α-Catenin inhibits glioma cell migration, invasion, and proliferation by suppression of β-catenin transactivation

Haitao Ji, Ji Wang, Bingliang Fang, Xuexun Fang, Zhimin Lu

Research output: Contribution to journalArticle

20 Scopus citations

Abstract

Patients with glioblastomas, the most common primary tumors of the central nervous system, have poor prognoses because of uncontrolled tumor cell invasion and proliferation. β-Catenin plays an important role in tumor development. However, whether α-catenin expression contributes to β-catenin transactivation in glioma cells is largely unknown. We report here that α-catenin expression abrogates epidermal growth factor receptor (EGFR)-activation-induced β-catenin nuclear translocation in human glioblastoma cells, thereby attenuating β-catenin transactivation and the expression of its downstream genes CCND1 and c-myc. In addition, ectopic expression of α-catenin or depletion of β-catenin suppresses EGF-promoted glioblastoma cell migration, invasion, and proliferation. In contrast, α-catenin depletion promotes β-catenin nuclear translocation and transactivation, and tumor cell motility and growth. These findings reveal the importance of β-catenin regulation by α-catenin in cellular activities of glioblastoma cells.

Original languageEnglish (US)
Pages (from-to)445-451
Number of pages7
JournalJournal of neuro-oncology
Volume103
Issue number3
DOIs
StatePublished - Jul 1 2011

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Keywords

  • EGFR
  • Glioblastoma
  • Invasion
  • Migration
  • Proliferation
  • α-Catenin
  • β-Catenin

ASJC Scopus subject areas

  • Oncology
  • Neurology
  • Clinical Neurology
  • Cancer Research

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