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2020

Correction: LCE: an open web portal to explore gene expression and clinical associations in lung cancer (Oncogene, (2019), 38, 14, (2551-2564), 10.1038/s41388-018-0588-2)

Cai, L., Lin, S. Y., Girard, L., Zhou, Y., Yang, L., Ci, B., Zhou, Q., Luo, D., Yao, B., Tang, H., Allen, J., Huffman, K., Gazdar, A., Heymach, J., Wistuba, I., Xiao, G., Minna, J. & Xie, Y., Jan 16 2020, In : Oncogene. 39, 3, p. 718-719 2 p.

Research output: Contribution to journalComment/debate

Open Access
Oncogenes
Publications
Lung Neoplasms
Gene Expression
1 Citation (Scopus)

Multiplex Immunofluorescence Assays

Francisco-Cruz, A., Parra, E. R., Tetzlaff, M. T. & Wistuba, I. I., Jan 1 2020, Methods in Molecular Biology. Humana Press Inc., p. 467-495 29 p. (Methods in Molecular Biology; vol. 2055).

Research output: Chapter in Book/Report/Conference proceedingChapter

Fluorescent Antibody Technique
Paraffin
Formaldehyde
Neoplasms
Staining and Labeling
1 Citation (Scopus)

Pleural Fluid Cytokine Levels at Baseline and over Time are Associated with Time to IPC Removal: An Exploratory Study

Grosu, H. B., Lu, W., Ost, D. E., Vial, M. R., Hernandez, M., Ghosh, N., Noor, L., Hasan, A. M., Bashoura, L., Faiz, S., Balachandran, D., Casal, R., Eapen, G., Shannon, V., Sheshadri, A., Tang, X., Rahman, N. & Wistuba, I. I., Jan 1 2020, In : Journal of Bronchology and Interventional Pulmonology. 27, 1, p. 4-13 10 p.

Research output: Contribution to journalArticle

Indwelling Catheters
Cytokines
Pleurodesis
Interleukin-8
Area Under Curve

Therapeutic targeting of the PI4K2A/PKR lysosome network is critical for misfolded protein clearance and survival in cancer cells

Pataer, A., Ozpolat, B., Shao, R. P., Cashman, N. R., Plotkin, S. S., Samuel, C. E., Lin, S. H., Kabil, N. N., Wang, J., Majidi, M., Fang, B., Roth, J. A., Vaporciyan, A. A., Wistuba, I. I., Hung, M. C. & Swisher, S. G., Jan 23 2020, In : Oncogene. 39, 4, p. 801-813 13 p.

Research output: Contribution to journalArticle

Lysosomes
Protein Kinases
Survival
Neoplasms
Proteins
2019
2 Citations (Scopus)

5 protein-based signature for resectable lung squamous cell carcinoma improves the prognostic performance of the TNM staging

Martínez-Terroba, E., Behrens, M. D. C., Agorreta, J., Monsó, E., Millares, L., Felip, E., Rosell, R., Ramirez, J. L., Remirez, A., Torre, W., Gil-Bazo, I., Idoate, M. A., De-Torres, J. P., Pio, R., Wistuba, I. I., Pajares, M. J. & Montuenga, L. M., Apr 1 2019, In : Thorax. 74, 4, p. 371-379 9 p.

Research output: Contribution to journalArticle

Neoplasm Staging
Squamous Cell Carcinoma
Lung
Proteins
Disease-Free Survival

An Integrated Next-Generation Sequencing System for Analyzing DNA Mutations, Gene Fusions, and RNA Expression in Lung Cancer

Haynes, B. C., Blidner, R. A., Cardwell, R. D., Zeigler, R., Gokul, S., Thibert, J. R., Chen, L., Fujimoto, J., Papadimitrakopoulou, V. A., Wistuba, I. I. & Latham, G. J., Jun 1 2019, In : Translational Oncology. 12, 6, p. 836-845 10 p.

