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2020

Therapeutic targeting of the PI4K2A/PKR lysosome network is critical for misfolded protein clearance and survival in cancer cells

Pataer, A., Ozpolat, B., Shao, R. P., Cashman, N. R., Plotkin, S. S., Samuel, C. E., Lin, S. H., Kabil, N. N., Wang, J., Majidi, M., Fang, B., Roth, J. A., Vaporciyan, A. A., Wistuba, I. I., Hung, M. C. & Swisher, S. G., Jan 23 2020, In : Oncogene. 39, 4, p. 801-813 13 p.

Research output: Contribution to journalArticle

Lysosomes
Protein Kinases
Survival
Neoplasms
Proteins
1 Citation (Scopus)

Time Trends of Perioperative Outcomes in Early Stage Non-Small Cell Lung Cancer Resection Patients

Shewale, J. B., Correa, A. M., Brown, E. L., Leon-Novelo, L. G., Nyitray, A. G., Antonoff, M. B., Hofstetter, W. L., Mehran, R. J., Rice, D. C., Walsh, G. L., Roth, J., Vaporciyan, A. A., Swisher, S. G. & Sepesi, B., Feb 2020, In : Annals of Thoracic Surgery. 109, 2, p. 404-411 8 p.

Research output: Contribution to journalArticle

Non-Small Cell Lung Carcinoma
Lung
Patient Selection
Mortality
Pneumonia
2019
6 Citations (Scopus)

A 5-microRNA signature identified from serum microRNA profiling predicts survival in patients with advanced stage non-small cell lung cancer

Zhang, Y., Roth, J. A., Yu, H., Ye, Y., Xie, K., Zhao, H., Chang, D. W., Huang, M., Li, H., Qu, J. & Wu, X., Jul 4 2019, In : Carcinogenesis. 40, 5, p. 643-650 8 p.

Research output: Contribution to journalArticle

Open Access
MicroRNAs
Non-Small Cell Lung Carcinoma
Survival
Serum
Atlases
1 Citation (Scopus)

An improved patient-derived xenograft humanized mouse model for evaluation of lung cancer immune responses

Meraz, I. M., Majidi, M., Meng, F., Shao, R. P., Ha, M. J., Neri, S., Fang, B., Lin, S. H., Tinkey, P. T., Shpall, E. J., Morris, J. & Roth, J. A., Jan 1 2019, In : Cancer Immunology Research. 7, 8, p. 1267-1279 13 p.

Research output: Contribution to journalArticle

Heterografts
Lung Neoplasms
Neoplasms
Tissue Donors
T-Lymphocytes
Metastasectomy
Colorectal Neoplasms
Recurrence
Lung
Mutation
1 Citation (Scopus)
Adjuvant Radiotherapy
Databases
Radiation
Survival
Neoplasms
1 Citation (Scopus)
Natural Language Processing
Glass
Thorax
Incidence
Neoplasms
8 Citations (Scopus)

Inhibition of thioredoxin/thioredoxin reductase induces synthetic lethality in lung cancers with compromised glutathione homeostasis

Yan, X., Zhang, X., Wang, L., Zhang, R., Pu, X., Wu, S., Li, L., Tong, P., Wang, J., Meng, Q. H., Jensen, V. B., Girard, L., Minna, J. D., Roth, J. A., Swisher, S. G., Heymach, J. V. & Fang, B., Jan 1 2019, In : Cancer research. 79, 1, p. 125-132 8 p.

Research output: Contribution to journalArticle

Thioredoxin-Disulfide Reductase
Thioredoxins
Glutathione
Lung Neoplasms
Oxidoreductases
2 Citations (Scopus)

Local Consolidation Therapy (LCT) After First Line Tyrosine Kinase Inhibitor (TKI) for Patients With EGFR Mutant Metastatic Non–small-cell Lung Cancer (NSCLC)

Elamin, Y. Y., Gomez, D., Antonoff, M. B., Robichaux, J. P., Tran, H. T., Shorter, M. K., Bohac, J. M., Negrao, M. V., Le, X., Rinsurogkawong, W., Lewis, J., Lacerda, L., Roarty, E. B., Swisher, S. G., Roth, J. A., Zhang, J., Papadimitrakopoulou, V. A. & Heymach, J. V., Jan 1 2019, In : Clinical Lung Cancer. 20, 1, p. 43-47 5 p.

