Yared Hailemichael

Instructor

  • 737 Citations
  • 11 h-Index
20092018
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Research Output 2009 2018

  • 737 Citations
  • 11 h-Index
  • 19 Article
  • 2 Short survey
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Article
2018
17 Citations (Scopus)

Cancer vaccine formulation dictates synergy with CTLA-4 and PD-L1 checkpoint blockade therapy

Hailemichael, Y., Woods, A., Fu, T., He, Q., Nielsen, M. C., Hasan, F., Roszik, J., Xiao, Z., Vianden, C., Khong, H., Singh, M., Sharma, M., Faak, F., Moore, D., Dai, Z., Anthony, S. M., Schluns, K., Sharma, P., Engelhard, V. H. & Overwijk, W., Apr 2 2018, In : Journal of Clinical Investigation. 128, 4, p. 1338-1354 17 p.

Research output: Contribution to journalArticle

Cancer Vaccines
Cytotoxic T-Lymphocytes
Ligands
Vaccination
Proteins
4 Citations (Scopus)

Peptide vaccine formulation controls the duration of antigen presentation and magnitude of tumor-specific CD8 + t cell response

Khong, H., Volmari, A., Sharma, M., Dai, Z., Imo, C. S., Hailemichael, Y., Singh, M., Moore, D. T., Xiao, Z., Huang, X. F., Horvath, T. D., Hawke, D. H. & Overwijk, W. W., May 15 2018, In : Journal of Immunology. 200, 10, p. 3464-3474 11 p.

Research output: Contribution to journalArticle

Subunit Vaccines
Antigen Presentation
T-Lymphocytes
Tyrosine
Vaccination
14 Citations (Scopus)

Protein targeting chimeric molecules specific for bromodomain and extra-terminal motif family proteins are active against pre-clinical models of multiple myeloma

Zhang, X., Lee, H. C., Shirazi, F., Baladandayuthapani, V., Lin, H., Kuiatse, I., Wang, H., Jones, R. J., Berkova, Z., Singh, R. K., Lu, J., Qian, Y., Raina, K., Coleman, K. G., Crews, C. M., Li, B., Wang, H., Hailemichael, Y., Thomas, S. K., Wang, Z. & 2 others, Davis, R. E. & Orlowski, R. Z., Oct 1 2018, In : Leukemia. 32, 10, p. 2224-2239 16 p.

Research output: Contribution to journalArticle

Amino Acid Motifs
Protein Transport
Multiple Myeloma
Dexamethasone
Ubiquitination
2017
3 Citations (Scopus)

Absence of Grail promotes CD8 + T cell anti-tumour activity

Haymaker, C., Yang, Y., Wang, J., Zou, Q., Sahoo, A., Alekseev, A., Singh, D., Ritthipichai, K., Hailemichael, Y., Hoang, O. N., Qin, H., Schluns, K. S., Wang, T., Overwijk, W. W., Sun, S. C., Bernatchez, C., Kwak, L. W., Neelapu, S. S. & Nurieva, R., Dec 1 2017, In : Nature communications. 8, 1, 239.

Research output: Contribution to journalArticle

T-cells
Tumors
tumors
T-Lymphocytes
Interleukin-21 Receptors
7 Citations (Scopus)

Intratumoral CD40 activation and checkpoint blockade induces T cell-mediated eradication of melanoma in the brain

Singh, M., Vianden, C., Cantwell, M. J., Dai, Z., Xiao, Z., Sharma, M., Khong, H., Jaiswal, A. R., Faak, F., Hailemichael, Y., Janssen, L. M. E., Bharadwaj, U., Curran, M. A., Diab, A., Bassett, R. L., Tweardy, D. J., Hwu, P. & Overwijk, W. W., Dec 1 2017, In : Nature communications. 8, 1, 1447.

