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2020
1 Citation (Scopus)

Oxidative stress as candidate therapeutic target to overcome microenvironmental protection of CLL

Yosifov, D. Y., Idler, I., Bhattacharya, N., Reichenzeller, M., Close, V., Ezerina, D., Scheffold, A., Jebaraj, B. M. C., Kugler, S., Bloehdorn, J., Bahlo, J., Robrecht, S., Eichhorst, B., Fischer, K., Weigel, A., Busch, H., Lichter, P., Döhner, H., Dick, T. P., Stilgenbauer, S. & 1 others, Mertens, D., Jan 1 2020, In : Leukemia. 34, 1, p. 115-127 13 p.

Research output: Contribution to journalArticle

B-Cell Chronic Lymphocytic Leukemia
Oxidative Stress
Emetine
Therapeutics
Mesenchymal Stromal Cells
2019
6 Citations (Scopus)

Brainstem biopsy in pediatric diffuse intrinsic pontine glioma in the era of precision medicine: the INFORM study experience

Pfaff, E., El Damaty, A., Balasubramanian, G. P., Blattner-Johnson, M., Worst, B. C., Stark, S., Witt, H., Pajtler, K. W., van Tilburg, C. M., Witt, R., Milde, T., Jakobs, M., Fiesel, P., Frühwald, M. C., Hernáiz Driever, P., Thomale, U. W., Schuhmann, M. U., Metzler, M., Bochennek, K., Simon, T. & 16 others, Dürken, M., Karremann, M., Knirsch, S., Ebinger, M., von Bueren, A. O., Pietsch, T., Herold-Mende, C., Reuss, D. E., Kiening, K., Lichter, P., Eggert, A., Kramm, C. M., Pfister, S. M., Jones, D. T. W., Bächli, H. & Witt, O., Jun 2019, In : European Journal of Cancer. 114, p. 27-35 9 p.

Research output: Contribution to journalArticle

Precision Medicine
Glioma
Brain Stem
Pediatrics
Biopsy
1 Citation (Scopus)

CD8+ T-cells of CLL-bearing mice acquire a transcriptional program of T-cell activation and exhaustion

Llaó Cid, L., Hanna, B. S., Iskar, M., Roessner, P. M., Öztürk, S., Lichter, P., Zapatka, M. & Seiffert, M., Jan 1 2019, (Accepted/In press) In : Leukemia and Lymphoma.

Research output: Contribution to journalArticle

T-Cell Prolymphocytic Leukemia
T-Lymphocytes
B-Cell Chronic Lymphocytic Leukemia
Programmed Cell Death 1 Receptor
Adoptive Transfer
5 Citations (Scopus)

Comprehensive Analysis of Chromatin States in Atypical Teratoid/Rhabdoid Tumor Identifies Diverging Roles for SWI/SNF and Polycomb in Gene Regulation

Erkek, S., Johann, P. D., Finetti, M. A., Drosos, Y., Chou, H. C., Zapatka, M., Sturm, D., Jones, D. T. W., Korshunov, A., Rhyzova, M., Wolf, S., Mallm, J. P., Beck, K., Witt, O., Kulozik, A. E., Frühwald, M. C., Northcott, P. A., Korbel, J. O., Lichter, P., Eils, R. & 7 others, Gajjar, A., Roberts, C. W. M., Williamson, D., Hasselblatt, M., Chavez, L., Pfister, S. M. & Kool, M., Jan 14 2019, In : Cancer cell. 35, 1, p. 95-110.e8

Research output: Contribution to journalArticle

Chromatin Immunoprecipitation
Chromatin
Histone Code
Polycomb-Group Proteins
Repressor Proteins
7 Citations (Scopus)

Control of chronic lymphocytic leukemia development by clonally-expanded CD8 + T-cells that undergo functional exhaustion in secondary lymphoid tissues

Hanna, B. S., Roessner, P. M., Yazdanparast, H., Colomer, D., Campo, E., Kugler, S., Yosifov, D., Stilgenbauer, S., Schmidt, M., Gabriel, R., Lichter, P. & Seiffert, M., Mar 1 2019, In : Leukemia. 33, 3, p. 625-637 13 p.

Research output: Contribution to journalArticle

Lymphoid Tissue
B-Cell Chronic Lymphocytic Leukemia
T-Lymphocytes
Lymph Nodes
T-Cell Prolymphocytic Leukemia

DECIPHER pooled shRNA library screen identifies PP2A and FGFR signaling as potential therapeutic targets for diffuse intrinsic pontine gliomas

Schramm, K., Iskar, M., Statz, B., Jäger, N., Haag, D., Słabicki, M., Pfister, S. M., Zapatka, M., Gronych, J., Jones, D. T. W. & Lichter, P., Jul 11 2019, In : Neuro-oncology. 21, 7, p. 867-877 11 p., noz057.

Research output: Contribution to journalArticle

Protein Phosphatase 2
Fibroblast Growth Factor Receptors
Glioma
Small Interfering RNA
Histone Code
1 Citation (Scopus)

Desmoplastic/nodular medulloblastomas (DNMB) and medulloblastomas with extensive nodularity (MBEN) disclose similar epigenetic signatures but different transcriptional profiles

Korshunov, A., Sahm, F., Okonechnikov, K., Ryzhova, M., Stichel, D., Schrimpf, D., Casalini, B., Sievers, P., Meyer, J., Zheludkova, O., Golanov, A., Lichter, P., Jones, D. T. W., Pfister, S. M., Kool, M. & von Deimling, A., Jun 1 2019, In : Acta neuropathologica. 137, 6, p. 1003-1015 13 p.

