• 6767 Bertner Ave, Mitchell Basic Science Research Building

    77030 Houston

    United States

  • 5812 Citations
  • 41 h-Index
20022019
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Research Output 2002 2019

2019
Random Allocation
Randomisation
Clinical Trials
Confidence
Covariates

A flexible and robust method for assessing conditional association and conditional concordance

Liu, X., Ning, J., Cheng, Y., Huang, X. & Li, R., Aug 30 2019, In : Statistics in Medicine. 38, 19, p. 3656-3668 13 p.

Research output: Contribution to journalArticle

Concordance
Robust Methods
Covariates
Association Measure
Kendall's tau

An oncology clinical trial design with randomization adaptive to both short- and long-term responses

Liu, H., Lin, X. & Huang, X., Jul 1 2019, In : Statistical Methods in Medical Research. 28, 7, p. 2015-2031 17 p.

Research output: Contribution to journalArticle

Oncology
Random Allocation
Randomisation
Clinical Trials
Survival

Estimation of the distribution of longitudinal biomarker trajectories prior to disease progression

Huang, X., Liu, L., Ning, J., Li, L. & Shen, Y., May 20 2019, In : Statistics in Medicine. 38, 11, p. 2030-2046 17 p.

Research output: Contribution to journalArticle

Biomarkers
Progression
Disease Progression
Trajectory
Longitudinal Studies
Linear Transformation Model
Chronic Disease
Cohort Study
Landmarks
Prediction
3 Citations (Scopus)
Acute Myeloid Leukemia
Recurrence
Survival
Proteins
Disease-Free Survival

New Tool for Monitoring Molecular Response in Patients with Chronic Myeloid Leukemia

Badar, T., Luthra, R., Kantarjian, H. M., Jabbour, E. J., Borthakur, G., Garcia-Manero, G., Huang, X., Singh, R. R., Alvarez, B., Austermiller, B., Morrison, T. B., Patel, K. P. & Cortes, J. E., Jan 1 2019, In : Applied Immunohistochemistry and Molecular Morphology. 27, 1, p. 33-39 7 p.

Research output: Contribution to journalArticle

Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Nucleic Acids
Polymerase Chain Reaction
Molecular Pathology
Sample Size

Quantile residual lifetime regression with functional principal component analysis of longitudinal data for dynamic prediction

Lin, X., Li, R., Yan, F., Lu, T. & Huang, X., Apr 1 2019, In : Statistical Methods in Medical Research. 28, 4, p. 1216-1229 14 p.

Research output: Contribution to journalArticle

Functional Principal Component Analysis
Residual Lifetime
Longitudinal Data
Principal Component Analysis
Quantile
13 Citations (Scopus)

Randomized trial of ibrutinib vs ibrutinib plus rituximab in patients with chronic lymphocytic leukemia

Burger, J. A., Sivina, M., Jain, N., Kim, E., Kadia, T., Estrov, Z., Nogueras-Gonzalez, G. M., Huang, X., Jorgensen, J., Li, J., Cheng, M., Clow, F., Ohanian, M., Andreeff, M., Mathew, T., Thompson, P., Kantarjian, H., O'Brien, S., Wierda, W. G., Ferrajoli, A. & 1 others, Keating, M. J., Jan 1 2019, In : Blood. 133, 10, p. 1011-1019 9 p.

Research output: Contribution to journalArticle

B-Cell Chronic Lymphocytic Leukemia
Disease-Free Survival
Rituximab
PCI 32765
Confidence Intervals
2018
2 Citations (Scopus)

A Bayesian multi-stage cost-effectiveness design for animal studies in stroke research

Cai, C., Ning, J. & Huang, X., Apr 1 2018, In : Statistical Methods in Medical Research. 27, 4, p. 1219-1229 11 p.

