α-catenin: A tumor suppressor beyond adherens junctions

Yutong Sun, Jinsong Zhang, Li Ma

Research output: Contribution to journalReview article

9 Citations (Scopus)

Abstract

Downregulation or loss of α-catenin occurs in multiple human cancer types. The traditional view of α-catenin is that it is one of the core components of the E-cadherin-catenin complex and is required for maintaining the integrity of the intercellular adherens junction, a cell junction whose cytoplasmic face is linked to the actin cytoskeleton. Therefore, loss of α-catenin can result in loss of cell-cell adhesion, a common characteristic of cancer cells. There is an emerging recognition; however, that α-catenin also regulates multiple signaling pathways independent of adherens junctions. For instance, α-catenin functions as a tumor suppressor in E-cadherin-negative basal like breast cancer cells by inhibiting NF-κB signaling. In this perspective, we discuss the role and mechanisms of α-catenin in regulating several signaling pathways in cancer.

Original languageEnglish (US)
Pages (from-to)2334-2339
Number of pages6
JournalCell Cycle
Volume13
Issue number15
DOIs
StatePublished - Aug 1 2014

Fingerprint

Adherens Junctions
Catenins
Neoplasms
Intercellular Junctions
Cadherins
Actin Cytoskeleton
Cell Adhesion
Down-Regulation
Breast Neoplasms

Keywords

  • Cancer
  • Hedgehog
  • NF-kB
  • Tumor suppressor
  • YAP
  • α-catenin
  • β-catenin

ASJC Scopus subject areas

  • Molecular Biology
  • Developmental Biology
  • Cell Biology

Cite this

α-catenin : A tumor suppressor beyond adherens junctions. / Sun, Yutong; Zhang, Jinsong; Ma, Li.

In: Cell Cycle, Vol. 13, No. 15, 01.08.2014, p. 2334-2339.

Research output: Contribution to journalReview article

Sun, Yutong ; Zhang, Jinsong ; Ma, Li. / α-catenin : A tumor suppressor beyond adherens junctions. In: Cell Cycle. 2014 ; Vol. 13, No. 15. pp. 2334-2339.
@article{309df7f6a1a941d7b98129aa870f20b9,
title = "α-catenin: A tumor suppressor beyond adherens junctions",
abstract = "Downregulation or loss of α-catenin occurs in multiple human cancer types. The traditional view of α-catenin is that it is one of the core components of the E-cadherin-catenin complex and is required for maintaining the integrity of the intercellular adherens junction, a cell junction whose cytoplasmic face is linked to the actin cytoskeleton. Therefore, loss of α-catenin can result in loss of cell-cell adhesion, a common characteristic of cancer cells. There is an emerging recognition; however, that α-catenin also regulates multiple signaling pathways independent of adherens junctions. For instance, α-catenin functions as a tumor suppressor in E-cadherin-negative basal like breast cancer cells by inhibiting NF-κB signaling. In this perspective, we discuss the role and mechanisms of α-catenin in regulating several signaling pathways in cancer.",
keywords = "Cancer, Hedgehog, NF-kB, Tumor suppressor, YAP, α-catenin, β-catenin",
author = "Yutong Sun and Jinsong Zhang and Li Ma",
year = "2014",
month = "8",
day = "1",
doi = "10.4161/cc.29765",
language = "English (US)",
volume = "13",
pages = "2334--2339",
journal = "Cell Cycle",
issn = "1538-4101",
publisher = "Landes Bioscience",
number = "15",

}

TY - JOUR

T1 - α-catenin

T2 - A tumor suppressor beyond adherens junctions

AU - Sun, Yutong

AU - Zhang, Jinsong

AU - Ma, Li

PY - 2014/8/1

Y1 - 2014/8/1

N2 - Downregulation or loss of α-catenin occurs in multiple human cancer types. The traditional view of α-catenin is that it is one of the core components of the E-cadherin-catenin complex and is required for maintaining the integrity of the intercellular adherens junction, a cell junction whose cytoplasmic face is linked to the actin cytoskeleton. Therefore, loss of α-catenin can result in loss of cell-cell adhesion, a common characteristic of cancer cells. There is an emerging recognition; however, that α-catenin also regulates multiple signaling pathways independent of adherens junctions. For instance, α-catenin functions as a tumor suppressor in E-cadherin-negative basal like breast cancer cells by inhibiting NF-κB signaling. In this perspective, we discuss the role and mechanisms of α-catenin in regulating several signaling pathways in cancer.

AB - Downregulation or loss of α-catenin occurs in multiple human cancer types. The traditional view of α-catenin is that it is one of the core components of the E-cadherin-catenin complex and is required for maintaining the integrity of the intercellular adherens junction, a cell junction whose cytoplasmic face is linked to the actin cytoskeleton. Therefore, loss of α-catenin can result in loss of cell-cell adhesion, a common characteristic of cancer cells. There is an emerging recognition; however, that α-catenin also regulates multiple signaling pathways independent of adherens junctions. For instance, α-catenin functions as a tumor suppressor in E-cadherin-negative basal like breast cancer cells by inhibiting NF-κB signaling. In this perspective, we discuss the role and mechanisms of α-catenin in regulating several signaling pathways in cancer.

KW - Cancer

KW - Hedgehog

KW - NF-kB

KW - Tumor suppressor

KW - YAP

KW - α-catenin

KW - β-catenin

UR - http://www.scopus.com/inward/record.url?scp=84905917297&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84905917297&partnerID=8YFLogxK

U2 - 10.4161/cc.29765

DO - 10.4161/cc.29765

M3 - Review article

C2 - 25483184

AN - SCOPUS:84905917297

VL - 13

SP - 2334

EP - 2339

JO - Cell Cycle

JF - Cell Cycle

SN - 1538-4101

IS - 15

ER -