Research output: Contribution to journalArticle

Medulloblastoma
Epigenomics
Clinical Trials
RNA
Nervous System Neoplasms
1 Citation (Scopus)

Dissecting the prognostic significance and functional role of progranulin in chronic lymphocytic leukemia

Schulze-Edinghausen, L., Dürr, C., Öztürk, S., Zucknick, M., Benner, A., Kalter, V., Ohl, S., Close, V., Wuchter, P., Stilgenbauer, S., Lichter, P. & Seiffert, M., Jun 2019, In : Cancers. 11, 6, 822.

Research output: Contribution to journalArticle

Open Access
B-Cell Chronic Lymphocytic Leukemia
Coculture Techniques
Mesenchymal Stromal Cells
Tumor Microenvironment
Adoptive Transfer
4 Citations (Scopus)

DNA methylation profiling is a method of choice for molecular verification of pediatric WNT-activated medulloblastomas

Korshunov, A., Sahm, F., Zheludkova, O., Golanov, A., Stichel, D., Schrimpf, D., Ryzhova, M., Potapov, A., Habel, A., Meyer, J., Lichter, P., Jones, D. T. W., Von Deimling, A., Pfister, S. M. & Kool, M., Feb 14 2019, In : Neuro-oncology. 21, 2, p. 214-221 8 p.

Research output: Contribution to journalArticle

Medulloblastoma
DNA Fingerprinting
DNA Methylation
Pediatrics
Monosomy
9 Citations (Scopus)

Evolutionary Trajectories of IDH WT Glioblastomas Reveal a Common Path of Early Tumorigenesis Instigated Years ahead of Initial Diagnosis

Körber, V., Yang, J., Barah, P., Wu, Y., Stichel, D., Gu, Z., Fletcher, M. N. C., Jones, D., Hentschel, B., Lamszus, K., Tonn, J. C., Schackert, G., Sabel, M., Felsberg, J., Zacher, A., Kaulich, K., Hübschmann, D., Herold-Mende, C., von Deimling, A., Weller, M. & 5 others, Radlwimmer, B., Schlesner, M., Reifenberger, G., Höfer, T. & Lichter, P., Apr 15 2019, In : Cancer cell. 35, 4, p. 692-704.e12

Research output: Contribution to journalArticle

Glioblastoma
Carcinogenesis
Mutation
Chromosomes
Growth
5 Citations (Scopus)

Genomic and transcriptomic changes complement each other in the pathogenesis of sporadic Burkitt lymphoma

ICGC MMML-Seq Consortium, Dec 1 2019, In : Nature communications. 10, 1, 1459.

Research output: Contribution to journalArticle

pathogenesis
Burkitt Lymphoma
genome
mutations
complement
7 Citations (Scopus)

Integrated molecular characterization of IDH-mutant glioblastomas

Korshunov, A., Casalini, B., Chavez, L., Hielscher, T., Sill, M., Ryzhova, M., Sharma, T., Schrimpf, D., Stichel, D., Capper, D., Reuss, D. E., Sturm, D., Absalyamova, O., Golanov, A., Lambo, S., Bewerunge-Hudler, M., Lichter, P., Herold-Mende, C., Wick, W., Pfister, S. M. & 4 others, Kool, M., Jones, D. T. W., von Deimling, A. & Sahm, F., Feb 1 2019, In : Neuropathology and Applied Neurobiology. 45, 2, p. 108-118 11 p.

Research output: Contribution to journalArticle

Isocitrate Dehydrogenase
Glioblastoma
DNA Methylation
Astrocytoma
Genetic Markers
1 Citation (Scopus)

Linking aberrant chromatin features in chronic lymphocytic leukemia to transcription factor networks

Mallm, J. P., Iskar, M., Ishaque, N., Klett, L. C., Kugler, S. J., Muino, J. M., Teif, V. B., Poos, A. M., Großmann, S., Erdel, F., Tavernari, D., Koser, S. D., Schumacher, S., Brors, B., König, R., Remondini, D., Vingron, M., Stilgenbauer, S., Lichter, P., Zapatka, M. & 2 others, Mertens, D. & Rippe, K., May 2019, In : Molecular Systems Biology. 15, 5, e8339.

Research output: Contribution to journalArticle

Open Access
lymphocytic leukemia
Transcription factors
Chromatin
Leukemia
B-Cell Chronic Lymphocytic Leukemia
2 Citations (Scopus)

Longitudinal molecular trajectories of diffuse glioma in adults

The GLASS Consortium, Dec 5 2019, In : Nature. 576, 7785, p. 112-120 9 p.

Research output: Contribution to journalArticle

Glioma
Recurrence
Chromosome Deletion
Mutation
Survival
2 Citations (Scopus)

Mismatch repair deficiency drives durable complete remission by targeting programmed death receptor 1 in a metastatic luminal breast cancer patient

Fremd, C., Hlevnjak, M., Zapatka, M., Zoernig, I., Halama, N., Fejzibegovic, N., Thewes, V., Lichter, P., Schirmacher, P., Kloor, M., Marmé, F., Schütz, F., Kosaloglu, Z., Sinn, H. P., Jäger, D. & Schneeweiss, A., Mar 1 2019, In : Breast Care. 14, 1, p. 53-59 7 p.

Research output: Contribution to journalArticle

Death Domain Receptors
Breast Neoplasms
Exome
DNA Mismatch Repair
Neoplasms

Molecular progression of SHH-activated medulloblastomas

Korshunov, A., Okonechnikov, K., Sahm, F., Ryzhova, M., Stichel, D., Sievers, P., Meyer, J., Schrimpf, D., Zheludkova, O., Golanov, A., Lichter, P., Jones, D. T. W., Pfister, S. M., von Deimling, A. & Kool, M., Aug 1 2019, In : Acta neuropathologica. 138, 2, p. 327-330 4 p.

