Yutong Sun

Assistant Professor

  • 1839 Citations
  • 20 h-Index
19992019
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Research Output 1999 2019

  • 1839 Citations
  • 20 h-Index
  • 28 Article
  • 4 Review article
  • 1 Short survey
2019
6 Citations (Scopus)

New insights into long non-coding rna malat1 in cancer and metastasis

Sun, Y. & Ma, L., Feb 1 2019, In : Cancers. 11, 2, 216.

Research output: Contribution to journalReview article

Open Access
Long Noncoding RNA
Neoplasm Metastasis
Neoplasms
Prostatic Neoplasms
RNA Precursors
2018
11 Citations (Scopus)

Integrated Genomic Analysis of the Ubiquitin Pathway across Cancer Types

The Cancer Genome Atlas Research Network, Apr 3 2018, In : Cell Reports. 23, 1, p. 213-226.e3

Research output: Contribution to journalArticle

Ubiquitin
Genes
Neoplasms
Tumors
Amplification
33 Citations (Scopus)

Long noncoding RNA MALAT1 suppresses breast cancer metastasis

Kim, J., Piao, H. L., Kim, B. J., Yao, F., Han, Z., Wang, Y., Xiao, Z., Siverly, A. N., Lawhon, S. E., Ton, B. N., Lee, H., Zhou, Z., Gan, B., Nakagawa, S., Ellis, M. J., Liang, H., Hung, M. C., You, M. J., Sun, Y. & Ma, L., Dec 1 2018, In : Nature Genetics. 50, 12, p. 1705-1715 11 p.

Research output: Contribution to journalArticle

Long Noncoding RNA
Breast Neoplasms
Neoplasm Metastasis
Gene Silencing
Heterografts
33 Citations (Scopus)

MicroRNAs and metastasis: small RNAs play big roles

Kim, J., Yao, F., Xiao, Z., Sun, Y. & Ma, L., Mar 1 2018, In : Cancer and Metastasis Reviews. 37, 1, p. 5-15 11 p.

Research output: Contribution to journalArticle

MicroRNAs
RNA
Neoplasm Metastasis
Neoplasms
Biological Phenomena
8 Citations (Scopus)

SKP2- and OTUD1-regulated non-proteolytic ubiquitination of YAP promotes YAP nuclear localization and activity

Yao, F., Zhou, Z., Kim, J., Hang, Q., Xiao, Z., Ton, B. N., Chang, L., Liu, N., Zeng, L., Wang, W., Wang, Y., Zhang, P., Hu, X., Su, X., Liang, H., Sun, Y. & Ma, L., Dec 1 2018, In : Nature communications. 9, 1, 2269.

Research output: Contribution to journalArticle

Ubiquitination
Chemical activation
Phosphorylation
Ubiquitin-Protein Ligases
activation
2 Citations (Scopus)

ZRANB1 Is an EZH2 Deubiquitinase and a Potential Therapeutic Target in Breast Cancer

Zhang, P., Xiao, Z., Wang, S., Zhang, M., Wei, Y., Hang, Q., Kim, J., Yao, F., Rodriguez-Aguayo, C., Ton, B. N., Lee, M., Wang, Y., Zhou, Z., Zeng, L., Hu, X., Lawhon, S. E., Siverly, A. N., Su, X., Li, J., Xie, X. & 16 others, Cheng, X., Liu, L. C., Chang, H. W., Chiang, S. F., Lopez-Berestein, G., Sood, A. K., Chen, J., You, M. J., Sun, S. C., Liang, H., Huang, Y., Yang, X., Sun, D., Sun, Y., Hung, M. C. & Ma, L., Apr 17 2018, In : Cell Reports. 23, 3, p. 823-837 15 p.

Research output: Contribution to journalArticle

Cells
Triple Negative Breast Neoplasms
Breast Neoplasms
Small Interfering RNA
Neoplasms
2017
11 Citations (Scopus)

USP51 promotes deubiquitination and stabilization of ZEB1

Zhou, Z., Zhang, P., Hu, X., Kim, J., Yao, F., Xiao, Z., Zeng, L., Chang, L., Sun, Y. & Ma, L., Jan 1 2017, In : American Journal of Cancer Research. 7, 10, p. 2020-2031 12 p.