Research output: Contribution to journalArticle

Open Access
Gene Fusion
Lung Neoplasms
RNA
Mutation
Workflow
2 Citations (Scopus)

A proposal for pathologic processing of breast implant capsules in patients with suspected breast implant anaplastic large cell lymphoma

Lyapichev, K. A., Piña-Oviedo, S., Medeiros, L. J., Evans, M. G., Liu, H., Miranda, A. R., Hunt, K. K., Clemens, M. W., Stewart, J. M., Amin, M. B., Quesada, A. E., Chai, S. M., Di Napoli, A., Yoga, A., Dave, S. K., Wistuba, I. I., Wu, Y., Bueso-Ramos, C. E., Schlette, E. J., Ferrufino-Schmidt, M. C. & 4 others, Loghavi, S., Khoury, J. D., Young, K. H. & Miranda, R. N., Jan 1 2019, In : Modern Pathology.

Research output: Contribution to journalArticle

Anaplastic Large-Cell Lymphoma
Breast Implants
Capsules
Lymphoma
Neoplasms

Artificial intelligence in lung cancer pathology image analysis

Wang, S., Yang, D. M., Rong, R., Zhan, X., Fujimoto, J., Liu, H., Minna, J., Wistuba, I. I., Xie, Y. & Xiao, G., Nov 2019, In : Cancers. 11, 11, 1673.

Research output: Contribution to journalReview article

Open Access
Artificial Intelligence
Lung Neoplasms
Pathology
Learning
Technology

Author Correction: CPS1 maintains pyrimidine pools and DNA synthesis in KRAS/LKB1-mutant lung cancer cells (Nature, (2017), 546, 7656, (168-172), 10.1038/nature22359)

Kim, J., Hu, Z., Cai, L., Li, K., Choi, E., Faubert, B., Bezwada, D., Rodriguez-Canales, J., Villalobos, P., Lin, Y. F., Ni, M., Huffman, K. E., Girard, L., Byers, L. A., Unsal-Kacmaz, K., Peña, C. G., Heymach, J. V., Wauters, E., Vansteenkiste, J., Castrillon, D. H. & 6 others, Chen, B. P. C., Wistuba, I., Lambrechts, D., Xu, J., Minna, J. D. & DeBerardinis, R. J., May 16 2019, In : Nature. 569, 7756, p. E4

Research output: Contribution to journalComment/debate

Open Access
Carbamyl Phosphate
Lung Neoplasms
DNA
pyrimidine
phosphorylethanolamine
3 Citations (Scopus)
Merkel Cells
Merkel Cell Carcinoma
Blood Vessels
Endothelial Cells
Neoplasms
19 Citations (Scopus)

Best Practices Recommendations for Diagnostic Immunohistochemistry in Lung Cancer

Yatabe, Y., Dacic, S., Borczuk, A. C., Warth, A., Russell, P. A., Lantuejoul, S., Beasley, M. B., Thunnissen, E., Pelosi, G., Rekhtman, N., Bubendorf, L., Mino-Kenudson, M., Yoshida, A., Geisinger, K. R., Noguchi, M., Chirieac, L. R., Bolting, J., Chung, J. H., Chou, T. Y., Chen, G. & 12 others, Poleri, C., Lopez-Rios, F., Papotti, M., Sholl, L. M., Roden, A. C., Travis, W. D., Hirsch, F. R., Kerr, K. M., Tsao, M. S., Nicholson, A. G., Wistuba, I. & Moreira, A. L., Mar 2019, In : Journal of Thoracic Oncology. 14, 3, p. 377-407 31 p.

Research output: Contribution to journalArticle

Practice Guidelines
Lung Neoplasms
Immunohistochemistry
Pathology
Carcinoma
7 Citations (Scopus)

Centrifuged supernatants from FNA provide a liquid biopsy option for clinical next-generation sequencing of thyroid nodules

Ye, W., Hannigan, B., Zalles, S., Mehrotra, M., Barkoh, B. A., Williams, M. D., Cabanillas, M. E., Edeiken-Monroe, B., Hu, P., Duose, D., Wistuba, I. I., Medeiros, L. J., Stewart, J., Luthra, R. & Roy-Chowdhuri, S., Mar 2019, In : Cancer Cytopathology. 127, 3, p. 146-160 15 p.