Research output: Contribution to journalArticle

Epidermal Growth Factor Receptor
Non-Small Cell Lung Carcinoma
Protein-Tyrosine Kinases
Therapeutics
Disease-Free Survival
2 Citations (Scopus)
Adenocarcinoma
Esophagogastric Junction
Neoplasm Metastasis
Odds Ratio
Thoracic Diseases

Multidisciplinary treatment of thymic neuroendocrine tumors: Surgery remains a key component

Corsini, E. M., Mitchell, K. G., Sceusi, E. L., Mehran, R. J., Rice, D. C., Sepesi, B., Walsh, G. L., Swisher, S. G., Roth, J. A., Vaporciyan, A. A., Hofstetter, W. L. & Antonoff, M. B., Jan 1 2019, In : Journal of Thoracic Disease. 11, 8, p. 3391-3398 8 p.

Research output: Contribution to journalArticle

Thymus Neoplasms
Neuroendocrine Tumors
Survival
Recurrence
Neoplasms
3 Citations (Scopus)
Neoplasm Genes
HLA Antigens
Tumor Burden
Non-Small Cell Lung Carcinoma
Genotype
3 Citations (Scopus)

Robotic-Assisted Lobectomy for Non-Small Cell Lung Cancer: A Comprehensive Institutional Experience

Nelson, D. B., Mehran, R. J., Mitchell, K. G., Rajaram, R., Correa, A. M., Bassett, R. L., Antonoff, M. B., Hofstetter, W. L., Roth, J. A., Sepesi, B., Swisher, S. G., Walsh, G. L., Vaporciyan, A. A. & Rice, D. C., Aug 2019, In : Annals of Thoracic Surgery. 108, 2, p. 370-376 7 p.

Research output: Contribution to journalArticle

Robotics
Non-Small Cell Lung Carcinoma
Costs and Cost Analysis
Length of Stay
Morbidity
3 Citations (Scopus)
Neoplasm Metastasis
Recurrence
Lung
Neoplasms
Confidence Intervals
3 Citations (Scopus)

Targeted Tissue and Cell-Free Tumor DNA Sequencing of Advanced Lung Squamous-Cell Carcinoma Reveals Clinically Significant Prevalence of Actionable Alterations

Lam, V. K., Tran, H. T., Banks, K. C., Lanman, R. B., Rinsurongkawong, W., Peled, N., Lewis, J., Lee, J. J., Roth, J., Roarty, E. B., Swisher, S., Talasaz, A. A., Futreal, P. A., Papadimitrakopoulou, V., Heymach, J. V. & Zhang, J., Jan 2019, In : Clinical Lung Cancer. 20, 1, p. 30-36.e3

Research output: Contribution to journalArticle

DNA Sequence Analysis
Squamous Cell Carcinoma
Lung
Neoplasms
Histology
9 Citations (Scopus)

The Accuracy of Clinical Staging of Stage I-IIIa Non-Small Cell Lung Cancer: An Analysis Based on Individual Participant Data

NSCLC Meta-analysis Collaborative Group, Mar 2019, In : Chest. 155, 3, p. 502-509 8 p.