Research output: Contribution to journalArticle

Up-Regulation
Breast Neoplasms
Epithelial-Mesenchymal Transition
Ubiquitination
Cadherins
2016
20 Citations (Scopus)

Ablation of miR-10b suppresses oncogene-induced mammary tumorigenesis and metastasis and reactivates tumor-suppressive pathways

Kim, J., Siverly, A. N., Chen, D., Wang, M., Yuan, Y., Wang, Y., Lee, H., Zhang, J., Muller, W. J., Liang, H., Gan, B., Yang, X., Sun, Y., You, M. J. & Ma, L., Nov 1 2016, In : Cancer research. 76, 21, p. 6424-6435 12 p.

Research output: Contribution to journalArticle

Oncogenes
Carcinogenesis
Breast
Tumor Suppressor Genes
Breast Neoplasms
3 Citations (Scopus)

Powering Tumor Metastasis with Recycled Fuel

Hung, M-C., Yang, R. & Sun, Y., Sep 12 2016, In : Cancer cell. 30, 3, p. 374-375 2 p.

Research output: Contribution to journalShort survey

Recycling
Receptor Protein-Tyrosine Kinases
Neoplasm Metastasis
Hepatocellular Carcinoma
Neoplasms
2015
5 Citations (Scopus)

Pivotal role of extended linker 2 in the activation of Gα by G protein-coupled receptor

Huang, J., Sun, Y., Jillian Zhang, J. & Huang, X. Y., Jan 2 2015, In : Journal of Biological Chemistry. 290, 1, p. 272-283 12 p.

Research output: Contribution to journalArticle

G-Protein-Coupled Receptors
Chemical activation
GTP-Binding Proteins
Heterotrimeric GTP-Binding Proteins
ras Proteins
28 Citations (Scopus)

The emerging molecular machinery and therapeutic targets of metastasis

Sun, Y. & Ma, L., Jan 1 2015, In : Trends in Pharmacological Sciences. 36, 6, p. 349-359 11 p.

Research output: Contribution to journalReview article

Machinery
Neoplasm Metastasis
Stem cells
Plasticity
Therapeutics
179 Citations (Scopus)

ZEB1: At the crossroads of epithelial-mesenchymal transition, metastasis and therapy resistance

Zhang, P., Sun, Y. & Ma, L., Feb 15 2015, In : Cell Cycle. 14, 4, p. 481-487 7 p.

Research output: Contribution to journalReview article

Epithelial-Mesenchymal Transition
Neoplasm Metastasis
Neoplastic Stem Cells
Carcinoma
Therapeutics
2014
159 Citations (Scopus)

ATM-mediated stabilization of ZEB1 promotes DNA damage response and radioresistance through CHK1

Zhang, P., Wei, Y., Wang, L., Debeb, B. G., Yuan, Y., Zhang, J., Yuan, J., Wang, M., Chen, D., Sun, Y., Woodward, W., Liu, Y., Dean, D. C., Liang, H., Hu, Y., Ang, K. K., Hung, M-C., Chen, J. & Ma, L., Jan 1 2014, In : Nature cell biology. 16, 9, p. 864-875 12 p.

Research output: Contribution to journalArticle

Epithelial-Mesenchymal Transition
DNA Damage
Breast Neoplasms
Recombinational DNA Repair
Neoplastic Stem Cells
64 Citations (Scopus)

miR-100 Induces Epithelial-Mesenchymal Transition but Suppresses Tumorigenesis, Migration and Invasion

Chen, D., Sun, Y., Yuan, Y., Han, Z., Zhang, P., Zhang, J., You, M. J., Teruya-Feldstein, J., Wang, M., Gupta, S., Hung, M. C., Liang, H. & Ma, L., Feb 1 2014, In : PLoS genetics. 10, 2, e1004177.

Research output: Contribution to journalArticle

invasiveness
Epithelial-Mesenchymal Transition
tumor
carcinogenesis
targeting
84 Citations (Scopus)

MiR-205 acts as a tumour radiosensitizer by targeting ZEB1 and Ubc13

Zhang, P., Wang, L., Rodriguez-Aguayo, C., Yuan, Y., Debeb, B. G., Chen, D., Sun, Y., You, M. J., Liu, Y., Dean, D. C., Woodward, W. A., Liang, H., Yang, X., Lopez-Berestein, G., Sood, A. K., Hu, Y., Ang, K. K., Chen, J. & Ma, L., 2014, In : Nature communications. 5, 5671.

