2D magnetic titanium carbide MXene for cancer theranostics

Zhuang Liu, Menglong Zhao, Han Lin, Chen Dai, Caiyue Ren, Shengjian Zhang, Weijun Peng, Yu Chen

Research output: Contribution to journalArticle

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Abstract

Fast progress of two-dimensional (2D) materials has catalyzed the emergence of diverse new 2D nanosystems for versatile applications, among which 2D MXenes have attracted broad interest but their single functionality significantly restricts their extensive applications, especially in nanomedicine. Herein we report, for the first time, on the construction of superparamagnetic 2D Ti3C2 MXenes for highly efficient cancer theranostics, which is based on the surface chemistry of specific MXenes for the in situ growth of superparamagnetic Fe3O4 nanocrystals onto the surface of Ti3C2 MXenes. These magnetic Ti3C2-IONPs MXene composites exhibit a high T2 relaxivity of 394.2 mM-1 s-1 and efficient contrast-enhanced magnetic resonance imaging of tumors, providing the potential for therapeutic guidance. Importantly, these superparamagnetic MXenes have shown high photothermal conversion efficiency (48.6%) to guarantee the efficient photothermal killing of cancer cells and ablation of tumor tissues, which has been systematically demonstrated both in vitro and in vivo. The high biocompatibility of these elaborately designed magnetic Ti3C2-based MXene composites guarantees their further potential clinical translation. This report paves a new way for the functionalization of MXene-based 2D nanosheets for broadening their novel applications based on the unique surface chemistry of MXenes, especially in theranostic nanomedicine.

LanguageEnglish (US)
Pages3541-3548
Number of pages8
JournalJournal of Materials Chemistry B
Volume6
Issue number21
DOIs
StatePublished - Jan 1 2018

Fingerprint

Titanium carbide
Medical nanotechnology
Surface chemistry
Tumors
Nanosystems
Nanosheets
Composite materials
Magnetic resonance
Ablation
Biocompatibility
Nanocrystals
Conversion efficiency
Cells
Tissue
Imaging techniques
titanium carbide

ASJC Scopus subject areas

  • Chemistry(all)
  • Biomedical Engineering
  • Materials Science(all)

Cite this

Liu, Z., Zhao, M., Lin, H., Dai, C., Ren, C., Zhang, S., ... Chen, Y. (2018). 2D magnetic titanium carbide MXene for cancer theranostics. Journal of Materials Chemistry B, 6(21), 3541-3548. https://doi.org/10.1039/c8tb00754c

2D magnetic titanium carbide MXene for cancer theranostics. / Liu, Zhuang; Zhao, Menglong; Lin, Han; Dai, Chen; Ren, Caiyue; Zhang, Shengjian; Peng, Weijun; Chen, Yu.

In: Journal of Materials Chemistry B, Vol. 6, No. 21, 01.01.2018, p. 3541-3548.

Research output: Contribution to journalArticle

Liu, Z, Zhao, M, Lin, H, Dai, C, Ren, C, Zhang, S, Peng, W & Chen, Y 2018, '2D magnetic titanium carbide MXene for cancer theranostics' Journal of Materials Chemistry B, vol. 6, no. 21, pp. 3541-3548. https://doi.org/10.1039/c8tb00754c
Liu Z, Zhao M, Lin H, Dai C, Ren C, Zhang S et al. 2D magnetic titanium carbide MXene for cancer theranostics. Journal of Materials Chemistry B. 2018 Jan 1;6(21):3541-3548. https://doi.org/10.1039/c8tb00754c
Liu, Zhuang ; Zhao, Menglong ; Lin, Han ; Dai, Chen ; Ren, Caiyue ; Zhang, Shengjian ; Peng, Weijun ; Chen, Yu. / 2D magnetic titanium carbide MXene for cancer theranostics. In: Journal of Materials Chemistry B. 2018 ; Vol. 6, No. 21. pp. 3541-3548.
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