Research output: Contribution to journalArticle

Open Access
Non-Small Cell Lung Carcinoma
Radiotherapy
Random Allocation
Survival
Meta-Analysis
2 Citations (Scopus)

Tumor cellular proliferation is associated with enhanced immune checkpoint expression in stage I non–small cell lung cancer

MD Anderson Lung Cancer Immune Microenvironment Working Group, Sep 2019, In : Journal of Thoracic and Cardiovascular Surgery. 158, 3, p. 911-919.e6

Research output: Contribution to journalArticle

Non-Small Cell Lung Carcinoma
Cell Proliferation
Inducible T-Cell Co-Stimulator Protein
Indoleamine-Pyrrole 2,3,-Dioxygenase
Neoplasms
1 Citation (Scopus)
Heterografts
Non-Small Cell Lung Carcinoma
Neoplasms
Residual Neoplasm
Adenocarcinoma

Validation of the 12-gene predictive signature for adjuvant chemotherapy response in lung cancer

Xie, Y., Lu, W., Wang, S., Tang, X., Tang, H., Zhou, Y., Moran, C., Behrens, C., Roth, J. A., Zhou, Q., Johnson, D. H., Swisher, S. G., Heymach, J. V., Papadimitrakopoulou, V. A., Xiao, G., Minna, J. D. & Wistuba, I. I., Jan 1 2019, In : Clinical Cancer Research. 25, 1, p. 150-157 8 p.

Research output: Contribution to journalArticle

Adjuvant Chemotherapy
Lung Neoplasms
Genes
Non-Small Cell Lung Carcinoma
Paraffin
2018
4 Citations (Scopus)
Glass
Lung Neoplasms
Neoplasms
Coronary Artery Disease
Neoplasm Metastasis
Video-Assisted Thoracic Surgery
Thoracotomy
Lung Neoplasms
Muscles
Epidural Analgesia
Thorax
Catheters
Catheterization
Length of Stay
2 Citations (Scopus)

Early Metabolic Change after Induction Chemotherapy Predicts Histologic Response and Prognosis in Patients with Esophageal Cancer: Secondary Analysis of a Randomized Trial

Harada, K., Wang, X., Shimodaira, Y., Sagebiel, T., Bhutani, M., Lee, J. H., Weston, B., Elimova, E., Lin, Q., Amlashi, F. G., Mizrak Kaya, D., Lopez, A., Blum Murphy, M., Roth, J. A., Swisher, S. G., Skinner, H., Hofstetter, W. L., Rogers, J. E., Thomas, I., Maru, D. M. & 3 others, Komaki, R., Walsh, G. L. & Ajani, J. A., Feb 1 2018, In : Targeted oncology. 13, 1, p. 99-106 8 p.

Research output: Contribution to journalArticle

Induction Chemotherapy
Esophageal Neoplasms
Positron-Emission Tomography
Survival
31 Citations (Scopus)
Thoracotomy
Lung Neoplasms
Lung
Patient Readmission
Length of Stay
2 Citations (Scopus)
Critical Pathways
Lung Neoplasms
Cytokines
Single Nucleotide Polymorphism
Survival
1 Citation (Scopus)

Influence of induction chemotherapy in trimodality therapy-eligible oesophageal cancer patients: Secondary analysis of a randomised trial

Shimodaira, Y., Slack, R. S., Harada, K., Chen, H. C., Sagebiel, T., Bhutani, M., Lee, J. H., Weston, B., Elimova, E., Lin, Q., Amlashi, F. G., Mizrak Kaya, D., Blum Murphy, M., Roth, J. A., Swisher, S. G., Skinner, H., Hofstetter, W. L., Rogers, J. E., Mares, J., Thomas, I. & 4 others, Maru, D. M., Komaki, R., Walsh, G. L. & Ajani, J. A., Feb 6 2018, In : British journal of cancer. 118, 3, p. 331-337 7 p.

Research output: Contribution to journalArticle

Induction Chemotherapy
Esophageal Neoplasms
Survival
Therapeutics
Survival Rate
44 Citations (Scopus)

Landscape of EGFR-dependent and -independent resistance mechanisms to osimertinib and continuation therapy beyond progression in EGFR-mutant NSCLC

Le, X., Puri, S., Negrao, M. V., Nilsson, M. B., Robichaux, J., Boyle, T., Kevin Hicks, J., Lovinger, K. L., Roarty, E., Rinsurongkawong, W., Tang, M., Sun, H., Elamin, Y., Lacerda, L. C., Lewis, J., Roth, J. A., Swisher, S. G., Jack Lee, J., William, W. N., Glisson, B. S. & 4 others, Zhang, J., Papadimitrakopoulou, V. A., Gray, J. E. & Heymach, J. V., Dec 15 2018, In : Clinical Cancer Research. 24, 24, p. 6195-6203 9 p.

