breast Neoplasms
Degradation
Cells
Tumors
28 Citations (Scopus)

S6k1 promotes invasiveness of breast cancer cells in a model of metastasis of triple-negative breast cancer

Khotskaya, Y. B., Goverdhan, A., Shen, J., Ponz-Sarvise, M., Chang, S-S., Hsu, M. C., Wei, Y., Xia, W., Yu, D. & Hung, M-C., Jan 1 2014, In : American Journal of Translational Research. 6, 4, p. 361-376 16 p.

Research output: Contribution to journalArticle

Triple Negative Breast Neoplasms
Bone
Cells
Breast Neoplasms
Neoplasm Metastasis
2013
192 Citations (Scopus)

EGFR modulates microRNA maturation in response to hypoxia through phosphorylation of AGO2

Shen, J., Xia, W., Khotskaya, Y. B., Huo, L., Nakanishi, K., Lim, S-O., Du, Y., Wang, Y., Chang, W-C., Chen, C. H., Hsu, J. L., Wu, Y., Lam, Y. C., James, B. P., Liu, X., Liu, C-G., Patel, D. J. & Hung, M-C., May 16 2013, In : Nature. 497, 7449, p. 383-387 5 p.

Research output: Contribution to journalArticle

MicroRNAs
Epidermal Growth Factor Receptor
Phosphorylation
Neoplasms
Hypoxia
36 Citations (Scopus)

Epidermal growth factor receptor potentiates MCM7-mediated dna replication through tyrosine phosphorylation of lyn kinase in human cancers

Huang, T. H., Huo, L., Wang, Y. N., Xia, W., Wei, Y., Chang, S. S., Chang, W. C., Fang, Y. F., Chen, C. T., Lang, J. Y., Tu, C., Wang, Y., Hsu, M. C., Kuo, H. P., Ko, H. W., Shen, J., Lee, H. H., Lee, P. C., Wu, Y., Chen, C. H. & 1 others, Hung, M. C., Jun 10 2013, In : Cancer cell. 23, 6, p. 796-810 15 p.

Research output: Contribution to journalArticle

DNA Replication
Epidermal Growth Factor Receptor
Tyrosine
Phosphotransferases
Phosphorylation
20 Citations (Scopus)

Inhibition of Type I Insulin-Like Growth Factor Receptor Signaling Attenuates the Development of Breast Cancer Brain Metastasis

Saldana, S. M., Lee, H. H., Lowery, F. J., Khotskaya, Y. B., Xia, W., Zhang, C., Chang, S. S., Chou, C. K., Steeg, P. S., Yu, D. & Hung, M. C., Sep 5 2013, In : PloS one. 8, 9, e73406.

Research output: Contribution to journalArticle

IGF Type 1 Receptor
Brain Neoplasms
metastasis
breast neoplasms
Brain
26 Citations (Scopus)

SRC-3 coactivator regulates cell resistance to cytotoxic stress via TRAF4-mediated p53 destabilization

Yi, P., Xia, W., Wu, R. C., Lonard, D. M., Hung, M. C. & O'Malley, B. W., Feb 1 2013, In : Genes and Development. 27, 3, p. 274-287 14 p.

Research output: Contribution to journalArticle

TNF Receptor-Associated Factor 4
Nuclear Receptor Coactivator 3
Breast Neoplasms
Nuclear Receptor Coactivators
Ubiquitin-Specific Proteases
32 Citations (Scopus)

TIG1 promotes the development and progression of inflammatory breast cancer through activation of Axl kinase

Wang, X., Saso, H., Iwamoto, T., Xia, W., Gong, Y., Pusztai, L., Woodward, W. A., Reuben, J. M., Warner, S. L., Bearss, D. J., Hortobagyi, G. N., Hung, M. C. & Ueno, N. T., Nov 1 2013, In : Cancer research. 73, 21, p. 6516-6525 10 p.

Research output: Contribution to journalArticle

Inflammatory Breast Neoplasms
Phosphotransferases
Matrix Metalloproteinase 9
Proteasome Endopeptidase Complex
Cell Movement
2012
244 Citations (Scopus)

Epithelial-mesenchymal transition induced by TNF-α requires NF-κB-mediated transcriptional upregulation of Twist1

Li, C. W., Xia, W., Huo, L., Lim, S. O., Wu, Y., Hsu, J. L., Chao, C. H., Yamaguchi, H., Yang, N. K., Ding, Q., Wang, Y., Lai, Y. J., LaBaff, A. M., Wu, T. J., Lin, B. R., Yang, M. H., Hortobagyi, G. N. & Hung, M. C., Mar 1 2012, In : Cancer research. 72, 5, p. 1290-1300 11 p.

Research output: Contribution to journalArticle

Epithelial-Mesenchymal Transition
Up-Regulation
Tumor Microenvironment
Neoplasms
Breast Neoplasms

Erratum: APOBEC3G promotes liver metastasis in an orthotopic mouse model of colorectal cancer and predicts human hepatic metastasis (Journal of Clinical Investigation (2012) 122, 1 (419) DOI:10.1172/JCI61734)

Ding, Q., Chang, C. J., Xie, X., Xia, W., Yang, J. Y., Wang, S. C., Wang, Y., Xia, J., Chen, L., Cai, C., Li, H., Yen, C. J., Kuo, H. P., Lee, D. F., Lang, J., Huo, L., Cheng, X., Chen, Y. J., Li, C. W., Jeng, L. B. & 7 others, Hsu, J. L., Li, L. Y., Tan, A., Curley, S. A., Ellis, L. M., DuBois, R. N. & Hung, M. C., Jan 3 2012, In : Journal of Clinical Investigation. 122, 1, 1 p.

Research output: Contribution to journalComment/debate

Colorectal Neoplasms
Neoplasm Metastasis
Liver
62 Citations (Scopus)

IKKα Activation of NOTCH Links Tumorigenesis via FOXA2 Suppression

Liu, M., Lee, D. F., Chen, C. T., Yen, C. J., Li, L. Y., Lee, H. J., Chang, C. J., Chang, W. C., Hsu, J. M., Kuo, H. P., Xia, W., Wei, Y., Chiu, P. C., Chou, C. K., Du, Y., Dhar, D., Karin, M., Chen, C. H. & Hung, M. C., Jan 27 2012, In : Molecular cell. 45, 2, p. 171-184 14 p.

Research output: Contribution to journalArticle

Carcinogenesis
Neoplasms
Cell Proliferation
Inflammation
Critical Pathways
206 Citations (Scopus)

The Crosstalk of mTOR/S6K1 and Hedgehog Pathways

Wang, Y., Ding, Q., Yen, C. J., Xia, W., Izzo, G. J., Lang, J. Y., Li, C-W., Hsu, J. L., Miller, S. A., Wang, X., Lee, D. F., Hsu, J-M., Huo, L., LaBaff, A. M., Liu, D., Huang, T. H., Lai, C. C., Tsai, F-J., Chang, W-C., Chen, C. H. & 7 others, Wu, T. T., Buttar, N. S., Wang, K. K., Wu, Y., Wang, H., Ajani, J. A. & Hung, M-C., Mar 20 2012, In : Cancer cell. 21, 3, p. 374-387 14 p.

Research output: Contribution to journalArticle

Adenocarcinoma
Esophageal Neoplasms
Phosphorylation
Therapeutics