Research output: Contribution to journalLetter

Medulloblastoma
3 Citations (Scopus)

PI3Kδ inhibition modulates regulatory and effector T-cell differentiation and function in chronic lymphocytic leukemia

Hanna, B. S., Roessner, P. M., Scheffold, A., Jebaraj, B. M. C., Demerdash, Y., Öztürk, S., Lichter, P., Stilgenbauer, S. & Seiffert, M., Jun 1 2019, In : Leukemia. 33, 6, p. 1427-1438 12 p.

Research output: Contribution to journalArticle

Regulatory T-Lymphocytes
B-Cell Chronic Lymphocytic Leukemia
Phosphatidylinositol 3-Kinases
Cell Differentiation
T-Lymphocytes
3 Citations (Scopus)

Rejection of adoptively transferred Eµ-TCL1 chronic lymphocytic leukemia cells in C57BL/6 substrains or knockout mouse lines

Öztürk, S., Roessner, P. M., Schulze-Edinghausen, L., Yazdanparast, H., Kalter, V., Lichter, P., Hanna, B. S. & Seiffert, M., Jun 1 2019, In : Leukemia. 33, 6, p. 1514-1539 26 p.

Research output: Contribution to journalLetter

B-Cell Chronic Lymphocytic Leukemia
Knockout Mice
2 Citations (Scopus)

Selective BTK inhibition improves bendamustine therapy response and normalizes immune effector functions in chronic lymphocytic leukemia

Lee-Vergés, E., Hanna, B. S., Yazdanparast, H., Rodríguez, V., Rodríguez, M. L., Giró, A., Vidal-Crespo, A., Rosich, L., Amador, V., Aymerich, M., Villamor, N., Delgado, J., Lichter, P., Pérez-Galán, P., López-Guerra, M., Campo, E., Seiffert, M. & Colomer, D., Jun 1 2019, In : International Journal of Cancer. 144, 11, p. 2762-2773 12 p.

Research output: Contribution to journalArticle

B-Cell Chronic Lymphocytic Leukemia
Therapeutics
T-Lymphocytes
Adoptive Transfer
Chemotaxis

TBET-expressing Th1 CD4+ T cells accumulate in chronic lymphocytic leukaemia without affecting disease progression in Eµ-TCL1 mice

Roessner, P. M., Hanna, B. S., Öztürk, S., Schulz, R., Llaó Cid, L., Yazdanparast, H., Scheffold, A., Colomer, D., Stilgenbauer, S., Lichter, P. & Seiffert, M., Jan 1 2019, (Accepted/In press) In : British Journal of Haematology.

Research output: Contribution to journalArticle

Open Access
B-Cell Chronic Lymphocytic Leukemia
Th1 Cells
Disease Progression
T-Lymphocytes
Leukemia

TelomereHunter - In silico estimation of telomere content and composition from cancer genomes

Feuerbach, L., Sieverling, L., Deeg, K. I., Ginsbach, P., Hutter, B., Buchhalter, I., Northcott, P. A., Mughal, S. S., Chudasama, P., Glimm, H., Scholl, C., Lichter, P., Fröhling, S., Pfister, S. M., Jones, D. T. W., Rippe, K. & Brors, B., May 28 2019, In : BMC bioinformatics. 20, 1, 272.

Research output: Contribution to journalArticle

Open Access
Telomere
Computer Simulation
Cancer
Genome
Genes
2018
12 Citations (Scopus)

A biobank of patient-derived pediatric brain tumor models

Brabetz, S., Leary, S. E. S., Gröbner, S. N., Nakamoto, M. W., Şeker-Cin, H., Girard, E. J., Cole, B., Strand, A. D., Bloom, K. L., Hovestadt, V., Mack, N. L., Pakiam, F., Schwalm, B., Korshunov, A., Balasubramanian, G. P., Northcott, P. A., Pedro, K. D., Dey, J., Hansen, S., Ditzler, S. & 7 others, Lichter, P., Chavez, L., Jones, D. T. W., Koster, J., Pfister, S. M., Kool, M. & Olson, J. M., Nov 1 2018, In : Nature medicine. 24, 11, p. 1752-1761 10 p.

Research output: Contribution to journalArticle

Pediatrics
Brain Neoplasms
Tumors
Brain
Heterografts
3 Citations (Scopus)

Altered nuclear envelope structure and proteasome function of micronuclei

Maass, K. K., Rosing, F., Ronchi, P., Willmund, K. V., Devens, F., Hergt, M., Herrmann, H., Lichter, P. & Ernst, A., Oct 15 2018, In : Experimental Cell Research. 371, 2, p. 353-363 11 p.

Research output: Contribution to journalArticle

Nuclear Envelope
Proteasome Endopeptidase Complex
Nuclear Proteins
Lysosomes
DNA Damage
4 Citations (Scopus)

A novel cloning strategy for one-step assembly of multiplex CRISPR vectors

Zuckermann, M., Hlevnjak, M., Yazdanparast, H., Zapatka, M., Jones, D. T. W., Lichter, P. & Gronych, J., Dec 1 2018, In : Scientific reports. 8, 1, 17499.