Research output: Contribution to journalArticle

boxes
Zinc
Tumors
tumors
zinc
8 Citations (Scopus)

α-catenin: A tumor suppressor beyond adherens junctions

Sun, Y., Zhang, J. & Ma, L., Aug 1 2014, In : Cell Cycle. 13, 15, p. 2334-2339 6 p.

Research output: Contribution to journalReview article

Adherens Junctions
Catenins
Neoplasms
Intercellular Junctions
Cadherins
38 Citations (Scopus)

α-Catenin acts as a tumour suppressor in E-cadherin-negative basal-like breast cancer by inhibiting NF-κB signalling

Piao, H. L., Yuan, Y., Wang, M., Sun, Y., Liang, H. & Ma, L., Jan 1 2014, In : Nature cell biology. 16, 3, p. 245-254 10 p.

Research output: Contribution to journalArticle

Catenins
Cadherins
Breast Neoplasms
Neoplasms
Ubiquitination
2013
66 Citations (Scopus)

Deubiquitylation and stabilization of PTEN by USP13

Zhang, J., Zhang, P., Wei, Y., Piao, H. L., Wang, W., Maddika, S., Wang, M., Chen, D., Sun, Y., Hung, M-C., Chen, J. & Ma, L., Jan 1 2013, In : Nature cell biology. 15, 12, p. 1486-1494 9 p.

Research output: Contribution to journalArticle

PTEN Phosphohydrolase
Glycolysis
Breast Neoplasms
Neoplasms
Down-Regulation
2012
74 Citations (Scopus)

Adiponectin regulates expression of hepatic genes critical for glucose and lipid metabolism

Liu, Q., Yuan, B., Lo, K. A., Patterson, H. C., Sun, Y. & Lodish, H. F., Sep 4 2012, In : Proceedings of the National Academy of Sciences of the United States of America. 109, 36, p. 14568-14573 6 p.

Research output: Contribution to journalArticle

Adiponectin
Lipid Metabolism
Knockout Mice
Gene Expression
Glucose
206 Citations (Scopus)

LIFR is a breast cancer metastasis suppressor upstream of the Hippo-YAP pathway and a prognostic marker

Chen, D., Sun, Y., Wei, Y., Zhang, P., Rezaeian, A. H., Teruya-Feldstein, J., Gupta, S., Liang, H., Lin, H. K., Hung, M. C. & Ma, L., Oct 1 2012, In : Nature medicine. 18, 10, p. 1511-1517 7 p.

Research output: Contribution to journalArticle

OSM-LIF Receptors
Breast Neoplasms
Neoplasm Metastasis
Proteins
Tumors
2010
30 Citations (Scopus)

Adiponectin deficiency promotes tumor growth in mice by reducing macrophage infiltration

Sun, Y. & Lodish, H. F., Oct 15 2010, In : PloS one. 5, 8, e11987.

Research output: Contribution to journalArticle

adiponectin
Macrophages
Adiponectin
Infiltration
Tumors
2007
82 Citations (Scopus)

Dosage-dependent switch from G protein-coupled to G protein-independent signaling by a GPCR

Sun, Y., Huang, J., Xiang, Y., Bastepe, M., Jüppner, H., Kobilka, B. K., Zhang, J. J. & Huang, X. Y., Jan 10 2007, In : EMBO Journal. 26, 1, p. 53-64 12 p.

Research output: Contribution to journalArticle

G-Protein-Coupled Receptors
GTP-Binding Proteins
Switches
Adrenergic Receptors
Heterotrimeric GTP-Binding Proteins
59 Citations (Scopus)

When a G protein-coupled receptor does not couple to a G protein

Sun, Y., McGarrigle, D. & Huang, X. Y., Jan 1 2007, In : Molecular BioSystems. 3, 12, p. 849-854 6 p.

