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2020

FLT3 inhibitors in acute myeloid leukemia: ten frequently asked questions

Antar, A. I., Otrock, Z. K., Jabbour, E., Mohty, M. & Bazarbachi, A., Jan 1 2020, (Accepted/In press) In : Leukemia.

Research output: Contribution to journalReview article

Acute Myeloid Leukemia
Protein-Tyrosine Kinases
4'-N-benzoylstaurosporine
Phosphotransferases
Consolidation Chemotherapy

Impact of minimal residual disease status in patients with relapsed/refractory acute lymphoblastic leukemia treated with inotuzumab ozogamicin in the phase III INO-VATE trial

Jabbour, E., Gökbuget, N., Advani, A., Stelljes, M., Stock, W., Liedtke, M., Martinelli, G., O'Brien, S., Wang, T., Laird, A. D., Vandendries, E., Neuhof, A., Nguyen, K., Dakappagari, N., DeAngelo, D. J. & Kantarjian, H., Jan 2020, In : Leukemia Research. 88, 106283.

Research output: Contribution to journalArticle

Open Access
Residual Neoplasm
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Survival
Inotuzumab Ozogamicin
Disease-Free Survival
Gene Frequency
Acute Myeloid Leukemia
Mutation
Survival
Leukocyte Count
Leukemia, Myeloid, Chronic Phase
Pleural Effusion
Therapeutics
Cytogenetics
bcr-abl Fusion Proteins

Targeted therapy paves the way for the cure of acute lymphoblastic leukaemia

Rafei, H., Kantarjian, H. M. & Jabbour, E. J., Jan 1 2020, In : British Journal of Haematology. 188, 2, p. 207-223 17 p.

Research output: Contribution to journalReview article

Precursor Cell Lymphoblastic Leukemia-Lymphoma
Protein-Tyrosine Kinases
Therapeutics
Bispecific Antibodies
Philadelphia Chromosome

The face of remission induction

Paul, S., Rausch, C. R. & Jabbour, E. J., Jan 1 2020, In : British Journal of Haematology. 188, 1, p. 101-115 15 p.

Research output: Contribution to journalReview article

Remission Induction
Acute Myeloid Leukemia
Therapeutics
Age Factors
Standard of Care
2019
1 Citation (Scopus)
Homologous Transplantation
Graft vs Host Disease
Neoplasms
Stem Cell Transplantation
Lymphoma
7 Citations (Scopus)

Analysis of cardiovascular and arteriothrombotic adverse events in chronic-phase CML patients after frontline TKIs

Jain, P., Kantarjian, H., Boddu, P. C., Nogueras-González, G. M., Verstovsek, S., Garcia-Manero, G., Borthakur, G., Sasaki, K., Kadia, T. M., Sam, P., Ahaneku, H., O’Brien, S., Estrov, Z., Ravandi, F., Jabbour, E. & Cortes, J. E., Mar 26 2019, In : Blood Advances. 3, 6, p. 851-861 11 p.

Research output: Contribution to journalArticle

Open Access
Leukemia, Myeloid, Chronic Phase
Protein-Tyrosine Kinases
Incidence
Confidence Intervals
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
3 Citations (Scopus)

A phase 2 study of pracinostat combined with ruxolitinib in patients with myelofibrosis

Bose, P., Swaminathan, M., Pemmaraju, N., Ferrajoli, A., Jabbour, E. J., Daver, N., DiNardo, C., Alvarado, Y., Yilmaz, M., Huynh-Lu, J., Qiao, W., Wang, X., Matamoros Jr, A., Zhou, L., Pierce, S., Schroeder, K. D., Kantarjian, H. M. & Verstovsek, S., Jun 7 2019, In : Leukemia and Lymphoma. 60, 7, p. 1767-1774 8 p.

Research output: Contribution to journalArticle

Primary Myelofibrosis
Histone Deacetylase Inhibitors
Palpation
Splenomegaly
INCB018424
Leukemia, Myelomonocytic, Chronic
Myelodysplastic Syndromes
Diploidy
Cytogenetics
Survival

Blinatumomab for the treatment of acute lymphoblastic leukemia: an update

Rausch, C. R., Paul, S., Nasnas, P. E., Kantarjian, H. M. & Jabbour, E. J., Feb 1 2019, In : Expert Opinion on Orphan Drugs. 7, 2, p. 41-46 6 p.