Research output: Contribution to journalArticle

Cost-effectiveness
Stroke
Cost-Benefit Analysis
Animals
Adaptive Design
8 Citations (Scopus)

A Bayesian Simulation Model for Breast Cancer Screening, Incidence, Treatment, and Mortality

Huang, X., Li, Y., Song, J. & Berry, D. A., Apr 1 2018, In : Medical Decision Making. 38, 1_suppl, p. 78S-88S

Research output: Contribution to journalArticle

Early Detection of Cancer
Breast Neoplasms
Mortality
Incidence
Mammography
16 Citations (Scopus)

A pilot study of lower doses of ibrutinib in patients with chronic lymphocytic leukemia

Chen, L. S., Bose, P., Cruz, N. D., Jiang, Y., Wu, Q., Thompson, P. A., Feng, S., Kroll, M. H., Qiao, W., Huang, X., Jain, N., Wierda, W. G., Keating, M. J. & Gandhi, V., Nov 22 2018, In : Blood. 132, 21, p. 2249-2259 11 p.

Research output: Contribution to journalArticle

B-Cell Chronic Lymphocytic Leukemia
Pharmacodynamics
Pharmacokinetics
Plasmas
Chemokine CCL4
33 Citations (Scopus)

Association of screening and treatment with breast cancer mortality by molecular subtype in US women, 2000-2012

Plevritis, S. K., Munoz, D., Kurian, A. W., Stout, N. K., Alagoz, O., Near, A. M., Lee, S. J., Van Den Broek, J. J., Huang, X., Schechter, C. B., Sprague, B. L., Song, J., De Koning, H. J., Trentham-Dietz, A., Van Ravesteyn, N. T., Gangnon, R., Chandler, Y., Li, Y., Xu, C., Ali Ergun, M. & 3 others, Huang, H., Berry, D. A. & Mandelblatt, J. S., Jan 9 2018, In : JAMA - Journal of the American Medical Association. 319, 2, p. 154-164 11 p.

Research output: Contribution to journalReview article

Breast Neoplasms
Mortality
Estrogen Receptors
Therapeutics
Mammography
14 Citations (Scopus)
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Stem Cell Transplantation
Drug Therapy
Vincristine
Cyclophosphamide
13 Citations (Scopus)
Philadelphia Chromosome
Vincristine
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Doxorubicin
Cyclophosphamide

Design and inference for 3-stage bioequivalence testing with serial sampling data

Yan, F., Zhu, H., Liu, J., Jiang, L. & Huang, X., Jan 1 2018, (Accepted/In press) In : Pharmaceutical statistics.

Research output: Contribution to journalArticle

Bioequivalence
Therapeutic Equivalency
Sample Size
Testing
Drugs
7 Citations (Scopus)

Effects of radiotherapy in early-stage, low-recurrence risk, hormone-sensitive breast cancer

CISNET-BOLD Collaborative Group , Jan 1 2018, In : Journal of the National Cancer Institute. 110, 12, djy128.

Research output: Contribution to journalArticle

Radiotherapy
Hormones
Breast Neoplasms
Recurrence
Segmental Mastectomy

Efficient Two-Stage Designs and Proper Inference for Animal Studies

Cai, C., Piao, J., Ning, J. & Huang, X., Apr 1 2018, In : Statistics in Biosciences. 10, 1, p. 217-232 16 p.

Research output: Contribution to journalArticle

Two-stage Design
Animals
Sample Size
Cost-Benefit Analysis
Familywise Error Rate
1 Citation (Scopus)
Functional Principal Component Analysis
Time Windows
Longitudinal Data
Biomarkers
Prediction
16 Citations (Scopus)
Myelodysplastic Syndromes
Proxy
Mutation
Survival
Neoplasms
1 Citation (Scopus)
Idarubicin
Cytarabine
Acute Myeloid Leukemia
CXCR4 Receptors
Salvage Therapy

Mean residual life regression with functional principal component analysis on longitudinal data for dynamic prediction

Lin, X., Lu, T., Yan, F., Li, R. & Huang, X., Dec 1 2018, In : Biometrics. 74, 4, p. 1482-1491 10 p.