Research output: Contribution to journalArticle

Thyroid Nodule
Fine Needle Biopsy
Biopsy
Mutation
Thyroid Gland

Characterization and comparison of GITR expression in solid tumors

Vence, L., Bucktrout, S. L., Curbelo, I. F., Blando, J., Smith, B. M., Mahne, A. E., Lin, J. C., Park, T., Pascua, E., Sai, T., Chaparro-Riggers, J., Subudhi, S. K., Scutti, J. B., Higa, M. G., Zhao, H., Yadav, S. S., Maitra, A., Wistuba, I. I., Allison, J. P. & Sharma, P., Nov 1 2019, In : Clinical Cancer Research. 25, 21, p. 6501-6510 10 p.

Research output: Contribution to journalArticle

Renal Cell Carcinoma
Non-Small Cell Lung Carcinoma
Melanoma
Neoplasms
Flow Cytometry
44 Citations (Scopus)

Combining Immune Checkpoint Blockade and Tumor-Specific Vaccine for Patients with Incurable Human Papillomavirus 16-Related Cancer: A Phase 2 Clinical Trial

Massarelli, E., William, W., Johnson, F., Kies, M., Ferrarotto, R., Guo, M., Feng, L., Lee, J. J., Tran, H., Kim, Y. U., Haymaker, C., Bernatchez, C., Curran, M., Zecchini Barrese, T., Rodriguez Canales, J., Wistuba, I., Li, L., Wang, J., Van Der Burg, S. H., Melief, C. J. & 1 others, Glisson, B., Jan 2019, In : JAMA Oncology. 5, 1, p. 67-73 7 p.

Research output: Contribution to journalArticle

Cancer Vaccines
Human papillomavirus 16
Papillomaviridae
Clinical Trials
Neoplasms
1 Citation (Scopus)

ConvPath: A software tool for lung adenocarcinoma digital pathological image analysis aided by a convolutional neural network

Wang, S., Wang, T., Yang, L., Yang, D. M., Fujimoto, J., Yi, F., Luo, X., Yang, Y., Yao, B., Lin, S. Y., Moran, C., Kalhor, N., Weissferdt, A., Minna, J., Xie, Y., Wistuba, I. I., Mao, Y. & Xiao, G., Dec 2019, In : EBioMedicine. 50, p. 103-110 8 p.

Research output: Contribution to journalArticle

Open Access
Image analysis
Tumors
Software
Neural networks
Pathology

Correction: Distinct co-acquired alterations and genomic evolution during TKI treatment in non-small-cell lung cancer patients with or without acquired T790M mutation (Oncogene, (2019), 10.1038/s41388-019-1104-z)

Jin, Y., Bao, H., Le, X., Fan, X., Tang, M., Shi, X., Zhao, J., Yan, J., Xu, Y., Quek, K., Elamin, Y. Y., Zhang, J., Futreal, P. A., Wistuba, I. I., Heymach, J. V., Lou, G., Shao, L., He, Q., Lin, C., Wu, X. & 8 others, Shao, Y. W., Wang, X., He, J., Chen, Y., Stebbing, J., Chen, M., Zhang, J. & Yu, X., Jan 1 2019, (Accepted/In press) In : Oncogene.

Research output: Contribution to journalComment/debate

Open Access
Oncogenes
Non-Small Cell Lung Carcinoma
Delivery of Health Care
Mutation
Singapore
1 Citation (Scopus)

Correction to: Circulating tumor DNA analysis depicts subclonal architecture and genomic evolution of small cell lung cancer (Nature Communications, (2018), 9, 1, (3114), 10.1038/s41467-018-05327-w)

Nong, J., Gong, Y., Guan, Y., Yi, X., Yi, Y., Chang, L., Yang, L., Lv, J., Guo, Z., Jia, H., Chu, Y., Liu, T., Chen, M., Byers, L., Roarty, E., Lam, V. K., Papadimitrakopoulou, V. A., Wistuba, I., Heymach, J. V., Glisson, B. & 7 others, Liao, Z., Lee, J. J., Futreal, P. A., Zhang, S., Xia, X., Zhang, J. & Wang, J., Dec 1 2019, In : Nature communications. 10, 1, 552.