Research output: Contribution to journalArticle

Clustered Regularly Interspaced Short Palindromic Repeats
Guide RNA
Organism Cloning
Plasmids
Activation Analysis
1 Citation (Scopus)

A PRDX1-p38α heterodimer amplifies MET-driven invasion of IDH-wildtype and IDH-mutant gliomas

Wirthschaft, P., Bode, J., Simon, A. E. M., Hoffmann, E., van Laack, R., Krüwel, T., Dietrich, F., Bucher, D., Hahn, A., Sahm, F., Breckwoldt, M. O., Kurz, F. T., Hielscher, T., Fischer, B., Dross, N., Ruiz de Almodovar, C., von Deimling, A., Herold-Mende, C., Plass, C., Boulant, S. & 5 others, Wiestler, B., Reifenberger, G., Lichter, P., Wick, W. & Tews, B., Sep 1 2018, In : International Journal of Cancer. 143, 5, p. 1176-1187 12 p.

Research output: Contribution to journalArticle

Peroxiredoxins
Isocitrate Dehydrogenase
Glioma
Hepatocyte Growth Factor
Brain
2 Citations (Scopus)

Cited4 is a sex-biased mediator of the antidiabetic glitazone response in adipocyte progenitors

Bayindir-Buchhalter, I., Wolff, G., Lerch, S., Sijmonsma, T., Schuster, M., Gronych, J., Billeter, A. T., Babaei, R., Krunic, D., Ketscher, L., Spielmann, N., Hrabe de Angelis, M., Ruas, J. L., Müller-Stich, B. P., Heikenwalder, M., Lichter, P., Herzig, S. & Vegiopoulos, A., Aug 2018, In : EMBO Molecular Medicine. 10, 8, e8613.

Research output: Contribution to journalArticle

rosiglitazone
Thiazolidinediones
Hypoglycemic Agents
Adipocytes
Adipose Tissue

Correction: The landscape of genomic alterations across childhood cancers (Nature (2018) DOI: 10.1038/nature25480)

Gröbner, S. N., Worst, B. C., Weischenfeldt, J., Buchhalter, I., Kleinheinz, K., Rudneva, V. A., Johann, P. D., Balasubramanian, G. P., Segura-Wang, M., Brabetz, S., Bender, S., Hutter, B., Sturm, D., Pfaff, E., Hübschmann, D., Zipprich, G., Heinold, M., Eils, J., Lawerenz, C., Erkek, S. & 64 others, Lambo, S., Waszak, S., Blattmann, C., Borkhardt, A., Kuhlen, M., Eggert, A., Fulda, S., Gessler, M., Wegert, J., Kappler, R., Baumhoer, D., Burdach, S., Kirschner-Schwabe, R., Kontny, U., Kulozik, A. E., Lohmann, D., Hettmer, S., Eckert, C., Bielack, S., Nathrath, M., Niemeyer, C., Richter, G. H., Schulte, J., Siebert, R., Westermann, F., Molenaar, J. J., Vassal, G., Witt, H., Burkhardt, B., Kratz, C. P., Witt, O., Van Tilburg, C. M., Kramm, C. M., Fleischhack, G., Dirksen, U., Rutkowski, S., Frühwald, M., Von Hoff, K., Wolf, S., Klingebiel, T., Koscielniak, E., Landgraf, P., Koster, J., Resnick, A. C., Zhang, J., Liu, Y., Zhou, X., Waanders, A. J., Zwijnenburg, D. A., Raman, P., Brors, B., Weber, U. D., Northcott, P. A., Pajtler, K. W., Kool, M., Piro, R. M., Korbel, J. O., Schlesner, M., Eils, R., Jones, D. T. W., Lichter, P., Chavez, L., Zapatka, M. & Pfister, S. M., Jul 19 2018, In : Nature. 559, 7714, p. E10

Research output: Contribution to journalComment/debate

Neurobiology
Research
Neoplasms

Cortactin expression: Association with disease progression and survival in oral squamous cell carcinoma

Horn, D., Gross, M., Dyckhoff, G., Fuchs, J., Grabe, N., Weichert, W., Herpel, E., Herold-Mende, C., Lichter, P., Hoffmann, J., Hess, J. & Freier, K., Dec 1 2018, In : Head and Neck. 40, 12, p. 2685-2694 10 p.

Research output: Contribution to journalArticle

Cortactin
Disease Progression
Squamous Cell Carcinoma
Survival
Gene Expression Profiling
1 Citation (Scopus)

CRISPR-mediated loss of function analysis in cerebellar granule cells using in utero electroporation-based gene transfer

Feng, W., Herbst, L., Lichter, P., Pfister, S. M., Liu, H. K. & Kawauchi, D., Jun 9 2018, In : Journal of Visualized Experiments. 2018, 136, e57311.

Research output: Contribution to journalArticle

Clustered Regularly Interspaced Short Palindromic Repeats
Gene transfer
Electroporation
Genes
Brain
2 Citations (Scopus)

Defective DNA damage repair leads to frequent catastrophic genomic events in murine and human tumors

Ratnaparkhe, M., Wong, J. K. L., Wei, P. C., Hlevnjak, M., Kolb, T., Simovic, M., Haag, D., Paul, Y., Devens, F., Northcott, P., Jones, D. T. W., Kool, M., Jauch, A., Pastorczak, A., Mlynarski, W., Korshunov, A., Kumar, R., Downing, S. M., Pfister, S. M., Zapatka, M. & 4 others, McKinnon, P. J., Alt, F. W., Lichter, P. & Ernst, A., Nov 12 2018, In : Nature communications. 9, 1, 1 p.