Research output: Contribution to journalArticle

Non-Small Cell Lung Carcinoma
Lung Neoplasms
Therapeutics
cdc Genes
Epithelial-Mesenchymal Transition
4 Citations (Scopus)
Lung Neoplasms
Non-Small Cell Lung Carcinoma
Drug Therapy
Survival
Mutation
5 Citations (Scopus)
Natural History
Glass
Lung Neoplasms
Odds Ratio
Adenocarcinoma
3 Citations (Scopus)
Survival
Survival Rate
Pathology
1 Citation (Scopus)

Patient-derived tumor immune microenvironments in patient-derived xenografts of lung cancer

Pu, X., Zhang, R., Wang, L., Chen, Y., Xu, Y., Pataer, A., Meraz, I. M., Zhang, X., Wu, S., Wu, L., Su, D., Mao, W., Heymach, J. V., Roth, J. A., Swisher, S. G. & Fang, B., Nov 26 2018, In : Journal of translational medicine. 16, 1, 328.

Research output: Contribution to journalArticle

Tumor Microenvironment
Heterografts
Tumors
Lung Neoplasms
T-cells
2 Citations (Scopus)
Non-Small Cell Lung Carcinoma
Hospital Emergency Service
Perioperative Period
Sex Characteristics
Length of Stay
3 Citations (Scopus)
Sarcoma
Thoracic Wall
Thorax
Survival
Drug Therapy
7 Citations (Scopus)
Therapeutics
Malignant Mesothelioma
Drug Therapy
Neoplasms
Insurance
10 Citations (Scopus)

Serum MicroRNA-150 Predicts Prognosis for Early-Stage Non-Small Cell Lung Cancer and Promotes Tumor Cell Proliferation by Targeting Tumor Suppressor Gene SRCIN1

Zhang, L., Lin, J., Ye, Y., Oba, T., Gentile, E., Lian, J., Wang, J., Zhao, Y., Gu, J., Wistuba, I. I., Roth, J. A., Ji, L. & Wu, X., Jun 2018, In : Clinical pharmacology and therapeutics. 103, 6, p. 1061-1073 13 p.

Research output: Contribution to journalArticle

Tumor Suppressor Genes
MicroRNAs
Non-Small Cell Lung Carcinoma
Cell Proliferation
Serum
4 Citations (Scopus)

TUSC2 immunogene therapy synergizes with Anti-PD-1 through enhanced proliferation and infiltration of natural killer cells in syngeneic kras-mutant mouse lung cancer models

Meraz, I. M., Majidi, M., Cao, X., Lin, H., Li, L., Wang, J., Baladandayuthapani, V., Rice, D., Sepesi, B., Ji, L. & Roth, J. A., Feb 2018, In : Cancer Immunology Research. 6, 2, p. 163-177 15 p.

Research output: Contribution to journalArticle

Natural Killer Cells
Lung Neoplasms
Non-Small Cell Lung Carcinoma
Neoplasms
Interleukin-15
4 Citations (Scopus)
Gene Frequency
Mutation
DNA
Neoplasms
Heterografts
2017
52 Citations (Scopus)
Non-Small Cell Lung Carcinoma
Radiotherapy
Clinical Trials
Neoplasm Staging
Recurrence
3 Citations (Scopus)

A miR-SNP biomarker linked to an increased lung cancer survival by miRNA-mediated down-regulation of FZD4 expression and Wnt signaling

Lin, J., Zandi, R., Shao, R., Gu, J., Ye, Y., Wang, J., Zhao, Y., Pertsemlidis, A., Wistuba, I. I., Wu, X., Roth, J. A. & Ji, L., Dec 1 2017, In : Scientific reports. 7, 1, 9029.