Research output: Contribution to journalComment/debate

Open Access
document markup languages
HTML
Small Cell Lung Carcinoma
lungs
Labels
Colorectal Neoplasms
DNA
Libraries
Neoplasms
Residual Neoplasm

Development and Validation of a Pathology Image Analysis-based Predictive Model for Lung Adenocarcinoma Prognosis - A Multi-cohort Study

Luo, X., Yin, S., Yang, L., Fujimoto, J., Yang, Y., Moran, C., Kalhor, N., Weissferdt, A., Xie, Y., Gazdar, A., Minna, J., Wistuba, I. I., Mao, Y. & Xiao, G., Dec 1 2019, In : Scientific reports. 9, 1, 6886.

Research output: Contribution to journalArticle

Open Access
Cohort Studies
Pathology
Adenocarcinoma
Lung
Neoplasms
2 Citations (Scopus)

Distinct co-acquired alterations and genomic evolution during TKI treatment in non-small-cell lung cancer patients with or without acquired T790M mutation

Jin, Y., Bao, H., Le, X., Fan, X., Tang, M., Shi, X., Zhao, J., Yan, J., Xu, Y., Quek, K., Elamin, Y. Y., Zhang, J., Futreal, P. A., Wistuba, I. I., Heymach, J. V., Lou, G., Shao, L., He, Q., Lin, C., Wu, X. & 8 others, Shao, Y. W., Wang, X., He, J., Chen, Y., Stebbing, J., Chen, M., Zhang, J. & Yu, X., Jan 1 2019, (Accepted/In press) In : Oncogene.

Research output: Contribution to journalArticle

Non-Small Cell Lung Carcinoma
Protein-Tyrosine Kinases
Clonal Evolution
Mutation
Disease-Free Survival
4 Citations (Scopus)

Driver mutations in normal airway epithelium elucidate spatiotemporal resolution of lung cancer

Kadara, H., Sivakumar, S., Jakubek, Y., Anthony San Lucas, F., Lang, W., McDowell, T., Weber, Z., Behrens, C., Davies, G. E., Kalhor, N., Moran, C., El-Zein, R., Mehran, R., Swisher, S. G., Wang, J., Zhang, J., Fujimoto, J., Fowler, J., Heymach, J. V., Dubinett, S. & 4 others, Spira, A. E., Ehli, E. A., Wistuba, I. I. & Scheet, P., Sep 15 2019, In : American journal of respiratory and critical care medicine. 200, 6, p. 742-750 9 p.

Research output: Contribution to journalArticle

Non-Small Cell Lung Carcinoma
Lung Neoplasms
Epithelium
Mutation
Allelic Imbalance

Erratum: Stress hormones promote EGFR inhibitor resistance in NSCLC: Implications for combinations with β-blockers (Science Translational Medicine DOI: 10.1126/scitranslmed.aao4307)

Nilsson, M. B., Sun, H., Diao, L., Tong, P., Liu, D., Li, L., Fan, Y., Poteete, A., Lim, S. O., Howells, K., Haddad, V., Gomez, D., Tran, H., Pena, G. A., Sequist, L. V., Yang, J. C., Wang, J., Kim, E. S., Herbst, R., Lee, J. J. & 5 others, Hong, W. K., Wistuba, I., Hung, M. C., Sood, A. K. & Heymach, J. V., May 22 2019, In : Science Translational Medicine. 11, 493, eaax9987.

