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2020

A phase II study of addition of pracinostat to a hypomethylating agent in patients with myelodysplastic syndromes who have not responded to previous hypomethylating agent therapy

Yalniz, F. F., Berdeja, J. G., Maris, M. B., Lyons, R. M., Reeves, J. A., Essell, J. H., Patel, P., Sekeres, M., Hughes, A., Mappa, S. & Garcia-Manero, G., Feb 1 2020, In : British Journal of Haematology. 188, 3, p. 404-412 9 p.

Research output: Contribution to journalArticle

Myelodysplastic Syndromes
Proxy
Therapeutics
Bone Marrow
Histone Deacetylase Inhibitors
Gene Frequency
Acute Myeloid Leukemia
Mutation
Survival
Leukocyte Count
Germ-Line Mutation
Myelodysplastic Syndromes
lenalidomide
2019
7 Citations (Scopus)

Analysis of cardiovascular and arteriothrombotic adverse events in chronic-phase CML patients after frontline TKIs

Jain, P., Kantarjian, H., Boddu, P. C., Nogueras-González, G. M., Verstovsek, S., Garcia-Manero, G., Borthakur, G., Sasaki, K., Kadia, T. M., Sam, P., Ahaneku, H., O’Brien, S., Estrov, Z., Ravandi, F., Jabbour, E. & Cortes, J. E., Mar 26 2019, In : Blood Advances. 3, 6, p. 851-861 11 p.

Research output: Contribution to journalArticle

Open Access
Leukemia, Myeloid, Chronic Phase
Protein-Tyrosine Kinases
Incidence
Confidence Intervals
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
6 Citations (Scopus)

An oral fixed-dose combination of decitabine and cedazuridine in myelodysplastic syndromes: a multicentre, open-label, dose-escalation, phase 1 study

Savona, M. R., Odenike, O., Amrein, P. C., Steensma, D. P., DeZern, A. E., Michaelis, L. C., Faderl, S., Harb, W., Kantarjian, H. M., Lowder, J., Oganesian, A., Azab, M. & Garcia-Manero, G., Apr 1 2019, In : The Lancet Haematology. 6, 4, p. e194-e203

Research output: Contribution to journalArticle

decitabine
Myelodysplastic Syndromes
Area Under Curve
Cytidine Deaminase
3 Citations (Scopus)
Myelodysplastic Syndromes
Clinical Trials
Blood Platelets
Therapeutics
Standard of Care
Leukemia, Myelomonocytic, Chronic
Myelodysplastic Syndromes
Diploidy
Cytogenetics
Survival
1 Citation (Scopus)

Clinical Benefit-Risk Profile of Lenalidomide in Patients With Lower-risk Myelodysplastic Syndromes Without del(5q): Results of a Phase III Trial

Garcia-Manero, G., Almeida, A., Fenaux, P., Gattermann, N., Giagounidis, A., Goldberg, S. L., Ozawa, K., Weaver, J. & Santini, V., Apr 2019, In : Clinical Lymphoma, Myeloma and Leukemia. 19, 4, p. 213-219.e4

Research output: Contribution to journalArticle

Myelodysplastic Syndromes
Erythrocyte Transfusion
Placebos
Therapeutics
lenalidomide
13 Citations (Scopus)

Clinical resistance to crenolanib in acute myeloid leukemia due to diverse molecular mechanisms

Zhang, H., Savage, S., Schultz, A. R., Bottomly, D., White, L., Segerdell, E., Wilmot, B., McWeeney, S. K., Eide, C. A., Nechiporuk, T., Carlos, A., Henson, R., Lin, C., Searles, R., Ho, H., Lam, Y. L., Sweat, R., Follit, C., Jain, V., Lind, E. & 10 others, Borthakur, G., Garcia-Manero, G., Ravandi, F., Kantarjian, H. M., Cortes, J., Collins, R., Buelow, D. R., Baker, S. D., Druker, B. J. & Tyner, J. W., Dec 1 2019, In : Nature communications. 10, 1, 244.

Research output: Contribution to journalArticle

Open Access
leukemias
mutations
Acute Myeloid Leukemia
Mutation
inhibitors

Clonal Dynamics and Clinical Implications of Post-Remission Clonal Hematopoiesis in Acute Myeloid Leukemia (AML)

Tanaka, T., Morita, K., Wang, F., Little, L., Gumbs, C., Matthews, J., DiNardo, C. D., Kadia, T. M., Ravandi, F., Konopleva, M. Y., Kantarjian, H. M., Champlin, R. E., Garcia-Manero, G., Futreal, P. A. & Takahashi, K., Nov 13 2019, In : Blood. 134, 1, 1 p.