Research output: Contribution to journalArticle

Precursor Cell Lymphoblastic Leukemia-Lymphoma
Philadelphia Chromosome
Therapeutics
Phase III Clinical Trials
Expert Testimony
5 Citations (Scopus)

CD123 expression patterns and selective targeting with a CD123-targeted antibody-drug conjugate (IMGN632) in acute lymphoblastic leukemia

Angelova, E., Audette, C., Kovtun, Y., Daver, N., Wang, S. A., Pierce, S., Konoplev, S. N., Khogeer, H., Jorgensen, J. L., Konopleva, M., Zweidler-McKay, P. A., Medeiros, L. J., Kantarjian, H. M., Jabbour, E. J. & Khoury, J. D., Mar 31 2019, In : Haematologica. 104, 4, p. 749-755 7 p.

Research output: Contribution to journalArticle

Open Access
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Antibodies
Pharmaceutical Preparations
2 Citations (Scopus)
Myelodysplastic Syndromes
Hematopoiesis
Comorbidity
Mutation
Janus Kinase 2
B-Cell Chronic Lymphocytic Leukemia
Research
Therapeutics
Advisory Committees
PCI 32765

Complexity of chronic-phase CML management after failing a second-generation TKI

El Fakih, R., Chaudhri, N., Alfraih, F., Rausch, C. R., Naqvi, K. & Jabbour, E., Jan 1 2019, (Accepted/In press) In : Leukemia and Lymphoma.

Research output: Contribution to journalReview article

Leukemia, Myeloid, Chronic Phase
Protein-Tyrosine Kinases
Treatment Failure
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Protein Synthesis Inhibitors

Development of a symptom assessment in patients with myelofibrosis: Qualitative study findings

Mesa, R. A., Su, Y., Woolfson, A., Prchal, J. T., Turnbull, K., Jabbour, E., Scherber, R., Shields, A. L., Krohe, M., Ojo, F., Pompilus, F., Cappelleri, J. C. & Harrison, C., Apr 11 2019, In : Health and Quality of Life Outcomes. 17, 1, 61.

Research output: Contribution to journalArticle

Open Access
Primary Myelofibrosis
Symptom Assessment
Sweat
Splenomegaly
Ribs
3 Citations (Scopus)
Thymoma
Mediastinal Neoplasms
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Flow Cytometry
Lymphocytes
3 Citations (Scopus)
Open Access
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Therapeutics
In Vitro Techniques
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
Immunophenotyping

Economic modeling to evaluate the impact of chronic myeloid leukemia therapy management on the oncology care model in the US

Jabbour, E. J., Mendiola, M. F., Lingohr-Smith, M., Lin, J. & Makenbaeva, D., Nov 2 2019, In : Journal of Medical Economics. 22, 11, p. 1113-1118 6 p.

Research output: Contribution to journalArticle

Open Access
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Protein-Tyrosine Kinases
Economics
Health Care Costs
Economic Models
33 Citations (Scopus)
Open Access
Azacitidine
Acute Myeloid Leukemia
Biomarkers
Safety
Bone Marrow
Open Access
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Safety
Imatinib Mesylate
Leukemia, Myeloid, Chronic Phase
Generic Drugs
10 Citations (Scopus)

Guadecitabine (SGI-110) in patients with intermediate or high-risk myelodysplastic syndromes: phase 2 results from a multicentre, open-label, randomised, phase 1/2 trial

Garcia-Manero, G., Roboz, G., Walsh, K., Kantarjian, H., Ritchie, E., Kropf, P., O'Connell, C., Tibes, R., Lunin, S., Rosenblat, T., Yee, K., Stock, W., Griffiths, E., Mace, J., Podoltsev, N., Berdeja, J., Jabbour, E., Issa, J. P. J., Hao, Y., Keer, H. N. & 2 others, Azab, M. & Savona, M. R., Jun 2019, In : The Lancet Haematology. 6, 6, p. e317-e327

Research output: Contribution to journalArticle

Myelodysplastic Syndromes
decitabine
Therapeutics
SGI-110
Pneumonia
Residual Neoplasm
Acute Myeloid Leukemia
Transplantation
Transplants
Melphalan
10 Citations (Scopus)

High-grade B-cell lymphomas with TdT expression: a diagnostic and classification dilemma

Ok, C. Y., Medeiros, L. J., Thakral, B., Tang, G., Jain, N., Jabbour, E., Pierce, S. A. & Konoplev, S., Jan 1 2019, In : Modern Pathology. 32, 1, p. 48-58 11 p.