Research output: Contribution to journalComment/debate

Translational Medical Research
Hormones
Research
1 Citation (Scopus)

Erratum: The Immune Landscape of Cancer (Immunity (2018) 48(4) (812–830.e14), (S1074761318301213), (10.1016/j.immuni.2018.03.023))

The Cancer Genome Atlas Research Network, Aug 20 2019, In : Immunity. 51, 2, p. 411-412 2 p.

Research output: Contribution to journalComment/debate

Open Access
Immunity
Names
Genes
Neoplasms
Research Design
Epithelial-Mesenchymal Transition
Vimentin
Pancreatic Ducts
Adenocarcinoma
Neoadjuvant Therapy

From clinical specimens to human cancer preclinical models—a journey the NCI-cell line database—25 years later

Mulshine, J. L., Ujhazy, P., Antman, M., Burgess, C. M., Kuzmin, I., Bunn, P. A., Johnson, B. E., Roth, J. A., Pass, H. I., Ross, S. M., Aldige, C. R., Wistuba, I. I. & Minna, J. D., Jan 1 2019, (Accepted/In press) In : Journal of cellular biochemistry.

Research output: Contribution to journalArticle

National Cancer Institute (U.S.)
Cells
Cell Line
Neoplasms
Research
1 Citation (Scopus)
Keratosis
Gene Expression Profiling
Dermatitis
Innate Immunity
Monocytes
2 Citations (Scopus)

Genetic characterization of medullary thyroid cancer in childhood survivors of the Chernobyl accident

Fisher, S. B., Cote, G. J., Bui-Griffith, J. H., Lu, W., Tang, X., Hai, T., Fisher, K. E., Williams, M. D., Wistuba, I. I., Waguespack, S. G., Dorman, C. M., Ludwig, M. S., Graham, P. H., Perrier, N. D., Lee, J. E. & Grubbs, E. G., Jan 2019, In : Surgery (United States). 165, 1, p. 58-63 6 p.

Research output: Contribution to journalArticle

Accidents
Survivors
Germ-Line Mutation
Radiation
Oncogene Fusion
2 Citations (Scopus)

Genomic landscape of allelic imbalance in premalignant atypical adenomatous hyperplasias of the lung

Sivakumar, S., San Lucas, F. A., Jakubek, Y. A., McDowell, T. L., Lang, W., Kallsen, N., Peyton, S., Davies, G. E., Fukuoka, J., Yatabe, Y., Zhang, J., Futreal, P. A., Fowler, J., Fujimoto, J., Ehli, E. A., Hawk, E. T., Wistuba, I. I., Kadara, H. & Scheet, P., Apr 2019, In : EBioMedicine. 42, p. 296-303 8 p.

Research output: Contribution to journalArticle

Open Access
Allelic Imbalance
Aberrations
Hyperplasia
Chromosome Aberrations
Lung

High OX-40 expression in the tumor immune infiltrate is a favorable prognostic factor of overall survival in non-small cell lung cancer

Massarelli, E., Lam, V. K., Parra, E. R., Rodriguez-Canales, J., Behrens, C., Diao, L., Wang, J., Blando, J., Byers, L. A., Yanamandra, N., Brett, S., Morley, P., Sharma, P., Allison, J., Wistuba, I. I. & Heymach, J. V., Dec 16 2019, In : Journal for immunotherapy of cancer. 7, 1, 351.

Research output: Contribution to journalArticle

Open Access
Non-Small Cell Lung Carcinoma
Immunohistochemistry
Granzymes
Biomarkers
Neoplasms
2 Citations (Scopus)

Hybrid oncocytic/chromophobe renal tumors are molecularly distinct from oncocytoma and chromophobe renal cell carcinoma

Ruiz-Cordero, R., Rao, P., Li, L., Qi, Y., Atherton, D., Peng, B., Singh, R. R., Kim, T. B., Kawakami, F., Routbort, M. J., Alouch, N., Chow, C. W. B., Tang, X., Lu, W., Brimo, F., Matin, S. F., Wood, C. G., Tannir, N. M., Wistuba, I. I., Chen, K. & 5 others, Wang, J., Medeiros, L. J., Karam, J. A., Tamboli, P. & Sircar, K., Nov 1 2019, In : Modern Pathology. 32, 11, p. 1698-1707 10 p.