Research output: Contribution to journalArticle

Hematopoiesis
Acute Myeloid Leukemia
Research
Advisory Committees
Actinium
2 Citations (Scopus)
Myelodysplastic Syndromes
Hematopoiesis
Comorbidity
Mutation
Janus Kinase 2
4 Citations (Scopus)
Mutation
Neoplasms
Germ-Line Mutation
Myelodysplastic Syndromes
Acute Myeloid Leukemia
Transplantation (surgical)
Hematopoiesis
Graft vs Host Disease
Grafts
Transplantation
33 Citations (Scopus)
Open Access
Azacitidine
Acute Myeloid Leukemia
Biomarkers
Safety
Bone Marrow
Open Access
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Safety
Imatinib Mesylate
Leukemia, Myeloid, Chronic Phase
Generic Drugs

Fatigue, symptom burden, and health-related quality of life in patients with myelodysplastic syndrome, aplastic anemia, and paroxysmal nocturnal hemoglobinuria

Escalante, C. P., Chisolm, S., Song, J., Richardson, M., Salkeld, E., Aoki, E. & Garcia-Manero, G., Feb 1 2019, In : Cancer medicine. 8, 2, p. 543-553 11 p.

Research output: Contribution to journalArticle

Open Access
Paroxysmal Hemoglobinuria
Aplastic Anemia
Myelodysplastic Syndromes
Fatigue
Quality of Life
10 Citations (Scopus)

Guadecitabine (SGI-110) in patients with intermediate or high-risk myelodysplastic syndromes: phase 2 results from a multicentre, open-label, randomised, phase 1/2 trial

Garcia-Manero, G., Roboz, G., Walsh, K., Kantarjian, H., Ritchie, E., Kropf, P., O'Connell, C., Tibes, R., Lunin, S., Rosenblat, T., Yee, K., Stock, W., Griffiths, E., Mace, J., Podoltsev, N., Berdeja, J., Jabbour, E., Issa, J. P. J., Hao, Y., Keer, H. N. & 2 others, Azab, M. & Savona, M. R., Jun 2019, In : The Lancet Haematology. 6, 6, p. e317-e327

Research output: Contribution to journalArticle

Myelodysplastic Syndromes
decitabine
Therapeutics
SGI-110
Pneumonia
1 Citation (Scopus)
Second Primary Neoplasms
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Protein-Tyrosine Kinases
Incidence
SEER Program

Investigating protein patterns in human leukemia cell line experiments: A Bayesian approach for extremely small sample sizes

Chekouo, T., Stingo, F. C., Class, C. A., Yan, Y., Bohannan, Z., Wei, Y., Garcia-Manero, G., Hanash, S. & Do, K-A., Jan 1 2019, In : Statistical Methods in Medical Research.

Research output: Contribution to journalArticle

Bayes Theorem
Leukemia
Small Sample Size
Bayesian Approach
Sample Size
1 Citation (Scopus)
Janus Kinase 2
Acute Myeloid Leukemia
Neoplasms
Primary Myelofibrosis
Mutation
5 Citations (Scopus)
Clonal Evolution
Acute Myeloid Leukemia
Leukemia
Recurrence
Therapeutics
11 Citations (Scopus)

Managing clonal hematopoiesis in patients with solid tumors

Bolton, K. L., Gillis, N. K., Coombs, C. C., Takahashi, K., Zehir, A., Bejar, R., Garcia-Manero, G., Futreal, A., Jensen, B. C., Diaz, L. A., Gupta, D., Mantha, S., Klimek, V., Papaemmanuil, E., Levine, R. & Padron, E., Jan 1 2019, In : Journal of Clinical Oncology. 37, 1, p. 7-11 5 p.

Research output: Contribution to journalComment/debate

Hematopoiesis
Neoplasms
2 Citations (Scopus)

Melatonin enhances sorafenib-induced cytotoxicity in FLT3-ITD acute myeloid leukemia cells by redox modification

Tian, T., Li, J., Li, Y., Lu, Y. X., Tang, Y. L., Wang, H., Zheng, F., Shi, D., Long, Q., Chen, M., Garcia-Manero, G., Hu, Y., Qin, L. & Deng, W., Jan 1 2019, In : Theranostics. 9, 13, p. 3768-3779 12 p.

Research output: Contribution to journalArticle

Open Access
Myeloid Cells
Melatonin
Acute Myeloid Leukemia
Oxidation-Reduction
Leukemia
2 Citations (Scopus)

Metabolic reprogramming and redox adaptation in sorafenib-resistant leukemia cells: Detected by untargeted metabolomics and stable isotope tracing analysis

You, X., Jiang, W., Lu, W., Zhang, H., Yu, T., Tian, J., Wen, S-J., Garcia-Manero, G., Huang, P. & Hu, Y-M., Apr 4 2019, In : Cancer Communications. 39, 1, 17.