Research output: Contribution to journalArticle

B-Cell Lymphoma
Non-Hodgkin's Lymphoma
Neoplasms
Follicular Lymphoma
B-Lymphoid Precursor Cells
34 Citations (Scopus)
B-Cell Chronic Lymphocytic Leukemia
Chromosome Deletion
Residual Neoplasm
Therapeutics
PCI 32765
1 Citation (Scopus)

Impact of earlier versus later monitoring on disease progression and healthcare costs among patients with chronic myeloid leukemia in the United States

Jabbour, E. J., Siegartel, L. R., Lin, J., Lingohr-Smith, M., Menges, B. & Makenbaeva, D., Feb 23 2019, In : Leukemia and Lymphoma. 60, 3, p. 668-674 7 p.

Research output: Contribution to journalArticle

Cost of Illness
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Health Care Costs
Disease Progression
Odds Ratio
1 Citation (Scopus)
Second Primary Neoplasms
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Protein-Tyrosine Kinases
Incidence
SEER Program
16 Citations (Scopus)

Inotuzumab ozogamicin versus standard of care in relapsed or refractory acute lymphoblastic leukemia: Final report and long-term survival follow-up from the randomized, phase 3 INO-VATE study

Kantarjian, H. M., DeAngelo, D. J., Stelljes, M., Liedtke, M., Stock, W., Gökbuget, N., O’Brien, S. M., Jabbour, E., Wang, T., Liang White, J., Sleight, B., Vandendries, E. & Advani, A. S., Jul 15 2019, In : Cancer. 125, 14, p. 2474-2487 14 p.

Research output: Contribution to journalArticle

Open Access
Standard of Care
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Survival
Hepatic Veno-Occlusive Disease
B-Lymphoid Precursor Cells
5 Citations (Scopus)
Clonal Evolution
Acute Myeloid Leukemia
Leukemia
Recurrence
Therapeutics
2 Citations (Scopus)

Maintenance therapy in AML: The past, the present and the future

Molica, M., Breccia, M., Foa, R., Jabbour, E. & Kadia, T. M., Nov 1 2019, In : American journal of hematology. 94, 11, p. 1254-1265 12 p.

Research output: Contribution to journalReview article

Acute Myeloid Leukemia
Therapeutics
Play Therapy
Recurrence
Standard of Care
Protein-Tyrosine Kinases

New Tool for Monitoring Molecular Response in Patients with Chronic Myeloid Leukemia

Badar, T., Luthra, R., Kantarjian, H., Jabbour, E., Borthakur, G., Garcia-Manero, G., Huang, X., Singh, R., Alvarez, B., Austermiller, B., Morrison, T. B., Patel, K. P. & Cortes, J., Jan 1 2019, In : Applied Immunohistochemistry and Molecular Morphology. 27, 1, p. 33-39 7 p.

Research output: Contribution to journalArticle

Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Nucleic Acids
Polymerase Chain Reaction
Molecular Pathology
Sample Size
3 Citations (Scopus)
B-Cell Leukemia
Myelodysplastic Syndromes
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Bone Marrow
Mutation
2 Citations (Scopus)

NPM1 mutations define a specific subgroup of MDS and MDS/MPN patients with favorable outcomes with intensive chemotherapy

Montalban-Bravo, G., Kanagal-Shamanna, R., Sasaki, K., Patel, K., Ganan-Gomez, I., Jabbour, E., Kadia, T., Ravandi, F., DiNardo, C., Borthakur, G., Takahashi, K., Konopleva, M., Komrokji, R. S., DeZern, A., Kuzmanovic, T., Maciejewski, J., Pierce, S., Colla, S., Sekeres, M. A., Kantarjian, H. & 2 others, Bueso-Ramos, C. & Garcia-Manero, G., Mar 26 2019, In : Blood Advances. 3, 6, p. 922-933 12 p.

Research output: Contribution to journalArticle

Myelodysplastic Syndromes
Drug Therapy
Mutation
Stem Cell Transplantation
Karyotype

Optimizing the use of the hyperCVAD regimen: Clinical vignettes and practical management

Rausch, C. R., Jabbour, E. J., Kantarjian, H. M. & Kadia, T. M., Jan 1 2019, (Accepted/In press) In : Cancer.