Research output: Contribution to journalArticle

G-Protein-Coupled Receptors
GTP-Binding Proteins
Arrestins
PDZ Domains
Guanine Nucleotides
2005
20 Citations (Scopus)

Requirement of Src-family tyrosine kinases in fat accumulation

Sun, Y., Ma, Y. C., Huang, J., Chen, K. Y., McGarrigle, D. K. & Huang, X. Y., Nov 8 2005, In : Biochemistry. 44, 44, p. 14455-14462 8 p.

Research output: Contribution to journalArticle

src-Family Kinases
Adipogenesis
Fats
Phosphorylation
Fibroblasts
2004
26 Citations (Scopus)

Distinct roles for Src tyrosine kinase in β2-adrenergic receptor signaling to MAPK and in receptor internalization

Huang, J., Sun, Y. & Huang, X. Y., May 14 2004, In : Journal of Biological Chemistry. 279, 20, p. 21637-21642 6 p.

Research output: Contribution to journalArticle

TYK2 Kinase
src-Family Kinases
Mitogen-Activated Protein Kinases
Adrenergic Receptors
Fibroblasts
2002
472 Citations (Scopus)

BRCA2 function in DNA binding and recombination from a BRCA2-DSS1-ssDNA structure

Yang, H., Jeffrey, P. D., Miller, J., Kinnucan, E., Sun, Y., Thomä, N. H., Zheng, N., Chen, P. L., Lee, W. H. & Pavletich, N. P., Sep 13 2002, In : Science. 297, 5588, p. 1837-1848 12 p.

Research output: Contribution to journalArticle

Helix-Turn-Helix Motifs
Double-Stranded DNA Breaks
Homologous Recombination
Genetic Recombination
Chromosomal Instability
3 Citations (Scopus)
beta 2-Glycoprotein I
Phospholipids
insertion
Monolayers
Unithiol
2000
40 Citations (Scopus)

Membrane-induced conformational change in human apolipoprotein H

Wang, S. X., Sun, Y. & Sui, S. F., May 15 2000, In : Biochemical Journal. 348, 1, p. 103-106 4 p.

Research output: Contribution to journalArticle

beta 2-Glycoprotein I
Membranes
Liposomes
Phospholipids
Cardiolipins
8 Citations (Scopus)

Penetration of human apolipoprotein H into air/water interface with and without phospholipid monolayers

Sun, Y., Wang, S. X. & Sui, S. F., Dec 15 2000, In : Colloids and Surfaces A: Physicochemical and Engineering Aspects. 175, 1-2, p. 105-112 8 p.

Research output: Contribution to journalArticle

beta 2-Glycoprotein I
Phospholipids
Monolayers
penetration
Hydrogen
1 Citation (Scopus)

Quantitative determination of surface concentration of human apolipoprotein H with capillary electrophoresis

Wang, S. X., Sun, Y., Ru, Q. H., Luo, G. A. & Sui, S. F., Jul 17 2000, In : IUBMB Life. 49, 5, p. 437-440 4 p.

Research output: Contribution to journalArticle

beta 2-Glycoprotein I
Capillary electrophoresis
Capillary Electrophoresis
Monolayers
Proteins
29 Citations (Scopus)

Surface plasmon resonance study of DNA polymerases binding to template/primer DNA duplexes immobilized on supported lipid monolayers

Tsoi, P. Y., Yang, J., Sun, Y., Sui, S. F. & Yang, M., Aug 8 2000, In : Langmuir. 16, 16, p. 6590-6596 7 p.

Research output: Contribution to journalArticle

primers
Exonucleases
Surface plasmon resonance
surface plasmon resonance
Lipids
1999
2 Citations (Scopus)
HIV Envelope Protein gp41
human immunodeficiency virus
Surface plasmon resonance
liquid-solid interfaces
bioinstrumentation
29 Citations (Scopus)

Calcium-dependent binding of rabbit C-reactive protein to supported lipid monolayers containing exposed phosphorylcholine group

Sui, S. F., Sun, Y. & Mi, L. Z., Jan 1 1999, In : Biophysical journal. 76, 1 I, p. 333-341 9 p.

Research output: Contribution to journalArticle

Phosphorylcholine
C-Reactive Protein
Rabbits
Calcium
Lipids