Research output: Contribution to journalArticle

DNA Repair
DNA Damage
Tumors
Repair
tumors
276 Citations (Scopus)

DNA methylation-based classification of central nervous system tumours

Capper, D., Jones, D. T. W., Sill, M., Hovestadt, V., Schrimpf, D., Sturm, D., Koelsche, C., Sahm, F., Chavez, L., Reuss, D. E., Kratz, A., Wefers, A. K., Huang, K., Pajtler, K. W., Schweizer, L., Stichel, D., Olar, A., Engel, N. W., Lindenberg, K., Harter, P. N. & 123 others, Braczynski, A. K., Plate, K. H., Dohmen, H., Garvalov, B. K., Coras, R., Hölsken, A., Hewer, E., Bewerunge-Hudler, M., Schick, M., Fischer, R., Beschorner, R., Schittenhelm, J., Staszewski, O., Wani, K., Varlet, P., Pages, M., Temming, P., Lohmann, D., Selt, F., Witt, H., Milde, T., Witt, O., Aronica, E., Giangaspero, F., Rushing, E., Scheurlen, W., Geisenberger, C., Rodriguez, F. J., Becker, A., Preusser, M., Haberler, C., Bjerkvig, R., Cryan, J., Farrell, M., Deckert, M., Hench, J., Frank, S., Serrano, J., Kannan, K., Tsirigos, A., Brück, W., Hofer, S., Brehmer, S., Seiz-Rosenhagen, M., Hänggi, D., Hans, V., Rozsnoki, S., Hansford, J. R., Kohlhof, P., Kristensen, B. W., Lechner, M., Lopes, B., Mawrin, C., Ketter, R., Kulozik, A., Khatib, Z., Heppner, F., Koch, A., Jouvet, A., Keohane, C., Mühleisen, H., Mueller, W., Pohl, U., Prinz, M., Benner, A., Zapatka, M., Gottardo, N. G., Driever, P. H., Kramm, C. M., Müller, H. L., Rutkowski, S., Von Hoff, K., Frühwald, M. C., Gnekow, A., Fleischhack, G., Tippelt, S., Calaminus, G., Monoranu, C. M., Perry, A., Jones, C., Jacques, T. S., Radlwimmer, B., Gessi, M., Pietsch, T., Schramm, J., Schackert, G., Westphal, M., Reifenberger, G., Wesseling, P., Weller, M., Collins, V. P., Blümcke, I., Bendszus, M., Debus, J., Huang, A., Jabado, N., Northcott, P. A., Paulus, W., Gajjar, A., Robinson, G. W., Taylor, M. D., Jaunmuktane, Z., Ryzhova, M., Platten, M., Unterberg, A., Wick, W., Karajannis, M. A., Mittelbronn, M., Acker, T., Hartmann, C., Aldape, K., Schüller, U., Buslei, R., Lichter, P., Kool, M., Herold-Mende, C., Ellison, D. W., Hasselblatt, M., Snuderl, M., Brandner, S., Korshunov, A., Von Deimling, A. & Pfister, S. M., Mar 22 2018, In : Nature. 555, 7697, p. 469-474 6 p.

Research output: Contribution to journalArticle

Central Nervous System Neoplasms
DNA Methylation
Neoplasms
Observer Variation
Age Groups
26 Citations (Scopus)

Epithelioid glioblastomas stratify into established diagnostic subsets upon integrated molecular analysis

Korshunov, A., Chavez, L., Sharma, T., Ryzhova, M., Schrimpf, D., Stichel, D., Capper, D., Sturm, D., Kool, M., Habel, A., Kleinschmidt-DeMasters, B. K., Rosenblum, M., Absalyamova, O., Golanov, A., Lichter, P., Pfister, S. M., Jones, D. T. W., Perry, A. & von Deimling, A., Sep 1 2018, In : Brain Pathology. 28, 5, p. 656-662 7 p.

Research output: Contribution to journalArticle

Glioblastoma
Neoplasms
Methylation
Young Adult
Pediatrics
1 Citation (Scopus)

Erratum to: BCAT1 restricts αKG levels in AML stem cells leading to IDHmut-like DNA hypermethylation (Nature, (2017), 551, 7680, (384-388), 10.1038/nature24294)

Raffel, S., Falcone, M., Kneisel, N., Hansson, J., Wang, W., Lutz, C., Bullinger, L., Poschet, G., Nonnenmacher, Y., Barnert, A., Bahr, C., Zeisberger, P., Przybylla, A., Sohn, M., Tönjes, M., Erez, A., Adler, L., Jensen, P., Scholl, C., Fröhling, S. & 14 others, Cocciardi, S., Wuchter, P., Thiede, C., Flörcken, A., Westermann, J., Ehninger, G., Lichter, P., Hiller, K., Hell, R., Herrmann, C., Ho, A. D., Krijgsveld, J., Radlwimmer, B. & Trumpp, A., Aug 16 2018, In : Nature. 560, 7718, p. E28

Research output: Contribution to journalComment/debate

Proteome
Flow Cytometry
Stem Cells
Phenotype
DNA
8 Citations (Scopus)

Molecular characterization of medulloblastomas with extensive nodularity (MBEN)

Korshunov, A., Sahm, F., Stichel, D., Schrimpf, D., Ryzhova, M., Zheludkova, O., Golanov, A., Lichter, P., Jones, D. T. W., von Deimling, A., Pfister, S. M. & Kool, M., Aug 1 2018, In : Acta neuropathologica. 136, 2, p. 303-313 11 p.

Research output: Contribution to journalArticle

Medulloblastoma
Histology
Germ Cells
Mutation
DNA Methylation
8 Citations (Scopus)

NFATC1 activation by DNA hypomethylation in chronic lymphocytic leukemia correlates with clinical staging and can be inhibited by ibrutinib

Wolf, C., Garding, A., Filarsky, K., Bahlo, J., Robrecht, S., Becker, N., Zucknick, M., Rouhi, A., Weigel, A., Claus, R., Weichenhan, D., Eichhorst, B., Fischer, K., Hallek, M., Kuchenbauer, F., Plass, C., Döhner, H., Stilgenbauer, S., Lichter, P. & Mertens, D., Jan 15 2018, In : International Journal of Cancer. 142, 2, p. 322-333 12 p.

