TY - JOUR
T1 - 2021 American Thyroid Association Guidelines for Management of Patients with Anaplastic Thyroid Cancer
AU - Bible, Keith C.
AU - Kebebew, Electron
AU - Brierley, James
AU - Brito, Juan P.
AU - Cabanillas, Maria E.
AU - Clark, Thomas J.
AU - Di Cristofano, Antonio
AU - Foote, Robert
AU - Giordano, Thomas
AU - Kasperbauer, Jan
AU - Newbold, Kate
AU - Nikiforov, Yuri E.
AU - Randolph, Gregory
AU - Rosenthal, M. Sara
AU - Sawka, Anna M.
AU - Shah, Manisha
AU - Shaha, Ashok
AU - Smallridge, Robert
AU - Wong-Clark, Carol K.
N1 - Publisher Copyright:
© Copyright 2021, Mary Ann Liebert, Inc., publishers American Thyroid Association 2021.
PY - 2021/3
Y1 - 2021/3
N2 - Background: Anaplastic thyroid cancer (ATC) is a rare but highly lethal form of thyroid cancer. Since the guidelines for the management of ATC by the American Thyroid Association were first published in 2012, significant clinical and scientific advances have occurred in the field. The aim of these guidelines is to inform clinicians, patients, and researchers on published evidence relating to the diagnosis and management of ATC. Methods: The specific clinical questions and topics addressed in these guidelines were based on prior versions of the guidelines, stakeholder input, and input of the Task Force members (authors of the guideline). Relevant literature was reviewed, including serial PubMed searches supplemented with additional articles. The American College of Physicians Guideline Grading System was used for critical appraisal of evidence and grading strength of recommendations. Results: The guidelines include the diagnosis, initial evaluation, establishment of treatment goals, approaches to locoregional disease (surgery, radiotherapy, targeted/systemic therapy, supportive care during active therapy), approaches to advanced/metastatic disease, palliative care options, surveillance and long-term monitoring, and ethical issues, including end of life. The guidelines include 31 recommendations and 16 good practice statements. Conclusions: We have developed evidence-based recommendations to inform clinical decision-making in the management of ATC. While all care must be individualized, such recommendations provide, in our opinion, optimal care paradigms for patients with ATC.
AB - Background: Anaplastic thyroid cancer (ATC) is a rare but highly lethal form of thyroid cancer. Since the guidelines for the management of ATC by the American Thyroid Association were first published in 2012, significant clinical and scientific advances have occurred in the field. The aim of these guidelines is to inform clinicians, patients, and researchers on published evidence relating to the diagnosis and management of ATC. Methods: The specific clinical questions and topics addressed in these guidelines were based on prior versions of the guidelines, stakeholder input, and input of the Task Force members (authors of the guideline). Relevant literature was reviewed, including serial PubMed searches supplemented with additional articles. The American College of Physicians Guideline Grading System was used for critical appraisal of evidence and grading strength of recommendations. Results: The guidelines include the diagnosis, initial evaluation, establishment of treatment goals, approaches to locoregional disease (surgery, radiotherapy, targeted/systemic therapy, supportive care during active therapy), approaches to advanced/metastatic disease, palliative care options, surveillance and long-term monitoring, and ethical issues, including end of life. The guidelines include 31 recommendations and 16 good practice statements. Conclusions: We have developed evidence-based recommendations to inform clinical decision-making in the management of ATC. While all care must be individualized, such recommendations provide, in our opinion, optimal care paradigms for patients with ATC.
KW - BRAF
KW - IMRT (intensity-modulated radiotherapy)
KW - SBRT (stereotactic body radiation therapy)
KW - chemoradiation
KW - chemotherapy
KW - chemotherapy
KW - ethics
KW - multimodality therapy
KW - palliative care
KW - radiation therapy
KW - squamous cell cancer of the thyroid
KW - surgery
KW - targeted therapy
KW - undifferentiated thyroid cancer
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U2 - 10.1089/thy.2020.0944
DO - 10.1089/thy.2020.0944
M3 - Review article
C2 - 33728999
AN - SCOPUS:85102904475
SN - 1050-7256
VL - 31
SP - 337
EP - 386
JO - Thyroid
JF - Thyroid
IS - 3
ER -