Find Research Outputs

2018
1 Citations

24-Month Overall Survival from KEYNOTE-021 Cohort G: Pemetrexed and Carboplatin with or without Pembrolizumab as First-Line Therapy for Advanced Nonsquamous Non–Small Cell Lung Cancer

Borghaei, H., Langer, C. J., Gadgeel, S., Papadimitrakopoulou, V. A., Patnaik, A., Powell, S. F., Gentzler, R. D., Martins, R. G., Stevenson, J. P., Jalal, S. I., Panwalkar, A., Chih-Hsin Yang, J., Gubens, M., Sequist, L. V., Awad, M. M., Fiore, J., Saraf, S., Keller, S. M. & Gandhi, L., Jan 1 2018, (Accepted/In press) In : Journal of Thoracic Oncology.

Research output: Contribution to journalArticle

Pemetrexed
Carboplatin
Non-Small Cell Lung Carcinoma
Survival
Therapeutics
hyperglycemia
obesity
adenosine monophosphate
Obese Mice
diets
1 Citations

2D magnetic titanium carbide MXene for cancer theranostics

Liu, Z., Zhao, M., Lin, H., Dai, C., Ren, C., Zhang, S., Peng, W. & Chen, Y., Jan 1 2018, In : Journal of Materials Chemistry B. 6, 21, p. 3541-3548 8 p.

Research output: Contribution to journalArticle

Titanium carbide
Medical nanotechnology
Surface chemistry
Tumors
Nanosystems
5 Citations

2D superparamagnetic tantalum carbide composite MXenes for efficient breast-cancer theranostics

Liu, Z., Lin, H., Zhao, M., Dai, C., Zhang, S., Peng, W. & Chen, Y., Jan 1 2018, In : Theranostics. 8, 6, p. 1648-1664 17 p.

Research output: Contribution to journalArticle

Tantalum
Breast Neoplasms
Magnetic Resonance Imaging
Diagnostic Imaging
Soybeans

2-Phenyl-4-quinolone (YT-1) induces G2/M phase arrest and an intrinsic apoptotic mechanism in human leukemia cells

Lin, M. W., Yang, J. S., Lu, C. C., Lin, C., Kuo, S. C., Tsai, F. J. & Lee, M. R., Mar 1 2018, In : Oncology reports. 39, 3, p. 1331-1337 7 p.

Research output: Contribution to journalArticle

U937 Cells
G2 Phase
Cell Division
Leukemia
Propidium

2-Phenylnaphthyridin-4-one derivative LYF-11 inhibits interleukin-6-mediated epithelial–to–Mesenchymal transition via the inhibition of JAK2/STAT3 signaling pathway in MCF-7 cells

Liu, L. C., Wu, Y. C., Kuo, S. C., Ho, C. T., Way, T. D. & Chen, S. T., May 1 2018, In : Anticancer Research. 38, 5, p. 2849-2859 11 p.

Research output: Contribution to journalArticle

Janus Kinase 2
STAT3 Transcription Factor
Epithelial-Mesenchymal Transition
MCF-7 Cells
Interleukin-6
4 Citations

2′-O-methylation in mRNA disrupts tRNA decoding during translation elongation

Choi, J., Indrisiunaite, G., Demirci, H., Ieong, K. W., Wang, J., Petrov, A., Prabhakar, A., Rechavi, G., Dominissini, D., He, C., Ehrenberg, M. & Puglisi, J. D., Mar 1 2018, In : Nature Structural and Molecular Biology. 25, 3, p. 208-216 9 p.

Research output: Contribution to journalArticle

Transfer RNA
Methylation
Messenger RNA
Codon
Peptide Elongation Factor Tu

3D convolutional neural network for differentiating pre-invasive lesions from invasive adenocarcinomas appearing as ground-glass nodules with diameters ≤3 cm using HRCT

Wang, S., Wang, R., Zhang, S., Li, R., Fu, Y., Sun, X., Li, Y., Sun, X., Jiang, X., Guo, X., Zhou, X., Chang, J. & Peng, W., Jun 1 2018, In : Quantitative Imaging in Medicine and Surgery. 8, 5, p. 491-499 9 p.

Research output: Contribution to journalArticle

Glass
Adenocarcinoma
ROC Curve
Lung Neoplasms
Area Under Curve
2 Citations

3D prompt gamma imaging for proton beam range verification

Draeger, E., Mackin, D., Peterson, S., Chen, H., Avery, S., Beddar, S. & Polf, J. C., Feb 1 2018, In : Physics in medicine and biology. 63, 3, 035019.