Research output: Contribution to journalArticle

Oxyphilic Adenoma
Renal Cell Carcinoma
Kidney
Neoplasms
Renal oncocytoma

Immunotherapy response evaluation with magnetic resonance elastography (MRE) in advanced HCC

Qayyum, A., Hwang, K. P., Stafford, J., Verma, A., Maru, D. M., Sandesh, S., Sun, J., Pestana, R. C., Avritscher, R., Hassan, M. M., Amin, H., Rashid, A., Wistuba, I. I., Ehman, R. L., Ma, J. & Kaseb, A. O., Nov 28 2019, In : Journal for immunotherapy of cancer. 7, 1, 329.

Research output: Contribution to journalArticle

Open Access
Elasticity Imaging Techniques
Immunotherapy
Hepatocellular Carcinoma
Disease Progression
Biopsy
2 Citations (Scopus)

Inhibitor of differentiation-1 sustains mutant KRAS-driven progression, maintenance, and metastasis of lung adenocarcinoma via regulation of a FOSL1 network

Román, M., López, I., Guruceaga, E., Baraibar, I., Ecay, M., Collantes, M., Nadal, E., Vallejo, A., Cadenas, S., Miguel, M. E., Jang, J. H., Martin-Uriz, P. S., Castro-Labrador, L., Vilas-Zornoza, A., Lara-Astiaso, D., Ponz-Sarvise, M., Rolfo, C., Santos, E. S., Raez, L. E., Taverna, S. & 5 others, Behrens, C., Weder, W., Wistuba, I. I., Vicent, S. & Gil-Bazo, I., Jan 1 2019, In : Cancer research. 79, 3, p. 625-638 14 p.

Research output: Contribution to journalArticle

Maintenance
Neoplasm Metastasis
Survival
Adenocarcinoma of lung
Oncogenes
3 Citations (Scopus)

LCE: an open web portal to explore gene expression and clinical associations in lung cancer

Cai, L., Lin, S. Y., Girard, L., Zhou, Y., Yang, L., Ci, B., Zhou, Q., Luo, D., Yao, B., Tang, H., Allen, J., Huffman, K., Gazdar, A., Heymach, J., Wistuba, I., Xiao, G., Minna, J. & Xie, Y., Apr 4 2019, In : Oncogene. 38, 14, p. 2551-2564 14 p.

Research output: Contribution to journalArticle

Lung Neoplasms
Gene Expression
Databases
Survival Analysis
Meta-Analysis
5 Citations (Scopus)

Liquid biopsy assay for lung carcinoma using centrifuged supernatants from fine-needle aspiration specimens

Hannigan, B., Ye, W., Mehrotra, M., Lam, V., Bolivar, A., Zalles, S., Barkoh, B. A., Duose, D., Hu, P. C., Broaddus, R., Stewart, J., Heymach, J., Medeiros, L. J., Wistuba, I., Luthra, R. & Roy-Chowdhuri, S., Jun 1 2019, In : Annals of Oncology. 30, 6, p. 963-969 7 p., mdz102.

Research output: Contribution to journalArticle

Fine Needle Biopsy
Carcinoma
Biopsy
Lung
Mutation
8 Citations (Scopus)

METTL13 Methylation of eEF1A Increases Translational Output to Promote Tumorigenesis

Liu, S., Hausmann, S., Carlson, S. M., Fuentes, M. E., Francis, J. W., Pillai, R., Lofgren, S. M., Hulea, L., Tandoc, K., Lu, J., Li, A., Nguyen, N. D., Caporicci, M., Kim, M. P., Maitra, A., Wang, H., Wistuba, I. I., Porco, J. A., Bassik, M. C., Elias, J. E. & 5 others, Song, J., Topisirovic, I., Van Rechem, C., Mazur, P. K. & Gozani, O., Jan 24 2019, In : Cell. 176, 3, p. 491-504.e21

