Geç gebelik si{dotless}rasi{dotless}nda erken membran rüptürünün doǧru tani{dotless}si{dotless} için vajinal yi{dotless}kama si{dotless}vi{dotless}si{dotless}nda β-human koryonik gonodatropin ölçümü

Translated title of the contribution: β-human chorionic gonadotropin assay in vaginal washing fluid for the accurate diagnosis of premature rupture of membranes during late pregnancy

Orhan Temel, Ebru Çöǧendez, Selçuk Selçuk, Mehmet Reşit Asoǧlu, Erdal Kaya

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Objective: To determine whether the measurement of beta-human chorionic gonadotropin (β-hCG) levels in vaginal fluid is useful for the diagnosis of premature rupture of membranes (PROM). Material and Methods: A total of 92 pregnant women between 24 and 40 weeks gestation participated in this study. The patients with fluid leaking from the vagina were designated Group 1, the patients with no fluid leaking from the vagina were Group 2, and those with a suspicion of fluid leaking from the vagina were classified as Group 3. Irrigating the posterior vaginal fornix with 5 mL sterile saline was used to measure β-hCG levels of the patients. Receiver operator curve (ROC) analysis was used to determine the cut-off value for a positive diagnosis. Results: The β-hCG levels of vaginal fluid were measured as 20.5±25.0 mIU/mL, 254.6±346.8 mIU/mL, and 74.3±100.8 mIU/mL in Group 1, Group 2, and Group 3, respectively. Vaginal β-hCG level was higher statistically significantly in Group 2 than Group 1 and 3 (p<0.001). 100 mIU/mL was accepted as a cut-off value by using the receiver operating characteristic curve. According to 100 mIU/mL, sensitivity, specificity, positive predictive and negative predictive values were calculated as 71.2, 100, 100, and 65.1%, respectively. Conclusion: The study showed that the measurement of β-hCG level in vaginal washing fluid is an efficient and easy diagnostic test for predicting the amount of fluid leaking from the vagina. However, due to the low negative predictive value of the test, it would not be convenient in daily practice.

Original languageTurkish
Pages (from-to)201-204
Number of pages4
JournalJournal of the Turkish German Gynecology Association
Volume14
Issue number4
DOIs
StatePublished - Dec 1 2013

Fingerprint

Vagina
Chorionic Gonadotropin
Rupture
Pregnancy
Membranes
Predictive Value of Tests
Routine Diagnostic Tests
ROC Curve
Pregnant Women
Sensitivity and Specificity

Keywords

  • Beta-human chorionic gonadotropin
  • Diagnosis
  • Premature rupture of membranes

ASJC Scopus subject areas

  • Obstetrics and Gynecology

Cite this

Geç gebelik si{dotless}rasi{dotless}nda erken membran rüptürünün doǧru tani{dotless}si{dotless} için vajinal yi{dotless}kama si{dotless}vi{dotless}si{dotless}nda β-human koryonik gonodatropin ölçümü. / Temel, Orhan; Çöǧendez, Ebru; Selçuk, Selçuk; Asoǧlu, Mehmet Reşit; Kaya, Erdal.

In: Journal of the Turkish German Gynecology Association, Vol. 14, No. 4, 01.12.2013, p. 201-204.

Research output: Contribution to journalArticle

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abstract = "Objective: To determine whether the measurement of beta-human chorionic gonadotropin (β-hCG) levels in vaginal fluid is useful for the diagnosis of premature rupture of membranes (PROM). Material and Methods: A total of 92 pregnant women between 24 and 40 weeks gestation participated in this study. The patients with fluid leaking from the vagina were designated Group 1, the patients with no fluid leaking from the vagina were Group 2, and those with a suspicion of fluid leaking from the vagina were classified as Group 3. Irrigating the posterior vaginal fornix with 5 mL sterile saline was used to measure β-hCG levels of the patients. Receiver operator curve (ROC) analysis was used to determine the cut-off value for a positive diagnosis. Results: The β-hCG levels of vaginal fluid were measured as 20.5±25.0 mIU/mL, 254.6±346.8 mIU/mL, and 74.3±100.8 mIU/mL in Group 1, Group 2, and Group 3, respectively. Vaginal β-hCG level was higher statistically significantly in Group 2 than Group 1 and 3 (p<0.001). 100 mIU/mL was accepted as a cut-off value by using the receiver operating characteristic curve. According to 100 mIU/mL, sensitivity, specificity, positive predictive and negative predictive values were calculated as 71.2, 100, 100, and 65.1{\%}, respectively. Conclusion: The study showed that the measurement of β-hCG level in vaginal washing fluid is an efficient and easy diagnostic test for predicting the amount of fluid leaking from the vagina. However, due to the low negative predictive value of the test, it would not be convenient in daily practice.",
keywords = "Beta-human chorionic gonadotropin, Diagnosis, Premature rupture of membranes",
author = "Orhan Temel and Ebru {\cC}{\"o}ǧendez and Sel{\cc}uk Sel{\cc}uk and Asoǧlu, {Mehmet Reşit} and Erdal Kaya",
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AU - Temel, Orhan

AU - Çöǧendez, Ebru

AU - Selçuk, Selçuk

AU - Asoǧlu, Mehmet Reşit

AU - Kaya, Erdal

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AB - Objective: To determine whether the measurement of beta-human chorionic gonadotropin (β-hCG) levels in vaginal fluid is useful for the diagnosis of premature rupture of membranes (PROM). Material and Methods: A total of 92 pregnant women between 24 and 40 weeks gestation participated in this study. The patients with fluid leaking from the vagina were designated Group 1, the patients with no fluid leaking from the vagina were Group 2, and those with a suspicion of fluid leaking from the vagina were classified as Group 3. Irrigating the posterior vaginal fornix with 5 mL sterile saline was used to measure β-hCG levels of the patients. Receiver operator curve (ROC) analysis was used to determine the cut-off value for a positive diagnosis. Results: The β-hCG levels of vaginal fluid were measured as 20.5±25.0 mIU/mL, 254.6±346.8 mIU/mL, and 74.3±100.8 mIU/mL in Group 1, Group 2, and Group 3, respectively. Vaginal β-hCG level was higher statistically significantly in Group 2 than Group 1 and 3 (p<0.001). 100 mIU/mL was accepted as a cut-off value by using the receiver operating characteristic curve. According to 100 mIU/mL, sensitivity, specificity, positive predictive and negative predictive values were calculated as 71.2, 100, 100, and 65.1%, respectively. Conclusion: The study showed that the measurement of β-hCG level in vaginal washing fluid is an efficient and easy diagnostic test for predicting the amount of fluid leaking from the vagina. However, due to the low negative predictive value of the test, it would not be convenient in daily practice.

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