Research output: Contribution to journalArticle

B-Cell Chronic Lymphocytic Leukemia
B-Lymphocytes
DNA
DNA Methylation
NFATC Transcription Factors
44 Citations (Scopus)

Risk-adapted therapy for young children with medulloblastoma (SJYC07): therapeutic and molecular outcomes from a multicentre, phase 2 trial

Robinson, G. W., Rudneva, V. A., Buchhalter, I., Billups, C. A., Waszak, S. M., Smith, K. S., Bowers, D. C., Bendel, A., Fisher, P. G., Partap, S., Crawford, J. R., Hassall, T., Indelicato, D. J., Boop, F., Klimo, P., Sabin, N. D., Patay, Z., Merchant, T. E., Stewart, C. F., Orr, B. A. & 13 others, Korbel, J. O., Jones, D. T. W., Sharma, T., Lichter, P., Kool, M., Korshunov, A., Pfister, S. M., Gilbertson, R. J., Sanders, R. P., Onar-Thomas, A., Ellison, D. W., Gajjar, A. & Northcott, P. A., Jun 2018, In : The lancet oncology. 19, 6, p. 768-784 17 p.

Research output: Contribution to journalArticle

Medulloblastoma
Disease-Free Survival
Methylation
Therapeutics
Cyclophosphamide
43 Citations (Scopus)

Spectrum and prevalence of genetic predisposition in medulloblastoma: a retrospective genetic study and prospective validation in a clinical trial cohort

Waszak, S. M., Northcott, P. A., Buchhalter, I., Robinson, G. W., Sutter, C., Groebner, S., Grund, K. B., Brugières, L., Jones, D. T. W., Pajtler, K. W., Morrissy, A. S., Kool, M., Sturm, D., Chavez, L., Ernst, A., Brabetz, S., Hain, M., Zichner, T., Segura-Wang, M., Weischenfeldt, J. & 67 others, Rausch, T., Mardin, B. R., Zhou, X., Baciu, C., Lawerenz, C., Chan, J. A., Varlet, P., Guerrini-Rousseau, L., Fults, D. W., Grajkowska, W., Hauser, P., Jabado, N., Ra, Y. S., Zitterbart, K., Shringarpure, S. S., De La Vega, F. M., Bustamante, C. D., Ng, H. K., Perry, A., MacDonald, T. J., Hernáiz Driever, P., Bendel, A. E., Bowers, D. C., McCowage, G., Chintagumpala, M. M., Cohn, R., Hassall, T., Fleischhack, G., Eggen, T., Wesenberg, F., Feychting, M., Lannering, B., Schüz, J., Johansen, C., Andersen, T. V., Röösli, M., Kuehni, C. E., Grotzer, M., Kjaerheim, K., Monoranu, C. M., Archer, T. C., Duke, E., Pomeroy, S. L., Shelagh, R., Frank, S., Sumerauer, D., Scheurlen, W., Ryzhova, M. V., Milde, T., Kratz, C. P., Samuel, D., Zhang, J., Solomon, D. A., Marra, M., Eils, R., Bartram, C. R., von Hoff, K., Rutkowski, S., Ramaswamy, V., Gilbertson, R. J., Korshunov, A., Taylor, M. D., Lichter, P., Malkin, D., Gajjar, A., Korbel, J. O. & Pfister, S. M., Jun 2018, In : The lancet oncology. 19, 6, p. 785-798 14 p.

Research output: Contribution to journalArticle

Medulloblastoma
Genetic Predisposition to Disease
Retrospective Studies
Clinical Trials
Germ-Line Mutation
177 Citations (Scopus)

The landscape of genomic alterations across childhood cancers

Gröbner, S. N., Worst, B. C., Weischenfeldt, J., Buchhalter, I., Kleinheinz, K., Rudneva, V. A., Johann, P. D., Balasubramanian, G. P., Segura-Wang, M., Brabetz, S., Bender, S., Hutter, B., Sturm, D., Pfaff, E., Hübschmann, D., Zipprich, G., Heinold, M., Eils, J., Lawerenz, C., Erkek, S. & 64 others, Lambo, S., Waszak, S., Blattmann, C., Borkhardt, A., Kuhlen, M., Eggert, A., Fulda, S., Gessler, M., Wegert, J., Kappler, R., Baumhoer, D., Burdach, S., Kirschner-Schwabe, R., Kontny, U., Kulozik, A. E., Lohmann, D., Hettmer, S., Eckert, C., Bielack, S., Nathrath, M., Niemeyer, C., Richter, G. H., Schulte, J., Siebert, R., Westermann, F., Molenaar, J. J., Vassal, G., Witt, H., Zapatka, M., Burkhardt, B., Kratz, C. P., Witt, O., Tilburg, C. M. V., Kramm, C. M., Fleischhack, G., Dirksen, U., Rutkowski, S., Frühwald, M., Hoff, K. V., Wolf, S., Klingebiel, T., Koscielniak, E., Landgraf, P., Koster, J., Resnick, A. C., Zhang, J., Liu, Y., Zhou, X., Waanders, A. J., Zwijnenburg, D. A., Raman, P., Brors, B., Weber, U. D., Northcott, P. A., Pajtler, K. W., Kool, M., Piro, R. M., Korbel, J. O., Schlesner, M., Eils, R., Jones, D. T. W., Lichter, P., Chavez, L. & Pfister, S. M., Mar 15 2018, In : Nature. 555, 7696, p. 321-327 7 p.