Research output: Contribution to journalArticle

Functional Principal Component Analysis
Mean Residual Life
Biomarkers
Longitudinal Data
Principal Component Analysis
7 Citations (Scopus)

Modeling Ductal Carcinoma In Situ (DCIS): An Overview of CISNET Model Approaches

van Ravesteyn, N. T., van den Broek, J. J., Li, X., Weedon-Fekjær, H., Schechter, C. B., Alagoz, O., Huang, X., Weaver, D. L., Burnside, E. S., Punglia, R. S., de Koning, H. J. & Lee, S. J., Apr 1 2018, In : Medical Decision Making. 38, 1_suppl, p. 126S-139S

Research output: Contribution to journalArticle

Carcinoma, Intraductal, Noninfiltrating
Neoplasms
Breast Neoplasms
Information Storage and Retrieval
Mammography
9 Citations (Scopus)

Results of second salvage therapy in 673 adults with acute myelogenous leukemia treated at a single institution since 2000

Kantarjian, H. M., DiNardo, C., Nogueras-Gonzalez, G. M., Kadia, T. M., Jabbour, E. J., Bueso-Ramos, C. E., O'Brien, S. M., Konopleva, M., Jain, N., Daver, N., Shpall, E., Champlin, R. E., Simkins, A., Garcia-Manero, G., Keating, M. J., Huang, X., Cortes, J. E., Pierce, S. A., Ravandi-Kashani, F. & Freireich, E. J., Jun 15 2018, In : Cancer. 124, 12, p. 2534-2540 7 p.

Research output: Contribution to journalArticle

Salvage Therapy
Acute Myeloid Leukemia
Survival
Cytarabine
Karyotype
40 Citations (Scopus)
Philadelphia Chromosome
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Clinical Trials
Survival Rate
Residual Neoplasm
2 Citations (Scopus)

Semiparametric accelerated failure time cure rate mixture models with competing risks

Choi, S., Zhu, L. & Huang, X., Jan 15 2018, In : Statistics in Medicine. 37, 1, p. 48-59 12 p.

Research output: Contribution to journalArticle

Competing Risks
Failure Time
Mixture Model
Cause-specific Hazard
kernel
1 Citation (Scopus)

Semiparametric Estimation of Longitudinal Medical Cost Trajectory

Li, L., Wu, C. H., Ning, J., Huang, X., Shih, Y-C. T. & Shen, Y., Apr 3 2018, In : Journal of the American Statistical Association. 113, 522, p. 582-592 11 p.

Research output: Contribution to journalArticle

Semiparametric Estimation
Trajectory
Costs
Health
Bivariate Splines
1 Citation (Scopus)

Simulation modeling of cancer clinical trials: Application to omitting radiotherapy in low-risk breast cancer

CISNET-BOLD Collaborative Group , Jan 1 2018, In : Journal of the National Cancer Institute. 110, 12, djy059.

Research output: Contribution to journalArticle

Radiotherapy
Clinical Trials
Breast Neoplasms
Recurrence
Neoplasms

Smoothed quantile regression analysis of competing risks

Choi, S., Kang, S. & Huang, X., Sep 2018, In : Biometrical Journal. 60, 5, p. 934-946 13 p.

Research output: Contribution to journalArticle

Competing Risks
Quantile Regression
Regression Analysis
Censored Regression
Covariates
2017
14 Citations (Scopus)
Azacitidine
Myelodysplastic Syndromes
Acute Myeloid Leukemia
Clinical Trials
Survival
14 Citations (Scopus)

Antileukemia efficacy and mechanisms of action of SL-101, a novel anti-CD123 antibody conjugate, in acute myeloid leukemia

Han, L., Jorgensen, J. L., Brooks, C., Shi, C., Zhang, Q., Nogueras Gonzalez, G. M., Cavazos, A., Pan, R., Mu, H., Wang, S., Zhou, J., Ai-Atrash, G., Ciurea, S. O., Rettig, M., Dipersio, J. F., Cortes, J. E., Huang, X., Kantarjian, H. M., Andreeff, M., Ravandi-Kashani, F. & 1 others, Konopleva, M., Jul 1 2017, In : Clinical Cancer Research. 23, 13, p. 3385-3395 11 p.

