Abstract
Background: The emergence of two-dimensional MXenes has spurred their versatile applications in broad fields, but the exploring of novel MXene-based family members and their potential applications in theranostic nanomedicine (concurrent diagnostic imaging and therapy) have been rarely explored. In this work, we report the construction of a novel superparamagnetic MXene-based theranostic nanoplatform for efficient breast-cancer theranostics, which was based on intriguing tantalum carbide (Ta 4 C 3 ) MXene and its further rational surface-superparamagnetic iron-oxide functionalization (Ta 4 C 3 -IONP-SPs composite MXenes) for efficient breast-cancer theranostic. Methods: The fabrication of ultrathin Ta 4 C 3 nanosheets was based on an exfoliation strategy and superparamagnetic iron oxide nanoparticles were in-situ grown onto the surface of Ta 4 C 3 MXene according to the redox reaction of MXene. Ta 4 C 3 -IONP MXenes were modified with soybean phospholipid (SP) to guarantee high stability in physiological conditions. The photothermal therapy, contrast-enhanced CT, T 2 -weighted magnetic resonance imaging and the high biocompatibility of these composite nanosheets have also been evaluated in vitro at cellular level and in vivo on mice breast tumor allograft tumor model. Results: The Ta component of Ta 4 C 3 -IONP-SPs exhibits high performance for contrast-enhanced CT imaging because of its high atomic number and high X-ray attenuation coefficient, and the integrated superparamagnetic IONPs act as excellent contrast agents for T 2 -weighted magnetic resonance imaging. Especially, these Ta 4 C 3 -IONP-SPs composite nanosheets with high photothermal-conversion efficiency (n: 32.5%) has achieved complete tumor eradication without reoccurrence, verifying their highly efficient breast-tumor photo-ablation performance. Conclusion: This work not only significantly broadens the biomedical applications of MXene-based nanoplatforms (Ta 4 C 3 MXene) by exploring their novel family members and further functionalization strategies (magnetic functionalization in this work), but also provides a novel and efficient theranostic nanoplatform for efficient breast-cancer theranostics.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1648-1664 |
| Number of pages | 17 |
| Journal | Theranostics |
| Volume | 8 |
| Issue number | 6 |
| DOIs | |
| State | Published - Jan 1 2018 |
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Keywords
- Fe O
- MXene
- Multimodal imaging
- Nanomedicine
- Photothermal therapy
- Tantalum carbide
ASJC Scopus subject areas
- Medicine (miscellaneous)
- Pharmacology, Toxicology and Pharmaceutics (miscellaneous)
Cite this
2D superparamagnetic tantalum carbide composite MXenes for efficient breast-cancer theranostics. / Liu, Zhuang; Lin, Han; Zhao, Menglong; Dai, Chen; Zhang, Shengjian; Peng, Weijun; Chen, Yu.