Research output: Contribution to journalArticle

Protons
Plastics

3D treatment planning system—Varian Eclipse for proton therapy planning

Sahoo, N., Poenisch, F., Zhang, X., Li, Y., Lii, M. F., Li, H., Gautam, A. S., Wu, R., Gillin, M. & Zhu, X. R., Jun 1 2018, In : Medical Dosimetry. 43, 2, p. 184-194 11 p.

Research output: Contribution to journalReview article

Proton Therapy
Therapeutics
Uncertainty
Leukemia, Myelomonocytic, Chronic
Neoplasms
Chromosome Aberrations
Mutation
Disease Progression

42,573 cases of hepatectomy in China: a multicenter retrospective investigation

Zhang, B., Zhang, B., Zhang, Z., Huang, Z., Chen, Y., Chen, M., Bie, P., Peng, B., Wu, L., Wang, Z., Li, B., Fan, J., Qin, L., Chen, P., Liu, J., Tang, Z., Niu, J., Yin, X., Li, D., He, S. & 4 othersJiang, B., Mao, Y., Zhou, W. & Chen, X., Jun 1 2018, In : Science China Life Sciences. 61, 6, p. 660-670 11 p.

Research output: Contribution to journalArticle

Hepatectomy
hepatoma
Liver
Hepatocellular Carcinoma
China
3 Citations

4β-Hydroxywithanolide E selectively induces oxidative DNA damage for selective killing of oral cancer cells

Tang, J. Y., Huang, H. W., Wang, H. R., Chan, Y. C., Haung, J. W., Shu, C. W., Wu, Y-C. & Chang, H. W., Mar 1 2018, In : Environmental Toxicology. 33, 3, p. 295-304 10 p.

Research output: Contribution to journalArticle

Mouth Neoplasms
DNA Damage
cancer
Cells
DNA
1 Citations

5-Aminolevulinic acid fluorescence guided resection of malignant glioma: Hong Kong experience

Chan, D. T. M., Yi-Pin Sonia, H. & Poon, W. S., Sep 1 2018, In : Asian Journal of Surgery. 41, 5, p. 467-472 6 p.

Research output: Contribution to journalArticle

Aminolevulinic Acid
Hong Kong
Glioma
Fluorescence
Gadolinium

5-Chloro-2,4-dihydroxypyridine, CDHP, prevents lung metastasis of basal-like breast cancer cells by reducing nascent adhesion formation

Itou, J., Tsukihara, H., Nukatsuka, M., Toi, M. & Takechi, T., Feb 1 2018, In : Cancer medicine. 7, 2, p. 463-470 8 p.

Research output: Contribution to journalArticle

Breast Neoplasms
Neoplasm Metastasis
Lung
Focal Adhesions
Weights and Measures
5 Citations

68Ga-PSMA PET/CT for the detection of bone metastases in prostate cancer: a systematic review of the published literature

Zacho, H. D., Nielsen, J. B., Haberkorn, U., Stenholt, L. & Petersen, L. J., Nov 1 2018, In : Clinical Physiology and Functional Imaging. 38, 6, p. 911-922 12 p.

Research output: Contribution to journalReview article

Prostatic Neoplasms
Neoplasm Metastasis
Bone and Bones
Castration
human glutamate carboxypeptidase II
1 Citations

68Ga-PSMA PET/CT in Patients with Biochemical Recurrence of Prostate Cancer: A Prospective, 2-Center Study

Zacho, H. D., Nielsen, J. B., Dettmann, K., Haberkorn, U., Langkilde, N. C., Jensen, J. B. & Petersen, L. J., Aug 1 2018, In : Clinical nuclear medicine. 43, 8, p. 579-585 7 p.

Research output: Contribution to journalArticle

Prostatic Neoplasms
Recurrence
Prostate-Specific Antigen
Radiotherapy
Salvage Therapy
3 Citations

68Ga-PSMA PET/CT in the evaluation of bone metastases in prostate cancer

Sachpekidis, C., Bäumer, P., Kopka, K., Hadaschik, B. A., Hohenfellner, M., Kopp-Schneider, A., Haberkorn, U. & Dimitrakopoulou-Strauss, A., Jun 1 2018, In : European Journal of Nuclear Medicine and Molecular Imaging. 45, 6, p. 904-912 9 p.

Research output: Contribution to journalArticle

Prostatic Neoplasms
Neoplasm Metastasis
Bone and Bones
Recurrence
Bone Neoplasms
1 Citations
Chromosome Aberrations
Dendritic Cells
Neoplasms
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Drug Therapy
9 Citations

8th Edition of the AJCC Cancer Staging Manual: Pancreas and Hepatobiliary Cancers

Chun, Y. S., Pawlik, T. M. & Vauthey, J. N., Apr 1 2018, In : Annals of surgical oncology. 25, 4, p. 845-847 3 p.