Research output: Contribution to journalArticle

Neoplasms
Mutation
Polyploidy
Workflow
Neoplasm Genes
44 Citations (Scopus)

Therapeutic targeting of ependymoma as informed by oncogenic enhancer profiling

Mack, S. C., Pajtler, K. W., Chavez, L., Okonechnikov, K., Bertrand, K. C., Wang, X., Erkek, S., Federation, A., Song, A., Lee, C., Wang, X., McDonald, L., Morrow, J. J., Saiakhova, A., Sin-Chan, P., Wu, Q., Michaelraj, K. A., Miller, T. E., Hubert, C. G., Ryzhova, M. & 55 others, Garzia, L., Donovan, L., Dombrowski, S., Factor, D. C., Luu, B., Valentim, C. L. L., Gimple, R. C., Morton, A., Kim, L., Prager, B. C., Lee, J. J. Y., Wu, X., Zuccaro, J., Thompson, Y., Holgado, B. L., Reimand, J., Ke, S. Q., Tropper, A., Lai, S., Vijayarajah, S., Doan, S., Mahadev, V., Miñan, A. F., Gröbner, S. N., Lienhard, M., Zapatka, M., Huang, Z., Aldape, K. D., Carcaboso, A. M., Houghton, P. J., Keir, S. T., Milde, T., Witt, H., Li, Y., Li, C. J., Bian, X. W., Jones, D. T. W., Scott, I., Singh, S. K., Huang, A., Dirks, P. B., Bouffet, E., Bradner, J. E., Ramaswamy, V., Jabado, N., Rutka, J. T., Northcott, P. A., Lupien, M., Lichter, P., Korshunov, A., Scacheri, P. C., Pfister, S. M., Kool, M., Taylor, M. D. & Rich, J. N., Jan 4 2018, In : Nature. 553, 7686, p. 101-105 5 p.

Research output: Contribution to journalArticle

Ependymoma
Gene Fusion
Therapeutics
Neoplasms
Subependymal Glioma
2 Citations (Scopus)

Tumor necrosis factor receptor signaling is a driver of chronic lymphocytic leukemia that can be therapeutically targeted by the flavonoid wogonin

Dürr, C., Hanna, B. S., Schulz, A., Lucas, F., Zucknick, M., Benner, A., Clear, A., Ohl, S., Öztürk, S., Zenz, T., Stilgenbauer, S., Li-Weber, M., Krammer, P. H., Gribben, J. G., Lichter, P. & Seiffert, M., Mar 23 2018, In : Haematologica. 103, 4, p. 688-697 10 p.

Research output: Contribution to journalArticle

Tumor Necrosis Factor Receptors
B-Cell Chronic Lymphocytic Leukemia
Flavonoids
Leukemia
B-Lymphocytes
2017
1 Citation (Scopus)

After 50 years: Future challenges in publishing cancer research

Lichter, P., Jan 1 2017, In : International Journal of Cancer. 140, 1, 1 p.

Research output: Contribution to journalEditorial

Research
Neoplasms
44 Citations (Scopus)

BCAT1 restricts αkG levels in AML stem cells leading to IDHmut-like DNA hypermethylation

Raffel, S., Falcone, M., Kneisel, N., Hansson, J., Wang, W., Lutz, C., Bullinger, L., Poschet, G., Nonnenmacher, Y., Barnert, A., Bahr, C., Zeisberger, P., Przybylla, A., Sohn, M., Tönjes, M., Erez, A., Adler, L., Jensen, P., Scholl, C., Fröhling, S. & 14 others, Cocciardi, S., Wuchter, P., Thiede, C., Flörcken, A., Westermann, J., Ehninger, G., Lichter, P., Hiller, K., Hell, R., Herrmann, C., Ho, A. D., Krijgsveld, J., Radlwimmer, B. & Trumpp, A., Nov 16 2017, In : Nature. 551, 7680, p. 384-388 5 p.

Research output: Contribution to journalArticle

Myeloid Progenitor Cells
Transaminases
Acute Myeloid Leukemia
DNA
Leukemia
7 Citations (Scopus)

Branched-chain ketoacids secreted by glioblastoma cells via MCT1 modulate macrophage phenotype

Silva, L. S., Poschet, G., Nonnenmacher, Y., Becker, H. M., Sapcariu, S., Gaupel, A. C., Schlotter, M., Wu, Y., Kneisel, N., Seiffert, M., Hell, R., Hiller, K., Lichter, P. & Radlwimmer, B., Dec 1 2017, In : EMBO reports. 18, 12, p. 2172-2185 14 p.

Research output: Contribution to journalArticle

Macrophages
Glioblastoma
Tumors
Phenotype
Branched Chain Amino Acids
36 Citations (Scopus)

Chd7 is indispensable for mammalian brain development through activation of a neuronal differentiation programme

Feng, W., Kawauchi, D., Körkel-Qu, H., Deng, H., Serger, E., Sieber, L., Ariel Lieberman, J., Jimeno-Gonzalez, S., Lambo, S., Hanna, B. S., Harim, Y., Jansen, M., Neuerburg, A., Friesen, O., Zuckermann, M., Rajendran, V., Gronych, J., Ayrault, O., Korshunov, A., Jones, D. T. W. & 6 others, Kool, M., Northcott, P. A., Lichter, P., Cortés-Ledesma, F., Pfister, S. M. & Liu, H. K., Mar 20 2017, In : Nature communications. 8, 14758.