In: Theranostics, Vol. 8, No. 6, 01.01.2018, p. 1648-1664.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - 2D superparamagnetic tantalum carbide composite MXenes for efficient breast-cancer theranostics
AU - Liu, Zhuang
AU - Lin, Han
AU - Zhao, Menglong
AU - Dai, Chen
AU - Zhang, Shengjian
AU - Peng, Weijun
AU - Chen, Yu
PY - 2018/1/1
Y1 - 2018/1/1
N2 - Background: The emergence of two-dimensional MXenes has spurred their versatile applications in broad fields, but the exploring of novel MXene-based family members and their potential applications in theranostic nanomedicine (concurrent diagnostic imaging and therapy) have been rarely explored. In this work, we report the construction of a novel superparamagnetic MXene-based theranostic nanoplatform for efficient breast-cancer theranostics, which was based on intriguing tantalum carbide (Ta 4 C 3 ) MXene and its further rational surface-superparamagnetic iron-oxide functionalization (Ta 4 C 3 -IONP-SPs composite MXenes) for efficient breast-cancer theranostic. Methods: The fabrication of ultrathin Ta 4 C 3 nanosheets was based on an exfoliation strategy and superparamagnetic iron oxide nanoparticles were in-situ grown onto the surface of Ta 4 C 3 MXene according to the redox reaction of MXene. Ta 4 C 3 -IONP MXenes were modified with soybean phospholipid (SP) to guarantee high stability in physiological conditions. The photothermal therapy, contrast-enhanced CT, T 2 -weighted magnetic resonance imaging and the high biocompatibility of these composite nanosheets have also been evaluated in vitro at cellular level and in vivo on mice breast tumor allograft tumor model. Results: The Ta component of Ta 4 C 3 -IONP-SPs exhibits high performance for contrast-enhanced CT imaging because of its high atomic number and high X-ray attenuation coefficient, and the integrated superparamagnetic IONPs act as excellent contrast agents for T 2 -weighted magnetic resonance imaging. Especially, these Ta 4 C 3 -IONP-SPs composite nanosheets with high photothermal-conversion efficiency (n: 32.5%) has achieved complete tumor eradication without reoccurrence, verifying their highly efficient breast-tumor photo-ablation performance. Conclusion: This work not only significantly broadens the biomedical applications of MXene-based nanoplatforms (Ta 4 C 3 MXene) by exploring their novel family members and further functionalization strategies (magnetic functionalization in this work), but also provides a novel and efficient theranostic nanoplatform for efficient breast-cancer theranostics.
AB - Background: The emergence of two-dimensional MXenes has spurred their versatile applications in broad fields, but the exploring of novel MXene-based family members and their potential applications in theranostic nanomedicine (concurrent diagnostic imaging and therapy) have been rarely explored. In this work, we report the construction of a novel superparamagnetic MXene-based theranostic nanoplatform for efficient breast-cancer theranostics, which was based on intriguing tantalum carbide (Ta 4 C 3 ) MXene and its further rational surface-superparamagnetic iron-oxide functionalization (Ta 4 C 3 -IONP-SPs composite MXenes) for efficient breast-cancer theranostic. Methods: The fabrication of ultrathin Ta 4 C 3 nanosheets was based on an exfoliation strategy and superparamagnetic iron oxide nanoparticles were in-situ grown onto the surface of Ta 4 C 3 MXene according to the redox reaction of MXene. Ta 4 C 3 -IONP MXenes were modified with soybean phospholipid (SP) to guarantee high stability in physiological conditions. The photothermal therapy, contrast-enhanced CT, T 2 -weighted magnetic resonance imaging and the high biocompatibility of these composite nanosheets have also been evaluated in vitro at cellular level and in vivo on mice breast tumor allograft tumor model. Results: The Ta component of Ta 4 C 3 -IONP-SPs exhibits high performance for contrast-enhanced CT imaging because of its high atomic number and high X-ray attenuation coefficient, and the integrated superparamagnetic IONPs act as excellent contrast agents for T 2 -weighted magnetic resonance imaging. Especially, these Ta 4 C 3 -IONP-SPs composite nanosheets with high photothermal-conversion efficiency (n: 32.5%) has achieved complete tumor eradication without reoccurrence, verifying their highly efficient breast-tumor photo-ablation performance. Conclusion: This work not only significantly broadens the biomedical applications of MXene-based nanoplatforms (Ta 4 C 3 MXene) by exploring their novel family members and further functionalization strategies (magnetic functionalization in this work), but also provides a novel and efficient theranostic nanoplatform for efficient breast-cancer theranostics.
KW - Fe O
KW - MXene
KW - Multimodal imaging
KW - Nanomedicine
KW - Photothermal therapy
KW - Tantalum carbide
UR - http://www.scopus.com/inward/record.url?scp=85042191882&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85042191882&partnerID=8YFLogxK
U2 - 10.7150/thno.23369
DO - 10.7150/thno.23369
M3 - Article
VL - 8
SP - 1648
EP - 1664
JO - Theranostics
JF - Theranostics
SN - 1838-7640
IS - 6
ER -