Research output: Contribution to journalArticle

T-cells
brain
Tumors
Melanoma
Brain
T-cells
Antigens
Assays
Vaccination
T-Lymphocytes
18 Citations (Scopus)

Macrophages facilitate resistance to anti-VEGF therapy by altered VEGFR expression

Dalton, H. J., Pradeep, S., McGuire, M., Hailemichael, Y., Ma, S., Lyons, Y. A., Armaiz-Pena, G. N., Previs, R. A., Hansen, J. M., Rupaimoole, R., Gonzalez-Villasana, V., Cho, M. S., Wu, S., Mangala, L. S., Jennings, N. B., Hu, W., Langley, R., Mu, H., Andreeff, M., Bar Eli, M. & 5 others, Overwijk, W., Ram, P., Lopez, G., Coleman, R. & Sood, A. K., Nov 15 2017, In : Clinical Cancer Research. 23, 22, p. 7034-7046 13 p.

Research output: Contribution to journalArticle

Vascular Endothelial Growth Factor A
Macrophages
Anti-Idiotypic Antibodies
Therapeutics
Neoplasms
6 Citations (Scopus)

Multifaceted role of BTLA in the control of CD8+ T-cell fate after antigen encounter

Ritthipichai, K., Haymaker, C. L., Martinez, M., Aschenbrenner, A., Yi, X., Zhang, M., Kale, C., Vence, L. M., Roszik, J., Hailemichael, Y., Overwijk, W. W., Varadarajan, N., Nurieva, R., Radvanyi, L. G., Hwu, P. & Bernatchez, C., Oct 15 2017, In : Clinical Cancer Research. 23, 20, p. 6151-6165 15 p.

Research output: Contribution to journalArticle

T-Lymphocytes
Antigens
Tumor-Infiltrating Lymphocytes
Neoplasms
Single-Cell Analysis
2015
4 Citations (Scopus)

Mouse model for pre-clinical study of human cancer immunotherapy

Ya, Z., Hailemichael, Y., Overwijk, W. & Restifo, N. P., Jan 1 2015, In : Current Protocols in Immunology. 2015, p. 20.1.1-20.1.43

Research output: Contribution to journalArticle

Immunotherapy
Experimental Melanomas
Adoptive Transfer
Neoplasm Metastasis
T-Lymphocytes
11 Citations (Scopus)

Soluble interleukin-15 complexes are generated in vivo by type i interferon dependent and independent pathways

Anthony, S. M., Howard, M. E., Hailemichael, Y., Overwijk, W. & Schluns, K., Mar 10 2015, In : PLoS One. 10, 3, e0120274.

Research output: Contribution to journalArticle

Interleukin-15
interferons
Interferons
Vesiculovirus
mice
2014
88 Citations (Scopus)

Generation of a new therapeutic peptide that depletes myeloid-derived suppressor cells in tumor-bearing mice

Qin, H., Lerman, B., Sakamaki, I., Wei, G., Cha, S-C., Rao, S. S., Qian, J., Hailemichael, Y., Nurieva, R., Dwyer, K. C., Roth, J., Yi, Q., Overwijk, W. & Kwak, L. W., Jan 1 2014, In : Nature medicine. 20, 6, p. 676-681 6 p.

Research output: Contribution to journalArticle

Bearings (structural)
Tumors
Peptides
Neoplasms
Bacteriophages
2013
18 Citations (Scopus)

Peptide-based anticancer vaccines the making and unmaking of a T-cell graveyard

Hailemichael, Y. & Overwijk, W. W., Sep 4 2013, In : OncoImmunology. 2, 7, e24743.

Research output: Contribution to journalArticle

Cemeteries
Vaccines
T-Lymphocytes
Peptides
Neoplasms
216 Citations (Scopus)

Persistent antigen at vaccination sites induces tumor-specific CD8+ T cell sequestration, dysfunction and deletion

Hailemichael, Y., Dai, Z., Jaffarzad, N., Ye, Y., Medina, M. A., Huang, X. F., Dorta-Estremera, S., Greeley, N. R., Nitti, G., Peng, W., Liu, C., Lou, Y., Wang, Z., Ma, W., Rabinovich, B., Schluns, K., Davis, R. E., Hwu, P. & Overwijk, W., Apr 1 2013, In : Nature medicine. 19, 4, p. 465-472 8 p.