Research output: Contribution to journalComment/debate

1 Citation (Scopus)
Leukemia, Myeloid, Chronic Phase
Therapeutics
ponatinib
Blood Vessels
Outcome Assessment (Health Care)
1 Citation (Scopus)

Phase 1/2 study of DFP-10917 administered by continuous intravenous infusion in patients with recurrent or refractory acute myeloid leukemia

Kantarjian, H. M., Jabbour, E. J., Garcia-Manero, G., Kadia, T. M., DiNardo, C. D., Daver, N. G., Borthakur, G., Jain, N., Waukau, J. B., Kwari, M. I., Ravandi, F., Anderson, B. D., Iizuka, K., Jin, C., Zhang, C. & Plunkett, W. K., May 15 2019, In : Cancer. 125, 10, p. 1665-1673 9 p.

Research output: Contribution to journalArticle

Isoflurophate
Intravenous Infusions
Acute Myeloid Leukemia
Maximum Tolerated Dose
Diarrhea
6 Citations (Scopus)
Mitogen-Activated Protein Kinase Kinases
Acute Myeloid Leukemia
Extracellular Signal-Regulated MAP Kinases
Myelodysplastic Syndromes
Mitogens
Philadelphia Chromosome
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Protein-Tyrosine Kinases
Recurrence
Survival

Prognostic implications of cytogenetics in adults with acute lymphoblastic leukemia treated with inotuzumab ozogamicin

Jabbour, E., Advani, A. S., Stelljes, M., Stock, W., Liedtke, M., Gökbuget, N., Martinelli, G., O'Brien, S., White, J. L., Wang, T., Luisa Paccagnella, M., Sleight, B., Vandendries, E., DeAngelo, D. J. & Kantarjian, H. M., Apr 2019, In : American journal of hematology. 94, 4, p. 408-416 9 p.

Research output: Contribution to journalArticle

Precursor Cell Lymphoblastic Leukemia-Lymphoma
Cytogenetics
Metaphase
Diploidy
Karyotype
6 Citations (Scopus)

Recent Advances in Adult Acute Lymphoblastic Leukemia

Richard-Carpentier, G., Kantarjian, H. & Jabbour, E., Jan 1 2019, In : Current hematologic malignancy reports.

Research output: Contribution to journalReview article

Precursor Cell Lymphoblastic Leukemia-Lymphoma
Drug Therapy
Protein-Tyrosine Kinases
Antigen Receptors
T-Cell Antigen Receptor

Recent advances in the treatment of acute lymphoblastic leukemia

Rafei, H., Kantarjian, H. M. & Jabbour, E. J., Sep 19 2019, In : Leukemia and Lymphoma. 60, 11, p. 2606-2621 16 p.

Research output: Contribution to journalReview article

Precursor Cell Lymphoblastic Leukemia-Lymphoma
Protein-Tyrosine Kinases
Therapeutics
Bispecific Antibodies
Philadelphia Chromosome
10 Citations (Scopus)

Recommendations for the assessment and management of measurable residual disease in adults with acute lymphoblastic leukemia: A consensus of North American experts

Short, N. J., Jabbour, E., Albitar, M., de Lima, M., Gore, L., Jorgensen, J., Logan, A. C., Park, J., Ravandi, F., Shah, B., Radich, J. & Kantarjian, H., Feb 1 2019, In : American journal of hematology. 94, 2, p. 257-265 9 p.

Research output: Contribution to journalReview article

Precursor Cell Lymphoblastic Leukemia-Lymphoma
Therapeutics
Leukemia
Recurrence
Survival
Cell- and Tissue-Based Therapy
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Peroxidase
T-Lymphocytes

Reply to Mini-HCVD plus inotuzumab plus or minus blinatumomab: Hype or hope?

Sasaki, K., Kantarjian, H. M. & Jabbour, E. J., Nov 1 2019, In : Cancer. 125, 21, p. 3891-3892 2 p.

Research output: Contribution to journalLetter

blinatumomab
3 Citations (Scopus)

Risk Factors for Development of and Progression of Hepatic Veno-Occlusive Disease/Sinusoidal Obstruction Syndrome

Corbacioglu, S., Jabbour, E. J. & Mohty, M., Jul 2019, In : Biology of Blood and Marrow Transplantation. 25, 7, p. 1271-1280 10 p.

Research output: Contribution to journalReview article

Open Access
Hepatic Veno-Occlusive Disease
oxaliplatin
Drug Therapy
Product Labeling
Thrombelastography