Research output: Contribution to journalArticle

DNA-Binding Proteins
neurons
chromatin
Neurons
brain
10 Citations (Scopus)

Genomic profiling of Acute lymphoblastic leukemia in ataxia telangiectasia patients reveals tight link between ATM mutations and chromothripsis

Ratnaparkhe, M., Hlevnjak, M., Kolb, T., Jauch, A., Maass, K. K., Devens, F., Rode, A., Hovestadt, V., Korshunov, A., Pastorczak, A., Mlynarski, W., Sungalee, S., Korbel, J., Hoell, J., Fischer, U., Milde, T., Kramm, C., Nathrath, M., Chrzanowska, K., Tausch, E. & 18 others, Takagi, M., Taga, T., Constantini, S., Loeffen, J., Meijerink, J., Zielen, S., Gohring, G., Schlegelberger, B., Maass, E., Siebert, R., Kunz, J., Kulozik, A. E., Worst, B., Jones, D. T., Pfister, S. M., Zapatka, M., Lichter, P. & Ernst, A., Oct 1 2017, In : Leukemia. 31, 10, p. 2048-2056 9 p.

Research output: Contribution to journalArticle

Ataxia Telangiectasia
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Mutation
Genomic Instability
Chromosomes
17 Citations (Scopus)

Novel MYC-driven medulloblastoma models from multiple embryonic cerebellar cells

Kawauchi, D., Ogg, R. J., Liu, L., Shih, D. J. H., Finkelstein, D., Murphy, B. L., Rehg, J. E., Korshunov, A., Calabrese, C., Zindy, F., Phoenix, T., Kawaguchi, Y., Gronych, J., Gilbertson, R. J., Lichter, P., Gajjar, A., Kool, M., Northcott, P. A., Pfister, S. M. & Roussel, M. F., Sep 14 2017, In : Oncogene. 36, 37, p. 5231-5242 12 p.

Research output: Contribution to journalArticle

Medulloblastoma
Fourth Ventricle
Molecular Models
Electroporation
Luciferases
40 Citations (Scopus)

Spatial heterogeneity in medulloblastoma

Morrissy, A. S., Cavalli, F. M. G., Remke, M., Ramaswamy, V., Shih, D. J. H., Holgado, B. L., Farooq, H., Donovan, L. K., Garzia, L., Agnihotri, S., Kiehna, E. N., Mercier, E., Mayoh, C., Papillon-Cavanagh, S., Nikbakht, H., Gayden, T., Torchia, J., Picard, D., Merino, D. M., Vladoiu, M. & 59 others, Luu, B., Wu, X., Daniels, C., Horswell, S., Thompson, Y. Y., Hovestadt, V., Northcott, P. A., Jones, D. T. W., Peacock, J., Wang, X., Mack, S. C., Reimand, J., Albrecht, S., Fontebasso, A. M., Thiessen, N., Li, Y., Schein, J. E., Lee, D., Carlsen, R., Mayo, M., Tse, K., Tam, A., Dhalla, N., Ally, A., Chuah, E., Cheng, Y., Plettner, P., Li, H. I., Corbett, R. D., Wong, T., Long, W., Loukides, J., Buczkowicz, P., Hawkins, C. E., Tabori, U., Rood, B. R., Myseros, J. S., Packer, R. J., Korshunov, A., Lichter, P., Kool, M., Pfister, S. M., Schüller, U., Dirks, P., Huang, A., Bouffet, E., Rutka, J. T., Bader, G. D., Swanton, C., Ma, Y., Moore, R. A., Mungall, A. J., Majewski, J., Jones, S. J. M., Das, S., Malkin, D., Jabado, N., Marra, M. A. & Taylor, M. D., May 1 2017, In : Nature Genetics. 49, 5, p. 780-788 9 p.

Research output: Contribution to journalArticle

Medulloblastoma
Biopsy
Glioma
Neoplasms
Mutation

Special Section: From Genes to Bedside and Back

Lichter, P. & von Kalle, C., Sep 1 2017, In : International Journal of Cancer. 141, 5, 1 p.

Research output: Contribution to journalEditorial

Genes
4 Citations (Scopus)

TALEN/CRISPR-mediated engineering of a promoterless anti-viral RNAi hairpin into an endogenous miRNA locus

Seńis, E., Mockenhaupt, S., Rupp, D., Bauer, T., Paramasivam, N., Knapp, B., Gronych, J., Grosse, S., Windisch, M. P., Schmidt, F., Theis, F. J., Eils, R., Lichter, P., Schlesner, M., Bartenschlager, R. & Grimm, D., Jan 1 2017, In : Nucleic acids research. 45, 1, e3.

Research output: Contribution to journalArticle

Clustered Regularly Interspaced Short Palindromic Repeats
RNA Interference
MicroRNAs
Hepacivirus
Genome
14 Citations (Scopus)

The branched-chain amino acid transaminase 1 sustains growth of antiestrogen-resistant and ERα-negative breast cancer

Thewes, V., Simon, R., Hlevnjak, M., Schlotter, M., Schroeter, P., Schmidt, K., Wu, Y., Anzeneder, T., Wang, W., Windisch, P., Kirchgäßner, M., Melling, N., Kneisel, N., Büttner, R., Deuschle, U., Sinn, H. P., Schneeweiss, A., Heck, S., Kaulfuss, S., Hess-Stumpp, H. & 7 others, Okun, J. G., Sauter, G., Lykkesfeldt, A. E., Zapatka, M., Radlwimmer, B., Lichter, P. & Tönjes, M., Jul 20 2017, In : Oncogene. 36, 29, p. 4124-4134 11 p.

Research output: Contribution to journalArticle

Estrogen Receptor Modulators
Breast Neoplasms
Growth
Tamoxifen
branched-chain-amino-acid transaminase