Research output: Contribution to journalEditorial

7 Citations

A 12-Year Follow-up on the Long-Term Effectiveness of the Quadrivalent Human Papillomavirus Vaccine in 4 Nordic Countries

Kjaer, S. K., Nygård, M., Dillner, J., Marshall, J. B., Radley, D., Li, M., Munk, C., Hansen, B. T., Sigurdardottir, L. G., Hortlund, M., Tryggvadottir, L., Joshi, A., Das, R. & Saah, A. J., Jan 18 2018, In : Clinical Infectious Diseases. 66, 3, p. 339-345 7 p.

Research output: Contribution to journalArticle

Scandinavian and Nordic Countries
Papillomavirus Vaccines
Registries
Incidence
Vaccines

A 27-Year-Old Female with Multiple Intracranial Lesions

Al-Hussaini, M., Al-Shbool, G. & Samaha, M., Mar 1 2018, In : Brain Pathology. 28, 2, p. 303-305 3 p.

Research output: Contribution to journalComment/debate

A 4D global respiratory motion model of the thorax based on CT images: A proof of concept

Fayad, H., Gilles, M., Pan, T. & Visvikis, D., Jul 1 2018, In : Medical Physics. 45, 7, p. 3043-3051 9 p.

Research output: Contribution to journalArticle

Thorax
Four-Dimensional Computed Tomography
Radiotherapy
Optical Devices
Skin
1 Citations

A 5′ AMP-Activated Protein Kinase Enzyme Activator, Compound 59, Induces Autophagy and Apoptosis in Human Oral Squamous Cell Carcinoma

Weng, J. R., Dokla, E. M. E., Bai, L-Y., Chen, C. S., Chiu, S. J. & Shieh, T. M., Jul 1 2018, In : Basic and Clinical Pharmacology and Toxicology. 123, 1, p. 21-29 9 p.

Research output: Contribution to journalArticle

Enzyme Activators
AMP-Activated Protein Kinases
Autophagy
Squamous Cell Carcinoma
Protein Tyrosine Phosphatases

A B7-CD28 family based signature demonstrates significantly different prognoses and tumor immune landscapes in lung adenocarcinoma

Zheng, S., Luo, X., Dong, C., Zheng, D., Xie, J., Zhuge, L., Sun, Y. & Chen, H., Nov 15 2018, In : International Journal of Cancer. 143, 10, p. 2592-2601 10 p.

Research output: Contribution to journalArticle

Immunotherapy
Atlases
Neoplasms
Transcriptome
Disease-Free Survival

A balancing act: dual immune-checkpoint inhibition for oesophagogastric cancer

Harada, K., Abdelhakeem, A. A. F. & Ajani, J. A., Jan 1 2018, (Accepted/In press) In : Nature Reviews Clinical Oncology.

Research output: Contribution to journalArticle

CD274 Antigen
Adenocarcinoma
Biomarkers
Morbidity
Mortality

A Bayesian Approach for Learning Gene Networks Underlying Disease Severity in COPD

Shaddox, E., Stingo, F. C., Peterson, C. B., Jacobson, S., Cruickshank-Quinn, C., Kechris, K., Bowler, R. & Vannucci, M., Apr 1 2018, In : Statistics in Biosciences. 10, 1, p. 59-85 27 p.

Research output: Contribution to journalArticle

Gene Networks
Bayes Theorem
Gene Regulatory Networks
Bayesian Approach
Chronic Obstructive Pulmonary Disease
2 Citations

A Bayesian basket trial design using a calibrated Bayesian hierarchical model

Chu, Y. & Yuan, Y., Apr 1 2018, In : Clinical Trials. 15, 2, p. 149-158 10 p.

Research output: Contribution to journalArticle

Therapeutics
Neoplasms
Molecular Biology
Software
Research
Bayesian Learning
Machine Learning
Decision Rules
Q-learning
Regression Model
1 Citations

A Bayesian multi-stage cost-effectiveness design for animal studies in stroke research

Cai, C., Ning, J. & Huang, X., Apr 1 2018, In : Statistical Methods in Medical Research. 27, 4, p. 1219-1229 11 p.

Research output: Contribution to journalArticle

Cost-effectiveness
Stroke
Cost-Benefit Analysis
Animals
Adaptive Design
1 Citations

A Bayesian Phase I/II Trial Design for Immunotherapy

Liu, S., Guo, B. & Yuan, Y., Jul 3 2018, In : Journal of the American Statistical Association. 113, 523, p. 1016-1027 12 p.