Research output: Contribution to journalArticle

Acute Myeloid Leukemia
Anti-Idiotypic Antibodies
Leukemia
Stem Cells
Residual Neoplasm
14 Citations (Scopus)
Idarubicin
Cytarabine
Acute Myeloid Leukemia
Disease-Free Survival
Survival Rate
2 Citations (Scopus)
Functional Principal Component Analysis
Leukemia
Biomarkers
Progression
Principal component analysis
1 Citation (Scopus)

Estimating treatment effects in observational studies with both prevalent and incident cohorts

Ning, J., Hong, C., Li, L., Huang, X. & Shen, Y., Jun 1 2017, In : Canadian Journal of Statistics. 45, 2, p. 202-219 18 p.

Research output: Contribution to journalArticle

Observational Study
Treatment Effects
Radiation Therapy
Propensity Score
Selection Bias
2 Citations (Scopus)

Factors associated with risk of central nervous system relapse in patients with non-core binding factor acute myeloid leukemia

Jabbour, E. J., Guastad Daver, N., Short, N. J., Huang, X., Chen, H. C., Maiti, A., Ravandi-Kashani, F., Cortes, J. E., Abi Aad, S., Garcia-Manero, G., Estrov, Z., Kadia, T. M., O'Brien, S., Dabaja, B. S., Bueso-Ramos, C. E., Strati, P., Bivins, C., Pierce, S. & Kantarjian, H. M., Sep 1 2017, In : American journal of hematology. 92, 9, p. 924-928 5 p.

Research output: Contribution to journalArticle

Acute Myeloid Leukemia
Central Nervous System
Recurrence
Central Nervous System Diseases
Cytarabine
24 Citations (Scopus)
Residual Neoplasm
Acute Myeloid Leukemia
Flow Cytometry
Idarubicin
Cytarabine
94 Citations (Scopus)

Preleukaemic clonal haemopoiesis and risk of therapy-related myeloid neoplasms: a case-control study

Takahashi, K., Wang, F., Kantarjian, H. M., Doss, D., Khanna, K., Thompson, E., Zhao, L., Patel, K. P., Neelapu, S. S., Gumbs, C., Bueso-Ramos, C. E., DiNardo, C., Colla, S., Ravandi-Kashani, F., Zhang, J., Huang, X., Wu, X., Samaniego, F., Garcia-Manero, G. & Futreal, A., Jan 1 2017, In : The lancet oncology. 18, 1, p. 100-111 12 p.

Research output: Contribution to journalArticle

Second Primary Neoplasms
Case-Control Studies
Neoplasms
Lymphoma
Bone Marrow
34 Citations (Scopus)

Randomized phase 2 study of low-dose decitabine vs low-dose azacitidine in lower-risk MDS and MDS/MPN

Jabbour, E., Short, N. J., Montalban-Bravo, G., Huang, X., Bueso-Ramos, C., Qiao, W., Yang, H., Zhao, C., Kadia, T., Borthakur, G., Pemmaraju, N., Sasaki, K., Estrov, Z., Cortes, J., Ravandi, F., Alvarado, Y., Komrokji, R., Sekeres, M. A., Steensma, D. P., DeZern, A. & 3 others, Roboz, G., Kantarjian, H. & Garcia-Manero, G., Sep 28 2017, In : Blood. 130, 13, p. 1514-1522 9 p.

Research output: Contribution to journalArticle

decitabine
Azacitidine
Myelodysplastic Syndromes
Neoplasms
Leukemia, Myelomonocytic, Chronic
8 Citations (Scopus)

Ruxolitinib for symptom control in patients with chronic lymphocytic leukaemia: a single-group, phase 2 trial

Jain, P., Keating, M., Renner, S., Cleeland, C., Huang, X., Gonzalez, G. N., Harris, D., Li, P., Liu, Z., Veletic, I., Rozovski, U., Jain, N., Thompson, P. A., Bose, P., DiNardo, C., Ferrajoli, A., O'Brien, S., Burger, J. A., Wierda, W. G., Verstovsek, S. & 2 others, Kantarjian, H. M. & Estrov, Z., Feb 1 2017, In : The Lancet Haematology. 4, 2, p. e67-e74

Research output: Contribution to journalArticle

B-Cell Chronic Lymphocytic Leukemia
Fatigue
Equipment and Supplies
Therapeutics
Primary Myelofibrosis

Semiparametric accelerated intensity models for correlated recurrent and terminal events

Choi, S., Huang, X., Ju, H. & Ning, J., Apr 2017, In : Statistica Sinica. 27, 2, p. 625-643 19 p.