Research output: Contribution to journalArticle

Peptide Elongation Factors
Architectural Accessibility
Methylation
GTP Phosphohydrolases
Carcinogenesis
1 Citation (Scopus)

Multi-region exome sequencing reveals genomic evolution from preneoplasia to lung adenocarcinoma

Hu, X., Fujimoto, J., Ying, L., Fukuoka, J., Ashizawa, K., Sun, W., Reuben, A., Chow, C. W., McGranahan, N., Chen, R., Hu, J., Godoy, M. C., Tabata, K., Kuroda, K., Shi, L., Li, J., Behrens, C., Parra, E. R., Little, L. D., Gumbs, C. & 22 others, Mao, X., Song, X., Tippen, S., Thornton, R. L., Kadara, H., Scheet, P., Roarty, E., Ostrin, E. J., Wang, X., Carter, B. W., Antonoff, M. B., Zhang, J., Vaporciyan, A. A., Pass, H., Swisher, S. G., Heymach, J. V., Lee, J. J., Wistuba, I. I., Hong, W. K., Futreal, P. A., Su, D. & Zhang, J., Dec 1 2019, In : Nature communications. 10, 1, 2978.

Research output: Contribution to journalArticle

Open Access
Exome
sequencing
lungs
Adenocarcinoma
Nucleotides
1 Citation (Scopus)

Non-invasive genotyping of metastatic colorectal cancer using circulating cell free DNA

Shi, X., Duose, D. Y., Mehrotra, M., Harmon, M. A., Hu, P., Wistuba, I. I., Kopetz, S. & Luthra, R., Sep 2019, In : Cancer Genetics. 237, p. 82-89 8 p.

Research output: Contribution to journalArticle

Colorectal Neoplasms
DNA
DNA Sequence Analysis
Gene Frequency
Neoplasms
1 Citation (Scopus)

Oncogenic enhancer of zeste homolog 2 is an actionable target in patients with non-small cell lung cancer

Shi, B., Behrens, C., Vaghani, V., Riquelme, E. M., Rodriguez-Canales, J., Kadara, H., Lin, H., Lee, J., Liu, H., Wistuba, I. & Simon, G., Oct 1 2019, In : Cancer medicine. 8, 14, p. 6383-6392 10 p.

Research output: Contribution to journalArticle

Open Access
Non-Small Cell Lung Carcinoma
Histone Deacetylases
Histone Deacetylase Inhibitors
Cell Line
Enhancer of Zeste Homolog 2 Protein
3 Citations (Scopus)
Neoplasm Genes
HLA Antigens
Tumor Burden
Non-Small Cell Lung Carcinoma
Genotype
Pemetrexed
Cisplatin
Drug Therapy
Disease-Free Survival
Platinum
Endodermal Sinus Tumor
Glypicans
Neoplasms
Staining and Labeling
Fetal Proteins
Hematologic Neoplasms
Mutation Rate
Polymerase Chain Reaction
Gene Frequency
Clonal Evolution
1 Citation (Scopus)

Rcrnorm: An integrated system of random-coefficient hierarchical regression models for normalizing nanostring ncounter data

Jia, G., Wang, X., Li, Q., Lu, W. E. I., Tang, X., Wistuba, I. & Xie, Y., Sep 2019, In : Annals of Applied Statistics. 13, 3, p. 1617-1647 31 p.

Research output: Contribution to journalArticle

Open Access
Random Coefficients
Hierarchical Model
Integrated System
Formaldehyde
Paraffins
2 Citations (Scopus)

Reanalysis of the NCCN PD-L1 companion diagnostic assay study for lung cancer in the context of PD-L1 expression findings in triple-negative breast cancer

Rimm, D. L., Han, G., Taube, J. M., Yi, E. S., Bridge, J. A., Flieder, D. B., Homer, R., Roden, A. C., Hirsch, F. R., Wistuba, I. I. & Pusztai, L., Jun 13 2019, In : Breast Cancer Research. 21, 1, 72.