Research output: Contribution to journalArticle

Immunotherapy
Dose
Immune Response
Toxicity
Efficacy

A Bayesian screening approach for hepatocellular carcinoma using multiple longitudinal biomarkers

Tayob, N., Stingo, F., Do, K. A., Lok, A. S. F. & Feng, Z., Mar 1 2018, In : Biometrics. 74, 1, p. 249-259 11 p.

Research output: Contribution to journalArticle

Bayes Theorem
Change Point
Biomarkers
hepatoma
Screening

A Bayesian semiparametric latent variable approach to causal mediation

Kim, C., Daniels, M., Li, Y., Milbury, K. & Cohen, L., Mar 30 2018, In : Statistics in Medicine. 37, 7, p. 1149-1161 13 p.

Research output: Contribution to journalArticle

Mediation
Latent Variables
Bayes Theorem
Renal Cell Carcinoma
Cluster Analysis
6 Citations

A Bayesian Simulation Model for Breast Cancer Screening, Incidence, Treatment, and Mortality

Huang, X., Li, Y., Song, J. & Berry, D. A., Apr 1 2018, In : Medical Decision Making. 38, 1_suppl, p. 78S-88S

Research output: Contribution to journalArticle

Early Detection of Cancer
Breast Neoplasms
Mortality
Incidence
Mammography

Abbreviated MRI Protocols in Breast Cancer Diagnostics

Deike-Hofmann, K., Koenig, F., Paech, D., Dreher, C., Delorme, S., Schlemmer, H-P. & Bickelhaupt, S., Jan 1 2018, (Accepted/In press) In : Journal of Magnetic Resonance Imaging.

Research output: Contribution to journalArticle

Breast
Breast Neoplasms
Magnets
Early Detection of Cancer
Costs and Cost Analysis

Abdominal Wall Reconstruction

Selber, J. C., Aug 1 2018, In : Seminars in Plastic Surgery. 32, 3, 1 p.

Research output: Contribution to journalEditorial

Abdominal Wall

Abdominal Wall Reconstruction: An Integrated Approach

Boukovalas, S., Sisk, G. & Selber, J. C., Aug 1 2018, In : Seminars in Plastic Surgery. 32, 3, p. 107-119 13 p.

Research output: Contribution to journalArticle

Abdominal Wall
Surgeons

Abemaciclib for the treatment of breast cancer

Kotake, T. & Toi, M., Mar 24 2018, In : Expert Opinion on Pharmacotherapy. 19, 5, p. 517-524 8 p.

Research output: Contribution to journalArticle

Breast Neoplasms
Clinical Trials
Therapeutics
Neoplasm Metastasis
Survival
1 Citations

A benchmark for comparing precision medicine methods in thyroid cancer diagnosis using tissue microarrays

Wang, C. W., Lee, Y. C., Calista, E., Zhou, F., Zhu, H., Suzuki, R., Komura, D., Ishikawa, S. & Cheng, S. P., May 15 2018, In : Bioinformatics. 34, 10, p. 1767-1773 7 p.

Research output: Contribution to journalArticle

Benchmarking
Precision Medicine
Microarrays
Thyroid Neoplasms
Microarray
1 Citations

Aberrant FGFR tyrosine kinase signaling enhances the warburg effect by reprogramming LDH Isoform expression and activity in prostate cancer

Liu, J., Chen, G., Liu, Z., Liu, S., Cai, Z., You, P., Ke, Y., Lai, L., Huang, Y., Gao, H., Zhao, L., Pelicano, H., Huang, P., McKeehan, W. L., Wu, C. L., Wang, C., Zhong, W. & Wang, F., Aug 15 2018, In : Cancer Research. 78, 16, p. 4459-4470 12 p.

Research output: Contribution to journalArticle

L-Lactate Dehydrogenase
Protein-Tyrosine Kinases
Receptor, Fibroblast Growth Factor, Type 1
Prostatic Neoplasms
Protein Isoforms
2 Citations

Aberrant hypermethylation of the HOXD10 gene in papillary thyroid cancer with BRAFV600E mutation

Cao, Y. M., Gu, J., Zhang, Y. S., Wei, W. J., Qu, N., Wen, D., Liao, T., Shi, R. L., Zhang, L., Ji, Q. H., Wang, Y., Sun, G. H., Zhao, Y. X., Wang, Y. J., Yu, J. & Zhu, Y. X., Jan 1 2018, In : Oncology reports. 39, 1, p. 338-348 11 p.

