Abstract
Downregulation or loss of α-catenin occurs in multiple human cancer types. The traditional view of α-catenin is that it is one of the core components of the E-cadherin-catenin complex and is required for maintaining the integrity of the intercellular adherens junction, a cell junction whose cytoplasmic face is linked to the actin cytoskeleton. Therefore, loss of α-catenin can result in loss of cell-cell adhesion, a common characteristic of cancer cells. There is an emerging recognition; however, that α-catenin also regulates multiple signaling pathways independent of adherens junctions. For instance, α-catenin functions as a tumor suppressor in E-cadherin-negative basal like breast cancer cells by inhibiting NF-κB signaling. In this perspective, we discuss the role and mechanisms of α-catenin in regulating several signaling pathways in cancer.
Original language | English (US) |
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Pages (from-to) | 2334-2339 |
Number of pages | 6 |
Journal | Cell Cycle |
Volume | 13 |
Issue number | 15 |
DOIs | |
State | Published - Aug 1 2014 |
Keywords
- Cancer
- Hedgehog
- NF-kB
- Tumor suppressor
- YAP
- α-catenin
- β-catenin
ASJC Scopus subject areas
- Molecular Biology
- Developmental Biology
- Cell Biology