Abstract
Gene expression profiling of β-catenin, Cripto and Wnt3 mutant mouse embryos has been used to characterise the genetic networks that regulate early embryonic development. We have defined genes whose expression is regulated by β-catenin during formation of the anteroposterior axis and the mesoderm, and have identified Cripto, which encodes a Nodal co-receptor, as a primary target of β-catenin signals both in embryogenesis as well as in colon carcinoma cell lines and tissues. We have also defined groups of genes regulated by Wnt3/β-catenin signalling during primitive streak and mesoderm formation. Our data assign a key role to β-catenin upstream of two distinct gene expression programs during anteroposterior axis and mesoderm formation.
Original language | English (US) |
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Pages (from-to) | 6283-6294 |
Number of pages | 12 |
Journal | Development |
Volume | 130 |
Issue number | 25 |
DOIs | |
State | Published - Dec 2003 |
Keywords
- Anteroposterior axis
- Gastrulation
- Microarray
- Nanog
- Signalling pathways
- Tdgf1
ASJC Scopus subject areas
- Molecular Biology
- Developmental Biology