Research output: Contribution to journalArticle

Open Access
Metabolomics
Isotopes
Protein-Tyrosine Kinases
Oxidation-Reduction
Leukemia
3 Citations (Scopus)
Acute Myeloid Leukemia
Recurrence
Survival
Proteins
Disease-Free Survival

New Tool for Monitoring Molecular Response in Patients with Chronic Myeloid Leukemia

Badar, T., Luthra, R., Kantarjian, H., Jabbour, E., Borthakur, G., Garcia-Manero, G., Huang, X., Singh, R., Alvarez, B., Austermiller, B., Morrison, T. B., Patel, K. P. & Cortes, J., Jan 1 2019, In : Applied Immunohistochemistry and Molecular Morphology. 27, 1, p. 33-39 7 p.

Research output: Contribution to journalArticle

Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Nucleic Acids
Polymerase Chain Reaction
Molecular Pathology
Sample Size
3 Citations (Scopus)
B-Cell Leukemia
Myelodysplastic Syndromes
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Bone Marrow
Mutation
2 Citations (Scopus)

NPM1 mutations define a specific subgroup of MDS and MDS/MPN patients with favorable outcomes with intensive chemotherapy

Montalban-Bravo, G., Kanagal-Shamanna, R., Sasaki, K., Patel, K., Ganan-Gomez, I., Jabbour, E., Kadia, T., Ravandi, F., DiNardo, C., Borthakur, G., Takahashi, K., Konopleva, M., Komrokji, R. S., DeZern, A., Kuzmanovic, T., Maciejewski, J., Pierce, S., Colla, S., Sekeres, M. A., Kantarjian, H. & 2 others, Bueso-Ramos, C. & Garcia-Manero, G., Mar 26 2019, In : Blood Advances. 3, 6, p. 922-933 12 p.

Research output: Contribution to journalArticle

Myelodysplastic Syndromes
Drug Therapy
Mutation
Stem Cell Transplantation
Karyotype
1 Citation (Scopus)
Leukemia, Myeloid, Chronic Phase
Therapeutics
ponatinib
Blood Vessels
Outcome Assessment (Health Care)
1 Citation (Scopus)

Phase 1/2 study of DFP-10917 administered by continuous intravenous infusion in patients with recurrent or refractory acute myeloid leukemia

Kantarjian, H. M., Jabbour, E. J., Garcia-Manero, G., Kadia, T. M., DiNardo, C. D., Daver, N. G., Borthakur, G., Jain, N., Waukau, J. B., Kwari, M. I., Ravandi, F., Anderson, B. D., Iizuka, K., Jin, C., Zhang, C. & Plunkett, W. K., May 15 2019, In : Cancer. 125, 10, p. 1665-1673 9 p.

Research output: Contribution to journalArticle

Isoflurophate
Intravenous Infusions
Acute Myeloid Leukemia
Maximum Tolerated Dose
Diarrhea
6 Citations (Scopus)
Mitogen-Activated Protein Kinase Kinases
Acute Myeloid Leukemia
Extracellular Signal-Regulated MAP Kinases
Myelodysplastic Syndromes
Mitogens
Philadelphia Chromosome
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Protein-Tyrosine Kinases
Recurrence
Survival
3 Citations (Scopus)

Pracinostat plus azacitidine in older patients with newly diagnosed acute myeloid leukemia: Results of a phase 2 study

Garcia-Manero, G., Abaza, Y., Takahashi, K., Medeiros, B. C., Arellano, M., Khaled, S. K., Patnaik, M., Odenike, O., Sayar, H., Tummala, M., Patel, P., Maness-Harris, L., Stuart, R., Traer, E., Karamlou, K., Yacoub, A., Ghalie, R., Giorgino, R. & Atallah, E., Feb 26 2019, In : Blood Advances. 3, 4, p. 508-518 11 p.

Research output: Contribution to journalArticle

Azacitidine
Acute Myeloid Leukemia
Disease-Free Survival
Leukemia
Confidence Intervals
2 Citations (Scopus)
Acute Myeloid Leukemia
Alleles
Drug Therapy
Idarubicin
Survival
6 Citations (Scopus)

Proposals for revised IWG 2018 hematological response criteria in patients with MDS included in clinical trials

Platzbecker, U., Fenaux, P., Adès, L., Giagounidis, A., Santini, V., Van De Loosdrecht, A. A., Bowen, D., De Witte, T., Garcia-Manero, G., Hellström-Lindberg, E., Germing, U., Stauder, R., Malcovati, L., Sekeres, M. A., Steensma, D. P. & Gloaguen, S., Mar 7 2019, In : Blood. 133, 10, p. 1020-1030 11 p.

