15-Lipoxygenase-1 transcriptional silencing by DNA methyltransferase-1 independently of DNA methylation

Keyphrases

• DNA Methylation (DNAm) 100%
• Transcriptional Repression 100%
• DNA Methyltransferase 1 (DNMT1) 100%
• 15-lipoxygenase (15-LOX) 100%
• Promoter Methylation 31%
• Methylation 15%
• Mechanistic Role 10%
• Promoter DNA 10%
• Suberoylanilide Hydroxamic Acid 10%
• Tumor Suppressor Gene 5%
• Tissue Sampling 5%
• Transcriptional Regulation 5%
• Histone Deacetylase Inhibitor (HDACi) 5%
• Colorectal Cancer 5%
• In Cancer 5%
• Expression Level 5%
• Colorectal Cancer Patients 5%
• Transcriptional Activation 5%
• Tumorigenesis 5%
• Colon Cancer Cells 5%
• Tumor Tissue 5%
• Human Subjects 5%
• Spearman 5%
• SiRNA Knockdown 5%
• Colorectal Cancer Cells 5%
• Human Colorectal Cancer 5%
• Normal Colonic mucosa 5%
• Dissociation 5%
• Colorectal Polyps 5%
• DNA Methylation Profiling 5%
• Hypomorphism 5%
• Genetic Disruption 5%

Biochemistry, Genetics and Molecular Biology

• DNA Methylation 100%
• DNA Methyltransferase 100%
• Lipoxygenase 100%
• Promoter Region 52%
• Methylation 21%
• Cancer Cell 10%
• Carcinogenesis 5%
• Genetics 5%
• Tumor Suppressor Gene 5%
• Transcription 5%
• Histone Deacetylase 5%
• Colon 5%
• Transactivation 5%
• Transcription Initiation 5%
• Demethylation 5%
• Homo sapiens 5%
• Colon Mucosa 5%
• Small Interfering RNA 5%
• Expression Level 5%

Pharmacology, Toxicology and Pharmaceutical Science

• Arachidonate 15 Lipoxygenase 100%
• DNA (Cytosine 5) Methyltransferase 1 100%
• Colorectal Carcinoma 21%
• Vorinostat 10%
• Neoplasm 5%
• Tumor Suppressor Protein 5%
• Malignant Neoplasm 5%
• Histone Deacetylase Inhibitor 5%
• Colon Carcinoma 5%
• Carcinogenesis 5%
• Small Interfering RNA 5%
• DNA Methyltransferase 5%
• Homo sapiens 5%
• Colorectal Polyp 5%