Research output: Contribution to journalReview article

Open Access
Triple Negative Breast Neoplasms
Lung Neoplasms
Routine Diagnostic Tests
Research Design
Neoplasms
6 Citations (Scopus)

Removal of N-Linked Glycosylation Enhances PD-L1 Detection and Predicts Anti-PD-1/PD-L1 Therapeutic Efficacy

Lee, H. H., Wang, Y. N., Xia, W., Chen, C. H., Rau, K. M., Ye, L., Wei, Y., Chou, C. K., Wang, S. C., Yan, M., Tu, C. Y., Hsia, T. C., Chiang, S. F., Chao, K. S. C., Wistuba, I. I., Hsu, J. L., Hortobagyi, G. N. & Hung, M. C., Aug 12 2019, In : Cancer cell. 36, 2, p. 168-178.e4

Research output: Contribution to journalArticle

Glycosylation
Leukocyte L1 Antigen Complex
Antibody Affinity
Therapeutics
Surface Antigens

Round Robin Evaluation of MET Protein Expression in Lung Adenocarcinomas Improves Interobserver Concordance

Lung Cancer Mutation Consortium (LCMC) Pathologist Panel Group, Jan 1 2019, (Accepted/In press) In : Applied Immunohistochemistry and Molecular Morphology.

Research output: Contribution to journalArticle

Songbirds
Epithelial-Mesenchymal Transition
Lung Neoplasms
Proteins
Immunohistochemistry
2 Citations (Scopus)

Sphingosine kinase 1 signaling promotes metastasis of triple-negative breast cancer

Acharya, S., Yao, J., Li, P., Zhang, C., Lowery, F. J., Zhang, Q., Guo, H., Qu, J., Yang, F., Wistuba, I. I., Piwnica-Worms, H., Sahin, A. A. & Yu, D., Aug 15 2019, In : Cancer research. 79, 16, p. 4211-4226 16 p.

Research output: Contribution to journalArticle

Triple Negative Breast Neoplasms
Neoplasm Metastasis
Breast Neoplasms
Lung
Computational Biology
6 Citations (Scopus)
Open Access
Paraffin
Staining and Labeling
Neoplasms
Translational Medical Research
Technology
3 Citations (Scopus)

Suppressed immune microenvironment and repertoire in brain metastases from patients with resected non-small-cell lung cancer

Kudo, Y., Haymaker, C., Zhang, J., Reuben, A., Duose, D. Y., Fujimoto, J., Roy-Chowdhuri, S., Solis Soto, L. M., Dejima, H., Parra, E. R., Mino, B., Abraham, R., Ikeda, N., Vaporcyan, A., Gibbons, D., Zhang, J., Lang, F. F., Luthra, R., Lee, J. J., Moran, C. & 3 others, Huse, J. T., Kadara, H. & Wistuba, I. I., Sep 1 2019, In : Annals of Oncology. 30, 9, p. 1521-1530 10 p.

Research output: Contribution to journalArticle

Non-Small Cell Lung Carcinoma
Neoplasm Metastasis
Brain
Brain Neoplasms
Tumor Microenvironment
44 Citations (Scopus)

Targeting DNA damage response promotes antitumor immunity through STING-mediated T-cell activation in small cell lung cancer

Sen, T., Rodriguez, B. L., Chen, L., Della Corte, C. M., Morikawa, N., Fujimoto, J., Cristea, S., Nguyen, T., Diao, L., Li, L., Fan, Y., Yang, Y., Wang, J., Glisson, B. S., Wistuba, I. I., Sage, J., Heymach, J. V., Gibbons, D. L. & Byers, L. A., May 2019, In : Cancer discovery. 9, 5, p. 646-661 16 p.

Research output: Contribution to journalArticle

Small Cell Lung Carcinoma
DNA Damage
Immunity
T-Lymphocytes
Immunotherapy