Research output: Contribution to journalArticle

T-cells
Tumors
Vaccination
T-Lymphocytes
Antigens
2012
2 Citations (Scopus)

Conference Scene: Immune effector mechanisms in tumor immunity

Sikora, A. G., Hailemichael, Y. & Overwijk, W., Feb 1 2012, In : Immunotherapy. 4, 2, p. 141-143 3 p.

Research output: Contribution to journalArticle

Immunity
Neoplasms
Immunotherapy
Translational Medical Research
Industry
89 Citations (Scopus)

Tumor-expressed inducible nitric oxide synthase controls induction of functional myeloid-derived suppressor cells through modulation of vascular endothelial growth factor release

Jayaraman, P., Parikh, F., Lopez-Rivera, E., Hailemichael, Y., Clark, A., Ma, G., Cannan, D., Ramacher, M., Kato, M., Overwijk, W. W., Chen, S. H., Umansky, V. Y. & Sikora, A. G., Jun 1 2012, In : Journal of Immunology. 188, 11, p. 5365-5376 12 p.

Research output: Contribution to journalArticle

Nitric Oxide Synthase Type II
Vascular Endothelial Growth Factor A
Nitric Oxide Synthase
Neoplasms
Melanoma
2011
33 Citations (Scopus)

Antitumor activity mediated by CpG: The route of administration is critical

Lou, Y., Liu, C., Lizée, G., Peng, W., Xu, C., Ye, Y., Rabinovich, B. A., Hailemichael, Y., Gelbard, A., Zhou, D., Overwijk, W. W. & Hwu, P., Apr 1 2011, In : Journal of Immunotherapy. 34, 3, p. 279-288 10 p.

Research output: Contribution to journalArticle

T-Lymphocytes
Neoplasm Antigens
Neoplasms
Chemokines
Intravenous Injections
2010
37 Citations (Scopus)

Inhibition of p-STAT3 enhances IFN-α efficacy against metastatic melanoma in a murine model

Kong, L. Y., Gelbard, A., Wei, J., Reina-Ortiz, C., Wang, Y., Yang, E. C., Hailemichael, Y., Fokt, I., Jayakumar, A., Qiao, W., Fuller, G. N., Overwijk, W. W., Priebe, W. & Heimberger, A. B., May 1 2010, In : Clinical Cancer Research. 16, 9, p. 2550-2561 12 p.

Research output: Contribution to journalArticle

STAT3 Transcription Factor
Melanoma
Immunotherapy
Therapeutics
T-Lymphocytes
86 Citations (Scopus)

Targeted inhibition of inducible nitric oxide synthase inhibits growth of human melanoma in vivo and synergizes with chemotherapy

Sikora, A. G., Gelbard, A., Davies, M. A., Sano, D., Ekmekcioglu, S., Kwon, J., Hailemichael, Y., Jayaraman, P., Myers, J. N., Grimm, E. A. & Overwijk, W., Mar 15 2010, In : Clinical Cancer Research. 16, 6, p. 1834-1844 11 p.

Research output: Contribution to journalArticle

Nitric Oxide Synthase Type II
Melanoma
Drug Therapy
Growth
Neoplasms
2009
74 Citations (Scopus)

IFN-α enhances peptide vaccine-induced CD8+ T cell numbers, effector function, and antitumor activity

Sikora, A. G., Jaffarzad, N., Hailemichael, Y., Gelbard, A., Stonier, S. W., Schluns, K., Frasca, L., Lou, Y., Liu, C., Andersson, H. A., Hwu, P. & Overwijk, W., Jun 15 2009, In : Journal of Immunology. 182, 12, p. 7398-7407 10 p.

Research output: Contribution to journalArticle

Subunit Vaccines
Vaccination
Cell Count
T-Lymphocytes
Peptides