Research output: Contribution to journalArticle

Open Access
Myelodysplastic Syndromes
Clinical Trials
Therapeutics
1 Citation (Scopus)

Relative survival following response to 7 + 3 versus azacytidine is similar in acute myeloid leukemia and high-risk myelodysplastic syndromes: an analysis of four SWOG studies

Othus, M., Sekeres, M. A., Nand, S., Garcia-Manero, G., Appelbaum, F. R., Erba, H. P. & Estey, E., Feb 1 2019, In : Leukemia. 33, 2, p. 371-378 8 p.

Research output: Contribution to journalArticle

Azacitidine
Myelodysplastic Syndromes
Acute Myeloid Leukemia
Survival
Therapeutics
2 Citations (Scopus)

Safety and tolerability of lurbinectedin (PM01183) in patients with acute myeloid leukemia and myelodysplastic syndrome

Benton, C. B., Chien, K. S., Tefferi, A., Rodriguez, J., Ravandi, F., Daver, N., Jabbour, E., Jain, N., Alvarado, Y., Kwari, M., Pierce, S., Maiti, A., Hornbaker, M., Santos, M. A., Martinez, S., Siguero, M., Zblewski, D., Al-Kali, A., Hogan, W. J., Kantarjian, H. & 2 others, Pardanani, A. & Garcia-Manero, G., Feb 1 2019, In : Hematological Oncology. 37, 1, p. 96-102 7 p.

Research output: Contribution to journalArticle

Myelodysplastic Syndromes
Acute Myeloid Leukemia
Safety
Appointments and Schedules
trabectedin
1 Citation (Scopus)

Second cycle remission achievement with 7+3 and survival in adults with newly diagnosed acute myeloid leukemia: analysis of recent SWOG trials

Othus, M., Estey, E. H., Garcia-Manero, G., Wood, B. L., Stirewalt, D. L., Godwin, J. E., Weick, J. K., Anderson, J. E., Appelbaum, F. R., Erba, H. P. & Walter, R. B., Feb 1 2019, In : Leukemia. 33, 2, p. 554-558 5 p.

Research output: Contribution to journalArticle

Acute Myeloid Leukemia
Acute Myeloid Leukemia
Drug Therapy
Survival
Induction Chemotherapy
4'-N-benzoylstaurosporine
18 Citations (Scopus)

The distribution of T-cell subsets and the expression of immune checkpoint receptors and ligands in patients with newly diagnosed and relapsed acute myeloid leukemia

Williams, P., Basu, S., Garcia-Manero, G., Hourigan, C. S., Oetjen, K. A., Cortes, J. E., Ravandi, F., Jabbour, E. J., Al-Hamal, Z., Konopleva, M., Ning, J., Xiao, L., Hidalgo Lopez, J., Kornblau, S. M., Andreeff, M., Flores, W., Bueso-Ramos, C., Blando, J., Galera, P., Calvo, K. R. & 5 others, Al-Atrash, G., Allison, J. P., Kantarjian, H. M., Sharma, P. & Daver, N. G., May 1 2019, In : Cancer. 125, 9, p. 1470-1481 12 p.

Research output: Contribution to journalArticle

Open Access
T-Lymphocyte Subsets
Acute Myeloid Leukemia
Ligands
T-Lymphocytes
Bone Marrow
4 Citations (Scopus)

The role of TGFβ in hematopoiesis and myeloid disorders

Bataller, A., Montalban Bravo, G., Soltysiak, K. A. & Garcia-Manero, G., May 1 2019, In : Leukemia. 33, 5, p. 1076-1089 14 p.

Research output: Contribution to journalReview article

Hematopoiesis
Transforming Growth Factors
Myelodysplastic Syndromes
Hematologic Diseases
Cell Differentiation
13 Citations (Scopus)

TP53 mutation status divides myelodysplastic syndromes with complex karyotypes into distinct prognostic subgroups

for the International Working Group for MDS Molecular Prognostic Committee, Jul 1 2019, In : Leukemia. 33, 7, p. 1747-1758 12 p.

Research output: Contribution to journalArticle

Open Access
Myelodysplastic Syndromes
Karyotype
Mutation
Chromosome Aberrations
Critical Care
1 Citation (Scopus)

Transcriptomic analysis implicates necroptosis in disease progression and prognosis in myelodysplastic syndromes

Montalban-Bravo, G., Class, C. A., Ganan-Gomez, I., Kanagal-Shamanna, R., Sasaki, K., Richard-Carpentier, G., Naqvi, K., Wei, Y., Yang, H., Soltysiak, K. A., Chien, K., Bueso-Ramos, C., Do, K. A., Kantarjian, H. & Garcia-Manero, G., Jan 1 2019, (Accepted/In press) In : Leukemia.

Research output: Contribution to journalArticle

Myelodysplastic Syndromes
Disease Progression
Leukemia, Myelomonocytic, Chronic
Cell Death
RNA
5 Citations (Scopus)
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Protein-Tyrosine Kinases
Clinical Trials
Life Expectancy
Interferons