Research output: Contribution to journalArticle

MicroRNAs
Single Nucleotide Polymorphism
Lung Neoplasms
Down-Regulation
Biomarkers
Myeloid Cells
Phosphatidylinositol 3-Kinases
Acute Myeloid Leukemia
Leukemia
Apoptosis
4 Citations (Scopus)

Cationic liquid crystalline nanoparticles for the delivery of synthetic RNAi-based therapeutics

Gentile, E., Oba, T., Lin, J., Shao, R., Meng, F., Cao, X., Lin, H. Y., Mourad, M., Pataer, A., Baladandayuthapani, V., Cai, D., Roth, J. A. & Ji, L., Jan 1 2017, In : Oncotarget. 8, 29, p. 48222-48239 18 p.

Research output: Contribution to journalArticle

RNA Interference
Nanoparticles
MicroRNAs
Small Interfering RNA
Lung Neoplasms
2 Citations (Scopus)
Non-Small Cell Lung Carcinoma
Drug Therapy
Survival
Caffeine
Metabolomics
3 Citations (Scopus)

Genetic variations in cancer-related significantly mutated genes and lung cancer susceptibility

Zhang, Y., Zhang, L., Li, R., Chang, D. W., Ye, Y., Minna, J. D., Roth, J. A., Han, B. & Wu, X., Jul 1 2017, In : Annals of oncology : official journal of the European Society for Medical Oncology. 28, 7, p. 1625-1630 6 p.

Research output: Contribution to journalArticle

Lung Neoplasms
Single Nucleotide Polymorphism
Genes
Atlases
Neoplasms
4 Citations (Scopus)

Hypoxia pathway genetic variants predict survival of non-small-cell lung cancer patients receiving platinumbased chemotherapy

Li, R., Gu, J., Heymach, J. V., Shu, X., Zhao, L., Han, B., Ye, Y., Roth, J. & Wu, X., Jan 1 2017, In : Carcinogenesis. 38, 4, p. 419-424 6 p.

Research output: Contribution to journalArticle

Non-Small Cell Lung Carcinoma
Drug Therapy
Survival
Genotype
Single Nucleotide Polymorphism
35 Citations (Scopus)
Propensity Score
Survival
Neoplasms
Drug Therapy
Radiotherapy
6 Citations (Scopus)
Dietary Iron
Regulator Genes
MicroRNAs
Iron Regulatory Protein 2
Lung Neoplasms
5 Citations (Scopus)

Overcoming resistance to anti-PD immunotherapy in a syngeneic mouse lung cancer model using locoregional virotherapy

Yan, X., Wang, L., Zhang, R., Pu, X., Wu, S., Yu, L., Meraz, I. M., Zhang, X., Wang, J. F., Gibbons, D. L., Mehran, R. J., Swisher, S. G., Roth, J. A. & Fang, B., Oct 30 2017, (Accepted/In press) In : OncoImmunology.

Research output: Contribution to journalArticle

Immunotherapy
Lung Neoplasms
Non-Small Cell Lung Carcinoma
Neoplasms
Tumor Necrosis Factor-alpha
3 Citations (Scopus)
clopidogrel
Lung
Stents
Hemorrhage
1 Citation (Scopus)
Acellular Dermis
Polytetrafluoroethylene
Skin
Empyema
Diaphragm
7 Citations (Scopus)

Serine proteases enhance immunogenic antigen presentation on lung cancer cells

Peters, H. L., Tripathi, S. C., Kerros, C., Katayama, H., Garber, H. R., John, L. S. S., Federico, L., Meraz, I. M., Roth, J. A., Sepesi, B., Majidi, M., Ruisaard, K., Clise-Dwyer, K., Roszik, J., Gibbons, D. L., Heymach, J. V., Swisher, S. G., Bernatchez, C., Alatrash, G., Hanash, S. & 1 others, Molldrem, J. J., Apr 2017, In : Cancer Immunology Research. 5, 4, p. 319-329 11 p.

Research output: Contribution to journalArticle

Antigen Presentation
Serine Proteases
Lung Neoplasms
Myeloblastin
Leukocyte Elastase