Research output: Contribution to journalArticle

Mutation
Genes
Methylation
Papillary Thyroid cancer
Cell Line

Aberrant methylation of EYA4 promotes epithelial-mesenchymal transition in esophageal squamous cell carcinoma

Luo, M., Li, Y., Shi, X., Yang, W., Zhou, F., Sun, N. & He, J., Jun 1 2018, In : Cancer Science. 109, 6, p. 1811-1824 14 p.

Research output: Contribution to journalArticle

Epithelial-Mesenchymal Transition
Methylation
trichostatin A
Glycogen Synthase Kinases
Cell Line
2 Citations

Ablation of colorectal liver metastasis: Interaction of ablation margins and RAS mutation profiling on local tumour progression-free survival

Calandri, M., Yamashita, S., Gazzera, C., Fonio, P., Veltri, A., Bustreo, S., Sheth, R. A., Yevich, S. M., Vauthey, J. N. & Odisio, B. C., Jul 1 2018, In : European Radiology. 28, 7, p. 2727-2734 8 p.

Research output: Contribution to journalArticle

Disease-Free Survival
Neoplasm Metastasis
Mutation
Liver
Neoplasms

Ablative Hypofractionated Radiation Therapy Enhances Non-Small Cell Lung Cancer Cell Killing via Preferential Stimulation of Necroptosis In Vitro and In Vivo

Wang, H. H., Wu, Z. Q., Qian, D., Zaorsky, N. G., Qiu, M. H., Cheng, J. J., Jiang, C., Wang, J., Zeng, X. L., Liu, C. L., Tian, L. J., Ying, G. G., Meng, M. B., Hao, X. S. & Yuan, Z. Y., May 1 2018, In : International Journal of Radiation Oncology Biology Physics. 101, 1, p. 49-62 14 p.

Research output: Contribution to journalArticle

stimulation
Non-Small Cell Lung Carcinoma
lungs
radiation therapy
Radiotherapy
1 Citations

Abrogation of glutathione peroxidase-1 drives EMT and chemoresistance in pancreatic cancer by activating ROS-mediated Akt/GSK3β/Snail signaling

Meng, Q., Shi, S., Liang, C., Liang, D., Hua, J., Zhang, B., Xu, J. & Yu, X., Jul 6 2018, (Accepted/In press) In : Oncogene. p. 1-15 15 p.

Research output: Contribution to journalArticle

Glycogen Synthase Kinases
Epithelial-Mesenchymal Transition
gemcitabine
Snails
Pancreatic Neoplasms

Absence of TERT promoter mutations in colorectal precursor lesions and cancer

Cruvinel-Carloni, A., Yamane, L., Scapulatempo-Neto, C., Guimarães, D. & Reis, R. M., Jan 1 2018, In : Genetics and Molecular Biology. 41, 1, p. 82-84 3 p.

Research output: Contribution to journalArticle

Mutation
Neoplasms
Colorectal Neoplasms
Skin Neoplasms
Liver Neoplasms
7 Citations

Absolute number of new lesions on 18F-FDG PET/CT is more predictive of clinical response than SUV changes in metastatic melanoma patients receiving ipilimumab

Anwar, H., Sachpekidis, C., Winkler, J., Kopp-Schneider, A., Haberkorn, U., Hassel, J. C. & Dimitrakopoulou-Strauss, A., Mar 1 2018, In : European Journal of Nuclear Medicine and Molecular Imaging. 45, 3, p. 376-383 8 p.

Research output: Contribution to journalArticle

Fluorodeoxyglucose F18
Melanoma
Immunotherapy
Therapeutics
ipilimumab
Isogeneic Transplantation
Autologous Transplantation
Multiple Myeloma
Case-Control Studies

A Case of Primary Pulmonary Combined Small Cell Carcinoma With Adenocarcinoma Harboring the Same KLC1-ALK Fusion in Both Histologic Components

Bai, Q., Li, Y., Zhang, X., Zhu, X. & Zhou, X., Oct 1 2018, In : Journal of Thoracic Oncology. 13, 10, p. e197-e199

Research output: Contribution to journalLetter

Small Cell Carcinoma
Adenocarcinoma
Lung
1 Citations

A case of radiation-induced bullous morphea/lichen sclerosus overlap in a breast cancer patient

Petersen, E., Yazdani, L. & Hymes, S. R., Jan 1 2018, In : Reports of Practical Oncology and Radiotherapy. 23, 1, p. 47-49 3 p.

Research output: Contribution to journalArticle

Lichen Sclerosus et Atrophicus
Localized Scleroderma
Radiation
Breast Neoplasms
Radiodermatitis