Research output: Contribution to journalArticle

Recurrent Events
Intensity Function
Model
Accelerated Failure Time Model
Kernel Smoothing
10 Citations (Scopus)
Residual Neoplasm
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Flow Cytometry
Recurrence
Color
2016
2 Citations (Scopus)

A Bayesian multivariate joint frailty model for disease recurrences and survival

Wen, S., Huang, X., Frankowski, R. F., Cormier, J. N. & Pisters, P., Nov 20 2016, In : Statistics in Medicine. 35, 26, p. 4794-4812 19 p.

Research output: Contribution to journalArticle

Frailty Model
Joint Model
Recurrence
Joints
Hybrid Algorithm
34 Citations (Scopus)
decitabine
Myelodysplastic Syndromes
Acute Myeloid Leukemia
Medical Futility
Primary Myelofibrosis
59 Citations (Scopus)

ATF4 induction through an atypical integrated stress response to ONC201 triggers p53-independent apoptosis in hematological malignancies

Ishizawa, J., Kojima, K., Chachad, D., Ruvolo, P., Ruvolo, V., Jacamo, R. O., Borthakur, G., Mu, H., Zeng, Z., Tabe, Y., Allen, J. E., Wang, Z., Ma, W., Lee, H. C., Orlowski, R., Sarbassov, D., Lorenzi, P. L., Huang, X., Neelapu, S. S., McDonnell, T. J. & 6 others, Miranda, R., Wang, L., Kantarjian, H. M., Konopleva, M., Davis, R. E. & Andreeff, M., Feb 16 2016, In : Science Signaling. 9, 415, ra17.

Research output: Contribution to journalArticle

Hematologic Neoplasms
Apoptosis
Unfolded Protein Response
Phosphorylation
Cells
8 Citations (Scopus)

A two-stage approach for dynamic prediction of time-to-event distributions

Huang, X., Yan, F., Ning, J., Feng, Z., Choi, S. & Cortes, J. E., Jun 15 2016, In : Statistics in Medicine. 35, 13, p. 2167-2182 16 p.

Research output: Contribution to journalArticle

Biomarkers
Prediction
Trajectory
Joint Modeling
Model Misspecification
90 Citations (Scopus)

Collaborative modeling of the benefits and harms associated with different U.S. Breast cancer screening strategies

Mandelblatt, J. S., Stout, N. K., Schechter, C. B., Van Den Broek, J. J., Miglioretti, D. L., Krapcho, M., Trentham-Dietz, A., Munoz, D., Lee, S. J., Berry, D., Van Ravesteyn, N. T., Alagoz, O., Kerlikowske, K., Tosteson, A. N. A., Near, A. M., Hoeffken, A., Chang, Y., Heijnsdijk, E. A., Chisholm, G., Huang, X. & 8 others, Huang, H., Ergun, M. A., Gangnon, R., Sprague, B. L., Plevritis, S., Feuer, E., De Koning, H. J. & Cronin, K. A., Feb 16 2016, In : Annals of internal medicine. 164, 4, p. 215-225 11 p.

Research output: Contribution to journalArticle

Early Detection of Cancer
Breast Neoplasms
Mammography
Comorbidity
Mortality
46 Citations (Scopus)

Combined targeting of BCL-2 and BCR-ABL tyrosine kinase eradicates chronic myeloid leukemia stem cells

Carter, B. Z., Mak, P. Y., Mu, H., Zhou, H., Mak, D. H., Schober, W., Leverson, J. D., Zhang, B., Bhatia, R., Huang, X., Cortes, J. E., Kantarjian, H. M., Konopleva, M. & Andreeff, M., Sep 7 2016, In : Science Translational Medicine. 8, 355, 355ra117.

Research output: Contribution to journalArticle

Myeloid Progenitor Cells
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Protein-Tyrosine Kinases
Blast Crisis
Stem Cells